dehydroepiandrosterone and Pregnancy studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
" In the present study 20 infertile women with polycystic ovary syndrome were prospectively randomized in a placebo-controlled study to receive either placebo or prednisolone 10 mg at night, during standard in-vitro fertilization (IVF) treatment."	9.09	Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization. ( Carlström, K; Fridström, M; Hillensjö, T; Sjöblom, P, 1999)
"Dehydroepiandrosterone sulfate induces a significant decrease in the uterine artery PI, which suggests a possible decrease in uterine vascular impedance in term pregnancy."	9.08	Effect of dehydroepiandrosterone sulfate on uterine artery flow velocity waveforms in term pregnancy. ( Hata, K; Hata, T; Kitao, M; Masumura, S; Senoh, D, 1995)
"To investigate whether bolus injection of dehydroepiandrosterone sulfate (DHAS) is associated with changes in fetal middle cerebral artery flow velocity waveforms in term pregnancy."	9.08	Effect of dehydroepiandrosterone sulfate on fetal middle cerebral artery flow velocity waveforms in term pregnancy. ( Hata, K; Hata, T; Kitao, M; Masumura, S; Senoh, D, 1996)
" This study aimed to reveal the mechanism of leptin and NPY in the onset of puberty in male offspring rats after androgen intervention during pregnancy."	8.31	Mechanism of leptin-NPY on the onset of puberty in male offspring rats after androgen intervention during pregnancy. ( Cao, R; Fu, L; Liu, J; Peng, X; Wang, Y; Yuan, Y; Zhang, Y, 2023)
"Almost every female classic galactosemia patient develops primary ovarian insufficiency (POI)."	7.91	Dehydroepiandrosterone supplementation attenuates ovarian ageing in a galactose-induced primary ovarian insufficiency rat model. ( Akouri, R; Demir, N; Erman, M; Gunduz, T; Ozekinci, M; Sozen, B, 2019)
"To determine if in a population of women with diminished oocyte reserve as evidenced by day 3 serum follicle stimulating hormone (FSH) levels > 12 mIU/ml women with lower dehydroepiandrosterone sulfate (DHEA-s) levels produce fewer oocytes or have lower pregnancy rates following in vitro fertilization-embryo transfer (IVF-ET) compared to women with higher levels."	7.78	No evidence to support the concept that low serum dehydroepiandrosterone (DHEA) sulfate (s) levels are associated with less oocyte production or lower pregnancy rates. ( Borman, E; Check, JH; Cohen, R; Mitchell-Williams, J, 2012)
"Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances in women with diminished ovarian reserve (DOR), and to reduce miscarriage rates by 50-80%."	7.76	Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS). ( Barad, DH; Gleicher, N; Weghofer, A, 2010)
"The aim of the present report was to study the role of high levels of dehydroepiandrosterone (DHEA) on the ovarian function and embryonic resorption during early pregnancy in BALB/c mice."	7.73	The influence of dehydroepiandrosterone on early pregnancy in mice. ( Di Girolamo, G; Elia, E; Gonzalez, C; Luchetti, CG; Motta, AB; Sander, V; Solano, ME, 2005)
"Since dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) have been suggested to have immunoregulatory effects, changes in the levels of these substances during and after pregnancy might affect the maternal immune system."	7.72	Serum concentrations of dehydroepiandrosterone and dehydroepiandrosterone sulfate and their relation to cytokine production during and after normal pregnancy. ( Amino, N; Hidaka, Y; Kobayashi, Y; Shimaoka, Y; Tagawa, N; Takano, T, 2004)
"Since it is known that androstenediol (ADIOL) has potent immunoregulatory effects, changes in ADIOL levels during and after pregnancy might affect the maternal immune system."	7.72	Serum concentrations of androstenediol and androstenediol sulfate, and their relation to cytokine production during and after normal pregnancy. ( Amino, N; Hidaka, Y; Kobayashi, Y; Shimaoka, Y; Tagawa, N; Takano, T, 2004)
" We undertook GC/MS analysis of steroids in random maternal urine samples and quantified oestriol, oestriol precursors (dehydroepiandrosterone (DHEA), 5-androstene-3 beta, 17 beta-diol, 16 alpha-hydroxy-dehydroepiandrosterone and 5-androstene-3 beta, 16 alpha, 17 beta-triol), pregnanediol, and five other steroids largely unaffected by pregnancy (androsterone, etiocholanolone, tetrahydrocortisol, 5 alpha-tetrahydrocortisol and tetrahydrocortisone)."	7.70	Steroid sulphatase deficiency is the major cause of extremely low oestriol production at mid-pregnancy: a urinary steroid assay for the discrimination of steroid sulphatase deficiency from other causes. ( Chang, T; Glass, IA; Lam, RC; Roitman, E; Shackleton, CH; Shapiro, LJ, 1998)
"To search for possible effect of dehydroepiandrosterone sulfate (DHAS) on maternal cardiac function in term pregnancy, impedance cardiographic assessments were made on 15 normal full-term pregnant women before and 5, 10, 15, 20, 25, and 30 minutes after the administration of a 200 mg intravenous dose of DHAS in 20 mL of 5% dextrose."	7.69	Effect of dehydroepiandrosterone sulfate on maternal cardiac function in term pregnancy. ( Fujiwaki, R; Hata, K; Hata, T; Kitao, M; Masumura, S; Ryukoh, K, 1996)
" This study sought to examine the changes in peripheral cortisol, progesterone and dehydroepiandrosterone sulphate (DHEAS) in unstressed fetuses during pregnancy."	7.68	Changes in concentrations of cortisol, dehydroepiandrosterone sulphate and progesterone in fetal and maternal serum during pregnancy. ( Donaldson, A; Nicolini, U; Rodeck, CH; Symes, EK; Tannirandorn, Y, 1991)
"Peripheral serum levels of unconjugated (E1) and total (tE1) oestrone, unconjugated oestradiol-17 beta, unconjugated (E3) and total (tE3) oestriol, progesterone, unconjugated dehydroepiandrosterone (DHA) and dehydroepiandrosterone sulphate (DHAS), and urinary tE3 excretion were determined in pre-eclamptic patients at gestational weeks 32 and 36 and in women with normal pregnancy at the corresponding length of gestation."	7.67	Serum levels of unconjugated and total oestrogens and dehydroepiandrosterone, progesterone and urinary oestriol excretion in pre-eclampsia. ( Carlström, K; Rosing, U, 1984)
"Testosterone (T), dihydrotestosterone (DHT), androstenedione (delta 4) and dehydroepiandrosterone (DHA) were measured by radioimmunoassay in peripheral plasma, uterine vein plasma, ovary and placentae within the last 3-4 days of pregnancy in Sprague-Dawley rats."	7.67	Testosterone, dihydrotestosterone, androstenedione and dehydroepiandrosterone concentrations in placentae, ovaries and plasma of the rat in late pregnancy. ( Legrand, C; Maltier, JP; Marie, J, 1984)
"PGF2 alpha) and dehydroepiandrosterone-sulfate (DHA-S) in amniotic fluid and plasma during late pregnancy, labor, and puerperium, were measured by radioimmunoassay and gas chromatography-mass spectrometry."	7.67	[Changes in 13,14-dihydro-15-keto-prostaglandin F2 alpha and dehydroepiandrosterone-sulfate (DHA-S) levels in amniotic fluid and maternal peripheral venous blood in late pregnancy and during labor]. ( Chiba, H; Funatsu, M; Hirato, K; Moriyama, S; Nakayama, T; Saito, H; Yanaihara, T, 1989)
"Plasma levels of dehydroepiandrosterone (DEA) and 17-hydroxyprogesterone (17-HP) were studied in 43 pregnant females 11 with normal pregnancy and labor and 32 at high risk of obstetric complications (primary powerless labor, prematurity, postmaturity, rapid parturition)."	7.67	[Analysis of plasma levels of dehydroepiandrosterone and 17-hydroxyprogesterone in physiologic and pathologic pregnancy and labor]. ( Beloglazova, SE; Malysheva, VA; Starostina, TA; Zakharova, OI, 1989)
" In the present study, cultured human choriocarcinoma JEG-3 cells were used as an experimental model in order to examine the effect of dehydroepiandrosterone sulfate on both de novo and low-density lipoprotein-stimulated progesterone secretion."	7.67	The effect of dehydroepiandrosterone sulfate on de novo and low-density lipoprotein-stimulated progesterone secretion by human choriocarcinoma JEG-3 cells. ( Benveniste, R; Ilekis, J; Moise, J; Scommegna, A, 1986)
"The estradiol (E2) to estriol (E3) ratio during human pregnancy depends on fetal liver hydroxylation of fetal adrenal dehydroepiandrosterone sulfate (DHEAS) and conversion by the trophoblast of DHEAS and 16 alpha-hydroxy-DHEAS (16 OH-DHEAS) to estrone (E1), estradiol (E2), and estriol (E3), respectively."	7.67	Competitive studies with dehydroepiandrosterone sulfate and 16 alpha-hydroxydehydroepiandrosterone sulfate in cultured human choriocarcinoma JEG-3 cells: effect on estrone, 17 beta-estradiol, and estriol secretion. ( Benveniste, R; Ilekis, J; Scommegna, A; Zbella, EA, 1986)
"We compared serum concentrations of total and free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS), and sex-hormone-binding globulin in 40 pregnant women exhibiting consistent alcohol abuse and in 20 abstinent pregnant controls."	7.67	Testosterone, androstenedione, dehydroepiandrosterone sulfate, and sex-hormone-binding globulin in pregnant alcohol abusers. ( Halmesmäki, E; Stenman, UH; Ylikorkala, O, 1988)
"Intravenous application of dehydroepiandrosterone sulphate (DHEA-S) was performed in 6 women with normal progress of pregnancy, 3 pregnant women with multiple pregnancy and 4 pregnants with intrauterine death of the foetus (32nd to 38th week)."	7.67	Dehydroepiandrosterone sulphate loading test and determination of plasma oestetrol concentration in late pregnancy. ( Schollberg, K; Seiler, E; Wagner, S, 1985)
"In the last trimester of pregnancy, a correlation was established between the serum dehydroepiandrosterone sulfate (DHAS) half-life of the mother (n = 40) after DHAS loading (50 mg i."	7.66	Diagnosis of intrauterine fetal growth retardation by prolongation of dehydroepiandrosterone sulfate (DHAS) half-life after DHAS loading. ( Koeppen, U; Kubli, F; Rabe, T; Runnebaum, B; Widmaier, G, 1982)
"Hirsutism and menstrual patterns were evaluated in 32 female patients with documented diethylstilbestrol (DES) exposure in utero."	7.66	Hirsutism and menstrual patterns in women exposed to diethylstilbestrol in utero. ( Mathur, RS; Peress, MR; Tsai, CC; Williamson, HO, 1982)
"The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described."	7.66	Inhibition of 3-beta-hydroxy steroid dehydrogenase activity in first trimester human pregnancy with trilostane and WIN 32729. ( Jacobs, HS; James, VH; Jones, DL; Paintin, DB; Piura, B; van der Spuy, ZM; Wright, CS, 1983)
"Using constant infusion of unlabeled steroid, we have studied the metabolic clearance rate (MCR), half-life (T 1/2), and conversion ratio of androstenedione (A) into androgens and estrogens throughout human pregnancy."	7.66	The metabolism of androstenedione in human pregnancy: the use of constant infusion of unlabeled steroid to assess its metabolic clearance rate, its production rate, and its conversion into androgens and estrogens. ( Belisle, S; Brault, J; Lehoux, JG, 1980)
"The aim of the present study was to determine whether pregnancy complications themselves influence the conversion rate of dehydroepiandrosterone sulphate (DHAS) to oestrogens during pregnancy."	7.66	Conversion of dehydroepiandrosterone sulphate to oestrogens in intraphepatic cholestasis and other complications of pregnancy. ( Kauppila, A; Reinilä, M; Tuimala, R; Ylikorkala, O; Ylöstalo, P, 1980)
"Serum levels of DHA, 16 alpha OH-DHA and estriol (E3) were determined in maternal peripheral vein by gas chromatography-mass spectrometry (GC-MS) with application of deuterated steroids as internal standards during late pregnancy and labor."	7.66	[Changes of dehydroepiandrosterone (DHA), 16 alpha OH-DHA and estriol levels in maternal peripheral blood during late pregnancy and labor--measured by gas chromatography-mass spectrometry with application of deuterated steroids as internal standards (auth ( Hashino, M; Kozaki, T; Maruyama, M; Mori, H; Nakayama, T; Yanaihara, T, 1981)
"A mixture of 3H-15alpha-hydroxyandrostenedione and 14C-15alpha-hydroxydehydroisoandrosterone was injected intravenously into two subjects in the third trimester of pregnancy and, in a second study, directly into two fetuses in utero during transfusion for erythroblastosis fetalis."	7.66	Formation of 15alpha-hydroxyestriol and 15alpha-hydroxyestradiol from C19 15alpha-hydroxylated precursors in human pregnancy. ( Solomon, S; Stanczyk, FZ, 1978)
"Dehydroepiandrosterone sulphate (DHAS) was administered intravenously to 70 women in the third trimester of pregnancy."	7.65	Plasma estrogen response to dehydroepiandrosterone sulphate injection in normal and complicated late pregnancy. ( Bacon, L; Drife, J; Fraser, IS; Leask, R; Michie, E, 1976)
"An intravenous injection of 50 mg dehydroepiandrosterone was given to 19 women at the 38th week of pregnancy."	7.65	Placental metabolism of dehydroepiandrosterone sulphate in normal pregnancy. ( Jandial, V; Klopper, A; Varela-Torres, R, 1976)
"To investigate the metabolic pathway from dehydroepiandrosterone sulfate (DHAS) to estriol (E3) in late human pregnancy, DHAS (50 to 100 mg) was given intravenously or intraamniotically to 13 volunteers (from cases of normal pregnant women, pregnant women with a live anencephalic fetus, intrauterine fetal death or hydatidiform mole and a patient complicated with cancer of the cervix)."	7.65	[Study on metabolic pathway from dehydroepiandrosterone sulfate to estrogen in late pregnancy (author's transl)]. ( Ichimaru, S, 1975)
"Corticosterone was measured by radioimmunoassay and DHEA by ELISA."	5.91	Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets. ( Chavira, R; Gerow, KG; Lomas-Soria, C; Nathanielsz, PW; Reyes-Castro, LA; Rodríguez-González, GL; Zambrano, E, 2023)
"Dehydroepiandrosterone (DHEA) is a weak androgen and a crucial precursor of sex steroids."	5.48	Effects of dehydroepiandrosterone on the ovarian reserve and pregnancy outcomes in perimenopausal rats (DHEA and fertility in perimenopausal rats). ( Abo-Zeid, FS; Fares, NH; Mahmoud, AA; Mahmoud, YI, 2018)
" These results show that a low intravenous dosage of betamethason and collection of blood samples for E3 assays in intervals of 12 hours can be used as a functional test of the fetoplacental unit."	5.27	[The betamethasone test in the diagnosis of placental insufficiency]. ( Bernaschek, G; Bieglmayer, C; Friedrich, F, 1983)
"Ten women in pregnancy complicated by EPH gestosis were examined prior to and during treatment."	5.26	[Dehydro-epiandrosterone in blood serum and urine of women in pregnancy complicated by EPH gestosis (author's transl)]. ( Kudelski, Z, 1982)
"This study aimed to present a narrative review regarding androgen production, androgens' role in folliculogenesis, and the available therapeutic approaches for androgen supplementation, and to perform a systematic review and meta-analysis regarding the impact of androgens (dehydroepiandrosterone/testosterone) compared with placebo or no treatment on ovarian response and pregnancy outcomes in patients with diminished ovarian reserve and/or poor ovarian responders."	5.22	Androgens and diminished ovarian reserve: the long road from basic science to clinical implementation. A comprehensive and systematic review with meta-analysis. ( Montoya-Botero, P; Neves, AR; Polyzos, NP, 2022)
