dehydroepiandrosterone has been researched along with Polycystic Ovary Syndrome in 423 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Polycystic Ovary Syndrome: A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia." | 9.41 | Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. ( Heshmati, J; Moini, A; Mojtahedi, MF; Morvaridzadeh, M; Palmowski, A; Salehi, M; Sepidarkish, M; Shidfar, F, 2021) |
| "Previous studies have shown that chronic inflammation and oxidative stress may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS), and glutamine (Gln) have showed the anti-inflammatory and antioxidant properties." | 9.34 | The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats. ( Ding, J; Hu, X; Wu, G; Yang, J, 2020) |
| " It also indicates that the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism as compared to metformin alone." | 9.19 | In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone. ( Belfiore, A; D'Orrico, B; Fava, A; Fruci, B; Guzzi, P; Malaguarnera, R; Mazza, A; Veltri, P, 2014) |
| "Hyperandrogenaemia in polycystic ovary syndrome (PCOS) represents a composite of raised serum concentrations of testosterone, androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS)." | 9.16 | Atorvastatin therapy decreases androstenedione and dehydroepiandrosterone sulphate concentrations in patients with polycystic ovary syndrome: randomized controlled study. ( Atkin, SL; Coady, AM; Kilpatrick, ES; Sathyapalan, T; Smith, KA, 2012) |
| "The objective of the study was to assess the therapeutic effects of rosiglitazone in overweight women with polycystic ovary syndrome (PCOS)." | 9.12 | Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study. ( Morin-Papunen, LC; Rautio, K; Ruokonen, A; Tapanainen, JS, 2006) |
| "To study the endocrinologic and metabolic effects of metformin in combination with compound cyproterone acetate (CPA) on patients with polycystic ovarian syndrome (PCOS)." | 9.10 | [Endocrine and metabolic effects of metformin in combination with compound cyproterone acetate in women with polycystic ovarian syndrome]. ( Lin, JJ; Lin, WQ; Yang, HY; Ye, BL; Zhao, JZ, 2003) |
| " In the present study 20 infertile women with polycystic ovary syndrome were prospectively randomized in a placebo-controlled study to receive either placebo or prednisolone 10 mg at night, during standard in-vitro fertilization (IVF) treatment." | 9.09 | Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization. ( Carlström, K; Fridström, M; Hillensjö, T; Sjöblom, P, 1999) |
| "To determine the clinical, hormonal, and biochemical effects of 4-6 months of metformin therapy in obese patients with polycystic ovary syndrome (PCOS)." | 9.08 | Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. ( Koivunen, RM; Martikainen, HK; Morin-Papunen, LC; Ruokonen, A, 1998) |
| "Ten hirsute women with polycystic ovarian syndrome (PCO) and nine with idiopathic hirsutism (IH) underwent selective ovarian suppression with leuprolide for 5-6 months and then were randomized to receive, in addition, dexamethasone or placebo for 4 more months." | 9.06 | Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism. ( Rittmaster, RS; Thompson, DL, 1990) |
| "This study was implemented to address the role of Roflumilast in polycystic ovary syndrome (PCOS) as well as to discuss its reaction mechanism in vivo and in vitro." | 8.31 | PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro. ( Dong, X; Ji, X; Liu, S; Wang, L; Ye, Y, 2023) |
| "Although nerolidol (NRL) is a naturally occurring sesquiterpene alcohol with many pharmacological activities, its role in dehydroepiandrosterone DHEA-induced polycystic ovary syndrome PCOS is unknown." | 8.31 | Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosis. ( Aydın, M; Çiftçi, O; Doğan, A; Hayal, TB; Özek, DA; Taşlıdere, A; Türkmen, NB; Ünüvar, S; Yaşar, Ş; Yüce, H, 2023) |
| "Both Dehydroepiandrosterone (DHEA) and letrozole (LET) treatments induced a PCOS phenotype and liver dysfunction." | 8.31 | Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid. ( Chen, S; Fan, Y; Gao, H; Li, T; Li, Y; Liu, R; Yin, C; Zhang, T, 2023) |
| "Female Sprague Dawley (SD) rats were treated with Dehydroepiandrosterone (DHEA) (6 mg/100g) opting the post-pubertal approach for developing rat model of polycystic ovarian syndrome, Metformin was used as standard." | 8.12 | Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis. ( Hu, Y; Peng, F; Peng, S; Shi, L; Zeng, N, 2022) |
| " The present research explores potentially advantageous BHF impacts and whereby BHF alleviates dehydroepiandrosterone (DHEA)-induced inflammation and endocrine disruption." | 8.12 | Inhibitory effect of bushen huoxue formula against dehydroepiandrosterone-induced inflammation in granulosa cells through TLR4/NF-κB signaling pathway. ( Chen, X; Cui, M; Fu, B; Jin, W; Sun, L; Wang, C; Wang, M, 2022) |
| "The possible relationship between dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) and epigenetic changes (ECs) leading to the impaired oocyte quality, has not been investigated yet." | 8.02 | Metformin improves epigenetic modification involved in oocyte growth and embryo development in polycystic ovary syndrome mice model. ( Amani Abkenari, S; Amidi, F; Aryanpour, R; Hosseini, A; Safdarian, L; Salahi, E; Sobhani, A, 2021) |
| " Blood samples were taken after overnight fasting at baseline and three months into the study to assess the levels of fasting glucose, insulin, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), free testosterone, dehydroepiandrosterone (DHEA), and the insulin resistance index (HOMA-IR)." | 7.91 | Effects of L-carnitine on Polycystic Ovary Syndrome. ( Gachkar, L; Hoseini, S; Moghaddam, PB; Nazari, L; Salehpour, S, 2019) |
| " Here, we found that 3 weeks of rutin (a novel compound for BAT activation) treatment increased BAT activation, thereby it improved thermogenesis and systemic insulin sensitivity in dehydroepiandrosterone (DHEA)-induced PCOS rat." | 7.85 | Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. ( Dong, M; Hu, T; Huang, Y; Jin, W; Lee, HJ; Lim, W; Lin, J; Liu, Q; Wei, G; Ye, R; Yuan, X; Zhang, C; Zhang, H; Zhou, H, 2017) |
| " Metformin has been introduced in the treatment of PCOS to manage insulin resistance and hyperglycemia." | 7.81 | Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model. ( Abramovich, D; Bas, D; Bianchi, MS; Di Pietro, M; Irusta, G; Parborell, F; Pascuali, N; Tesone, M, 2015) |
| "To investigate the expression of silent information regulator 1 (SIRT1) in rats with polycystic ovary syndrome (PCOS) and its alteration after exenatide treatment." | 7.81 | Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide. ( Ge, SQ; Tao, X; Zhang, B; Zhang, EH; Zhang, X, 2015) |
| "The authors evaluate the effects of 2 months of treatment with 250 mg flutamide daily on adrenal steroidogenesis (ACTH test) and metabolic parameters (lipids, insulin resistance) in 12 PCOS women aged 33." | 7.72 | Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome. ( Dvoráková, K; Hill, M; Stanická, S; Stárka, L; Vondra, K; Vrbíková, J, 2004) |
| "The plasma levels of beta-endorphin were studied in 64 women with polycystic ovarian disease (PCOD), from whom was selected a group of 23 women with normal weight and amenorrhea of < 36 days." | 7.70 | Circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome. ( Alonso, F; Alonso-Briz, E; Bodega, A; Cordero, J; Díaz, F; Ferrer, J; Guerrero, M; Martinez-Guisasola, J, 1999) |
| "We examined the effects of an oral glucose load on plasma insulin, androgens, and beta-endorphin (beta EP) concentrations in patients carefully selected as having polycystic ovary syndrome (PCOS) and normal glucose tolerance." | 7.69 | Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome. ( Barini, A; Dell'Acqua, S; Liberale, I; Lucisano, A; Martino, G; Menini, E; Tropeano, G; Vuolo, IP, 1994) |
| "This study was designed to assess the variability of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulfate (DHEAS) levels over time in women with polycystic ovary syndrome (PCOS)." | 7.68 | Variability of serum gonadotropin and dehydroepiandrosterone sulfate concentrations in women with polycystic ovary syndrome. ( Kazer, RR; Oei, ML, 1992) |
| "To explore the clinical usefulness of the antiandrogen flutamide in the treatment modality for hirsutism in women." | 7.68 | Treatment of hirsutism in women with flutamide. ( Kirschner, MA; Luthold, WW; Marcondes, JA; Minnani, SL; Samojlik, E; Wajchenberg, BL, 1992) |
| "It has been hypothesized that the androgens testosterone and dehydroepiandrosterone (DHEA) may have opposing actions on insulin sensitivity." | 7.68 | Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females. ( Buffington, CK; Givens, JR; Kitabchi, AE, 1991) |
| "The objective of this study was to define the relationship among the circulating insulin level (IRI), the MCR of dehydroepiandrosterone (MCR-D), and the production rate of DHEA (PR-D) in 10 women with the polycystic ovary syndrome and acanthosis nigricans (PCOS-AN)." | 7.68 | Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans. ( Farah, MJ; Givens, JR; Kitabchi, AE, 1990) |
| "To investigate the glucagon status of women with polycystic ovary syndrome (PCO) and to relate this to serum concentrations of insulin, androgens and SHBG, 44 women with PCO and 23 control subjects underwent a 75-g oral glucose tolerance test." | 7.68 | Glucagon in women with polycystic ovary syndrome (PCO): relationship to abnormalities of insulin and androgens. ( Elstein, M; Golland, IM; Laing, I; Shalet, SM; Vaughan Williams, CA, 1990) |
| "035 mg ethinyl estradiol and 2 mg cyproterone acetate (EE35-CPA) on hormonal and clinical parameters of 66 patients with polycystic ovary syndrome." | 7.68 | Long-term treatment with the combination ethinylestradiol and cyproterone acetate in polycystic ovary syndrome. ( Falsetti, L; Galbignani, E, 1990) |
| "Ten clomiphene-resistant, normoprolactinemic women with polycystic ovary syndrome (PCOS) were treated by continuous and increasing administration of bromocriptine (Brc), and changes in hormonal profiles as well as therapeutic efficacy were examined." | 7.67 | Aggravation of inappropriate luteinizing hormone secretion by bromocriptine in polycystic ovary syndrome with elevated serum dehydroepiandrosterone sulfate. ( Ihara, Y; Mori, T; Taii, S; Takai, I; Takakura, K, 1989) |
| "Both metformin and statin have been used as methods to ameliorate symptoms and improve prognosis." | 6.80 | Inadequacy of initiating rosuvastatin then metformin on biochemical profile of polycystic ovarian syndrome patients. ( Abbas, HA; Awwad, J; Ghazeeri, G; Harajly, S; Skaff, B, 2015) |