"Objective To observe the effect of Chinese herbs combined dehydroepiandrosterone (DHEA) pretreatment on pregnancy outcomes of elderly patients with normal ovarian function undergoing in vitro fertilization-embryo transfer ( IVF-ET)."	5.22	[Effect of Chinese Herbs Combined DHEA Pretreatment on Pregnancy Outcomes of Elderly Pa- tients with Normal Ovarian Reserve Undergoing IVF-ET]. ( Cui, W; Li, J; Liang, Q; Teng, T, 2016)
"The aim of this paper was to evaluate the hypothesis that pretreatment with dehydroepiandrosterone (DEHA) may improve the result on in vitro fertilization (IVF) and the pregnancy outcome among infertile women with normal ovarian reserve."	5.20	Potential benefit of dehydroepiandrosterone supplementation for infertile but not poor responder patients in a IVF program. ( Alrasheed, H; Baldini, D; Damiani, GR; De Pergola, G; De Salvia, MA; Loverro, G; Pellegrino, A; Tartagni, M; Tartagni, MV, 2015)
" In the present study 20 infertile women with polycystic ovary syndrome were prospectively randomized in a placebo-controlled study to receive either placebo or prednisolone 10 mg at night, during standard in-vitro fertilization (IVF) treatment."	5.09	Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization. ( Carlström, K; Fridström, M; Hillensjö, T; Sjöblom, P, 1999)
"To evaluate the effect of dehydroepiandrosterone (DHEA) therapy on the ovarian response and pregnancy outcome in patients with diminished ovarian reserve (DOR)."	4.95	The effect of dehydroepiandrosterone (DHEA) supplementation on women with diminished ovarian reserve (DOR) in IVF cycle: Evidence from a meta-analysis. ( Fan, L; Qin, AP; Qin, JC, 2017)
" Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances with DOR, and is now utilized by approximately one third of all IVF centers world-wide."	4.87	Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). ( Barad, DH; Gleicher, N, 2011)
"To present the possible positive effect of dehydroepiandrosterone administration in assisted reproduction and especially in poor responders, women with diminished ovarian reserve, premature ovarian failure and premature ovarian aging in the course of ovarian stimulation protocols followed either by intrauterine insemination or IVF."	4.85	Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. ( Mamas, E; Mamas, L, 2009)
"16alpha-Hydroxydehydroepiandrosterone is the precursor of fetal 16alpha-hydroxylated estrogens, the main phenolic steroids in pregnancy."	4.80	Minireview: 16alpha-hydroxylated metabolites of dehydroepiandrosterone and their biological significance. ( Hampl, R; Starka, L, 2000)
" In addition to drug metabolism, CYP3A7 is responsible for metabolizing endogenous ligands in the developing human liver, including the steroid precursor dehydroepiandrosterone 3-sulfate (DHEA-S), essential for estriol synthesis during pregnancy, along with the morphogen all-trans-retinoic acid (atRA)."	4.31	Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement. ( Gracey, EG; Hvizdak, M; Kandel, SE; Lampe, JN; McCullough, RL; Work, HM, 2023)
"Oxytocin (OXT) plays a significant role during pregnancy, especially toward the end of pregnancy."	4.31	Oxytocin modulates steroidogenesis-associated genes and estradiol levels in the placenta. ( An, BS; An, SM; Jeong, JS; Kim, DS; Kim, MJ; Kim, SC; Kim, SY, 2023)
" This study aimed to reveal the mechanism of leptin and NPY in the onset of puberty in male offspring rats after androgen intervention during pregnancy."	4.31	Mechanism of leptin-NPY on the onset of puberty in male offspring rats after androgen intervention during pregnancy. ( Cao, R; Fu, L; Liu, J; Peng, X; Wang, Y; Yuan, Y; Zhang, Y, 2023)
"Cortisol and dehydroepiandrosterone-sulfate (DHEA-S) are indispensable hormones for normal pregnancy."	4.02	Comparative profiling of prenatal cortisol and DHEA-S among pregnant women with poor birth outcome and pregnant women with normal birth outcome. ( Natesan, S; Saiyed, S; Sundararajan, A; Vora, K, 2021)
"In the prospective Odense Child Cohort, maternal pregnancy serum concentrations of five PFAAs: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured at median gestational week 12 (IQR: 10, 15) in 1628 women."	3.96	Prenatal exposure to perfluorodecanoic acid is associated with lower circulating concentration of adrenal steroid metabolites during mini puberty in human female infants. The Odense Child Cohort. ( Andersen, HR; Andersen, MS; Andersson, AM; Frederiksen, H; Gade Timmermann, CA; Glintborg, D; Grandjean, P; Jensen, RC; Jensen, TK; Juul, A; Kyhl, HB; Nielsen, F; Sidelmann, JJ, 2020)
"Almost every female classic galactosemia patient develops primary ovarian insufficiency (POI)."	3.91	Dehydroepiandrosterone supplementation attenuates ovarian ageing in a galactose-induced primary ovarian insufficiency rat model. ( Akouri, R; Demir, N; Erman, M; Gunduz, T; Ozekinci, M; Sozen, B, 2019)
" Only dehydroepiandrosterone (DHEA) seems to increase embryonic quality and pregnancy rate, however further exploration and complementary prospective studies are necessary."	3.85	[Poor responders: How could we improve our results?] ( Anahory, T; Bringer-Deutsch, S; Duport Percier, M; Ranisavljevic, N, 2017)
"To investigate whether androgen conversion rates after supplementation with dehydroepiandrosterone (DHEA) differ, and whether differences between patients with diminished ovarian reserve (DOR) are predictive of pregnancy chances in association with in vitro fertilization (IVF)."	3.79	Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization (IVF) pregnancy rates in women with diminished ovarian reserve (DOR). ( Barad, DH; Gleicher, N; Kim, A; Lazzaroni, E; Lee, HJ; Shohat-Tal, A; Weghofer, A, 2013)
" We here explore whether quantification of major fetal steroids, dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEAS), with liquid chromatography/tandem mass spectrometry in infant nails is a tool to assess fetal stress biology in response to maternal stressful life events during pregnancy."	3.77	Dehydroepiandrosterone in nails of infants: a potential biomarker of intrauterine responses to maternal stress. ( Jamey, C; Khelil, MB; Ludes, B; Meinlschmidt, G; Raul, JS; Tegethoff, M, 2011)
"Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances in women with diminished ovarian reserve (DOR), and to reduce miscarriage rates by 50-80%."	3.76	Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS). ( Barad, DH; Gleicher, N; Weghofer, A, 2010)
"We evaluated the effect of hyperandrogenism in ovaries with functional and regressing corpora lutea (CL) and the action of metformin in preventing these possible alterations using a mouse model."	3.75	Effect of DHEA and metformin on corpus luteum in mice. ( Facorro, GB; Motta, AB; Piehl, L; Rubín de Celis, E; Sander, VA, 2009)
"The aim of the present report was to study the role of high levels of dehydroepiandrosterone (DHEA) on the ovarian function and embryonic resorption during early pregnancy in BALB/c mice."	3.73	The influence of dehydroepiandrosterone on early pregnancy in mice. ( Di Girolamo, G; Elia, E; Gonzalez, C; Luchetti, CG; Motta, AB; Sander, V; Solano, ME, 2005)
" From the mixture, PeCDD and PeCDF in the higher amount accumulated in the placental tissue caused an increase in oestrogen secretion and as a consequence could activate oxytocin secretion from the pituitary and early pregnancy outcome."	3.72	Comparison of accumulation and altered steroid secretion by placental tissue treated with TCDD and natural mixture of PCDDs-PCDFs. ( Augustowska, K; Chrzaszcz, R; Gregoraszczuk E, EŁ; Grochowalski, A; Krzysiek, J; Mika, M; Milewicz, T, 2003)
"Since it is known that androstenediol (ADIOL) has potent immunoregulatory effects, changes in ADIOL levels during and after pregnancy might affect the maternal immune system."	3.72	Serum concentrations of androstenediol and androstenediol sulfate, and their relation to cytokine production during and after normal pregnancy. ( Amino, N; Hidaka, Y; Kobayashi, Y; Shimaoka, Y; Tagawa, N; Takano, T, 2004)
"With a view to establishing whether first-trimester human placentas possess the ability to synthesize DHEA from cholesterol, homogenates of this tissue obtained from two groups of women undergoing elective termination of normally progressing pregnancy between 10 - 12 weeks gestation (n = 5, age 23 - 29 years and n = 5, age 21 - 27 years) were incubated separately with [26-(14)C]cholesterol for the generation of [14C]isocaproic acid + pregnenolone and [7n-3H]pregnenolone for the biosynthesis of [3H]DHEA."	3.71	Evidence for the biosynthesis of DHEA from cholesterol by first-trimester human placental tissue: source of androgens. ( Loganath, A; Peh, KL; Wong, PC, 2002)
" We undertook GC/MS analysis of steroids in random maternal urine samples and quantified oestriol, oestriol precursors (dehydroepiandrosterone (DHEA), 5-androstene-3 beta, 17 beta-diol, 16 alpha-hydroxy-dehydroepiandrosterone and 5-androstene-3 beta, 16 alpha, 17 beta-triol), pregnanediol, and five other steroids largely unaffected by pregnancy (androsterone, etiocholanolone, tetrahydrocortisol, 5 alpha-tetrahydrocortisol and tetrahydrocortisone)."	3.70	Steroid sulphatase deficiency is the major cause of extremely low oestriol production at mid-pregnancy: a urinary steroid assay for the discrimination of steroid sulphatase deficiency from other causes. ( Chang, T; Glass, IA; Lam, RC; Roitman, E; Shackleton, CH; Shapiro, LJ, 1998)
"When pregnant rats received whole body irradiations with 260 cGy gamma-ray at day 20 of pregnancy, and were then implanted with a diethylstilbestrol (DES) pellet for an experimental period of 1 year under feeding of a control diet, a high incidence (96."	3.69	Chemoprevention by dietary dehydroepiandrosterone against promotion/progression phase of radiation-induced mammary tumorigenesis in rats. ( Inano, H; Ishii-Ohba, H; Onoda, M; Suzuki, K; Wakabayashi, K; Yamanouchi, H, 1995)
" In the present study, we have examined the effect of dehydroepiandrosterone-3-O-methylthiophosphonate (DHA-3-MTP), pregnenolone-3-O-methylthiophosphonate (pregnenolone-3-MTP) and cholesterol-3-O-methylthiophosphonate (cholesterol-3-MTP) on the inhibition of oestrone sulphatase as well as DHA sulphatase activities in intact MCF-7 breast cancer cells and in placental microsomes."	3.69	Inhibition of steroid sulphatase activity by steroidal methylthiophosphonates: potential therapeutic agents in breast cancer. ( Howarth, NM; Potter, BV; Purohit, A; Reed, MJ, 1994)
"Measurement of progesterone, 17 alpha-hydroxyprogesterone, oestradiol-17 beta, testosterone, androstenedione, cortisol and dehydroepiandrosterone sulphate in matched samples of coelomic fluid, amniotic fluid and maternal serum collected before pregnancy termination from 12 women between 8 and 12 weeks gestation."	3.69	Steroids in human intrauterine fluids of early pregnancy. ( Atkinson, G; Campbell, DJ; Cawood, ML; Oakey, RE, 1996)
"Prior studies have provided evidence for reduced fetal adrenal production of dehydroepiandrosterone sulfate and normal or increased production of cortisol in association with pregnancy complications believed to result in fetal stress."	3.68	Altered adrenal steroid production in term infants having respiratory acidosis. ( Harlin, CA; Henson, B; Parker, CR; Tucker, JM; Winkler, CL, 1993)
"In amniotic fluid from the second trimester of pregnancy levels of total and free testosterone, 17 alpha-hydroxyprogesterone and dehydroepiandrosterone were assessed."	3.68	[Determination of steroid hormones in the amniotic fluid in prenatal genetic diagnosis]. ( Burjanková, J; Dvorák, P; Hampl, R; Macek, M; Stárka, L; Sulcová, J, 1991)
"Fetal adrenal steroid, dehydroepiandrosterone sulfate (DHA-S) is well known to promote cervical ripening in late pregnancy."	3.68	Possible evidence that dehydroepiandrosterone sulfate (DHA-S) stimulates cervical ripening by a membrane-mediated process: specific binding-sites in plasma membrane from human uterine cervix. ( Imai, A; Ohno, T; Tamaya, T, 1991)
"Peripheral serum levels of unconjugated (E1) and total (tE1) oestrone, unconjugated oestradiol-17 beta, unconjugated (E3) and total (tE3) oestriol, progesterone, unconjugated dehydroepiandrosterone (DHA) and dehydroepiandrosterone sulphate (DHAS), and urinary tE3 excretion were determined in pre-eclamptic patients at gestational weeks 32 and 36 and in women with normal pregnancy at the corresponding length of gestation."	3.67	Serum levels of unconjugated and total oestrogens and dehydroepiandrosterone, progesterone and urinary oestriol excretion in pre-eclampsia. ( Carlström, K; Rosing, U, 1984)
"Dehydroepiandrosterone sulphate (50 mg) was given intravenously to 15 women in the third trimester of pregnancy in which urinary oestrogen excretion was subnormal (less than 32 mumol/24 h) without recognizable clinical or therapeutic cause."	3.67	Antenatal detection of placental steroid sulphatase deficiency: use of a dehydroepiandrosterone sulphate loading test. ( Oakey, RE, 1984)
" Corpora lutea contained oestradiol-17 beta and oestrone during embryonic diapause and at all stages of pregnancy studied after blastocyst activation."	3.67	Ovarian steroid metabolism and oestrogens in the corpus luteum of the tammar wallaby. ( Flint, AP; Green, SW; Heap, RB; Renfree, MB, 1984)
"To study the control of production of prostaglandins (PG) during pregnancy and parturition, amniotic membranes obtained from normal vaginal delivery were incubated with the substrate of phosphatidylcholine containing [14C]arachidonic acid in the Sn-2 position."	3.67	Enhancement of human amniotic phospholipase A2 activity by steroid-sulphate derived from the foeto-placental unit. ( Hirato, K; Nakayama, T; Noguchi, Y; Ogawa, K; Saitoh, H; Tahara, R; Yanaihara, T, 1984)
" In this study the authors conferred the progesterone, DHAS, cortisol, oestradiol, oestriol, prolactin and HPL levels of male and female newborns in the maternal vein and in the umbilical vein and artery in the 28th-32th weeks (31 parturients, 15 male and 16 female fetuses), in the 33rd-36th weeks (43 parturients, 20 male and 23 female fetuses) and in the 40th week (34 parturients, 11 male and 23 female fetuses) of pregnancy."	3.67	Quantitative comparison of serum steroid and peptide hormone concentrations in male and female fetuses in the maternal-fetoplacental system during the 28th-40th weeks of pregnancy. ( Hercz, P; Kazy, Z; Siklós, P; Ungár, L, 1989)
"PGF2 alpha) and dehydroepiandrosterone-sulfate (DHA-S) in amniotic fluid and plasma during late pregnancy, labor, and puerperium, were measured by radioimmunoassay and gas chromatography-mass spectrometry."	3.67	[Changes in 13,14-dihydro-15-keto-prostaglandin F2 alpha and dehydroepiandrosterone-sulfate (DHA-S) levels in amniotic fluid and maternal peripheral venous blood in late pregnancy and during labor]. ( Chiba, H; Funatsu, M; Hirato, K; Moriyama, S; Nakayama, T; Saito, H; Yanaihara, T, 1989)
"To assess the endocrine performance of the fetoplacental system in anemia-complicated pregnancy, blood levels of dehydroepiandrosterone sulfate (DEAS), estriol (E3), estradiol (E2), progesterone (PRG) and placental hormone were studied in 287 normal women and female patients with varying anemias."	3.67	[Endocrine function of the feto-placental complex in anemia of varying degrees of severity]. ( Gavrilov, VIa, 1989)
"Plasma levels of dehydroepiandrosterone (DEA) and 17-hydroxyprogesterone (17-HP) were studied in 43 pregnant females 11 with normal pregnancy and labor and 32 at high risk of obstetric complications (primary powerless labor, prematurity, postmaturity, rapid parturition)."	3.67	[Analysis of plasma levels of dehydroepiandrosterone and 17-hydroxyprogesterone in physiologic and pathologic pregnancy and labor]. ( Beloglazova, SE; Malysheva, VA; Starostina, TA; Zakharova, OI, 1989)
"In distinction to Braunstein and Horton (1985) who reported an increase in maternal 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (ADG) plasma levels during pregnancy, we observed a decrease of these levels from the 10th week of pregnancy; the decrease parallels the decrease in dehydroepiandrosterone sulphate (DHEA-S) concentration."	3.67	Plasma androstanediol glucuronide levels during pregnancy. ( van Droogenbroeck, J; Vermeulen, A, 1989)
"The response to an intravenous load of 50 mg of dehydroepiandrosterone sulfate given to women with a pregnancy prolonged to more than 42 weeks was compared to the response in control pregnant women at 40 weeks."	3.67	Fetoplacental steroid metabolism in prolonged pregnancies. ( Burry, K; Carlson, CV; Reynolds, JW, 1986)
"The influence of early-onset pre-eclampsia upon the umbilical cord serum levels of cortisol and dehydroepiandrosterone sulfate was studied in fifty-one preterm infants not exposed prenatally to corticosteroids."	3.67	Umbilical cord dehydroepiandrosterone sulfate and cortisol levels in preterm infants born to pre-eclamptic mothers. ( Cecin, SK; Procianoy, RS, 1986)
" In the present study, cultured human choriocarcinoma JEG-3 cells were used as an experimental model in order to examine the effect of dehydroepiandrosterone sulfate on both de novo and low-density lipoprotein-stimulated progesterone secretion."	3.67	The effect of dehydroepiandrosterone sulfate on de novo and low-density lipoprotein-stimulated progesterone secretion by human choriocarcinoma JEG-3 cells. ( Benveniste, R; Ilekis, J; Moise, J; Scommegna, A, 1986)
"The estradiol (E2) to estriol (E3) ratio during human pregnancy depends on fetal liver hydroxylation of fetal adrenal dehydroepiandrosterone sulfate (DHEAS) and conversion by the trophoblast of DHEAS and 16 alpha-hydroxy-DHEAS (16 OH-DHEAS) to estrone (E1), estradiol (E2), and estriol (E3), respectively."	3.67	Competitive studies with dehydroepiandrosterone sulfate and 16 alpha-hydroxydehydroepiandrosterone sulfate in cultured human choriocarcinoma JEG-3 cells: effect on estrone, 17 beta-estradiol, and estriol secretion. ( Benveniste, R; Ilekis, J; Scommegna, A; Zbella, EA, 1986)
"We compared serum concentrations of total and free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS), and sex-hormone-binding globulin in 40 pregnant women exhibiting consistent alcohol abuse and in 20 abstinent pregnant controls."	3.67	Testosterone, androstenedione, dehydroepiandrosterone sulfate, and sex-hormone-binding globulin in pregnant alcohol abusers. ( Halmesmäki, E; Stenman, UH; Ylikorkala, O, 1988)
"To study the changes in circulating steroid levels during pregnancy, ten steroids which included Progesterone (P4), 16 alpha OH-Progesterone (16P4), free and conjugated Pregnenolone (P5), 16 alpha OH-Pregnenolone (16P5), Dehydroepiandrosterone (DHA) and 16 alpha OH-Dehydroepiandrosterone (16DHA) were measured simultaneously by RIA in 84 normal pregnant women from the 5th to 41st week of gestation."	3.67	[Changes in maternal plasma levels of C21 and C19 steroid hormones during pregnancy]. ( Hashino, M; Nakayama, T; Suzuki, H; Yanaihara, T, 1988)
" When compared with data in age- and weight-matched control infants of women having no pregnancy complications, umbilical cord serum levels of dehydroepiandrosterone sulfate, the major fetal adrenal precursor of placental estrogens, were subnormal (897 +/- 597 ng/ml, mean +/- SD) in 12 newborn infants with congenital syphilis (33."	3.67	The effects of syphilis on endocrine function of the fetoplacental unit. ( Parker, CR; Wendel, GD, 1988)
"The authors measured the serum levels of dehydroepiandrosterone sulfate (DHAS) in the maternal vein (MV), the umbilical vein (UV) and the umbilical artery (UA) during the 28th-36th weeks of pregnancy (n = 74) and in the 40th week (n = 34), to clarify the hormonal changes that occur between the maternal and fetal compartments."	3.67	Serum DHAS in the maternal-fetoplacental system during the 28th-40th weeks of pregnancy. ( Farquharson, RG; Hercz, P; Siklós, P; Ungár, L, 1988)
"So as to evaluate metabolism of catecholestrogens during pregnancy, changes in plasma unconjugated estradiol (E2), estrone (E1), 2-methoxyestradiol (2-mE2) and 2-methoxyestrone (2-mE1) concentrations were measured after a bolus injection of 40mg of estrone-sulfate (E1-S) or 100mg of dehydroepiandrosterone-sulfate (DHA-S) to normal pregnant women near term."	3.67	Studies of catecholestrogen metabolism during normal pregnancy: changes of plasma catecholestrogen levels after DHA-S or E1-S injection. ( Okatani, Y; Sagara, Y; Takeda, Y, 1986)
"Intravenous application of dehydroepiandrosterone sulphate (DHEA-S) was performed in 6 women with normal progress of pregnancy, 3 pregnant women with multiple pregnancy and 4 pregnants with intrauterine death of the foetus (32nd to 38th week)."	3.67	Dehydroepiandrosterone sulphate loading test and determination of plasma oestetrol concentration in late pregnancy. ( Schollberg, K; Seiler, E; Wagner, S, 1985)
"In the current investigation we sought to evaluate fetal adrenal dehydroepiandrosterone sulfate (DS) production during normal human pregnancy."	3.66	Umbilical cord plasma levels of dehydroepiandrosterone sulfate during human gestation. ( Carr, BR; Hauth, J; Leveno, K; MacDonald, PC; Parker, CR, 1982)
"In the last trimester of pregnancy, a correlation was established between the serum dehydroepiandrosterone sulfate (DHAS) half-life of the mother (n = 40) after DHAS loading (50 mg i."	3.66	Diagnosis of intrauterine fetal growth retardation by prolongation of dehydroepiandrosterone sulfate (DHAS) half-life after DHAS loading. ( Koeppen, U; Kubli, F; Rabe, T; Runnebaum, B; Widmaier, G, 1982)
"Hirsutism and menstrual patterns were evaluated in 32 female patients with documented diethylstilbestrol (DES) exposure in utero."	3.66	Hirsutism and menstrual patterns in women exposed to diethylstilbestrol in utero. ( Mathur, RS; Peress, MR; Tsai, CC; Williamson, HO, 1982)
"Twenty-two twin pregnancies each with one growth-retarded and one normal twin fetus were examined to determine the effects of fetal growth retardation on the maturation of the adrenal gland with respect to cortisol and dehydroepiandrosterone sulphate (DHEAS)."	3.66	Fetal adrenal gland maturation in growth-retarded twin pregnancies. ( Joubert, SM; Norman, RJ, 1982)
"The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described."	3.66	Inhibition of 3-beta-hydroxy steroid dehydrogenase activity in first trimester human pregnancy with trilostane and WIN 32729. ( Jacobs, HS; James, VH; Jones, DL; Paintin, DB; Piura, B; van der Spuy, ZM; Wright, CS, 1983)
"Using constant infusion of unlabeled steroid, we have studied the metabolic clearance rate (MCR), half-life (T 1/2), and conversion ratio of androstenedione (A) into androgens and estrogens throughout human pregnancy."	3.66	The metabolism of androstenedione in human pregnancy: the use of constant infusion of unlabeled steroid to assess its metabolic clearance rate, its production rate, and its conversion into androgens and estrogens. ( Belisle, S; Brault, J; Lehoux, JG, 1980)
"The aim of the present study was to determine whether pregnancy complications themselves influence the conversion rate of dehydroepiandrosterone sulphate (DHAS) to oestrogens during pregnancy."	3.66	Conversion of dehydroepiandrosterone sulphate to oestrogens in intraphepatic cholestasis and other complications of pregnancy. ( Kauppila, A; Reinilä, M; Tuimala, R; Ylikorkala, O; Ylöstalo, P, 1980)
"To evaluate whether intravenous injection of dehydroepiandrosterone sulfate (DHEAS), by enhancing estradiol (E2) production, would stimulate prolactin (PRL) secretion in late pregnancy, maternal serum PRL was determined before and 1 to 5 hours after administration of 100 mg of DHEAS in a total of 41 women with normal or complicated late pregnancies (twin pregnancy, pre-eclampsia, intrahepatic cholestasis of pregnancy, diabetes)."	3.66	Stable prolactin level after enhanced estradiol production following dehydroepiandrosterone sulfate. ( Kauppila, A; Ylikorkala, O, 1980)
"Plasma levels of dehydroepiandrosterone sulfate, dehydroepiandrosterone and delta 5-androstenediol were measured in several women throughout pregnancy."	3.66	Plasma C19-delta 5-steroid levels during normal human pregnancy. ( Bird, CE; Clark, AF; Cook, SJ; Dressel, DE, 1980)
"A case of pre-eclampsia is described where suspicion of placental insufficiency arose due to low estriol levels and a positive oxytocin challenge test (OCT)."	3.66	Incorrect diagnosis of placental insufficiency in a patient with pre-eclampsia. ( Axelsson, O; Weiner, E, 1980)
"Dehydroepiandrosterone sulfate loading tests (DLT) have been performed in 17 cases of clinically suspected intrauterine fetal growth retardation."	3.66	DHEA-S-loading test in cases of intrauterine growth retardation: relationship between the pattern of the maternal plasma metabolites and the fetoplacental dysfunction. ( Cedard, L; Tanguy, G; Thoumsin, HJ; Zorn, JR, 1981)
"Serum levels of DHA, 16 alpha OH-DHA and estriol (E3) were determined in maternal peripheral vein by gas chromatography-mass spectrometry (GC-MS) with application of deuterated steroids as internal standards during late pregnancy and labor."	3.66	[Changes of dehydroepiandrosterone (DHA), 16 alpha OH-DHA and estriol levels in maternal peripheral blood during late pregnancy and labor--measured by gas chromatography-mass spectrometry with application of deuterated steroids as internal standards (auth ( Hashino, M; Kozaki, T; Maruyama, M; Mori, H; Nakayama, T; Yanaihara, T, 1981)
"Prenatal diagnosis of X-linked ichthyosis in a case of steroid sulfatase deficiency was made at 16 weeks by the demonstration of (1) high levels of dehydroepiandrosterone sulfate in amniotic fluid; (2) gross deficiency of steroid sulfatase activity in cultured amniotic fluid cells; (3) very low estriol concentrations in maternal blood and urine; (4) increased maternal plasma dehydroepiandrosterone sulfate; and (5) a characteristic maternal urinary steroid profile with greatly increased levels of 16 alpha-hydroxydehydroepiandrosterone."	3.66	Prenatal diagnosis of X-linked ichthyosis. ( Hähnel, E; Hähnel, R; Hockey, A; Wilkinson, SP; Wysocki, SJ, 1982)
"In a 23-year old primipara who was in her 34th week of pregnancy, serum oestriol could not be identified, with no other abnormal clinical and endocrinological findings, which is why the authors suspected placental sulphatase deficiency."	3.66	[Diagnosis of placental sulphatase deficiency (author's transl)]. ( Bailer, P; Gips, H; Korte, K, 1978)
"A mixture of 3H-15alpha-hydroxyandrostenedione and 14C-15alpha-hydroxydehydroisoandrosterone was injected intravenously into two subjects in the third trimester of pregnancy and, in a second study, directly into two fetuses in utero during transfusion for erythroblastosis fetalis."	3.66	Formation of 15alpha-hydroxyestriol and 15alpha-hydroxyestradiol from C19 15alpha-hydroxylated precursors in human pregnancy. ( Solomon, S; Stanczyk, FZ, 1978)
"The transfer constants of conversion of maternal plasma dehydroisoandrosterone sulfate to estradiol ([rho]DS-E2BU) and to 16alphaOH-dehydroisoandrosterone sulfate ([rho]DS-160HDS BU) and of maternal plasma 16alphaOH-dehydroisoandrosterone sulfate to estriol ([rho]160HDS-E3 BU) were measured in women late in pregnancy."	3.66	Study of the kinetics of conversion of maternal plasma dehydroisoandrosterone sulfate to 16 alpha-hydroxydehydroisoandrosterone sulfate, estradiol, and estriol. ( Gant, NF; MacDonald, PC; Madden, JD, 1978)
"It is well known that in pregnancy dehydroepiandrosterone-sulphate (DHEAS) (90% synthetized by the fetal adrenals, 10% by the maternal ones) is converted into estrogens mainly in the placenta."	3.66	Evaluation of the feto-placental function by means of intraamniotic administration of dehydroepiandrosterone-sulphate. ( Bompiani, A; Dell'Acqua, S; Lucisano, A; Parlati, E; Plotti, G; Serri, F, 1979)
"Cholic and chenodeoxycholic acids were determined in 42 cord plasma samples after pregnancies complicated by maternal intrahepatic cholestasis and in 20 cord plasma samples after uncomplicated pregnancies with a gas-chromatographic method."	3.65	Fetal bile acid levels in pregnancies complicated by maternal intrahepatic cholestasis. ( Laatikainen, TJ, 1975)
"The biotransformation of pregnenolone-7alpha-3H and of progesterone-7alpha-3H by porcine fetal and maternal adrenal homogenates at 56 and 112 days of pregnancy and of dehydroepiandrosterone-7alpha-3H by fetal adrenal homogenates has been investigated in vitro."	3.65	Biotransformation of pregnenolone - 7alpha-3H, progesterone - 7alpha-3H and dehydroepiandrosterone - 7alpha-3H by porcine fetal and maternal adrenal homogenate preparations. ( Ainsworth, L; Nitchuk, WM, 1975)
"From 157 plasma samples taken randomly throughout normal pregnancy and from 42 plasma samples of nonpregnant women, total plasma dehydroepiandrosterone was measured by a method using Amberlite XAD-2 column chromatography at 45degreesC, enzyme hydrolysis, radioactive internal standard, thin-layer chromatography and gas-liquid chromatography after trimethylsilyl ether derivative formation."	3.65	Plasma dehydroepiandrosterone in pregnant and nonpregnant women. ( Gnad, K; Schindler, AE; Walk, T, 1975)
"To assess placental and fetoplacental function, 50 mg of dehydroepiandrosterone sulfate was administered intravenously to 11 normal obstetric patients at 35 to 40 weeks and to 36 high-risk patients at 35 to 43 weeks of pregnancy."	3.65	Dehydroepiandrosterone sulfate loading test in the diagnosis of complicated pregnancies. ( Finn, A; Osathanondh, R; Tulchinsky, D, 1976)
"Dehydroepiandrosterone sulphate (DHAS) was administered intravenously to 70 women in the third trimester of pregnancy."	3.65	Plasma estrogen response to dehydroepiandrosterone sulphate injection in normal and complicated late pregnancy. ( Bacon, L; Drife, J; Fraser, IS; Leask, R; Michie, E, 1976)
"An intravenous injection of 50 mg dehydroepiandrosterone was given to 19 women at the 38th week of pregnancy."	3.65	Placental metabolism of dehydroepiandrosterone sulphate in normal pregnancy. ( Jandial, V; Klopper, A; Varela-Torres, R, 1976)
"A pregnancy with placental sulfatase deficiency was suspected when a 36-year-old patient at 41 weeks of gestation was found to have extremely low urinary estriol excretion and an otherwise normal prenatal course."	3.65	Placental sulfatase deficiency: a case study. ( Canick, J; Osathanondh, R; Ryan, KJ; Tulchinsky, D, 1976)
"To investigate the metabolic pathway from dehydroepiandrosterone sulfate (DHAS) to estriol (E3) in late human pregnancy, DHAS (50 to 100 mg) was given intravenously or intraamniotically to 13 volunteers (from cases of normal pregnant women, pregnant women with a live anencephalic fetus, intrauterine fetal death or hydatidiform mole and a patient complicated with cancer of the cervix)."	3.65	[Study on metabolic pathway from dehydroepiandrosterone sulfate to estrogen in late pregnancy (author's transl)]. ( Ichimaru, S, 1975)