| "Metformin therapy has many useful effects in these patients." | 6.73 | Metformin therapy in girls with polycystic ovary syndrome: a self-controlled clinical trial. ( Bayat, R; Hamedi, M; Nazari, T, 2007) |
| "Inflammation is involved in the progression of polycystic ovary syndrome." | 5.91 | Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†. ( Ding, X; Li, G; Li, N; Lin, Y; Ma, Y; Wang, X; Xiong, C; Yang, Y; Yuan, Y; Zhang, Y; Zhang, Z, 2023) |
| " After 20 days, mice were divided into 2 groups, namely "Continue dosing group" and "Stop dosing group"." | 5.91 | Dehydroepiandrosterone-induced polycystic ovary syndrome mouse model requires continous treatments to maintain reproductive phenotypes. ( Kang, J; Wu, H; Yao, Q; Zhao, B, 2023) |
| "Leptin has been shown to stimulate the formation of FGF23 in bones." | 5.72 | The relationship between the level of vitamin D, leptin and FGF23 in girls and young women with polycystic ovary syndrome. ( Białka-Kosiec, A; Drosdzol-Cop, A; Gawlik, A; Orszulak, D, 2022) |
| "Treatment with quercetin increased the adiponectin level and expression of adipoR1 and nesfatin-1 and decreased both the expression of aromatase and the oestradiol level." | 5.56 | The phytoestrogen, quercetin, in serum, uterus and ovary as a potential treatment for dehydroepiandrosterone-induced polycystic ovary syndrome in the rat. ( Jafari Khorchani, M; Neisy, A; Zal, F, 2020) |
| " Baseline and end line assessment were performed for menstrual cycle regularity, ultrasonography scan for ovaries, total testosterone, dehydroepiandrosterone (DHEAS), insulin, luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio, fasting blood sugar (FBS), homeostatic model assessment-insulin resistance (HOMA-IR), weight reduction, waist-/hip circumference (WC, HC), waist to hip ratio (WHR), and body mass index (BMI)." | 5.51 | Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study. ( Ahire, J; Kaur, I; Medhi, B; Rana, SV; Sachdeva, N; Sahni, N; Singh, A; Suri, V, 2022) |
| "Inflammation is likely to be a crucial contributor to the pathogenesis of PCOS." | 5.51 | Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome. ( Bulbul, A; Chen, S; Cui, X; Li, Y; Liu, S; Sun, D; Yan, Q; Zheng, Q, 2019) |
| "Dehydroepiandrosterone (DHEA) is a weak androgen and a crucial precursor of sex steroids." | 5.48 | Effects of dehydroepiandrosterone on the ovarian reserve and pregnancy outcomes in perimenopausal rats (DHEA and fertility in perimenopausal rats). ( Abo-Zeid, FS; Fares, NH; Mahmoud, AA; Mahmoud, YI, 2018) |
| "Hyperandrogenism is the hallmark of polycystic ovary syndrome (PCOS)." | 5.48 | The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome. ( Ho, LT; Huang, SW; Juan, CC; Seow, KM; Ting, CH, 2018) |
| "These findings suggest that DHEA treatment induced depression-like behavior in PCOS mice, possibly through down-regulation of brain monoamines and/or their metabolites, which implies the contribution of hyperandrogenism to the psychological symptoms of women with PCOS." | 5.43 | Depression-Like Behavior in a Dehydroepiandrosterone-Induced Mouse Model of Polycystic Ovary Syndrome. ( Hao, S; Kang, J; Shen, Q; Song, X; Wang, H; Yu, Q, 2016) |
| "Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia." | 5.41 | Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. ( Heshmati, J; Moini, A; Mojtahedi, MF; Morvaridzadeh, M; Palmowski, A; Salehi, M; Sepidarkish, M; Shidfar, F, 2021) |
| "Previous studies have shown that chronic inflammation and oxidative stress may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS), and glutamine (Gln) have showed the anti-inflammatory and antioxidant properties." | 5.34 | The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats. ( Ding, J; Hu, X; Wu, G; Yang, J, 2020) |
| "Dehydroepiandrosterone production was increased by atRA and 9-cis RA in normal cells and by atRA, 9-cis RA, and retinol in PCOS." | 5.33 | Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. ( Hendricks, KL; Legro, RS; McAllister, JM; Nelson-DeGrave, VL; Strauss, JF; Wickenheisser, JK, 2005) |
| "Treatment with metformin in women with PCOS can lead to the increase in homocysteine levels--a risk factor for atherosclerosis." | 5.31 | Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome. ( Bicíková, M; Hill, M; Stárka, L; Tallová, J; Vrbíková, J, 2002) |
| "Hirsutism is a common symptom of women affected by polycystic ovary syndrome (PCOS)." | 5.29 | Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome. ( Angelini, F; Barletta, D; Gargani, M; Genazzani, AD; Genazzani, AR; Lippi, F; Luisi, M; Monzani, F; Pucci, E, 1995) |
| " It also indicates that the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism as compared to metformin alone." | 5.19 | In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone. ( Belfiore, A; D'Orrico, B; Fava, A; Fruci, B; Guzzi, P; Malaguarnera, R; Mazza, A; Veltri, P, 2014) |
| "Hyperandrogenaemia in polycystic ovary syndrome (PCOS) represents a composite of raised serum concentrations of testosterone, androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS)." | 5.16 | Atorvastatin therapy decreases androstenedione and dehydroepiandrosterone sulphate concentrations in patients with polycystic ovary syndrome: randomized controlled study. ( Atkin, SL; Coady, AM; Kilpatrick, ES; Sathyapalan, T; Smith, KA, 2012) |
| "The objective of the study was to assess the therapeutic effects of rosiglitazone in overweight women with polycystic ovary syndrome (PCOS)." | 5.12 | Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study. ( Morin-Papunen, LC; Rautio, K; Ruokonen, A; Tapanainen, JS, 2006) |
| "To study the endocrinologic and metabolic effects of metformin in combination with compound cyproterone acetate (CPA) on patients with polycystic ovarian syndrome (PCOS)." | 5.10 | [Endocrine and metabolic effects of metformin in combination with compound cyproterone acetate in women with polycystic ovarian syndrome]. ( Lin, JJ; Lin, WQ; Yang, HY; Ye, BL; Zhao, JZ, 2003) |
| " In the present study 20 infertile women with polycystic ovary syndrome were prospectively randomized in a placebo-controlled study to receive either placebo or prednisolone 10 mg at night, during standard in-vitro fertilization (IVF) treatment." | 5.09 | Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization. ( Carlström, K; Fridström, M; Hillensjö, T; Sjöblom, P, 1999) |
| "This study explored the effect of the anti-androgen spironolactone on sex-hormone binding globulin (SHBG) and the distribution of circulating testosterone (T) into various free and bound fractions in seven women with hirsutism assessed before and then monthly for three months on a regimen of spironolactone, 100 mg bid as the sole therapeutic agent." | 5.08 | The effects of spironolactone on testosterone fractions and sex-hormone binding globulin binding capacity in hirsute women. ( Kirschner, MA; Lerário, AC; Luthold, WW; Marcondes, JA; Mendonça, BB; Minanni, SL; Nery, M; Wajchenberg, BL, 1995) |
| "To determine the clinical, hormonal, and biochemical effects of 4-6 months of metformin therapy in obese patients with polycystic ovary syndrome (PCOS)." | 5.08 | Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. ( Koivunen, RM; Martikainen, HK; Morin-Papunen, LC; Ruokonen, A, 1998) |
| "Ten hirsute women with polycystic ovarian syndrome (PCO) and nine with idiopathic hirsutism (IH) underwent selective ovarian suppression with leuprolide for 5-6 months and then were randomized to receive, in addition, dexamethasone or placebo for 4 more months." | 5.06 | Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism. ( Rittmaster, RS; Thompson, DL, 1990) |
| "This study was implemented to address the role of Roflumilast in polycystic ovary syndrome (PCOS) as well as to discuss its reaction mechanism in vivo and in vitro." | 4.31 | PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro. ( Dong, X; Ji, X; Liu, S; Wang, L; Ye, Y, 2023) |
| "Although nerolidol (NRL) is a naturally occurring sesquiterpene alcohol with many pharmacological activities, its role in dehydroepiandrosterone DHEA-induced polycystic ovary syndrome PCOS is unknown." | 4.31 | Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosis. ( Aydın, M; Çiftçi, O; Doğan, A; Hayal, TB; Özek, DA; Taşlıdere, A; Türkmen, NB; Ünüvar, S; Yaşar, Ş; Yüce, H, 2023) |
| "Both Dehydroepiandrosterone (DHEA) and letrozole (LET) treatments induced a PCOS phenotype and liver dysfunction." | 4.31 | Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid. ( Chen, S; Fan, Y; Gao, H; Li, T; Li, Y; Liu, R; Yin, C; Zhang, T, 2023) |
| " In the present study, we aimed to explore how omega-3 PUFAs alleviate ovarian dysfunction and insulin resistance in mice with dehydroepiandrosterone (DHEA)-induced PCOS by modulating the gut microbiota." | 4.31 | Effects of gut microbiota on omega-3-mediated ovary and metabolic benefits in polycystic ovary syndrome mice. ( Cao, C; Chen, L; He, Z; Jing, J; Li, C; Li, Z; Ma, R; Ouyang, L; Qian, Z; Sun, S; Xu, R; Xue, M; Xue, T; Yao, B; Zhang, H; Zhang, K; Zheng, L, 2023) |
| "To investigate the effects of quercetin on ovulation disorder and expression of androgen receptor (AR) and C-type natriuretic peptide (CNP) / Natriuretic Peptide Receptor 2 (NPR2) in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat model." | 4.12 | Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP/NPR2 in PCOS model rats. ( Chen, Y; Li, M; Ma, M; Zheng, S, 2022) |
| "Female Sprague Dawley (SD) rats were treated with Dehydroepiandrosterone (DHEA) (6 mg/100g) opting the post-pubertal approach for developing rat model of polycystic ovarian syndrome, Metformin was used as standard." | 4.12 | Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis. ( Hu, Y; Peng, F; Peng, S; Shi, L; Zeng, N, 2022) |
| " To that end, we have established a Swiss albino mouse model of PCOS based on 3 weeks of daily treatment with letrozole (50 μg/day; intraperitoneal) and dehydroepiandrosterone (DHEA, 6 mg/100 g body weight; subcutaneous) in 5-week-old female mice fed on normal or high-fat diet (HFD)." | 4.12 | Distinctions in PCOS Induced by Letrozole Vs Dehydroepiandrosterone With High-fat Diet in Mouse Model. ( Adiga, SK; Bakkum-Gamez, J; Chang, AY; DeStephano, C; Kalthur, G; Kalthur, SG; Kannan, N; Kundapur, SD; Mutalik, S; Nayak, G; Panchanan, G; Poojary, PS; Rao, A; Sherman, M; Zhao, Y, 2022) |
| " The present research explores potentially advantageous BHF impacts and whereby BHF alleviates dehydroepiandrosterone (DHEA)-induced inflammation and endocrine disruption." | 4.12 | Inhibitory effect of bushen huoxue formula against dehydroepiandrosterone-induced inflammation in granulosa cells through TLR4/NF-κB signaling pathway. ( Chen, X; Cui, M; Fu, B; Jin, W; Sun, L; Wang, C; Wang, M, 2022) |
| "The aim of this study was to investigate the effects of berberine on polycystic ovary syndrome (PCOS) with insulin resistance (IR)." | 4.02 | Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites. ( Li, XL; Shen, HR; Xu, X; Ye, D, 2021) |
| "The possible relationship between dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) and epigenetic changes (ECs) leading to the impaired oocyte quality, has not been investigated yet." | 4.02 | Metformin improves epigenetic modification involved in oocyte growth and embryo development in polycystic ovary syndrome mice model. ( Amani Abkenari, S; Amidi, F; Aryanpour, R; Hosseini, A; Safdarian, L; Salahi, E; Sobhani, A, 2021) |
| "To investigate the effects of acupuncture on ovary morphology and function in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) model rats." | 4.02 | Effect of Acupuncture on Ovary Morphology and Function in DHEA-Induced Polycystic Ovary Syndrome Model Rats. ( Bai, P; Li, D; Qi, XH; Wang, ZP; Wu, JY; Xie, M; Zhao, RZ, 2021) |
| "This study clearly demonstrates that Aspirin has ameliorating effects against polycystic ovary syndrome via anti-inflammatory and hormonal modulatory pathways." | 3.96 | Ovarian Metabolic activity in Dehydroepiandrosterone-Induced Polycystic Ovary in Wistar rats Treated with Aspirin. ( Ayobami, D; Ayoola, O; Bamidele, O; Builders, M; Femi, A; Mali, PC; Olaniyan, OT; Uche, S, 2020) |
| "We used dehydroepiandrosterone (DHEA)-induced PCOS-like rat model to measure circadian clock genes and insulin resistance-related genes." | 3.96 | Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome. ( Di, F; Du, Y; Hu, M; Li, S; Liu, J; Zhai, J, 2020) |
| " Blood samples were taken after overnight fasting at baseline and three months into the study to assess the levels of fasting glucose, insulin, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), free testosterone, dehydroepiandrosterone (DHEA), and the insulin resistance index (HOMA-IR)." | 3.91 | Effects of L-carnitine on Polycystic Ovary Syndrome. ( Gachkar, L; Hoseini, S; Moghaddam, PB; Nazari, L; Salehpour, S, 2019) |
| " The following study investigates the ovarian hyperfibrosis forming via transforming growth factor-β (TGF-β) signaling pathway in Dehydroepiandrosterone (DHEA)- induced polycystic ovary syndrome (PCOS) rat model." | 3.88 | DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathway. ( Gao, Q; He, X; Liang, Q; Shen, S; Wang, D; Wang, H; Wang, W; Wang, Y; Xia, Y, 2018) |
| " Here, we found that 3 weeks of rutin (a novel compound for BAT activation) treatment increased BAT activation, thereby it improved thermogenesis and systemic insulin sensitivity in dehydroepiandrosterone (DHEA)-induced PCOS rat." | 3.85 | Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. ( Dong, M; Hu, T; Huang, Y; Jin, W; Lee, HJ; Lim, W; Lin, J; Liu, Q; Wei, G; Ye, R; Yuan, X; Zhang, C; Zhang, H; Zhou, H, 2017) |
| " Employing polymerase chain reaction and flow cytometry, we analyzed the transcript and expression levels of downstream molecules of RHOG, DOCK1, and RAC1 in the polycystic ovarian syndrome (PCOS) ovary along with normal antral follicular theca and granulosa cells after dehydroepiandrosterone (DHEA) supplementation." | 3.85 | RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model. ( Chadchan, S; Chaturvedi, H; Dwivedi, A; Jha, RK; Kumar, V; Maurya, R; Maurya, VK; Singh, R; Soni, UK; Ubba, V, 2017) |
| "0 g/kg/day, per os) on endometrial abnormalities in a dehydroepiandrosterone (DHEA, subcutaneous)-induced polycystic ovary syndrome (PCOS) rat model." | 3.83 | Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats. ( Bae, CS; Cho, IH; Jang, M; Kim, HJ; Kim, YO; Lee, MJ; Lee, S; Lee, SW; Park, KS, 2016) |
| " Metformin has been introduced in the treatment of PCOS to manage insulin resistance and hyperglycemia." | 3.81 | Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model. ( Abramovich, D; Bas, D; Bianchi, MS; Di Pietro, M; Irusta, G; Parborell, F; Pascuali, N; Tesone, M, 2015) |
| "To investigate the expression of silent information regulator 1 (SIRT1) in rats with polycystic ovary syndrome (PCOS) and its alteration after exenatide treatment." | 3.81 | Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide. ( Ge, SQ; Tao, X; Zhang, B; Zhang, EH; Zhang, X, 2015) |
| "The objective of this study was to investigate the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) in adipose tissue of the rat model of polycystic ovary syndrome (PCOS), induced by dehydroepiandrosterone (DHEA)." | 3.80 | Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA. ( Wang, YX; Xie, BG; Zhu, WJ, 2014) |
| "Because of the elevated dehydroepiandrosterone sulfate (DHEAS) levels in polycystic ovary syndrome (PCOS) and the heritability of DHEAS serum levels, genes encoding the enzymes that control the sulfation of dehydroepiandrosterone (DHEA) to DHEAS and vice versa are obvious candidate genes to explain part of the heritability of PCOS." | 3.79 | Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype. ( de Jong, FH; Fauser, BC; Laven, JS; Louwers, YV; Stolk, L; Uitterlinden, AG; van Herwaarden, NA, 2013) |
| "Twenty-seven women with polycystic ovary syndrome and 28 of their sisters underwent an adrenocorticotropic hormone stimulation test with measurement of the steroids dehydroepiandrosterone, androstenedione, and cortisol 60 minutes later." | 3.74 | Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters. ( Azziz, R; Goodarzi, MO; Guo, X; Stanczyk, FZ; Yildiz, BO, 2007) |
| "The authors evaluate the effects of 2 months of treatment with 250 mg flutamide daily on adrenal steroidogenesis (ACTH test) and metabolic parameters (lipids, insulin resistance) in 12 PCOS women aged 33." | 3.72 | Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome. ( Dvoráková, K; Hill, M; Stanická, S; Stárka, L; Vondra, K; Vrbíková, J, 2004) |
| " Anthropometric measurements, staging of pubertal maturation, and clinical manifestations of hyperandrogenism were assessed, as well as measurement of serum levels of testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), and free androgen index (FAI)." | 3.72 | Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy. ( Abd El-Basset, FZ; El Barbary, NS; El-Khayat, HA; Hakky, SM; Mohamed, MS; Nassef, NM; Tohamy, SM; Tomoum, HY; Zaky, AA, 2004) |
| "The plasma levels of beta-endorphin were studied in 64 women with polycystic ovarian disease (PCOD), from whom was selected a group of 23 women with normal weight and amenorrhea of < 36 days." | 3.70 | Circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome. ( Alonso, F; Alonso-Briz, E; Bodega, A; Cordero, J; Díaz, F; Ferrer, J; Guerrero, M; Martinez-Guisasola, J, 1999) |
| " Obesity itself exerted effects on endocrine variables, with the net result of a reduced LH/FSH ratio and lower serum levels of androstenedione and SHBG in both groups; obesity was associated with increased levels of DHEAS, testosterone and FAI exclusively in the women with PCOS." | 3.69 | The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women. ( Bergh, T; Gennarelli, G; Holte, J; Wide, L, 1994) |
| "We examined the effects of an oral glucose load on plasma insulin, androgens, and beta-endorphin (beta EP) concentrations in patients carefully selected as having polycystic ovary syndrome (PCOS) and normal glucose tolerance." | 3.69 | Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome. ( Barini, A; Dell'Acqua, S; Liberale, I; Lucisano, A; Martino, G; Menini, E; Tropeano, G; Vuolo, IP, 1994) |
| "The suppression of hyperinsulinism with diazoxide (300 mg/d during 30 days) in a young woman with PCOS and hirsutism, hyperinsulinism and insulinoresistance was followed by a modification of plasma androgens." | 3.69 | [Polycystic ovary and diazoxide. In vivo study]. ( Bercovici, JP; Brettes, JP; Floch, HH; Monguillon, P; Nahoul, K, 1996) |
| "This study was designed to assess the variability of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulfate (DHEAS) levels over time in women with polycystic ovary syndrome (PCOS)." | 3.68 | Variability of serum gonadotropin and dehydroepiandrosterone sulfate concentrations in women with polycystic ovary syndrome. ( Kazer, RR; Oei, ML, 1992) |
| "To explore the clinical usefulness of the antiandrogen flutamide in the treatment modality for hirsutism in women." | 3.68 | Treatment of hirsutism in women with flutamide. ( Kirschner, MA; Luthold, WW; Marcondes, JA; Minnani, SL; Samojlik, E; Wajchenberg, BL, 1992) |
| " Compared with the non-PCO group, the PCO subgroup without hirsutism (n = 31) had statistically significantly higher median values of LH, testosterone, androstenedione, and dehydroepiandrosterone sulphate concentrations, and free androgen index." | 3.68 | Oestrogen and androgen states in oligo-amenorrhoeic women with polycystic ovaries. ( Corrigan, E; Fox, R; Hull, MG; Thomas, PG, 1991) |
| "Hyperestronemia may be central to the development of polycystic ovary syndrome." | 3.68 | Sex steroids, adiposity and smoking in the pathogenesis of idiopathic hirsutism and polycystic ovary syndrome. ( Byrne, B; Conroy, R; Cunningham, S; Igoe, D; McKenna, TJ, 1991) |
| "It has been hypothesized that the androgens testosterone and dehydroepiandrosterone (DHEA) may have opposing actions on insulin sensitivity." | 3.68 | Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females. ( Buffington, CK; Givens, JR; Kitabchi, AE, 1991) |
| "In a previous report we found extreme hyperinsulinemia associated with high testosterone levels in patients with polycystic ovarian syndrome (PCO) and normal insulin levels in a small group of patients with elevated dehydroepiandrosterone (DHEA)." | 3.68 | Role of adrenal and gonadal androgens in insulin action and metabolism. ( Buffington, CK; Givens, J; Inouye, H; Kitabchi, AE, 1991) |
| " The degree of hirsutism, the menstrual abnormalities and the level of 17-ketosteroids, of DHEA, of 17-OH-corticoids in urine and RIA of total and free testosterone and of sex binding globulins (SHBG) in blood were performed." | 3.68 | [Endocrine and ultrasound examination of hirsutism]. ( Baron, JJ, 1991) |
| "The objective of this study was to define the relationship among the circulating insulin level (IRI), the MCR of dehydroepiandrosterone (MCR-D), and the production rate of DHEA (PR-D) in 10 women with the polycystic ovary syndrome and acanthosis nigricans (PCOS-AN)." | 3.68 | Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans. ( Farah, MJ; Givens, JR; Kitabchi, AE, 1990) |
| " Presented in this paper are the measurements of testosterone, androstendion, dehydroepiandrosterone-sulfate (DHAS), SHBG, androstandiol and free androgen index (FAI) in 51 women with hirsutism." | 3.68 | [Significance of sex hormone binding globulin and free androgen index in the estimation of androgenic cases]. ( Lauritzen, C; Qiao, FY, 1990) |