"Placental steroid sulfatase deficiency is an unusual cause of low estriol production during pregnancy."	3.65	Prenatal diagnosis of placental steroid sulfatase deficiency. ( Allen, A; Braunstein, GD; Van de Velde, R; Wade, ME; Zeil, FH, 1976)
"Adrenals obtained from human abortices at midpregnancy were kept under conditions of tissue culture and the production of cortisol and dehydroepiandrosterone sulfate (3beta-hydroxy-5-androsten-17-one, 3-sulfate; DHA-S) monitored by radioimmunoassays for up to 2 weeks."	3.65	Exploration of the human fetal pituitary adrenal axis: stimulation of cortisol and dehydroepiandrosterone sulfate biosynthesis by homologous pituitary in organ culture. ( Branchaud, C; Giroud, CJ; Goodyer, CG; Hall, CS, 1977)
"To study the biogenesis of estrogens by the fetoplacental unit in late pregnancy, dehydroepiandrosterone sulfate was injected directly into the fetus and maternal blood sampled at intervals for 2 hours thereafter."	3.65	Maternal plasma estrogens after dehydroepiandrosterone-sulfate injection into the fetus. ( Cuyas, J; Davi, E; Gamissans, O; Pujol-Amat, P; Wilson, GR, 1977)
"To study the effects of prolactin (PRL) on adrenocortical function in humans, dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), androstenedione (delta) and testosterone (T) were measured in serum obtained from 35 hyperprolactinemic women with galactorrhea and amenorrhea before and after treatment with bromocriptine-induced fall in mean PRL levels from 82 +/- 8 (SE) to 14 +/- 2 ng/ml (n = 39, P less than 0."	3.65	Adrenocortical function in hyperprolactinemic women. ( Carter, JN; Faiman, C; Friesen, HG; McNeilly, AS; Tyson, JE; Warne, GL, 1977)
"Estriol, estriol sulfate, progesterone, and 17 neutral steroid sulfates, including estriol precursors and progesterone metabolites, were determined in 27 cord plasma samples collected after pregnancies complicated by intrahepatic cholestasis of the mother."	3.65	Effect of maternal intrahepatic cholestasis on fetal steroid metabolism. ( Laatikainen, TJ; Nylander, PL; Peltonen, JI, 1974)
"Dehydroepiandrosterone (DHEA) is an important precursor of androgen and has been studied and researched extensively for improving the various outcome measures of ovarian stimulation in women with advanced age or poor ovarian response."	3.01	Dehydroepiandrosterone (DHEA) role in enhancement and maintenance of implantation (DREAM): randomised double-blind placebo-controlled trial-study protocol. ( Ashraf, M; Basheer, R; Jayaprakasan, K; Noushin, MA; Ramachandran, A; Sahu, A; Singh, S, 2021)
"To date, studies are limited by including small numbers of women, the difficulty of dosing androgens, and their cyclical variations."	2.82	Revisiting the physiological role of androgens in women. ( Anastasiadou, E; Lenzi, A; Rosato, E; Sciarra, F; Venneri, MA, 2022)
"Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy rates and lower miscarriage rates in women with diminished ovarian function."	2.80	Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old. ( Alrasheed, H; Baldini, D; Cicinelli, MV; DeSalvia, MA; Loverro, G; Montagnani, M; Tartagni, M; Tartagni, MV, 2015)
"Dehydroepiandrosterone (DHEA) has been aggressively sold as a dietary supplement to boost testosterone levels although the impact of DHEA supplementation on testosterone levels has not been fully established."	2.66	A dose-response and meta-analysis of dehydroepiandrosterone (DHEA) supplementation on testosterone levels: perinatal prediction of randomized clinical trials. ( Li, N; Li, Y; Liu, J; Low, TY; Ma, Z; Ren, J; Tan, SC, 2020)
" New preparations are being developed to better mimic normal physiological cortisol levels with convenient, once-daily dosing which may improve treatment outcomes."	2.49	Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe. ( Grossman, A; Johannsson, G; Quinkler, M; Zelissen, P, 2013)
"Adrenal insufficiency is a rare disease, but its prevalence is increasing."	2.43	Management of adrenal insufficiency in different clinical settings. ( Allolio, B; Hahner, S, 2005)
"Polycystic ovarian syndrome is characterized by elevated androgens and is a well-known risk factor for the occurrence of gestational diabetes mellitus."	1.91	Fetal sex and the development of gestational diabetes mellitus in polycystic ovarian syndrome gravidae. ( Aagaard, KM; Sangi-Haghpeykar, H; Sassin, AM, 2023)
"Corticosterone was measured by radioimmunoassay and DHEA by ELISA."	1.91	Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets. ( Chavira, R; Gerow, KG; Lomas-Soria, C; Nathanielsz, PW; Reyes-Castro, LA; Rodríguez-González, GL; Zambrano, E, 2023)
"Chlordecone is an endocrine-disrupting chemical with well recognized estrogenic and progestagenic properties."	1.62	( Ayhan, G; Cordier, S; Costet, N; Giton, F; Kadhel, P; Michineau, L; Monfort, C; Multigner, L; Oliva, A; Rouget, F; Thomé, JP, 2021)
"Dehydroepiandrosterone was irresponsive to ACTH treatment, and concentrations did not differ between lame and nonlame cows."	1.56	Cardiac vagal tone, plasma cortisol, and dehydroepiandrosterone response to an ACTH challenge in lame and nonlame dairy cows. ( Bakony, M; Bende, A; Jurkovich, V; Kézér, FL; Kovács, L; Laky, E; Ruff, F, 2020)
"Dehydroepiandrosterone (DHEA) is a weak androgen and a crucial precursor of sex steroids."	1.48	Effects of dehydroepiandrosterone on the ovarian reserve and pregnancy outcomes in perimenopausal rats (DHEA and fertility in perimenopausal rats). ( Abo-Zeid, FS; Fares, NH; Mahmoud, AA; Mahmoud, YI, 2018)
"01), while lower mean total gonadotropin dosage was administered after D + C supplementation compared with D (3414 ± 1141 IUs versus 3877 ± 1143 IUs respectively, p = 0."	1.43	The use of coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve. ( Balakier, H; Blanco Mejia, S; Claessens, A; Gat, I; Librach, CL; Ryan, EA, 2016)
"The study included 20 women with gestational diabetes mellitus and 27 controls tested using a 120 min."	1.39	Androgens in the maternal and fetal circulation: association with insulin resistance. ( Drolet, R; Dubé, MC; John Weisnagel, S; Labrie, F; Luu-The, V; Morisset, AS; Pelletier, M; Robitaille, J; Tchernof, A; Tremblay, Y, 2013)
"Dehydroepiandrosterone (DHEA) has been proposed as a treatment for improving ovarian reserve in poor responding women undergoing IVF."	1.38	DHEA for poor responders: can treatment be justified in the absence of evidence? ( Urman, B; Yakin, K, 2012)
"Dehydroepiandrosterone (DHEA) has been reported to improve oocyte/embryo yields and oocyte/embryo quality in women with diminished ovarian reserve."	1.36	Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation. ( Barad, DH; Gleicher, N; Weghofer, A, 2010)
"24 and 48h post-implantation) induces embryo resorption of early pregnant BALB/c mice while simultaneous treatment with metformin (240mg/kg, oral 24 and 48h post-implantation) prevents it."	1.35	Dehydroepiandrosterone and metformin modulate progesterone-induced blocking factor (PIBF), cyclooxygenase 2 (COX2) and cytokines in early pregnant mice. ( Luchetti, CG; Mikó, E; Motta, AB; Paz, DA; Szekeres-Bartho, J, 2008)
"Since a large majority of spontaneous miscarriages are associated with aneuploidy, one can speculate that DHEA supplementation may also reduce miscarriage rates."	1.35	Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study. ( Barad, DH; Blanco-Mejia, S; Gleicher, N; Ryan, E; Weghofer, A, 2009)
"Some research suggests that girls with congenital adrenal hyperplasia (CAH), who are exposed to higher than normal levels of prenatal androgens, perform better on spatial tasks, worse on verbal tasks and have a greater incidence of left-handedness than unaffected controls, all of which suggests the development of a more male-typical cognitive pattern."	1.33	Cognitive outcome in adult women affected by congenital adrenal hyperplasia due to 21-hydroxylase deficiency. ( Carson, KA; Malouf, MA; Migeon, CJ; Petrucci, L; Wisniewski, AB, 2006)
"Metformin treatment did not modify the percentage of CD4(+) and CD8(+) T cells from both axillar and retroperitoneal lymph nodes but prevented the increase of serum tumour necrosis factor +/- produced in DHEA-treated mice."	1.33	Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice. ( Di Girolamo, G; Elia, E; Gonzalez, C; Luchetti, CG; Motta, AB; Sander, V; Solano, ME, 2006)
"Evidence suggests that adult cancer risk of hormonally related tumors may be influenced by the in utero environment, and most speculation on the biological mechanism has focused on the hormonal component."	1.32	Correlation of serum hormone concentrations in maternal and umbilical cord samples. ( Cole, B; Harger, G; Hoover, RN; Lykins, D; Markovic, N; Potischman, N; Roberts, JM; Siiteri, P; Troisi, R, 2003)
"Memory deficits were not explained by mood disturbances."	1.30	Pregnancy, the postpartum, and steroid hormones: effects on cognition and mood. ( Bluestein, BW; Buckwalter, DK; Buckwalter, JG; Chang, L; Goodwin, TM; McCleary, CA; Rankin, KP; Stanczyk, FZ, 1999)
" Pregnant rats groups were given the drugs on the 19th day of gestation at dosage of 10, 20 and 40 mg/kg respectively."	1.29	[Ripening effect of mylis and tiluoan on the uterine cervix in pregnant rats]. ( Shi, SQ; Zuo, XC; Zuo, Z, 1994)
"Fetal hypoxemia was associated with dramatic increases in fetal plasma D, D sulfate, androstenedione, E1, and E2."	1.28	Fetal and maternal endocrine responses to reduced uteroplacental blood flow. ( Bethea, CL; Novy, MJ; Shepherd, RW; Stanczyk, FZ, 1992)
" In late pregnant rats, maximum plasma level (Cmax) appeared at 2-4 h after dosing and both Cmax and the area under the plasma concentration-time curve (AUC) increased proportionally with increased dose up to 4."	1.28	The biological fate of sodium prasterone sulfate after vaginal administration. I. Absorption and excretion in rats. ( Adachi, Y; Awata, N; Kawashima, T; Sakaguchi, M; Sakai, T, 1992)
" In a second experiment, the dose-response curve for oestradiol was examined."	1.28	Comparison of the adverse effects of adrenal and ovarian steroids on early pregnancy in mice. ( de Catanzaro, D; MacNiven, E; Ricciuti, F, 1991)
"Dehydroepiandrosterone sulfate (DHAS) has been shown to promote cervical ripening."	1.28	Dehydroepiandrosterone sulfate and induction of labor. ( Ishikawa, M; Shimizu, T, 1989)
" In Experiment II the effects of D-CH3 dosed at 20, 40 or 80 micrograms/day were measured in the same testing situation."	1.28	Suppressive effects of dehydroepiandrosterone and 3-beta-methylandrost-5-en-17-one on attack towards lactating female intruders by castrated male mice. ( Baulieu, EE; Brain, PF; Haug, M; Ouss-Schlegel, ML; Robel, P; Simon, V; Spetz, JF, 1989)
"One hundred and two women had a miscarriage, while 168 carried to term."	1.27	Hormone load tests in the first half of pregnancy--a diagnostic and therapeutic approach. ( Gerhard, I; Runnebaum, B, 1984)
" These results show that a low intravenous dosage of betamethason and collection of blood samples for E3 assays in intervals of 12 hours can be used as a functional test of the fetoplacental unit."	1.27	[The betamethasone test in the diagnosis of placental insufficiency]. ( Bernaschek, G; Bieglmayer, C; Friedrich, F, 1983)
"Preovulatory bovine follices (n = 73) were collected at different times after the onset of oestrus until shortly before ovulation, which occurred at 24 +/- 1 X 4 h after the peak concentration of LH in the peripheral blood."	1.27	Steroid and pituitary hormone concentrations in the fluid of preovulatory bovine follicles relative to the peak of LH in the peripheral blood. ( Bevers, MM; Dieleman, SJ; Poortman, J; van Tol, HT, 1983)
"Dehydroepiandrosterone sulfate treatment for 5 consecutive days from the 20th day of gestation stimulated the production of 6-keto PGF1 alpha in the cervix."	1.27	[Role of prostaglandin I2 (prostacyclin) on the maturation of human and rabbit uterine cervix]. ( Tanaka, M, 1984)
"Placentas obtained from women with preeclampsia produce more thromboxane, a potent vasoconstrictor, and less prostacyclin, a potent vasodilator, than normal."	1.27	Progesterone and estradiol production by normal and preeclamptic placentas. ( Walsh, SW, 1988)
" By contrast, there was no linear dose-response relationship in the conversion in A."	1.27	[Effect of steroids on the formation of progesterone in the fetal membrane]. ( Hori, D, 1985)
"Ten women in pregnancy complicated by EPH gestosis were examined prior to and during treatment."	1.26	[Dehydro-epiandrosterone in blood serum and urine of women in pregnancy complicated by EPH gestosis (author's transl)]. ( Kudelski, Z, 1982)
" All 3 tissues produced progesterone in a significant dose-response relationship with added pregnenolone but chorion was significantly more active than the other membranes."	1.26	Local modulation of progesterone production in human fetal membranes. ( Challis, J; Cruickshank, B; McLean, D; Mitchell, B, 1982)
"Androstenedione was quantitatively the highest and dehydroepiandrosterone the lowest of the ovarian androgens measured."	1.26	Androstenedione, dehydroepiandrosterone and testosterone in ovarian vein plasma and androstenedione in peripheral arterial plasma during the bovine oestrous cycle. ( Caton, D; Fields, MJ; Lehrer, AR; Thatcher, WW; Wise, TH, 1982)
" Furthermore, none of these peptides showed a synergistic effect upon DHA production when they were added to cultures together with concentrations of alpha-ACTH-(1-24) (10(2)-10(3) pg/ml) previously demonstrated to represent the middle of the dose-response curve."	1.26	The control of steroidogenesis by human fetal adrenal cells in tissue culture. III. The effects of various hormonal peptides. ( Faiman, C; Fujieda, K; Reyes, FI; Winter, JS, 1981)
"We have exploited the feasibility of utilizing constant infusion of unlabeled dehydroepiandrosterone (DHEA) for calculating its MCR, its half-life (t1/2), and its conversion ratio into estrogens."	1.26	The use of constant infusion of unlabeled dehydroepiandrosterone for the assessment of its metabolic clearance rate, its half-life, and its conversion into estrogens. ( Bélisle, S; Schiff, I; Tulchinsky, D, 1980)
"value in pregnancy was higher (61."	1.26	Urinary testosterone-17 beta-glucuronide as an indicator of androgen output in mice. ( Collins, WP; Simpson, J; Tyler, JP, 1980)
"Androstenedione was the main metabolite formed from each precursor at day 12 of gestation, while only trace amount of testosterone was detected."	1.26	Steroid metabolism in pregnant hamster. II. The metabolism of androgens by the hamster placenta. ( Marchut, M, 1981)
"Out of 3 women with intrauterine growth retardation (IUGR) 2 had an abnormal and 1 a normal response."	1.26	Assessment of placental function by estimation of testosterone in plasma after an intravenous injection of dehydroepiandrosterone sulphate (DHAS). ( Axelsson, O; Johansson, DB, 1981)
"In Japanese but not Caucasian breast cancer patients, the estradiol decreased."	1.26	Diet and endocrine-related cancer. ( Chan, P; Cohen, L; Hill, P; Kuno, K; Wynder, E, 1977)
"Dehydroepiandrosterone was the main constituent of the androgen excess."	1.25	Virilizing adrenocortical adenoma responsive to gonadotrophin. ( Albrechtsen, R; Blichert-Toft, M; Hehlet, H; Vejlsted, H, 1975)
"1."	1.25	Hydrolysis of dehydroepiandrosterone sulphate by human placental steroid 3beta-sulphatase in [18O] water. ( Logan, GG; Warren, JC, 1969)

Research

Studies (1,045)

Authors

Clinical Trials (24)

Trial Overview

Trial Outcomes

Change in Bishop Score From Insertion of Device to Extraction

Timeframe	Studies, this research(%)	All Research%
pre-1990	731 (69.95)	18.7374
1990's	97 (9.28)	18.2507
2000's	50 (4.78)	29.6817
2010's	118 (11.29)	24.3611
2020's	49 (4.69)	2.80

Authors	Studies
Richardson, A	1
Jayaprakasan, K	5
Probo, M	1
Peric, T	1
Fusi, J	1
Prandi, A	1
Faustini, M	1
Veronesi, MC	1
Yuan, T	1
Li, Y	8
Noushin, MA	1
Sahu, A	1
Singh, S	2
Basheer, R	1
Ramachandran, A	1
Ashraf, M	1
Ayhan, G	1
Rouget, F	1
Giton, F	1
Costet, N	1
Michineau, L	1
Monfort, C	1
Thomé, JP	1
Kadhel, P	1
Cordier, S	1
Oliva, A	1
Multigner, L	1
Wang, Z	3
Yang, A	1
Bao, H	1
Wang, A	1
Deng, X	1
Xue, D	1
Tan, H	1
Zhou, Y	3
Wu, C	1
Chen, ZJ	2
Shi, Y	3
Sun, Y	3
Dong, JJ	1
Shi, LL	1
Nakayama, SF	1
Kido, T	1
Jung, CR	1
Ma, C	1
Feng, H	1
Hang, JG	1
Sun, XL	1
Neves, AR	2
Montoya-Botero, P	3
Polyzos, NP	3
Sethi, A	1
Singh, N	3
Patel, G	1
Sunny, DE	1
Krüger, EL	1
Hammer, E	1
Völker, U	1
Heckmann, M	1
Cai, Z	1
Li, R	3
Leng, P	1
Liu, H	2
Liu, J	5
Mahai, G	1
Xu, S	1
Xia, W	1
Kruger, L	1
Yue, G	1
Mettu, VS	1
Paquette, A	1
Sathyanarayana, S	1
Prasad, B	1
Zhai, Y	2
Li, L	3
Lu, Y	1
Su, S	1
Liu, Y	2
Xu, Z	1
Xin, M	1
Zhang, Q	2
Cao, Z	1
Wilson, KS	1
Li, D	1
Valentine, I	1
McNeilly, A	1
Girling, S	1
Vanhaecke, L	1
Colin Duncan, W	1
Wauters, J	1
Wang, J	3
Liu, B	1
Wen, J	1
Qu, B	1
Kazzi, B	1
Ogunmoroti, O	1
Rodriguez, CP	1
Zhao, D	1
Minhas, AS	1
Osibogun, O	1
Subramanya, V	1
Allison, MA	1
Ouyang, P	1
Michos, ED	1
Rosato, E	1
Sciarra, F	1
Anastasiadou, E	1
Lenzi, A	1
Venneri, MA	1
Pourquet, A	3
Teoli, J	3
Bouty, A	3
Renault, L	4
Roucher, F	3
Mallet, D	3
Rigaud, C	3
Dijoud, F	3
Mouriquand, P	3
Mure, PY	3
Sanlaville, D	3
Ecochard, R	3
Plotton, I	3
Ghosh, D	4
Xu, H	1
Wang, Q	2
Li, T	1
Wang, Y	3
Cao, R	2
Peng, X	2
Yao, R	1
Han, H	1
Zhou, R	2
Fu, L	2
Hvizdak, M	1
Kandel, SE	1
Work, HM	1
Gracey, EG	1
McCullough, RL	1
Lampe, JN	1
El Mahdi, E	1
Fekry, N	1
Ahmed, M	1
Ghebremeskel, K	1
Sassin, AM	1
Sangi-Haghpeykar, H	1
Aagaard, KM	1
An, SM	1
Kim, MJ	1
Jeong, JS	1
Kim, SY	1
Kim, DS	1
An, BS	1
Kim, SC	1
Zambrano, E	1
Reyes-Castro, LA	1
Rodríguez-González, GL	1
Chavira, R	1
Lomas-Soria, C	1
Gerow, KG	1
Nathanielsz, PW	5
Pan, X	1
Zhou, J	2
Li, X	2
Wang, L	2
Yuan, Y	1
Zhang, Y	1
Ulziikhuu, B	1
Gombojav, E	1
Banzrai, C	1
Batsukh, S	1
Enkhtuya, E	1
Boldbaatar, B	1
Bellinger, DC	1
Lanphear, BP	1
McCandless, LC	1
Nepomnaschy, P	1
Salvante, K	1
Weinberg, J	1
Allen, RW	1
Viardot-Foucault, V	1
Bi, D	1
Takinami, Y	1
Chan, JKY	1
Lee, YH	1
McManus, JM	1
Chung, YM	1
Sharifi, N	1
Glachant, S	1
Salle, B	1
Langlois-Jacques, C	1
Labrune, E	1
Roy, P	1
Benchaib, M	1
Fraison, E	1
Zhang, J	2
Jia, H	1
Diao, F	1
Ma, X	1
Cui, Y	1
Koskivuori, J	1
Voutilainen, R	3
Storvik, M	1
Häkkinen, MR	1
Uusitalo, L	1
Keski-Nisula, L	1
Backman, K	1
Auriola, S	1
Lehtonen, M	1
Zhu, F	1
Yin, S	1
Yang, B	1
Li, S	1
Feng, X	1
Wang, T	2
Che, D	1
Gu, M	1
Cai, H	1
Deng, W	2
Tang, Y	1
Du, S	1
Wang, P	1
Wang, H	1
Sun, A	1
Kong, S	1
Sozen, B	1
Ozekinci, M	1
Erman, M	1
Gunduz, T	1
Demir, N	2
Akouri, R	1
Takeshita, RSC	1
Mendonça, RS	1
Bercovitch, FB	2
Huffman, MA	2
Jurkovich, V	1
Bakony, M	1
Laky, E	1
Ruff, F	1
Kézér, FL	1
Bende, A	1
Kovács, L	1
Jensen, RC	1
Glintborg, D	1
Gade Timmermann, CA	1
Nielsen, F	1
Kyhl, HB	1
Frederiksen, H	1
Andersson, AM	1
Juul, A	1
Sidelmann, JJ	1
Andersen, HR	1
Grandjean, P	1
Andersen, MS	1
Jensen, TK	1
Leff-Gelman, P	1
Flores-Ramos, M	1
Carrasco, AEÁ	1
Martínez, ML	1
Takashima, MFS	1
Coronel, FMC	1
Labonne, BF	1
Dosal, JAZ	1
Chávez-Peón, PB	1
Morales, SG	1
Camacho-Arroyo, I	1
Ozcil, MD	1
Kamin, HS	1
Bhatt, SS	1
Mulligan, CJ	1
Kertes, DA	1
Ren, J	1
Li, N	1
Tan, SC	1
Low, TY	1
Ma, Z	1
Ghassemi Nejad, J	1
Lee, BH	1
Kim, JY	1
Chemere, B	1
Sung, KI	1
Lee, HG	1
Habib, P	1
Neulen, J	1
Habib, S	1
Rösing, B	1
Zamponi, V	1
Mazzilli, R	1
Mazzilli, F	1
Fantini, M	1
Sundararajan, A	1
Vora, K	1
Saiyed, S	1
Natesan, S	1
Li, CJ	2
Lin, LT	4
Tsui, KH	4
Duport Percier, M	1
Anahory, T	1
Ranisavljevic, N	1
Bringer-Deutsch, S	1
Lundell, AC	1
Ryberg, H	1
Vandenput, L	1
Rudin, A	1
Ohlsson, C	1
Tivesten, Å	1
Qin, JC	1
Fan, L	2
Qin, AP	1
Hu, Q	1
Hong, L	1
Nie, M	1
Fang, Y	1
Dai, Y	1
Wang, S	1
Yin, C	1
Yang, X	1
Schury, K	1
Koenig, AM	1
Isele, D	1
Hulbert, AL	1
Krause, S	1
Umlauft, M	1
Kolassa, S	1
Ziegenhain, U	1
Karabatsiakis, A	1
Reister, F	1
Guendel, H	1
Fegert, JM	1
Kolassa, IT	1
Maliqueo, M	1
Cruz, G	1
Espina, C	1
Contreras, I	1
García, M	1
Echiburú, B	1
Crisosto, N	1
Al-Turki, HA	1
Bérard, A	1
Muanda, FT	1
Sheehy, O	1
Howard, JM	1
Legacki, EL	2
Ball, BA	2
Corbin, CJ	1
Loux, SC	1
Scoggin, KE	1
Stanley, SD	2
Conley, AJ	3
Narkwichean, A	3
Maalouf, W	2
Baumgarten, M	1
Polanski, L	1
Raine-Fenning, N	1
Campbell, B	1
Adamcová, K	1
Kolátorová, L	1
Chlupáčová, T	1
Šimková, M	1
Jandíková, H	1
Pařízek, A	1
Stárka, L	11
Dušková, M	2
Hu, L	1
Wang, F	1
Mahmoud, YI	1
Mahmoud, AA	1
Abo-Zeid, FS	1
Fares, NH	1
Sharma, D	1
Coridon, H	1
Aubry, E	1
Houeijeh, A	1
Houfflin-Debarge, V	1
Besson, R	1
Deruelle, P	1
Storme, L	1
Wang, R	1
Tiosano, D	1
Sánchez-Guijo, A	2
Hartmann, MF	3
Wudy, SA	2
Schwarze, JE	1
Canales, J	1
Crosby, J	1
Ortega-Hrepich, C	1
Villa, S	1
Pommer, R	1
Chern, CU	1
Vitale, SG	1
Chen, SN	2
Wang, PH	3
Cianci, A	1
Tsai, HW	1
Wen, ZH	2
Satué, K	1
Marcilla, M	1
Medica, P	1
Ferlazzo, A	1
Fazio, E	1
Schmelter, V	1
Antonaci, L	1
Fröhlich, S	1
Herebian, D	1
Verde, P	1
Heil, M	1
Hoehn, T	1
Li, J	4
Teng, T	1
Liang, Q	1
Cui, W	1
Wang, W	4
Wei, D	1
Ma, J	1
Rodriguez-Purata, J	1
Scholtz, EL	1
Esteller-Vico, A	1
Kunicki, M	1
Skowrońska, P	1
Pastuszek, E	1
Jakiel, G	1
Smolarczyk, R	1
Łukaszuk, K	1
Svensson, K	1
Just, AC	1
Fleisch, AF	1
Sanders, AP	1
Tamayo-Ortiz, M	1
Baccarelli, AA	1
Wright, RJ	1
Téllez-Rojo, MM	1
Wright, RO	1
Burris, HH	1
Monteiro, CS	1
Scheffer, BB	1
Carvalho, RF	1
Scheffer, JB	1
Song, J	1
Wang, X	2
Guo, Y	1
Yang, Y	1
Xu, K	1
Sa, Y	1
Yuan, L	1
Jiang, H	1
Guo, J	2
Sun, Z	1
Fabregat, A	1
Marcos, J	2
Garrostas, L	1
Segura, J	1
Pozo, OJ	1
Ventura, R	1
Borman, E	1
Check, JH	2
Mitchell-Williams, J	1
Cohen, R	1
Yilmaz, N	1
Uygur, D	1
Inal, H	1
Gorkem, U	1
Cicek, N	1
Mollamahmutoglu, L	1
Fenton, A	1
Panay, N	2
Campbell, BK	2
Fouany, MR	1
Sharara, FI	1
Pluchino, N	1
Santoro, A	1
Casarosa, E	1
Wenger, JM	1
Genazzani, AD	1
Petignat, P	1
Genazzani, AR	2
Fusi, FM	1
Ferrario, M	1
Bosisio, C	1
Arnoldi, M	1
Zanga, L	1
Zimmerman, Y	1
Coelingh Bennink, HJ	1
Wouters, W	1
Ebes, F	1
Fauser, BC	1
Zangmo, R	2
Kumar, S	2
Roy, KK	1
Sharma, JB	1
Malhotra, N	1
Vanamail, P	2
Grossman, A	1
Johannsson, G	1
Quinkler, M	1
Zelissen, P	1
Jimenez, PT	1
Frolova, AI	2
Chi, MM	1
Grindler, NM	1
Willcockson, AR	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Dehydroepiandrosterone on Live Birth Rate in Subfertile Patients With Poor Ovarian Responds[NCT02432248]		350 participants (Anticipated)	Interventional	2015-02-28	Recruiting
Drospirenone and Ethinyl Estradiol Combinations (Yasmin) as Infertility Treatments for Premature Ovarian Failure: a Perspective Follow-up Study.[NCT02757469]		20 participants (Anticipated)	Interventional	2016-05-31	Not yet recruiting
A Randomized Controlled Trial on the Effect of Dehydroepiandrosterone (DHEA) Supplementation on Ovarian Reserve Markers, Response to a Standard Low Dose FSH Stimulation and IVF Cycle Outcomes in Patients With Normal and Poor Ovarian Reserve[NCT01915186]		104 participants (Actual)	Interventional	2010-10-31	Completed
Does DHEA Improve Pregnancy Rate in Women Undergoing IVF/Intracytoplasmatic Sperm Injection(ICSI) With Expected Poor Ovarian Response According to the Bologna Criteria? A Double Blind Randomized Placebo Controlled Study[NCT02561793]	Phase 3	440 participants (Anticipated)	Interventional	2015-10-31	Recruiting
Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve[NCT02150330]	Phase 3	40 participants (Actual)	Interventional	2013-01-31	Completed
To Investigate the Effectiveness of Adjuvant Supplements Prior to in Vitro Fertilization Cycles[NCT05471453]		90 participants (Anticipated)	Interventional	2022-03-02	Recruiting
The Role of Dehydroepiandrosterone in the Maintenance of Mitochondrial Quality of Cumulus Cells in Poor Ovarian Responders[NCT03438812]		66 participants (Actual)	Interventional	2017-09-06	Completed
Antioxidants vs.Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve[NCT03621683]		78 participants (Actual)	Interventional	2016-01-06	Completed
Dehydroepiandrosterone Versus Growth Hormone in Women Undergoing ICSI With Expected Poor Ovarian Response[NCT02736591]	Phase 3	210 participants (Anticipated)	Interventional	2016-06-30	Recruiting
Evaluation of the Role of Combined Dehydropeiandrosterone and Growth Hormone in Women With Expected Poor Ovarian Response Undergoing ICSI: A Double Blind Placebo Controlled Study.[NCT02766764]	Phase 4	230 participants (Anticipated)	Interventional	2016-06-30	Recruiting
Does DHEA Improve Pregnancy Rate in Women Undergoing IVF/ICSI With Expected Poor Ovarian Response According to the Bologna Criteria? A Randomized Controlled Study[NCT02151006]	Phase 3	140 participants (Actual)	Interventional	2014-05-31	Completed
Ovarian Needle Puncture for Follicle Activation in IVF Patients With Diminished Ovarian Reserve[NCT04608695]		34 participants (Anticipated)	Interventional	2020-07-01	Recruiting
The Use of DHEA in Women With Premature Ovarian Failure[NCT01129947]	Early Phase 1	0 participants (Actual)	Interventional	2010-05-31	Withdrawn (stopped due to very poor patient recruitement)
The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation on the Number of Oocytes Obtained During IVF in Poor Ovarian Responders[NCT02357472]	Phase 4	50 participants (Anticipated)	Interventional	2014-12-31	Active, not recruiting
Assess the Effect of DHEA or Other Androgenic Agents on Ovarian Reserve Markers in Women With Diminished Ovarian Reserve[NCT02268032]	Phase 1	94 participants (Actual)	Interventional	2014-07-15	Completed
[NCT01145144]		0 participants	Interventional	2008-01-31	Completed
A Randomized Placebo-Controlled Trial of Dehydroepiandrosterone (DHEA) Treatment for Two Months Before Starting Ovulation Induction for in Vitro Fertilization (IVF)[NCT00419913]	Phase 2/Phase 3	8 participants (Actual)	Interventional	2007-01-31	Terminated (stopped due to Failure to recruit sufficient participants.)
[NCT00549081]		0 participants	Interventional	2008-01-31	Not yet recruiting
The Effect of DHEA on Markers of Ovarian Reserve in Women With Diminished Ovarian Reserve[NCT01129830]	Early Phase 1	200 participants (Actual)	Interventional	2010-01-31	Terminated (stopped due to Suboptimal recruitment)
Effect of DHEA on Skin Aging - Placebo-Controlled and Randomized Phase III Study in Postmenopausal Women.[NCT00248989]	Phase 3	150 participants (Actual)	Interventional	2004-11-01	Completed
Allosteric Regulation of Cytosolic Sulfotransferases in Humans[NCT03383133]	Early Phase 1	1 participants (Actual)	Interventional	2018-01-11	Completed
An Open-Label Randomized Controlled Trial (RCT) of 6 Weeks of Human Growth Hormone (HGH) Prior to Ovulation Induction for In Vitro Fertilization (IVF)[NCT02179255]	Phase 1/Phase 2	30 participants (Anticipated)	Interventional	2014-08-01	Enrolling by invitation
Transdermal Testosterone Gel for Poor Ovarian Responders. A Multicenter Double-blind Placebo Controlled Randomized Trial[NCT02418572]	Phase 3	400 participants (Anticipated)	Interventional	2015-04-30	Recruiting
Induction of Labor in Women With Unfavorable Cervix: Randomized Controlled Trial Comparing Outpatient to Inpatient Cervical Ripening Using Dilapan-S® (HOMECARE)[NCT03665688]		338 participants (Actual)	Interventional	2018-11-07	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Change in Bishop score (based on cervical dilation, position of cervix, effacement of cervix, fetal station and softness of cervix) . Calculated as Bishop score value at 12 hours minus value at baseline. Bishop score ranges from zero to 13, with zero meaning you're not ready for induction and 13 indicating a better chance for successful induction. A higher score means that labor is closer, and that induction has a good chance of being successful. (NCT03665688)
Timeframe: 12 hours