| "To investigate the glucagon status of women with polycystic ovary syndrome (PCO) and to relate this to serum concentrations of insulin, androgens and SHBG, 44 women with PCO and 23 control subjects underwent a 75-g oral glucose tolerance test." | 3.68 | Glucagon in women with polycystic ovary syndrome (PCO): relationship to abnormalities of insulin and androgens. ( Elstein, M; Golland, IM; Laing, I; Shalet, SM; Vaughan Williams, CA, 1990) |
| "035 mg ethinyl estradiol and 2 mg cyproterone acetate (EE35-CPA) on hormonal and clinical parameters of 66 patients with polycystic ovary syndrome." | 3.68 | Long-term treatment with the combination ethinylestradiol and cyproterone acetate in polycystic ovary syndrome. ( Falsetti, L; Galbignani, E, 1990) |
| "Ten clomiphene-resistant, normoprolactinemic women with polycystic ovary syndrome (PCOS) were treated by continuous and increasing administration of bromocriptine (Brc), and changes in hormonal profiles as well as therapeutic efficacy were examined." | 3.67 | Aggravation of inappropriate luteinizing hormone secretion by bromocriptine in polycystic ovary syndrome with elevated serum dehydroepiandrosterone sulfate. ( Ihara, Y; Mori, T; Taii, S; Takai, I; Takakura, K, 1989) |
| "Serum levels of sex hormone binding globulin (SHBG), total testosterone (T), free testosterone (fT), 4-androstene-3,17-dione (A-4) and dehydroepiandrosterone sulfate (DHAS) were determined in 30 patients with the polycystic ovary syndrome." | 3.67 | Free testosterone and testosterone/SHBG index in hirsute women: a comparison of diagnostic accuracy. ( Carlström, K; Gershagen, S; Rannevik, G, 1987) |
| "The endocrine effects of induction of ovulation with menotropins were studied in 43 patients: 11 with hypothalamic amenorrhea and 32 with the polycystic ovary syndrome." | 3.67 | Role of dehydroepiandrosterone sulfate as a prehormone for ovarian steroidogenesis. ( Austin, CW; Carlson, IH; Haning, RV; Kuzma, DL; Zweibel, WJ, 1985) |
| "Hirsutism can occur in the presence of normal or near normal levels of serum testosterone, unbound testosterone (uT), dehydroepiandrostene sulfate, androstenedione, and dihydrotestosterone." | 3.66 | Evidence for the importance of peripheral tissue events in the development of hirsutism in polycystic ovary syndrome. ( Goebelsmann, U; Horton, R; Lobo, RA, 1983) |
| "Serum androgen levels, including dehydroepiandrosterone sulphate (DHAS) which is thought to be solely of adrenal origin, are elevated in women with the polycystic ovarian syndrome." | 3.66 | Acth function in women with the polycystic ovarian syndrome. ( Butt, WR; Holder, G; Horrocks, PM; Kandeel, FR; Logan-Edwards, R; London, DR; Lynch, SS, 1983) |
| "Dehydroepiandrosterone, androstenedione, testosterone, pregnenolone and progesterone concentration was determined by our sensitive gas-liquid chromatographic method in ovarian tissues obtained from surgery of patients without hirsutism and with Stein-Leventhal syndrome." | 3.65 | Concentration of unconjugated adrenogenic hormones and their precursors in normal and polycystic ovaries. ( Fehér, T; Györy, G; Kiss, C; Poteczin, E, 1975) |
| "Serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women suffering from either idiopathic hirsutism or the polycystic ovary syndrome were determined before and during treatment with cyproterone acetate combined with ethinyl oestradiol." | 3.65 | The influence of combined cyproterone acetate-ethinyl oestradiol therapy on serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women. ( Frölich, M; Lachinsky, N; Moolenaar, AJ, 1977) |
| "Both metformin and statin have been used as methods to ameliorate symptoms and improve prognosis." | 2.80 | Inadequacy of initiating rosuvastatin then metformin on biochemical profile of polycystic ovarian syndrome patients. ( Abbas, HA; Awwad, J; Ghazeeri, G; Harajly, S; Skaff, B, 2015) |
| "For dose-response studies, blood samples were obtained before and at 0." | 2.76 | Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome. ( Chang, RJ; Coffler, MS; Donohue, MC; Duke, KB; Haggan, A; Rosencrantz, MA; Shayya, RF; Su, HI, 2011) |
| "Metformin therapy has many useful effects in these patients." | 2.73 | Metformin therapy in girls with polycystic ovary syndrome: a self-controlled clinical trial. ( Bayat, R; Hamedi, M; Nazari, T, 2007) |
| "Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries." | 2.72 | DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies. ( Benjamin, JJ; K N, M; K, M; Koshy, T; R, P, 2021) |
| "Polycystic ovary syndrome is the most common endocrinological problem associated with hirsutism." | 2.68 | Comparison of four different treatment regimes in hirsutism related to polycystic ovary syndrome. ( Gökmen, O; Gülekli, B; Işik, AZ; Senöz, S, 1996) |
| "Hirsutism is a common medical condition that in most women is due to the polycystic ovary syndrome or is idiopathic." | 2.39 | Approach to patients with hirsutism. ( Sakiyama, R, 1996) |
| "Polycystic ovarian syndrome is characterized by elevated androgens and is a well-known risk factor for the occurrence of gestational diabetes mellitus." | 1.91 | Fetal sex and the development of gestational diabetes mellitus in polycystic ovarian syndrome gravidae. ( Aagaard, KM; Sangi-Haghpeykar, H; Sassin, AM, 2023) |
| "Inflammation is involved in the progression of polycystic ovary syndrome." | 1.91 | Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†. ( Ding, X; Li, G; Li, N; Lin, Y; Ma, Y; Wang, X; Xiong, C; Yang, Y; Yuan, Y; Zhang, Y; Zhang, Z, 2023) |
| "Clinical hyperandrogenism was positively correlated with FAI in younger women with PCOS." | 1.91 | Correlation between biochemical and clinical hyperandrogenism parameter in polycystic ovary syndrome in relation to age. ( Chen, S; Guo, Z; Hao, Y; Hu, P; Jin, F; Yu, Q, 2023) |
| " After 20 days, mice were divided into 2 groups, namely "Continue dosing group" and "Stop dosing group"." | 1.91 | Dehydroepiandrosterone-induced polycystic ovary syndrome mouse model requires continous treatments to maintain reproductive phenotypes. ( Kang, J; Wu, H; Yao, Q; Zhao, B, 2023) |
| "Gut microbiota dysbiosis is critical in the etiology of polycystic ovary syndrome (PCOS)." | 1.72 | Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells. ( Chen, P; Huang, J; Liang, Q; Liang, X; Liu, J; Wu, T; Xiang, Y; Zeng, H; Zeng, Y; Zhou, C, 2022) |
| "Leptin has been shown to stimulate the formation of FGF23 in bones." | 1.72 | The relationship between the level of vitamin D, leptin and FGF23 in girls and young women with polycystic ovary syndrome. ( Białka-Kosiec, A; Drosdzol-Cop, A; Gawlik, A; Orszulak, D, 2022) |
| "PCOS mouse models were established by subcutaneous injection of DHEA alone or in combination with a HFD in wild-type and pseudo germ-free mice." | 1.72 | Effects of dehydroepiandrosterone alone or in combination with a high-fat diet and antibiotic cocktail on the heterogeneous phenotypes of PCOS mouse models by regulating gut microbiota. ( Ding, X; Gu, L; Peng, Y; Wang, X; Xiong, C; Zhang, Y, 2022) |
| "Treatment with quercetin increased the adiponectin level and expression of adipoR1 and nesfatin-1 and decreased both the expression of aromatase and the oestradiol level." | 1.56 | The phytoestrogen, quercetin, in serum, uterus and ovary as a potential treatment for dehydroepiandrosterone-induced polycystic ovary syndrome in the rat. ( Jafari Khorchani, M; Neisy, A; Zal, F, 2020) |
| "Inflammation is likely to be a crucial contributor to the pathogenesis of PCOS." | 1.51 | Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome. ( Bulbul, A; Chen, S; Cui, X; Li, Y; Liu, S; Sun, D; Yan, Q; Zheng, Q, 2019) |
| "Dehydroepiandrosterone (DHEA) is a weak androgen and a crucial precursor of sex steroids." | 1.48 | Effects of dehydroepiandrosterone on the ovarian reserve and pregnancy outcomes in perimenopausal rats (DHEA and fertility in perimenopausal rats). ( Abo-Zeid, FS; Fares, NH; Mahmoud, AA; Mahmoud, YI, 2018) |
| "Metformin and combined treatment groups reduced the body and ovary weights compared to the PCOS group." | 1.48 | Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study. ( Ceylan, S; Eraldemır, C; Furat Rencber, S; Guzel, E; Kum, T; Kurnaz Ozbek, S; Sezer, Z, 2018) |
| "Hyperandrogenism is the hallmark of polycystic ovary syndrome (PCOS)." | 1.48 | The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome. ( Ho, LT; Huang, SW; Juan, CC; Seow, KM; Ting, CH, 2018) |
| "Polycystic ovary syndrome is a common endocrine disorder and a major cause of anovulatory sterility in women at reproductive age." | 1.46 | The BMP4-Smad signaling pathway regulates hyperandrogenism development in a female mouse model. ( Ding, M; Dou, X; Du, SY; Liu, Y; Qian, SW; Tang, QQ; Wu, ZY; Xu, CJ; Zhang, FF; Zhang, W, 2017) |
| "These findings suggest that DHEA treatment induced depression-like behavior in PCOS mice, possibly through down-regulation of brain monoamines and/or their metabolites, which implies the contribution of hyperandrogenism to the psychological symptoms of women with PCOS." | 1.43 | Depression-Like Behavior in a Dehydroepiandrosterone-Induced Mouse Model of Polycystic Ovary Syndrome. ( Hao, S; Kang, J; Shen, Q; Song, X; Wang, H; Yu, Q, 2016) |
| "Hyperandrogenism is the primary manifestation of polycystic ovary syndrome (PCOS), which appears to be caused by excess exposure to androgen." | 1.40 | Long-term treatment with dehydroepiandrosterone may lead to follicular atresia through interaction with anti-Mullerian hormone. ( Baba, T; Endo, T; Honnma, H; Ikeda, K; Kiya, T; Morishita, M; Saito, T, 2014) |
| "PCOS (polycystic ovary syndrome) is a heterogeneous disease characterized by hyperandrogenaemia, hirsutism, oligo- or amenorrhea, insulin resistance and anovulation." | 1.37 | Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats. ( Abramovich, D; Bas, D; Hernandez, F; Tesone, M, 2011) |
| "Acne and hirsutism are common manifestations of hyperandrogenemia." | 1.36 | Ovarian morphology and prevalence of polycystic ovary syndrome in reproductive aged women with or without mild acne. ( Incki, K; Kelekci, KH; Kelekci, S; Ozdemir, O; Yilmaz, B, 2010) |
| "Dehydroepiandrosterone sulfate was first detected in the hepatoma G2 cell culture media at 12 hours of incubation." | 1.35 | Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells. ( Azziz, R; Magoffin, D; Nguyen, M; Pall, M, 2009) |
| "When metformin was administered together with DHEA uterine histology and apoptosis did not differ when compared with controls." | 1.35 | The effects of metformin on uterine tissue of hyperandrogenized BALB/c mice. ( Belgorosky, D; Elia, EM; Faut, M; Luigi, D; Motta, AB; Pustovrh, C; Vighi, S, 2009) |