Number of Participants With Cesarean Delivery

Number of Participants With Hospital Stay Longer Than 48 Hours

Intervention	score on a scale (Median)
Outpatient Dilapan-S	2
Inpatient Dilapan-S	2

Intervention	Participants (Count of Participants)
Outpatient Dilapan-S	42
Inpatient Dilapan-S	43

Rate of hospital stay longer than 48 hours (from admission to discharge) (NCT03665688)
Timeframe: 72 hours or discharge home time, whichever occurs first

Number of Participants With Operative Vaginal Delivery

Number of Participants With Vaginal Deliveries - 24 Hours

Intervention	Participants (Count of Participants)
Outpatient Dilapan-S	89
Inpatient Dilapan-S	152

Intervention	Participants (Count of Participants)
Outpatient Dilapan-S	6
Inpatient Dilapan-S	5

Rate of vaginal deliveries within 24 hours since admission to hospital (%) (NCT03665688)
Timeframe: 24 hours

Number of Participants With Vaginal Deliveries 2-4 Days

Time From Hospital Admission to Active Stage of Labor

Intervention	Participants (Count of Participants)
Outpatient Dilapan-S	117
Inpatient Dilapan-S	86

Intervention	Participants (Count of Participants)
Outpatient Dilapan-S	125
Inpatient Dilapan-S	128

Time from hospital admission to reach active stage of labor defined as cervical dilation of ≥ 6 cm (in minutes) (NCT03665688)
Timeframe: 1-2 days