| "The insulin resistance was calculated by the measurement of fasting serum glucose and insulin levels, serum insulin response to an oral glucose tolerance test and homeostasis model assessment." | 1.35 | Oxidative stress in nonobese women with polycystic ovary syndrome: correlations with endocrine and screening parameters. ( Erel, O; Verit, FF, 2008) |
| "Dehydroepiandrosterone production was increased by atRA and 9-cis RA in normal cells and by atRA, 9-cis RA, and retinol in PCOS." | 1.33 | Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. ( Hendricks, KL; Legro, RS; McAllister, JM; Nelson-DeGrave, VL; Strauss, JF; Wickenheisser, JK, 2005) |
| "Insulin resistance was estimated by fasting insulin level, fasting glucose/insulin ratio and 75 g 2 h glucose tolerance test." | 1.33 | The association of serum androgens and insulin resistance with fat distribution in polycystic ovary syndrome. ( Noyan, V; Sagsoz, N; Yucel, A, 2006) |
| "When metformin was administered together with DHEA, serum insulin, E and P levels, and ovarian PGE values did not differ when compared with controls." | 1.33 | Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone. ( Di Girolamo, G; Elia, E; Gonzalez, C; Luchetti, CG; Motta, AB; Sander, V; Solano, ME, 2006) |
| "When metformin was administered together with DHEA, the ovarian GSH content, NOS activity and PGE production did not differ when compared with controls." | 1.33 | The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice. ( Di Girolamo, G; Elia, E; Gonzalez, C; Luchetti, CG; Motta, AB; Sander, V; Solano, ME, 2006) |
| "Acne is an inflammatory process of follicle sebaceous unites." | 1.31 | [Correlations between acne and polycystic ovary. A study of 60 cases]. ( Iurassich, S; Pace, L; Palagiano, A; Trotta, C, 2001) |
| "On the other hand, hyperandrogenism is associated with certain insulin-resistant conditions with hyperinsulinaemia, including the polycystic ovary syndrome (PCO)." | 1.31 | Two hyperandrogenic adolescent girls with congenital portosystemic shunt. ( Fujisawa, T; Hachiya, M; Hachiya, Y; Hoshino, K; Saji, T; Satoh, M; Yokoya, S, 2001) |
| "Treatment with metformin in women with PCOS can lead to the increase in homocysteine levels--a risk factor for atherosclerosis." | 1.31 | Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome. ( Bicíková, M; Hill, M; Stárka, L; Tallová, J; Vrbíková, J, 2002) |
| "Hirsutism was present in 64." | 1.29 | Endocrinological, ultrasonographic and clinical findings in adolescent and adult polycystic ovary patients: a comparative study. ( Gökmen, O; Gülekli, B; Kükner, S; Oral, H; Senöz, S; Turhan, NO, 1993) |
| "However, PCO patients with NIDDM differed from those without diabetes in that they had elevated basal and corticotropin-stimulated adrenal steroids (cortisol, dehydroepiandrosterone [DHEA], dehydroepiandrosterone sulfate [DHEAS])." | 1.29 | Enhanced adrenocortical activity as a contributing factor to diabetes in hyperandrogenic women. ( Buffington, CK; Givens, JR; Kitabchi, AE, 1994) |
| "Hirsutism is a common symptom of women affected by polycystic ovary syndrome (PCOS)." | 1.29 | Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome. ( Angelini, F; Barletta, D; Gargani, M; Genazzani, AD; Genazzani, AR; Lippi, F; Luisi, M; Monzani, F; Pucci, E, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 122 (28.84) | 18.7374 |
| 1990's | 79 (18.68) | 18.2507 |
| 2000's | 55 (13.00) | 29.6817 |
| 2010's | 78 (18.44) | 24.3611 |
| 2020's | 89 (21.04) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, HR | 1 |
| Xu, X | 1 |
| Ye, D | 1 |
| Li, XL | 1 |
| Zheng, S | 1 |
| Chen, Y | 7 |
| Ma, M | 1 |
| Li, M | 1 |
| Amani Abkenari, S | 1 |
| Safdarian, L | 1 |
| Amidi, F | 4 |
| Hosseini, A | 2 |
| Aryanpour, R | 1 |
| Salahi, E | 1 |
| Sobhani, A | 2 |
| Ye, R | 4 |
| Yan, C | 2 |
| Zhou, H | 4 |
| Huang, Y | 5 |
| Dong, M | 4 |
| Zhang, H | 6 |
| Jiang, X | 2 |
| Yuan, S | 2 |
| Chen, L | 4 |
| Jiang, R | 2 |
| Cheng, Z | 2 |
| Zheng, K | 2 |
| Zhang, Q | 4 |
| Jin, W | 5 |
| Mahmoud, AA | 2 |
| Elfiky, AM | 1 |
| Abo-Zeid, FS | 3 |
| Lin, W | 1 |
| Wen, L | 1 |
| Wen, J | 1 |
| Xiang, G | 1 |
| Benjamin, JJ | 1 |
| K, M | 1 |
| Koshy, T | 1 |
| K N, M | 1 |
| R, P | 1 |
| Nikmard, F | 1 |
| Hosseini, E | 1 |
| Bakhtiyari, M | 1 |
| Ashrafi, M | 1 |
| Aflatoonian, R | 1 |
| Peng, F | 1 |
| Hu, Y | 1 |
| Peng, S | 1 |
| Zeng, N | 1 |
| Shi, L | 1 |
| Liao, B | 1 |
| Qi, X | 1 |
| Yun, C | 1 |
| Qiao, J | 3 |
| Pang, Y | 1 |
| Zhang, Y | 6 |
| Xu, L | 2 |
| Huang, J | 1 |
| Chen, P | 1 |
| Xiang, Y | 2 |
| Liang, Q | 2 |
| Wu, T | 1 |
| Liu, J | 4 |
| Zeng, Y | 1 |
| Zeng, H | 1 |
| Liang, X | 1 |
| Zhou, C | 1 |
| Ullah, A | 1 |
| Wang, MJ | 1 |
| Yang, JP | 1 |
| Adu-Gyamfi, EA | 1 |
| Czika, A | 1 |
| Sah, SK | 1 |
| Feng, Q | 1 |
| Wang, YX | 4 |
| Giordano, LA | 1 |
| Giordano, MV | 1 |
| Célia Teixeira Gomes, R | 1 |
| Dos Santos Simões, R | 1 |
| Baracat, MCP | 1 |
| Giordano, MG | 1 |
| Ferreira-Filho, ES | 1 |
| de Medeiros, SF | 2 |
| Baracat, EC | 1 |
| Soares-Júnior, JM | 1 |
| Li, Y | 4 |
| Xu, J | 1 |
| Li, L | 3 |
| Bai, L | 1 |
| Wang, Y | 17 |
| Zhang, J | 2 |
| Wang, H | 11 |
| El Leithy, AA | 1 |
| Al-Karmalawy, AA | 1 |
| Youssif, OM | 1 |
| Ebrahim, YA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenotypic Components of Polycystic Ovary Syndrome Determine Endometrial Vitamin D Receptor mRNA Expression Pattern[NCT05885633] | 64 participants (Actual) | Interventional | 2022-10-21 | Completed | |||
| Pilot Trial of Bicalutamide Versus Placebo in Reproductive-Aged Women With Nonalcoholic Fatty Liver Disease (NAFLD) and Polycystic Ovary Syndrome (PCOS)[NCT05979389] | Phase 1 | 50 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| The Effects of Acetyl L--Carnitine and Myo/Chiro-Inositol on Improving Ovulation, Pregnancy Rate, Ovarian Function and Perceived Stress Response in Patients With PCOS[NCT05767515] | 120 participants (Anticipated) | Interventional | 2023-04-15 | Not yet recruiting | |||
| Metformin Versus Metfotmin Plus Low-dose Spironolactone in the Treatment of Overweight/Obese Patients With Polycystic Ovary Syndrome: a Randomized Study[NCT01526616] | 56 participants (Actual) | Interventional | 2010-05-31 | Completed | |||
| Phase III Study of Efficacy of High Dose Erythropoietin to Prevent Hypoxic-ischemic Encephalopathy Sequelae in Term Newborn[NCT01732146] | Phase 3 | 120 participants (Actual) | Interventional | 2013-03-28 | Completed | ||
| Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS)[NCT02145247] | 39 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| Theca Cell Function in Women With Polycystic Ovary Syndrome[NCT00747617] | Phase 3 | 25 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Effect of Dehydroepiandrosterone on Live Birth Rate in Subfertile Patients With Poor Ovarian Responds[NCT02432248] | 350 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | |||
| Does DHEA Improve Pregnancy Rate in Women Undergoing IVF/ICSI With Expected Poor Ovarian Response According to the Bologna Criteria? A Randomized Controlled Study[NCT02151006] | Phase 3 | 140 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| Evaluation of Vitamin D With and Without Hormonal Contraception on Sexual Function in Women With Polycystic Ovary Syndrome[NCT02865187] | 47 participants (Actual) | Interventional | 2017-02-06 | Completed | |||
| Androgen Metabolism and Reproductive Outcome[NCT02106676] | 400 participants (Actual) | Observational | 2012-03-31 | Completed | |||
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| The Effects of Contraceptive Pill and Hormonal Vaginal Ring on Hormonal, Inflammatory and Metabolic Parameters in Women of Reproductive Age With Polycystic Ovary Syndrome (PCOS).[NCT01588873] | Phase 4 | 42 participants (Anticipated) | Interventional | 2012-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"On study day one, recombinant-hCG (r-hCG) will be administered intravenously at a dose of 25 micrograms.~Blood samples will be obtained before and after r-hCG adminstration" (NCT02145247)
Timeframe: before and 24 hours after adminisration of r-hCG
| Intervention | percent change (Mean) |
|---|---|
| Normal Adult Women | 67 |
| Women With PCOS | 140 |
Mean serum testosterone levels before and after hCG injection. Serum testosterone levels before (-0.5 and 0 hrs) were averaged to achieve a single value (NCT00747617)
Timeframe: -0.5, 0, 24 hrs
| Intervention | ng/ml (Mean) |
|---|---|
| PCOS | 0.6 |
| Normal | 0.3 |
Assess serum 17OHP levels following each dose of hCG adminstration in PCOS and normal subjects (NCT00747617)
Timeframe: 24 hrs post dose
| Intervention | ng/ml (Mean) | ||||
|---|---|---|---|---|---|
| 17OHP post 10 micrograms | 17OHP level post 1 micrograms | 17OHP level post 25 micrograms | 17OHP level post 100 micrograms | 17OHP level post 250 micrograms | |
| Normal | 1.2 | 1.0 | 1.7 | 2.2 | 2.1 |
| PCOS | 2.0 | 1.1 | 2.7 | 3.3 | 4.0 |
Prevalence rate of women with PCOS defined by scores of the FSFI (total scores range from 2-36; scores less than 26.55 represent presence/degree of sexual dysfunction) - For this outcome, total scores were converted, using the cutoff score of 26.55, into a dichotomous variable for presence or absence of sexual dysfunction. (NCT02865187)
Timeframe: Baseline
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin D + Hormonal Contraception | 26 |
| Vit D + Non-hormonal Contraception | 11 |
Female Sexual Function Index (FSFI) scores at Month 6 (Total score ranges from 2 - 36; scores less than 26.55 represent presence/degree of sexual dysfunction) (NCT02865187)
Timeframe: Month 6
| Intervention | score on a scale (Mean) |
|---|---|
| Vitamin D + Hormonal Contraception | 24.8 |
| Vit D + Non-hormonal Contraception | 26.0 |
28 reviews available for dehydroepiandrosterone and Polycystic Ovary Syndrome
| Article | Year |
|---|---|
DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies.
Topics: Biomarkers; Case-Control Studies; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrome; | 2021 |
The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis.
Topics: Anti-Mullerian Hormone; Dehydroepiandrosterone; Female; Gonadotropin-Releasing Hormone; Humans; Metf | 2022 |
The Effect of Statins on Levels of Dehydroepiandrosterone (DHEA) in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
Topics: Adult; Atorvastatin; China; Dehydroepiandrosterone; Female; Humans; Hydroxymethylglutaryl-CoA Reduct | 2019 |
DHEA, DHEAS and PCOS.
Topics: Androgens; Animals; Body Mass Index; Cardiovascular Diseases; Dehydroepiandrosterone; Dehydroepiandr | 2015 |
Reproductive endocrinology of adolescent polycystic ovary syndrome.
Topics: Adolescent; Adult; Androgens; Anovulation; Anti-Mullerian Hormone; Child; Dehydroepiandrosterone; Fe | 2010 |
Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome.
Topics: Androgens; Animals; Dehydroepiandrosterone; Disease Models, Animal; Embryo Loss; Female; Humans; Hyp | 2010 |
The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
Topics: Androgens; Animals; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Gonadotropins; Hum | 2011 |
The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
Topics: Androgens; Animals; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Gonadotropins; Hum | 2011 |
The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
Topics: Androgens; Animals; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Gonadotropins; Hum | 2011 |
The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
Topics: Androgens; Animals; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Gonadotropins; Hum | 2011 |
Androgen biosynthesis from cholesterol to DHEA.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Androgens; Animals; Cholesterol; Cholesterol Side-C | 2002 |
Key developments in endocrinology.
Topics: Addison Disease; Adjuvants, Immunologic; Dehydroepiandrosterone; Endocrine System Diseases; Female; | 2003 |
MULTIGLANDULAR ASPECTS OF THE STEIN-LEVENTHAL SYNDROME.
Topics: 17-Ketosteroids; Adrenal Gland Diseases; Androgens; Dehydroepiandrosterone; Female; Follicle Stimula | 1963 |
Disorders of androgen synthesis--from cholesterol to dehydroepiandrosterone.
Topics: Adrenal Cortex; Adrenal Hyperplasia, Congenital; Androgens; Cholesterol; Cholesterol Side-Chain Clea | 2005 |
[DHEA, DHEA-S].
Topics: Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Biomarkers; Cushing | 2005 |
Polycystic ovarian disease: the adrenal connection.
Topics: Adrenal Glands; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethaso | 2006 |
Polycystic ovarian disease: current concepts of pathophysiology and therapy.
Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Glands; Androgen Antagonists; Androstenedione; Animals; Cim | 1984 |
Polycystic ovarian disease.
Topics: Adrenal Cortex; Animals; Dehydroepiandrosterone; Dexamethasone; Disease Models, Animal; Female; Foll | 1981 |
Hirsutism.
Topics: 17-Ketosteroids; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adrenal Gland Neoplasms; Adrenal Hyperplasia | 1981 |
Hirsutism: evaluation and management.
Topics: Cushing Syndrome; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diagnosis, Differential; F | 1995 |
Approach to patients with hirsutism.
Topics: 17-alpha-Hydroxyprogesterone; Cushing Syndrome; Dehydroepiandrosterone; Female; Hirsutism; Humans; H | 1996 |
Early steps in androgen biosynthesis: from cholesterol to DHEA.
Topics: Adrenal Hyperplasia, Congenital; Cholesterol; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone | 1998 |
Polycystic ovary syndrome--searching for an animal model.
Topics: Androgens; Animals; Chorionic Gonadotropin; Dehydroepiandrosterone; Disease Models, Animal; Estradio | 1998 |
Hirsutism and hyperandrogenism.
Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Glands; Adult; Androgens; Androstenedio | 1976 |
Interrelationship between excessive levels of circulating androgens in blood and ovulatory failure.
Topics: Animals; Anovulation; Chemoreceptor Cells; Dehydroepiandrosterone; Disease Models, Animal; Estradiol | 1976 |
Disturbances of androgen secretion and metabolism in polycystic ovary syndrome.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Dehydroepiandrosterone; Dihydrotestosterone; Femal | 1985 |
Gonadal and adrenal androgen secretion in hirsute females.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Androgens; Androstenedione; Catheterization; Dehydroepiandr | 1986 |
Animal models for study of polycystic ovaries and ovarian atresia.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Follicular Atresia; Follicular Phas | 1987 |
Polycystic ovarian disease: animal models.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Endorphins; Estradiol; Female; Hypothalamus | 1988 |
The adrenal cortex and virilization.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyper | 1985 |
Relationship of androgens to female hirsutism and infertility.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Androstenedione; Androstenols; Dehydroepiandrostero | 1973 |
33 trials available for dehydroepiandrosterone and Polycystic Ovary Syndrome
| Article | Year |
|---|---|
Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study.
Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; Dehydroepiandrosterone; Diet; Female; Follicle St | 2022 |
The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.
Topics: Animals; Dehydroepiandrosterone; Female; Glutamine; Humans; Inflammation; Oxidative Stress; Polycyst | 2020 |
Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Androgens; Blood Glucose; Curcumin; Dehydroepiandrosterone; Dietary Supplements; | 2021 |
Effect of Low-Frequency Electro-Acupuncture in Unmarried Women With Polycystic Ovary Syndrome: A Randomized Controlled Study.
Topics: Acne Vulgaris; Acupuncture Therapy; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrom | 2022 |
In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Female; Hirsutism; | 2014 |
Inadequacy of initiating rosuvastatin then metformin on biochemical profile of polycystic ovarian syndrome patients.
Topics: Adult; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Drug Therapy, Combination; Female | 2015 |
17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Androstenedione; Anti-Mullerian Hormone; California; Child | 2016 |
Intravenous lipid and heparin infusion-induced elevation in free fatty acids and triglycerides modifies circulating androgen levels in women: a randomized, controlled trial.
Topics: Adult; Androgens; Androstenedione; Cross-Over Studies; Dehydroepiandrosterone; Dehydroepiandrosteron | 2008 |
Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome.
Topics: Adolescent; Adrenocortical Hyperfunction; Adult; Androstenedione; Basal Metabolism; Cosyntropin; Deh | 2009 |
Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone; Dose-Response Re | 2011 |
Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone; Dose-Response Re | 2011 |
Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone; Dose-Response Re | 2011 |
Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone; Dose-Response Re | 2011 |
Atorvastatin therapy decreases androstenedione and dehydroepiandrosterone sulphate concentrations in patients with polycystic ovary syndrome: randomized controlled study.
Topics: Adrenal Glands; Adult; Androstenedione; Atorvastatin; Dehydroepiandrosterone; Dehydroepiandrosterone | 2012 |
Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women.
Topics: Adult; Body Mass Index; Cell Nucleus; Cytokines; Dehydroepiandrosterone; Double-Blind Method; Female | 2012 |
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women.
Topics: Adult; Blood Glucose; Body Composition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Doub | 2012 |
Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome.
Topics: Adult; Androgens; Cholestenone 5 alpha-Reductase; Cross-Over Studies; Dehydroepiandrosterone; Dexame | 2003 |
Adrenocortical hyperresponsiveness to corticotropin in polycystic ovary syndrome patients with adrenal androgen excess.
Topics: 17-alpha-Hydroxyprogesterone; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex; Adrenocorticotropic H | 2004 |
[Endocrine and metabolic effects of metformin in combination with compound cyproterone acetate in women with polycystic ovarian syndrome].
Topics: Adult; Antineoplastic Agents; Cholesterol, HDL; Cyproterone Acetate; Dehydroepiandrosterone; Drug Th | 2003 |
Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Area Under Curve; Dehydroepiandrosterone; Double-Bl | 2006 |
Heritability of dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their sisters.
Topics: Adult; Androgens; Biomarkers; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrome; Sib | 2006 |
Plasma ghrelin concentrations in patients with polycystic ovary syndrome before and after 6months therapy: correlation with androgen levels.
Topics: Adult; Androgen Antagonists; Androgens; Androstenedione; Cyproterone Acetate; Dehydroepiandrosterone | 2006 |
Metformin therapy in girls with polycystic ovary syndrome: a self-controlled clinical trial.
Topics: Adolescent; Adult; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Humans; Hypoglycemi | 2007 |
Prorenin is elevated in polycystic ovary syndrome and may reflect hyperandrogenism.
Topics: Adolescent; Adult; Androstenedione; Angiotensin II; Clomiphene; Dehydroepiandrosterone; Dehydroepian | 1995 |
The effects of spironolactone on testosterone fractions and sex-hormone binding globulin binding capacity in hirsute women.
Topics: Adolescent; Adult; Body Weight; Dehydroepiandrosterone; Estradiol; Female; Hirsutism; Hormone Antago | 1995 |
Sensitivity of plasma insulin levels in obese and non-obese women with functional hyperandrogenism.
Topics: Adult; Androstenedione; Body Mass Index; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Fem | 1995 |
Treatment of polycystic ovarian disease during adolescence with ethinylestradiol/cyproterone acetate versus a D-Tr-6-LHRH analog.
Topics: Adolescent; Androstenedione; Cyproterone Acetate; Dehydroepiandrosterone; Dehydroepiandrosterone Sul | 1993 |
Transvaginal ultrasound imaging, histopathology and endocrinopathy in patients with polycystic ovarian syndrome.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Follicle Sti | 1994 |
The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.
Topics: Adult; Body Mass Index; Chromans; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Double-Bli | 1996 |
Comparison of four different treatment regimes in hirsutism related to polycystic ovary syndrome.
Topics: Adolescent; Adult; Androgen Antagonists; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Contrac | 1996 |
Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxyprogesterone; Adult; Androstenedione; Blood Glucose; Cohort Studies; Dehydroepiandro | 1998 |
Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization.
Topics: Adult; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Fertili | 1999 |
Effect of ketoconazole on plasma sex hormones, lipids, lipoproteins, and apolipoproteins in hyperandrogenic women.
Topics: Adolescent; Adult; Androgens; Apolipoproteins; Cholesterol; Dehydroepiandrosterone; Dehydroepiandros | 1990 |
Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism.
Topics: Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgens; Androstenedione; Bone Den | 1990 |
A controlled clinical trial for the effect of bromocriptine on the adrenal contribution in polycystic ovarian disease.
Topics: Adolescent; Adrenal Glands; Adult; Androstenedione; Bromocriptine; Clinical Trials as Topic; Dehydro | 1987 |
The effect of leuprolide acetate on ovulation induction with human menopausal gonadotropins in polycystic ovary syndrome.
Topics: Adult; Anovulation; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Folli | 1987 |
362 other studies available for dehydroepiandrosterone and Polycystic Ovary Syndrome
| Article | Year |
|---|---|
Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites.
Topics: Animals; Berberine; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Female; Gastrointestinal Micr | 2021 |
Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP/NPR2 in PCOS model rats.
Topics: Animals; bcl-2-Associated X Protein; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; H | 2022 |
Metformin improves epigenetic modification involved in oocyte growth and embryo development in polycystic ovary syndrome mice model.
Topics: Animals; Dehydroepiandrosterone; Embryonic Development; Epigenesis, Genetic; Female; Metformin; Mice | 2021 |
Brown Adipose Tissue Activation by Cold Treatment Ameliorates Polycystic Ovary Syndrome in Rat.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cold Temperature; Corpus Luteum; Dehydroepian | 2021 |
The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome.
Topics: Androgen Antagonists; Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Hyperandrogen | 2022 |
Effects of Sleeve Gastrectomy on Fecal Gut Microbiota and Short-Chain Fatty Acid Content in a Rat Model of Polycystic Ovary Syndrome.
Topics: Animals; Dehydroepiandrosterone; Diet, High-Fat; Fatty Acids, Volatile; Feces; Female; Gastrectomy; | 2021 |
The boosting effects of melatonin on the expression of related genes to oocyte maturation and antioxidant pathways: a polycystic ovary syndrome- mouse model.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Bone Morphogenetic Protein 15; Dehydro | 2022 |
Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis.
Topics: Animals; Apigenin; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Polycystic Ovary | 2022 |
Effects of Androgen Excess-Related Metabolic Disturbances on Granulosa Cell Function and Follicular Development.