Article	Year
The Use of Androgen Priming in Women with Reduced Ovarian Reserve Undergoing Assisted Reproductive Technology. Seminars in reproductive medicine, 2021, Volume: 39, Issue:5-06 Topics: Androgens; Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Ovarian Reserve; Ovulatio	2021
Androgens and diminished ovarian reserve: the long road from basic science to clinical implementation. A comprehensive and systematic review with meta-analysis. American journal of obstetrics and gynecology, 2022, Volume: 227, Issue:3 Topics: Androgens; Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Live Birth; Ovarian Reser	2022
The Role of Dehydroepiandrosterone in Improving Combinatorial chemistry & high throughput screening, 2023, Volume: 26, Issue:5 Topics: Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Ovary; Pregnancy; Pregnancy Rate; Re	2023
Revisiting the physiological role of androgens in women. Expert review of endocrinology & metabolism, 2022, Volume: 17, Issue:6 Topics: Androgens; Dehydroepiandrosterone; Female; Humans; Menopause; Menstrual Cycle; Pregnancy	2022
Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve. Drug discoveries & therapeutics, 2023, May-15, Volume: 17, Issue:2 Topics: Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Ovarian Reserve; Ovary; Pregnancy; P	2023
Efficacy of dehydroepiandrosterone priming in women with poor ovarian response undergoing IVF/ICSI: a meta-analysis. Frontiers in endocrinology, 2023, Volume: 14 Topics: Dehydroepiandrosterone; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Ovulat	2023
TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis. Reproductive biology and endocrinology : RB&E, 2023, Jul-18, Volume: 21, Issue:1 Topics: Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Network Meta-Analysis; Ovulation Ind	2023
Aromatase and steroid sulfatase from human placenta. Methods in enzymology, 2023, Volume: 689 Topics: Androgens; Aromatase; Dehydroepiandrosterone; Estrogens; Estrone; Female; Humans; Membrane Proteins;	2023
A dose-response and meta-analysis of dehydroepiandrosterone (DHEA) supplementation on testosterone levels: perinatal prediction of randomized clinical trials. Experimental gerontology, 2020, Volume: 141 Topics: Androgens; Dehydroepiandrosterone; Dietary Supplements; Female; Humans; Male; Pregnancy; Randomized	2020
Effect of sex hormones on human voice physiology: from childhood to senescence. Hormones (Athens, Greece), 2021, Volume: 20, Issue:4 Topics: Androgens; Androstenedione; Dehydroepiandrosterone; Estrogens; Female; Gonadal Steroid Hormones; Gon	2021
The Role of Androgen Supplementation in Women With Diminished Ovarian Reserve: Time to Randomize, Not Meta-Analyze. Frontiers in endocrinology, 2021, Volume: 12 Topics: Androgens; Animals; Dehydroepiandrosterone; Evidence-Based Medicine; Female; Fertilization in Vitro;	2021
The effect of dehydroepiandrosterone (DHEA) supplementation on women with diminished ovarian reserve (DOR) in IVF cycle: Evidence from a meta-analysis. Journal of gynecology obstetrics and human reproduction, 2017, Volume: 46, Issue:1 Topics: Abortion, Spontaneous; Adjuvants, Immunologic; Dehydroepiandrosterone; Female; Fertilization in Vitr	2017
Efficacy of dehydroepiandrosterone (DHEA) supplementation for in vitro fertilization and embryo transfer cycles: a systematic review and meta-analysis. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2018, Volume: 34, Issue:3 Topics: Dehydroepiandrosterone; Embryo Transfer; Female; Fertilization in Vitro; Humans; Pregnancy; Pregnanc	2018
DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve: A systematic review and meta-analysis. JBRA assisted reproduction, 2018, Nov-01, Volume: 22, Issue:4 Topics: Adult; Dehydroepiandrosterone; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Ooc	2018
Androgen supplementation in assisted reproduction: where are we in 2019? Current opinion in obstetrics & gynecology, 2019, Volume: 31, Issue:3 Topics: Administration, Cutaneous; Adult; Androgens; Animals; Clinical Trials as Topic; Dehydroepiandrostero	2019
The impact of dehydroepiandrosterone in poor ovarian responders on assisted reproduction technology treatment. JBRA assisted reproduction, 2019, 10-14, Volume: 23, Issue:4 Topics: Adult; Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Infertility, Female; Ovulatio	2019
Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis. Reproductive biology and endocrinology : RB&E, 2013, May-16, Volume: 11 Topics: Adjuvants, Immunologic; Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Ovary; Ovula	2013
Is there a role for DHEA supplementation in women with diminished ovarian reserve? Journal of assisted reproduction and genetics, 2013, Volume: 30, Issue:9 Topics: Adult; Anti-Mullerian Hormone; Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Infer	2013
Advances in neurosteroids: role in clinical practice. Climacteric : the journal of the International Menopause Society, 2013, Volume: 16 Suppl 1 Topics: Affect; Aging; Behavior; Brain Injuries; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone S	2013
Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe. European journal of endocrinology, 2013, Volume: 169, Issue:6 Topics: Addison Disease; Adrenal Insufficiency; Cardiovascular Diseases; Circadian Rhythm; Dehydroepiandrost	2013
Premature ovarian insufficiency: how to improve reproductive outcome? Climacteric : the journal of the International Menopause Society, 2014, Volume: 17, Issue:3 Topics: Adjuvants, Immunologic; Clomiphene; Contraceptives, Oral, Combined; Dehydroepiandrosterone; Female;	2014
Dehydroepiandrosterone, its metabolites and ion channels. The Journal of steroid biochemistry and molecular biology, 2015, Volume: 145 Topics: Animals; Central Nervous System; Dehydroepiandrosterone; Female; Glucose; Gonadotropin-Releasing Hor	2015
A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2015, Volume: 131, Issue:3 Topics: Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Ovarian Reserve; Pregnancy; Pregnanc	2015
The feto-placental unit, and potential roles of dehydroepiandrosterone (DHEA) in prenatal and postnatal brain development: A re-examination using the spiny mouse. The Journal of steroid biochemistry and molecular biology, 2016, Volume: 160 Topics: Adrenal Glands; Animals; Brain; Dehydroepiandrosterone; Female; Fetal Development; Humans; Mice; Pla	2016
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. The Cochrane database of systematic reviews, 2015, Nov-26, Issue:11 Topics: Abortion, Spontaneous; Adult; Androgens; Dehydroepiandrosterone; Estradiol; Female; Humans; Infertil	2015
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. The Cochrane database of systematic reviews, 2015, Nov-26, Issue:11 Topics: Abortion, Spontaneous; Adult; Androgens; Dehydroepiandrosterone; Estradiol; Female; Humans; Infertil	2015
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. The Cochrane database of systematic reviews, 2015, Nov-26, Issue:11 Topics: Abortion, Spontaneous; Adult; Androgens; Dehydroepiandrosterone; Estradiol; Female; Humans; Infertil	2015
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. The Cochrane database of systematic reviews, 2015, Nov-26, Issue:11 Topics: Abortion, Spontaneous; Adult; Androgens; Dehydroepiandrosterone; Estradiol; Female; Humans; Infertil	2015
Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis. Journal of assisted reproduction and genetics, 2016, Volume: 33, Issue:8 Topics: Abortion, Spontaneous; Dehydroepiandrosterone; Endometrium; Female; Humans; Ovarian Reserve; Ovulati	2016
Dehydroepiandrosterone (DHEA) supplementation and IVF outcome in poor responders. Human fertility (Cambridge, England), 2017, Volume: 20, Issue:2 Topics: Adjuvants, Immunologic; Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Infertility,	2017
Nonhuman primates as models for human adrenal androgen production: function and dysfunction. Reviews in endocrine & metabolic disorders, 2009, Volume: 10, Issue:1 Topics: Adrenal Cortex; Androgens; Animals; Callithrix; Dehydroepiandrosterone; Female; Fetus; Humans; Macac	2009
Therapeutic management of adrenal insufficiency. Best practice & research. Clinical endocrinology & metabolism, 2009, Volume: 23, Issue:2 Topics: Adrenal Insufficiency; Critical Care; Dehydroepiandrosterone; Female; Glucocorticoids; Hormone Repla	2009
Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Current opinion in obstetrics & gynecology, 2009, Volume: 21, Issue:4 Topics: Age Factors; Aging; Dehydroepiandrosterone; Female; Fertility Agents, Female; Humans; Infertility, F	2009
Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Current opinion in obstetrics & gynecology, 2009, Volume: 21, Issue:4 Topics: Age Factors; Aging; Dehydroepiandrosterone; Female; Fertility Agents, Female; Humans; Infertility, F	2009
Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Current opinion in obstetrics & gynecology, 2009, Volume: 21, Issue:4 Topics: Age Factors; Aging; Dehydroepiandrosterone; Female; Fertility Agents, Female; Humans; Infertility, F	2009
Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Current opinion in obstetrics & gynecology, 2009, Volume: 21, Issue:4 Topics: Age Factors; Aging; Dehydroepiandrosterone; Female; Fertility Agents, Female; Humans; Infertility, F	2009
The myotonic dystrophies: diagnosis and management. Journal of neurology, neurosurgery, and psychiatry, 2010, Volume: 81, Issue:4 Topics: Blotting, Southern; Chromosomes, Human, Pair 19; Creatine; Dehydroepiandrosterone; Diagnosis, Differ	2010
Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome. The Journal of steroid biochemistry and molecular biology, 2010, Volume: 119, Issue:3-5 Topics: Androgens; Animals; Dehydroepiandrosterone; Disease Models, Animal; Embryo Loss; Female; Humans; Hyp	2010
Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-analysis. Reproductive biomedicine online, 2011, Volume: 22, Issue:6 Topics: Androgens; Dehydroepiandrosterone; Female; Humans; Letrozole; Nitriles; Oocyte Retrieval; Ovulation	2011
Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). Reproductive biology and endocrinology : RB&E, 2011, May-17, Volume: 9 Topics: Animals; Cell Count; Dehydroepiandrosterone; Female; Fertility Agents, Female; Hormone Replacement T	2011
Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). Reproductive biology and endocrinology : RB&E, 2011, May-17, Volume: 9 Topics: Animals; Cell Count; Dehydroepiandrosterone; Female; Fertility Agents, Female; Hormone Replacement T	2011
Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). Reproductive biology and endocrinology : RB&E, 2011, May-17, Volume: 9 Topics: Animals; Cell Count; Dehydroepiandrosterone; Female; Fertility Agents, Female; Hormone Replacement T	2011
Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). Reproductive biology and endocrinology : RB&E, 2011, May-17, Volume: 9 Topics: Animals; Cell Count; Dehydroepiandrosterone; Female; Fertility Agents, Female; Hormone Replacement T	2011
Treatment of corticotroph deficiency. Annales d'endocrinologie, 2012, Volume: 73, Issue:1 Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Corticotrophs; Corticotropin-Releasing Hormone;	2012
Ovarian aging and implications for fertility female health. Minerva endocrinologica, 2012, Volume: 37, Issue:1 Topics: Adult; Aging; Dehydroepiandrosterone; Diagnostic Techniques, Obstetrical and Gynecological; Female;	2012
[The alternative androgen synthesis pathway in humans]. Klinische Padiatrie, 2013, Volume: 225, Issue:1 Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenal Hyperplasia, Con	2013
[A NEW PRODUCT OF ADRENOCORTICAL SECRETION: DEHYDROEPIANDROSTERONE SULFATE]. Revue francaise d'etudes cliniques et biologiques, 1965, Volume: 10 Topics: Adrenal Glands; Biological Assay; Chemical Phenomena; Chemistry; Dehydroepiandrosterone; Dehydroepia	1965
The human fetal adrenal: making adrenal androgens for placental estrogens. Seminars in reproductive medicine, 2004, Volume: 22, Issue:4 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Corticotropin-Releasing Hormone; Dehydroepia	2004
The rise in adrenal androgen biosynthesis: adrenarche. Seminars in reproductive medicine, 2004, Volume: 22, Issue:4 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Child; Dehydroepiandrosterone; Dehydroepiand	2004
Adrenal androgens and the immune system. Seminars in reproductive medicine, 2004, Volume: 22, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Adrenal Glands; Androgens; Animals; Arthritis, Rheumatoid; Criti	2004
Management of adrenal insufficiency in different clinical settings. Expert opinion on pharmacotherapy, 2005, Volume: 6, Issue:14 Topics: Acute Disease; Adrenal Insufficiency; Clinical Trials as Topic; Dehydroepiandrosterone; Drug Adminis	2005
Placental sulfatase deficiency. Biochemical and clinical aspects. Contributions to gynecology and obstetrics, 1982, Volume: 9 Topics: 3-Hydroxysteroid Dehydrogenases; Amniotic Fluid; Aromatase; Arylsulfatases; Dehydroepiandrosterone;	1982
[Chemical forms and metabolism of steroids]. Rinsho byori. The Japanese journal of clinical pathology, 1982, Volume: Suppl 52 Topics: Androsterone; Carrier Proteins; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Estradiol;	1982
[Endocrinological tests in pregnancy]. Rinsho byori. The Japanese journal of clinical pathology, 1984, Volume: Spec No 58 Topics: Chorionic Gonadotropin; Dehydroepiandrosterone; Estriol; Female; Fetal Monitoring; Humans; Infant, N	1984
Polycystic ovarian disease. Fertility and sterility, 1981, Volume: 35, Issue:4 Topics: Adrenal Cortex; Animals; Dehydroepiandrosterone; Dexamethasone; Disease Models, Animal; Female; Foll	1981
Extraglandular oestrogen formation and serum binding of oestradiol: relationship to cancer. The Journal of endocrinology, 1981, Volume: 89 Suppl Topics: Adipose Tissue; Androstenedione; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estrogens; Fem	1981
Deuterium labelled steroid hormones: syntheses and application in quantitation and endocrinology. Journal of steroid biochemistry, 1981, Volume: 14, Issue:8 Topics: Androstenedione; Chemical Phenomena; Chemistry; Dehydroepiandrosterone; Deuterium; Estradiol; Estrio	1981
Management of mild pregnancy-induced hypertension remote from term. Seminars in perinatology, 1994, Volume: 18, Issue:2 Topics: Adult; Ambulatory Care; Antihypertensive Agents; Bed Rest; Dehydroepiandrosterone; Dehydroepiandrost	1994
The unripe cervix and its management for labour induction. Annals of the Academy of Medicine, Singapore, 1993, Volume: 22, Issue:2 Topics: Administration, Intravaginal; Cervix Uteri; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate;	1993
Extrapulmonary effects of antenatally administered steroids. The Journal of pediatrics, 1996, Volume: 128, Issue:2 Topics: Adrenocorticotropic Hormone; Animals; Dehydroepiandrosterone; Ductus Arteriosus, Patent; Female; Fet	1996
Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids, 1999, Volume: 64, Issue:9 Topics: Adrenal Glands; Adult; Aging; Child; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female;	1999
Minireview: 16alpha-hydroxylated metabolites of dehydroepiandrosterone and their biological significance. Endocrine regulations, 2000, Volume: 34, Issue:3 Topics: Autoimmune Diseases; Body Fluids; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Estrogens;	2000
[Fetology in 1976]. La Revue du praticien, 1977, Feb-21, Volume: 27, Issue:11 Topics: Amniotic Fluid; Animals; Blood Flow Velocity; Blood Pressure; Dehydroepiandrosterone; Estrogens; Fem	1977
The applications of steroid hormone radioimmunoassays to clinical obstetrics. Obstetrics and gynecology, 1975, Volume: 46, Issue:4 Topics: Adrenal Cortex Hormones; Cholesterol; Dehydroepiandrosterone; Estetrol; Estradiol; Estriol; Estrone;	1975
Plasma levels and secretion rate of steroids with anabolic activity in man. Environmental quality and safety. Supplement, 1976, Issue:5 Topics: Adolescent; Adrenal Glands; Adult; Androstenedione; Child; Dehydroepiandrosterone; Estradiol; Female	1976
[Determination of oestrogens in pregnancy (author's transl)]. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1976, Volume: 14, Issue:12 Topics: Dehydroepiandrosterone; Estriol; Estrogens; Female; Fetal Diseases; Humans; Methods; Pregnancy; Radi	1976
Endocrine evaluation in the diagnosis of intrauterine growth retardation. Clinical obstetrics and gynecology, 1977, Volume: 20, Issue:4 Topics: Dehydroepiandrosterone; Estriol; Female; Fetal Distress; Fetal Growth Retardation; Fetus; Growth; Hu	1977
The role of lactogenic hormones in the pregnant woman and the fetus. American journal of obstetrics and gynecology, 1977, Dec-01, Volume: 129, Issue:7 Topics: Amniotic Fluid; Animals; Breast; Corpus Luteum Maintenance; Dehydroepiandrosterone; Female; Fetus; H	1977
Normal and abnormal androgen metabolism. Clinical obstetrics and gynecology, 1978, Volume: 21, Issue:1 Topics: Acne Vulgaris; Androgens; Animals; Dehydroepiandrosterone; Female; Fetus; Genitalia, Female; Hirsuti	1978
Concurrent hypertension and pregnancy. Clinical obstetrics and gynecology, 1978, Volume: 21, Issue:3 Topics: Amniotic Fluid; Antihypertensive Agents; Dehydroepiandrosterone; Diuretics; Estrogens; Female; Fetal	1978
Fetal considerations. Metabolic clearance rate of maternal plasma dehydroisoandrosterone sulfate. Seminars in perinatology, 1978, Volume: 2, Issue:1 Topics: Benzothiadiazines; Dehydroepiandrosterone; Diuretics; Estradiol; Female; Humans; Hypertension; Mater	1978
[The determination, secretion and plasma concentration of androgens]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1979, Oct-15, Volume: 34, Issue:20 Topics: Adolescent; Adult; Age Factors; Androgen Antagonists; Androgen-Binding Protein; Androgens; Androstan	1979
[Psoriasis: A general disease? Can psoriasis be explained biochemically?]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1977, Volume: 28, Issue:4 Topics: Adolescent; Adult; Chemical Phenomena; Chemistry; Child; Child, Preschool; Cyclic AMP; Deficiency Di	1977
[Endocrinological aspects of pregnancy]. Zentralblatt fur Gynakologie, 1977, Volume: 99, Issue:12 Topics: Antigen-Antibody Reactions; Cortisone; Cross Reactions; Dehydroepiandrosterone; Estrogens; Female; G	1977
Prolactin and human breast cancer: a review. European journal of cancer, 1979, Volume: 15, Issue:3 Topics: Adolescent; Adult; Aging; Breast Neoplasms; Child; Child, Preschool; Circadian Rhythm; Contraceptive	1979
[Dehydroepiandrosterone and dehydroepiandrosterone-sulfate content of the amniotic fluid]. Orvosi hetilap, 1991, Oct-20, Volume: 132, Issue:42 Topics: Amniocentesis; Amniotic Fluid; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Human	1991
Steroid sulfatase deficiency and the genetics of the short arm of the human X chromosome. Advances in human genetics, 1985, Volume: 14 Topics: Animals; Arylsulfatases; Cholesterol Esters; Chromosome Deletion; Chromosome Mapping; Cryptorchidism	1985
Breast development in puberty. Annals of the New York Academy of Sciences, 1986, Volume: 464 Topics: Adipose Tissue; Adolescent; Adult; Androgens; Breast; Breast Neoplasms; Cell Differentiation; Cell D	1986
[Ripening of the human cervix]. Zhonghua fu chan ke za zhi, 1985, Volume: 20, Issue:1 Topics: Cervix Uteri; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dinoprostone; Estradiol; Femal	1985
Sex hormones--effects on prolactin cells. Acta endocrinologica. Supplementum, 1974, Volume: 189 Topics: Adenoma; Adult; Animals; Dehydroepiandrosterone; Diethylstilbestrol; Dogs; Estradiol; Female; Gonada	1974
Some aspects of the pathogenesis of prostatic hyperplasia. Acta pathologica et microbiologica Scandinavica. Supplement, 1974, Volume: Suppl 248 Topics: Adrenocorticotropic Hormone; Animals; Dehydroepiandrosterone; Dihydrotestosterone; Estrogens; Female	1974
[Estriol production during pregnancy]. Sanfujinka no jissai. Practice of gynecology and obstetrics, 1967, Volume: 16, Issue:8 Topics: Anencephaly; Dehydroepiandrosterone; Estriol; Female; Humans; Hydatidiform Mole; Placenta; Pregnancy	1967
Endocrinology of the conceptus. The Australian & New Zealand journal of obstetrics & gynaecology, 1970, Volume: 10, Issue:3 Topics: Cholesterol; Dehydroepiandrosterone; Estradiol; Estrogens; Estrone; Female; Fetal Diseases; Fetus; H	1970
The antenatal treatment of the fetus of the diabetic mother. Canadian Medical Association journal, 1971, Aug-07, Volume: 105, Issue:3 Topics: Amniotic Fluid; Blood Glucose; Dehydroepiandrosterone; Delivery, Obstetric; Diet, Diabetic; Embryoni	1971
Aspects of corticosteroid biogenesis and metabolism during the perinatal period. Clinical obstetrics and gynecology, 1971, Volume: 14, Issue:3 Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Blood; Congenital Abnormalities; Dehydroepiandro	1971
[Vitamin A, steroid hormones and nutrition]. Bibliotheca nutritio et dieta, 1970, Volume: 15 Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Androstanes; Animal Nutritional Physiologi	1970
[Biosynthesis of steroids in the corpus luteum. (General review of literature and radioisotope study related to menstrual and pregnancy corpus luteum in humans]. Annali di ostetricia, ginecologia, medicina perinatale, 1971, Volume: 92, Issue:11 Topics: 17-Ketosteroids; Adult; Androstanes; Carbon Isotopes; Corpus Luteum; Corpus Luteum Hormones; Dehydro	1971
Inhibition of 3 -hydroxy- 5 -steroid dehydrogenase. Gynecologic investigation, 1971, Volume: 2, Issue:1 Topics: Adrenal Hyperplasia, Congenital; Androstenes; Animals; Antibodies; Cell Differentiation; Dehydroepia	1971
[SLE and pregnancy--effect of exogenous corticosteroids on urinary excretion of estriol]. Horumon to rinsho. Clinical endocrinology, 1973, Volume: 21, Issue:4 Topics: Adult; Corticosterone; Dehydroepiandrosterone; Estriol; Female; Humans; Lupus Erythematosus, Systemi	1973
[Value of hormone analysis for the assessment of placenta function in late pregnancy]. Deutsche medizinische Wochenschrift (1946), 1973, Nov-09, Volume: 98, Issue:45 Topics: Chorionic Gonadotropin; Dehydroepiandrosterone; Estriol; Female; Humans; Placenta; Placenta Diseases	1973
Congenital adrenal hyperplasia. Advances in human genetics, 1973, Volume: 4 Topics: Adrenal Gland Diseases; Adrenal Glands; Androstenedione; Body Height; Dehydroepiandrosterone; Diagno	1973
[Endocrinologic and enzymologic supervision of pregnancy]. Medizinische Klinik, 1974, Volume: 69, Issue:38 Topics: Alkaline Phosphatase; Amine Oxidase (Copper-Containing); Amniotic Fluid; Clinical Enzyme Tests; Cyst	1974
Endocrine relations between mother and fetus. Annual review of medicine, 1968, Volume: 19 Topics: Aldosterone; Angiotensin II; Animals; Biological Transport, Active; Breast; Dehydroepiandrosterone;	1968
Endocrine patterns in the African. Clinico-biochemical assessment. Tropical and geographical medicine, 1970, Volume: 22, Issue:2 Topics: Acromegaly; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Africa; Andr	1970
The progressive increase in estrogen production in human pregnancy: an appraisal of the factors responsible. Vitamins and hormones, 1970, Volume: 28 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Binding Sites; Dehydroepiandrosterone; Estro	1970
Toxemia of pregnancy. Mechanism and therapeutic management. The American journal of cardiology, 1973, Sep-20, Volume: 32, Issue:4 Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Dehydroepiandrosterone; Delivery, Obstetric; E	1973

Article	Year
Dehydroepiandrosterone (DHEA) role in enhancement and maintenance of implantation (DREAM): randomised double-blind placebo-controlled trial-study protocol. BMJ open, 2021, 10-27, Volume: 11, Issue:10 Topics: Dehydroepiandrosterone; Double-Blind Method; Embryo Implantation; Embryo Transfer; Female; Humans; L	2021
Effect of dehydroepiandrosterone administration before in vitro fertilization on the live birth rate in poor ovarian responders according to the Bologna criteria: A randomised controlled trial. BJOG : an international journal of obstetrics and gynaecology, 2022, Volume: 129, Issue:7 Topics: Birth Rate; Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Infertility, Female; Liv	2022
Authors' reply: Effect of dehydroepiandrosterone administration before IVF on the live birth rate in poor ovarian responders according to the Bologna criteria: a randomised controlled trial. BJOG : an international journal of obstetrics and gynaecology, 2022, Volume: 129, Issue:9 Topics: Birth Rate; Dehydroepiandrosterone; Female; Fertilization in Vitro; Humans; Live Birth; Ovulation In	2022
Who benefits most from a prenatal HEPA filter air cleaner intervention on childhood cognitive development? The UGAAR randomized controlled trial. Environmental research, 2023, Aug-15, Volume: 231, Issue:Pt 1 Topics: Air Pollution; Child; Child, Preschool; Cognition; Dehydroepiandrosterone; Female; Humans; Hydrocort	2023
Effect of alpine grazing on plasma and hair cortisol, serotonin, and DHEA in dairy cows and its welfare impact. Domestic animal endocrinology, 2021, Volume: 75 Topics: Animals; Cattle; Dehydroepiandrosterone; Female; Hair; Hydrocortisone; Lactation; Milk; Pregnancy; S	2021
Dehydroepiandrosterone Shifts Energy Metabolism to Increase Mitochondrial Biogenesis in Female Fertility with Advancing Age. Nutrients, 2021, Jul-17, Volume: 13, Issue:7 Topics: Adult; Aging; Cellular Senescence; Cumulus Cells; Dehydroepiandrosterone; Dietary Supplements; Energ	2021
The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women. Journal of ovarian research, 2017, May-04, Volume: 10, Issue:1 Topics: Adult; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Female; Fertilization in Vitro; Gra	2017
Efficacy of Dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): A proof of principle double blinded randomized placebo controlled trial. European journal of obstetrics, gynecology, and reproductive biology, 2017, Volume: 218 Topics: Adult; Aging; Androgens; Dehydroepiandrosterone; Double-Blind Method; Female; Fertilization in Vitro	2017
[Effect of Chinese Herbs Combined DHEA Pretreatment on Pregnancy Outcomes of Elderly Pa- tients with Normal Ovarian Reserve Undergoing IVF-ET]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2016, Volume: 36, Issue:9 Topics: Abortion, Spontaneous; Adult; Aged; Dehydroepiandrosterone; Drugs, Chinese Herbal; Embryo Transfer;	2016
Effect of preconceptional DHEA treatment on in vitro fertilization outcome in poor ovarian respond women: study protocol for a randomized controlled trial. Trials, 2019, Jan-15, Volume: 20, Issue:1 Topics: Dehydroepiandrosterone; Double-Blind Method; Embryo Culture Techniques; Embryo Transfer; Female; Fer	2019
Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count. European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 169, Issue:2 Topics: Adjuvants, Immunologic; Adult; Anti-Mullerian Hormone; Cross-Sectional Studies; Dehydroepiandrostero	2013
DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2013, Volume: 29, Issue:10 Topics: Adult; Cohort Studies; Dehydroepiandrosterone; Drug Administration Schedule; Female; Fertilization i	2013
The pharmacokinetics and pharmacodynamics of dehydroepiandrosterone during use of an ethinylestradiol- and drospirenone-containing oral contraceptive. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2013, Volume: 18, Issue:6 Topics: Adult; Analysis of Variance; Androstenes; Contraceptives, Oral, Combined; Cross-Over Studies; Dehydr	2013
A prospective study on role of dehydroepiandrosterone (DHEA) on improving the ovarian reserve markers in infertile patients with poor ovarian reserve. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2013, Volume: 29, Issue:11 Topics: Adult; Age Factors; Anti-Mullerian Hormone; Biomarkers; Dehydroepiandrosterone; Estradiol; Female; F	2013
Does dehydroepiandrosterone supplementation really affect IVF-ICSI outcome in women with poor ovarian reserve? European journal of obstetrics, gynecology, and reproductive biology, 2014, Volume: 173 Topics: Adult; Anti-Mullerian Hormone; Dehydroepiandrosterone; Female; Fertility Agents, Female; Fertilizati	2014
A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders. Fertility and sterility, 2014, Volume: 102, Issue:1 Topics: Adult; Anti-Mullerian Hormone; Biomarkers; Chorionic Gonadotropin; Dehydroepiandrosterone; Double-Bl	2014
A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders. Fertility and sterility, 2014, Volume: 102, Issue:1 Topics: Adult; Anti-Mullerian Hormone; Biomarkers; Chorionic Gonadotropin; Dehydroepiandrosterone; Double-Bl	2014
A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders. Fertility and sterility, 2014, Volume: 102, Issue:1 Topics: Adult; Anti-Mullerian Hormone; Biomarkers; Chorionic Gonadotropin; Dehydroepiandrosterone; Double-Bl	2014
A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders. Fertility and sterility, 2014, Volume: 102, Issue:1 Topics: Adult; Anti-Mullerian Hormone; Biomarkers; Chorionic Gonadotropin; Dehydroepiandrosterone; Double-Bl	2014
Potential benefit of dehydroepiandrosterone supplementation for infertile but not poor responder patients in a IVF program. Minerva ginecologica, 2015, Volume: 67, Issue:1 Topics: Abortion, Spontaneous; Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Double-Blind Method; F	2015
Dehydroepiandrosterone improves follicular fluid bone morphogenetic protein-15 and accumulated embryo score of infertility patients with diminished ovarian reserve undergoing in vitro fertilization: a randomized controlled trial. Journal of ovarian research, 2014, Oct-21, Volume: 7 Topics: Adult; Bone Morphogenetic Protein 15; Case-Control Studies; Dehydroepiandrosterone; Female; Follicul	2014
Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old. Reproductive biology and endocrinology : RB&E, 2015, Mar-09, Volume: 13 Topics: Adult; Age Factors; Dehydroepiandrosterone; Double-Blind Method; Female; Fertilization in Vitro; Hum	2015
Effects of dehydroepiandrosterone supplementation on women with poor ovarian response: A preliminary report and review. Taiwanese journal of obstetrics & gynecology, 2015, Volume: 54, Issue:2 Topics: Adult; Dehydroepiandrosterone; Drug Administration Schedule; Female; Fertility Agents, Female; Ferti	2015
Dehydroepiandrosterone plus climen supplementation shows better effects than dehydroepiandrosterone alone on infertility patients with diminished ovarian reserve of low-FSH level undergoing in-vitro fertilization cycles: a randomized controlled trial. Reproductive biology and endocrinology : RB&E, 2016, Feb-16, Volume: 14 Topics: Adult; Anti-Mullerian Hormone; Cyproterone Acetate; Dehydroepiandrosterone; Drug Combinations; Drug	2016
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human reproduction (Oxford, England), 2010, Volume: 25, Issue:10 Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fertility Agents, Female;	2010
Dehydroepiandrosterone in follicular fluid is produced locally, and levels correlate negatively with in vitro fertilization outcomes. Fertility and sterility, 2011, Volume: 95, Issue:5 Topics: Adult; Dehydroepiandrosterone; Embryo, Mammalian; Female; Fertilization in Vitro; Follicular Fluid;	2011
Maternal and fetal hypothalamo-pituitary-adrenal axis: different response depends upon the mode of parturition. Neuro endocrinology letters, 2004, Volume: 25, Issue:4 Topics: Adrenocorticotropic Hormone; Adult; Cesarean Section; Corticotropin-Releasing Hormone; Dehydroepiand	2004
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:11 Topics: Dehydroepiandrosterone; Embryo Transfer; Estradiol; Female; Fertilization; Fertilization in Vitro; H	2006
A randomized study of dexamethasone in ovulation induction with clomiphene citrate. Fertility and sterility, 1984, Volume: 41, Issue:6 Topics: Adrenal Glands; Anovulation; Clomiphene; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dex	1984
Intra-amniotic or intravenous injection of dehydroepiandrosterone sulphate: simultaneous changes in steroid levels in amniotic fluid and maternal serum. Clinical endocrinology, 1980, Volume: 12, Issue:3 Topics: Amnion; Amniotic Fluid; Dehydroepiandrosterone; Estradiol; Estriol; Female; Humans; Injections; Inje	1980
[The effect of sodium prasterone sulfate on lactation]. Zhonghua fu chan ke za zhi, 1995, Volume: 30, Issue:4 Topics: Adult; Cervix Uteri; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Huma	1995
Effect of dehydroepiandrosterone sulfate on uterine artery flow velocity waveforms in term pregnancy. Obstetrics and gynecology, 1995, Volume: 85, Issue:1 Topics: Arteries; Blood Flow Velocity; Blood Pressure; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfat	1995
Abnormal adrenal steroidogenesis in growth-retarded newborn infants. Pediatric research, 1994, Volume: 35, Issue:6 Topics: Adrenal Glands; Apolipoproteins B; Cholesterol; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfa	1994
[Clinical evaluation of DHEA-S plasma levels and possible therapeutic value of the hormone in the third trimester]. La Clinica terapeutica, 1993, Volume: 143, Issue:5 Topics: Adult; Dehydroepiandrosterone; Estriol; Female; Humans; Longitudinal Studies; Parity; Pregnancy; Pre	1993
Effect of dehydroepiandrosterone sulfate on fetal middle cerebral artery flow velocity waveforms in term pregnancy. Acta obstetricia et gynecologica Scandinavica, 1996, Volume: 75, Issue:4 Topics: Adult; Androgens; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Dehydroepiand	1996
Ovulation induction in clomiphene-resistant anovulatory women with normal dehydroepiandrosterone sulfate levels: beneficial effects of the addition of dexamethasone during the follicular phase. Fertility and sterility, 1996, Volume: 66, Issue:3 Topics: Adult; Anovulation; Clomiphene; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethason	1996
Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization. Human reproduction (Oxford, England), 1999, Volume: 14, Issue:6 Topics: Adult; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Fertili	1999

Authors	Studies
Richardson, A	1
Jayaprakasan, K	5
Probo, M	1
Peric, T	1
Fusi, J	1
Prandi, A	1
Faustini, M	1
Veronesi, MC	1
Yuan, T	1
Li, Y	8
Noushin, MA	1
Sahu, A	1
Singh, S	2
Basheer, R	1
Ramachandran, A	1
Ashraf, M	1
Ayhan, G	1
Rouget, F	1
Giton, F	1
Costet, N	1
Michineau, L	1
Monfort, C	1
Thomé, JP	1
Kadhel, P	1
Cordier, S	1
Oliva, A	1
Multigner, L	1
Wang, Z	3
Yang, A	1
Bao, H	1
Wang, A	1
Deng, X	1
Xue, D	1
Tan, H	1
Zhou, Y	3
Wu, C	1
Chen, ZJ	2
Shi, Y	3
Sun, Y	3
Dong, JJ	1

dehydroepiandrosterone and Pregnancy