Topics: Androgens; Animals; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Mice; Polycystic Ovary | 2022 |
Comparative study of DHEA and letrozole induced polycystic ovary syndrome in post-pubertal rats.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Follicle Stimulating Hormone; Human | 2022 |
Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells.
Topics: Animals; Apoptosis; Dehydroepiandrosterone; Disulfiram; DNA, Ribosomal; Dysbiosis; Estrogens; Female | 2022 |
Ovarian inflammatory mRNA profiles of a dehydroepiandrosterone plus high-fat diet-induced polycystic ovary syndrome mouse model.
Topics: Animals; Dehydroepiandrosterone; Diet, High-Fat; Disease Models, Animal; Female; Humans; Inflammatio | 2022 |
Effects of clinical and metabolic variables and hormones on the expression of immune protein biomarkers in the endometrium of women with polycystic ovary syndrome and normal-cycling controls.
Topics: bcl-2-Associated X Protein; Brazil; Caspase 3; Cross-Sectional Studies; Dehydroepiandrosterone; Endo | 2022 |
Inhibition of Nicotinamide adenine dinucleotide phosphate oxidase 4 attenuates cell apoptosis and oxidative stress in a rat model of polycystic ovary syndrome through the activation of Nrf-2/HO-1 signaling pathway.
Topics: Adult; Animals; Apoptosis; Dehydroepiandrosterone; Female; Humans; NADP; NADPH Oxidase 4; Oxidative | 2022 |
Spirulina therapeutic potentiality in polycystic ovarian syndrome management using DHEA-induced rat model.
Topics: Animals; bcl-2-Associated X Protein; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; | 2022 |
Integrated metabolomics and network pharmacology to reveal the therapeutic mechanism of Dingkun Pill on polycystic ovary syndrome.
Topics: Androgens; Animals; Dehydroepiandrosterone; Female; Humans; Metabolomics; Network Pharmacology; Poly | 2022 |
Irisin reduces the abnormal reproductive and metabolic phenotypes of PCOS by regulating the activity of brown adipose tissue in mice†.
Topics: Adipose Tissue, Brown; Animals; Dehydroepiandrosterone; Female; Fibronectins; Humans; Insulin Resist | 2022 |
Derailed peripheral circadian genes in polycystic ovary syndrome patients alters peripheral conversion of androgens synthesis.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Animals; ARNTL Transcription Factors; Dehydroepian | 2022 |
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Metformin; Mice; Polycystic | 2022 |
Brown adipose tissue activation with ginsenoside compound K ameliorates polycystic ovary syndrome.
Topics: Adipose Tissue, Brown; Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Ginsenosides | 2022 |
Divergent Associations Between Serum Androgens and Ovarian Reserve Markers Revealed in Patients With Polycystic Ovary Syndrome.
Topics: Androgens; Anti-Mullerian Hormone; Biomarkers; Chromatography, Liquid; Dehydroepiandrosterone; Femal | 2022 |
Distinctions in PCOS Induced by Letrozole Vs Dehydroepiandrosterone With High-fat Diet in Mouse Model.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Diet, High-Fat; Disease Models, Animal; Female; Humans | 2022 |
Inhibitory effect of bushen huoxue formula against dehydroepiandrosterone-induced inflammation in granulosa cells through TLR4/NF-κB signaling pathway.
Topics: Androgens; Cytokines; Dehydroepiandrosterone; Drugs, Chinese Herbal; Female; Granulosa Cells; Humans | 2022 |
Serum-Derived Exosomal microRNAs in Lipid Metabolism in Polycystic Ovary Syndrome.
Topics: Animals; Dehydroepiandrosterone; Exosomes; Female; Humans; Lipid Metabolism; Mice; MicroRNAs; Polycy | 2022 |
Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway.
Topics: Animals; Benzimidazoles; Dehydroepiandrosterone; DNA Glycosylases; Female; Guanine; Humans; Inflamma | 2022 |
The PNA mouse may be the best animal model of polycystic ovary syndrome.
Topics: Animals; Dehydroepiandrosterone; Diet, High-Fat; Disease Models, Animal; Female; Humans; Mice; Polyc | 2022 |
HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome.
Topics: Angiogenesis Inducing Agents; Angiopoietins; Animals; Catalase; Dehydroepiandrosterone; Disease Mode | 2022 |
Oxidative Stress as a Contributor to Insulin Resistance in the Skeletal Muscles of Mice with Polycystic Ovary Syndrome.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Dehydroepiandrosterone; Female; Humans; Insulin R | 2022 |
The ADMA-DDAH1 axis in ovarian apoptosis of polycystic ovary syndrome.
Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Dehydroepiandrosterone; Female; Humans; Polycystic Ov | 2023 |
The relationship between the level of vitamin D, leptin and FGF23 in girls and young women with polycystic ovary syndrome.
Topics: Adipokines; Adolescent; Androstadienes; Anti-Mullerian Hormone; Calcium; Dehydroepiandrosterone; Fem | 2022 |
Increased Prevalence of Elevated DHEAS in PCOS Women with Non-Classic (B or C) Phenotypes: A Retrospective Analysis in Patients Aged 20 to 29 Years.
Topics: Androgens; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; | 2022 |
Tempol modulates lncRNA-miRNA-mRNA ceRNA networks in ovaries of DHEA induced PCOS rats.
Topics: Animals; Dehydroepiandrosterone; Female; Gene Regulatory Networks; Humans; MicroRNAs; Polycystic Ova | 2023 |
Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome.
Topics: Animals; Carrier Proteins; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammasomes; I | 2023 |
Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome.
Topics: Animals; Carrier Proteins; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammasomes; I | 2023 |
Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome.
Topics: Animals; Carrier Proteins; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammasomes; I | 2023 |
Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome.
Topics: Animals; Carrier Proteins; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammasomes; I | 2023 |
Effects of myo-inositol plus folic acid on ovarian morphology and oocyte quality in PCOS mouse model.
Topics: Adenosine Triphosphate; Animals; Dehydroepiandrosterone; Female; Folic Acid; Glutathione; Humans; In | 2023 |
Effects of dehydroepiandrosterone alone or in combination with a high-fat diet and antibiotic cocktail on the heterogeneous phenotypes of PCOS mouse models by regulating gut microbiota.
Topics: Animals; Dehydroepiandrosterone; Diet, High-Fat; Female; Gastrointestinal Microbiome; Humans; Hypera | 2022 |
PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro.
Topics: Animals; Apoptosis; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammation; Lipids; M | 2023 |
Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosis.
Topics: Animals; Apoptosis; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Inflammation; Ox | 2023 |
Effects of a ketogenic diet on reproductive and metabolic phenotypes in mice with polycystic ovary syndrome†.
Topics: Animals; Dehydroepiandrosterone; Diet, Ketogenic; Disease Models, Animal; Female; Humans; Inflammati | 2023 |
Testosterone, sex hormone-binding globulin and dehydroepiandrosterone levels and cervical length of Egyptian women with a history of recurrent miscarriages, polycystic ovary syndrome and without the conditions at three stages of pregnancy.
Topics: Abortion, Habitual; Dehydroepiandrosterone; Egypt; Female; Humans; Polycystic Ovary Syndrome; Pregna | 2023 |
Fetal sex and the development of gestational diabetes mellitus in polycystic ovarian syndrome gravidae.
Topics: Dehydroepiandrosterone; Diabetes, Gestational; Female; Humans; Infertility; Male; Polycystic Ovary S | 2023 |
Isorhamnetin inhibits inflammatory response to alleviate DHEA-induced polycystic ovary syndrome in rats.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Insulin; Luteini | 2023 |
1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells.
Topics: Calcitriol; Dehydroepiandrosterone; Female; Ferroptosis; Humans; Hyperandrogenism; Polycystic Ovary | 2023 |
Association of Oxidative Stress with Kidney Injury in a Hyperandrogenemic Female Rat Model.
Topics: Animals; Antioxidants; Dehydroepiandrosterone; Female; Humans; Hyperandrogenism; Kidney; Kidney Dise | 2023 |
Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†.
Topics: Adipose Tissue, White; Animals; Dehydroepiandrosterone; Female; Glucagon-Like Peptide-1 Receptor; Hu | 2023 |
Chamomile and Urtica dioica extracts improve immunological and histological alterations associated with polycystic ovarian syndrome in DHEA -induced mice.
Topics: Animals; Antioxidants; Chamomile; Dehydroepiandrosterone; Female; Humans; Matrix Metalloproteinase 9 | 2023 |
Correlation between biochemical and clinical hyperandrogenism parameter in polycystic ovary syndrome in relation to age.
Topics: Acne Vulgaris; Aged; Androgens; Dehydroepiandrosterone; Female; Humans; Hyperandrogenism; Polycystic | 2023 |
Effects of Blue Light on Puberty and Ovary in Female Rats
Topics: Animals; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Humans; Leptin; Lu | 2023 |
Biochanin-A attenuates DHEA-induced polycystic ovary syndrome via upregulation of GDF9 and BMP15 signaling in vivo.
Topics: Adiponectin; Animals; Bone Morphogenetic Protein 15; Dehydroepiandrosterone; Estrogens; Female; Grow | 2023 |
Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid.
Topics: Animals; Dehydroepiandrosterone; Female; Gastrointestinal Microbiome; Humans; Letrozole; Liver Disea | 2023 |
Effects of gut microbiota on omega-3-mediated ovary and metabolic benefits in polycystic ovary syndrome mice.
Topics: Animals; Dehydroepiandrosterone; Dietary Supplements; Fatty Acids, Omega-3; Female; Gastrointestinal | 2023 |
Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS.
Topics: Animals; Carrier Proteins; Cell Cycle Proteins; Dehydroepiandrosterone; Endoribonucleases; Female; F | 2023 |
Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress.
Topics: Animals; Apoptosis; Dehydroepiandrosterone; Female; Humans; Hydrogen Peroxide; Oxidative Stress; Pol | 2023 |
Mechanisms of DHEA-induced AMH increase in the ovarian tissues of PCOS rat.
Topics: Animals; Anti-Mullerian Hormone; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrome; | 2023 |
Dingkun pill alleviates metabolic abnormalities in polycystic ovary syndrome through brown adipose tissue activation.
Topics: Adipose Tissue, Brown; Animals; Dehydroepiandrosterone; Down-Regulation; Female; Fertility; Humans; | 2023 |
The ameliorating effects of Guizhi Fuling Wan combined with rosiglitazone in a rat ovarian model of polycystic ovary syndrome by the PI3K/AKT/NF-κB and Nrf2/HO-1 pathways.
Topics: Animals; Dehydroepiandrosterone; Female; Humans; NF-E2-Related Factor 2; NF-kappa B; Phosphatidylino | 2023 |
Dehydroepiandrosterone-induced polycystic ovary syndrome mouse model requires continous treatments to maintain reproductive phenotypes.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Infant, Newborn; Mice; Mice | 2023 |
Hyperandrogenism drives ovarian inflammation and pyroptosis: A possible pathogenesis of PCOS follicular dysplasia.
Topics: Animals; Dehydroepiandrosterone; Female; Humans; Hyperandrogenism; Inflammation; Mice; Polycystic Ov | 2023 |
Ovarian Metabolic activity in Dehydroepiandrosterone-Induced Polycystic Ovary in Wistar rats Treated with Aspirin.
Topics: Animals; Antioxidants; Aspirin; Cytokines; Dehydroepiandrosterone; Female; Ovary; Oxidative Stress; | 2020 |
The phytoestrogen, quercetin, in serum, uterus and ovary as a potential treatment for dehydroepiandrosterone-induced polycystic ovary syndrome in the rat.
Topics: Adiponectin; Animals; Aromatase; Dehydroepiandrosterone; Disease Models, Animal; Estradiol; Female; | 2020 |
The implications of vitamin content in the plasma in reference to the parameters of carbohydrate metabolism and hormone and lipid profiles in PCOS.
Topics: Adult; Androstenedione; Antioxidants; Carbohydrate Metabolism; Dehydroepiandrosterone; Female; Folic | 2020 |
Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Glycation End Products, Advanced; G | 2020 |
Vitamin D3 affects mitochondrial biogenesis through mitogen-activated protein kinase in polycystic ovary syndrome mouse model.
Topics: Animals; Apoptosis; Catalase; Cholecalciferol; Dehydroepiandrosterone; Disease Models, Animal; Femal | 2020 |
Curcumin-loaded super-paramagnetic iron oxide nanoparticle affects on apoptotic factors expression and histological changes in a prepubertal mouse model of polycystic ovary syndrome-induced by dehydroepiandrosterone - A molecular and stereological study.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Curcumin; Dehydroepiandrosterone; Disease Models, Anima | 2020 |
Quercetin modulates granulosa cell mRNA androgen receptor gene expression in dehydroepiandrosterone-induced polycystic ovary in Wistar rats via metabolic and hormonal pathways.
Topics: Adjuvants, Immunologic; Animals; Antioxidants; Dehydroepiandrosterone; Disease Models, Animal; Femal | 2020 |
Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome.
Topics: 3T3-L1 Cells; Adipocytes; Animals; ARNTL Transcription Factors; Brain; Circadian Clocks; Dehydroepia | 2020 |
Polycystic ovary syndrome and endothelial dysfunction: A potential role for soluble lectin-like oxidized low density lipoprotein receptor-1.
Topics: Adult; Aryldialkylphosphatase; Dehydroepiandrosterone; Endothelium, Vascular; Estradiol; Female; Fol | 2020 |
γ-Linolenic acid ameliorates DHEA induced pro-inflammatory response in polycystic ovary syndrome via PPAR-γ signaling in rats.
Topics: Animals; Dehydroepiandrosterone; Female; gamma-Linolenic Acid; Gene Expression; Inflammation; Peroxi | 2020 |
White, brown, and bone marrow adipose tissue behavior in DHEA-induced PCOS mice.
Topics: Adipose Tissue; Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Insulin Resistance; | 2021 |
Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice†.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Metformin; Mice; Oocytes; Ovary; Po | 2020 |
Androgen receptor and uterine histoarchitecture in a PCOS rat model.
Topics: Animals; Animals, Newborn; Aquaporins; Collagen; Dehydroepiandrosterone; Disease Models, Animal; Est | 2020 |
CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression.
Topics: Adult; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Division; Cell Line, Tumor; Dehydroepiandros | 2020 |
The ameliorative effects of marjoram in dehydroepiandrosterone induced polycystic ovary syndrome in rats.
Topics: Adiponectin; Animals; Biomarkers; Body Weight; Dehydroepiandrosterone; Female; Gonadal Steroid Hormo | 2020 |
Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress.
Topics: Animals; Dehydroepiandrosterone; Electroacupuncture; Female; Insulin Resistance; Mitochondria; Oxida | 2020 |
Ultrasonographic and biochemical assessments as early prediction of polycystic ovarian syndrome in obese women.
Topics: Adult; Anovulation; Body Mass Index; Case-Control Studies; Dehydroepiandrosterone; Female; Follicle | 2020 |
Comparison of the efficacy of different androgens measured by LC-MS/MS in representing hyperandrogenemia and an evaluation of adrenal-origin androgens with a dexamethasone suppression test in patients with PCOS.
Topics: Adrenal Cortex Function Tests; Adult; Androstenedione; Area Under Curve; Case-Control Studies; Chrom | 2021 |
Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome via inactivation of TGF-β1/Smads signaling pathway
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Estrous Cycle; Female; Glucosides; Monoterp | 2021 |
Effect of Acupuncture on Ovary Morphology and Function in DHEA-Induced Polycystic Ovary Syndrome Model Rats.
Topics: Acupuncture Therapy; Animals; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrome; Rat | 2021 |
The effect of γ-linolenic acid on Polycystic Ovary Syndrome associated Focal Segmental Glomerulosclerosis via TGF-β pathway.
Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; Female; gamma-Linolenic Acid; Glomeruloscle | 2021 |
The Effect of Astaxanthin and Metformin on Oxidative Stress in Granulosa Cells of BALB C Mouse Model of Polycystic Ovary Syndrome.
Topics: Animals; Dehydroepiandrosterone; Female; Granulosa Cells; Metformin; Mice; Mice, Inbred BALB C; Oxid | 2021 |
Differential Effects of Various Androgens on Polycystic Ovary Syndrome.
Topics: Adult; Androgens; Body Mass Index; Cross-Sectional Studies; Dehydroepiandrosterone; Dehydroepiandros | 2021 |
Short-term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone-induced polycystic ovary syndrome mice.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Mice; Polycystic Ovary Synd | 2021 |
Genistein exhibits therapeutic potential for PCOS mice
Topics: Animals; Antioxidants; Dehydroepiandrosterone; Female; Forkhead Box Protein O1; Genistein; Granulosa | 2021 |
Dulaglutide, a long-acting GLP-1 receptor agonist, can improve hyperandrogenemia and ovarian function in DHEA-induced PCOS rats.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Disease Models, Animal; Female; Gene Expression Regula | 2021 |
ATP synthase β-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
Topics: Adenosine Triphosphate; Animals; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2017 |
Intracytoplasmic oxidative stress reverses epigenetic modifications in polycystic ovary syndrome.
Topics: Acetylation; Animals; Dehydroepiandrosterone; Disease Models, Animal; DNA Methylation; Estradiol; Fe | 2017 |
Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat.
Topics: Adipose Tissue, Brown; Animals; Anovulation; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity A | 2017 |
The BMP4-Smad signaling pathway regulates hyperandrogenism development in a female mouse model.
Topics: Androgens; Animals; Bone Morphogenetic Protein 4; Cells, Cultured; Dehydroepiandrosterone; Disease M | 2017 |
AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome.
Topics: 3-Hydroxysteroid Dehydrogenases; Adipocytes; Adolescent; Adult; Aldo-Keto Reductase Family 1 Member | 2017 |
Can the source of hyperandrogenism in adolescents with polycystic ovary syndrome predict metabolic phenotype?
Topics: Adolescent; Adrenal Glands; Cohort Studies; Dehydroepiandrosterone; Female; Humans; Hyperandrogenism | 2017 |
Abnormality of Klotho Signaling Is Involved in Polycystic Ovary Syndrome.
Topics: Animals; Apoptosis; Caspase 3; Cell Proliferation; Dehydroepiandrosterone; Female; Glucuronidase; Gr | 2018 |
Potential therapeutic effect of alkaline reduced water in polycystic ovarian syndrome.
Topics: Animals; Dehydroepiandrosterone; Female; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydr | 2017 |
Systemic adiponectin treatment reverses polycystic ovary syndrome-like features in an animal model.
Topics: Adiponectin; Androgens; Animals; Body Mass Index; Dehydroepiandrosterone; Disease Models, Animal; Fe | 2018 |
Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; DNA-Binding Proteins; Drugs, Chinese Herbal | 2017 |
DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathway.
Topics: Animals; Biomarkers; Dehydroepiandrosterone; Disease Models, Animal; Estrous Cycle; Female; Fibrosis | 2018 |
Effects of dehydroepiandrosterone on the ovarian reserve and pregnancy outcomes in perimenopausal rats (DHEA and fertility in perimenopausal rats).
Topics: Animals; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Female; Fertility; Male; Ovarian | 2018 |
Vitamin D3 regulates steroidogenesis in granulosa cells through AMP-activated protein kinase (AMPK) activation in a mouse model of polycystic ovary syndrome.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Cholecalciferol; Dehydroepiandrosterone; Di | 2018 |
Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model.
Topics: Aizoaceae; Androgens; Animals; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein | 2018 |
Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice.
Topics: Animals; Cells, Cultured; Dehydroepiandrosterone; Disease Models, Animal; Estradiol; Female; Hyperan | 2018 |
Hyperandrogenism Induces Histo-Architectural Changes in the Rat Uterus.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Estrogen Receptor alpha; Female; Hyperandro | 2019 |
Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Count; Dehydroepiandrosterone; Disease Model | 2018 |
Amelioration by quercetin of insulin resistance and uterine GLUT4 and ERα gene expression in rats with polycystic ovary syndrome (PCOS).
Topics: Animals; Antioxidants; Dehydroepiandrosterone; Disease Models, Animal; Estrogen Receptor alpha; Fema | 2019 |
The effect of cinnamon on polycystic ovary syndrome in a mouse model.
Topics: Animals; Cinnamomum zeylanicum; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Insu | 2018 |
MIF May Participate in Pathogenesis of Polycystic Ovary Syndrome in Rats through MAPK Signalling Pathway.
Topics: Animals; Dehydroepiandrosterone; Diet, High-Fat; Disease Models, Animal; Fasting; Female; Humans; In | 2018 |
The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome.
Topics: Adiposity; Animals; Blood Glucose; Dehydroepiandrosterone; Disease Models, Animal; Estrous Cycle; Fa | 2018 |
Effect of Hawthorn Leaf Flavonoids in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome in Rats.
Topics: Administration, Oral; Animals; Crataegus; Dehydroepiandrosterone; Disease Models, Animal; Female; Fl | 2019 |
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
Topics: Animals; Apoptosis; Cell Line; Dehydroepiandrosterone; Disease Models, Animal; Down-Regulation; Fema | 2019 |
Serum metabolomics analysis of patients with polycystic ovary syndrome by mass spectrometry.
Topics: Adult; Androgens; Bile Acids and Salts; Biomarkers; Carnitine; Chromatography, Liquid; Dehydroepiand | 2019 |
Nontargeted metabolomic analysis of skeletal muscle in a dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Metabolomics; Mice; Muscle, | 2019 |
Bisphenol S increases EZRIN expression and the detrimental effects induced by dehydroepiandrosterone in rat endometrium.
Topics: Animals; Cell Proliferation; Cell Survival; Cytoskeletal Proteins; Dehydroepiandrosterone; Disease M | 2019 |
Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents; Bacteria; Biomarkers; Cytokines; Dehydroepiandrosterone; Diet, Hi | 2019 |
Effects of L-carnitine on Polycystic Ovary Syndrome.
Topics: Adult; Blood Glucose; Body Mass Index; Carnitine; Dehydroepiandrosterone; Female; Humans; Insulin; I | 2019 |
Dietary Glycotoxins, Advanced Glycation End Products, Inhibit Cell Proliferation and Progesterone Secretion in Ovarian Granulosa Cells and Mimic PCOS-like Symptoms.
Topics: Animals; Cell Proliferation; Dehydroepiandrosterone; Diet; Female; Glucose; Glycation End Products, | 2019 |
Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.
Topics: Adult; Alleles; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Genetic Predispositi | 2013 |
Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats.
Topics: Animals; Dehydroepiandrosterone; Female; Fibrosis; Hypoglycemic Agents; Hypolipidemic Agents; Metfor | 2013 |
New insights into steroidogenesis in normo- and hyperandrogenic polycystic ovary syndrome patients.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult; Case-Control S | 2013 |
Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA.
Topics: Adipose Tissue; Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Gene Expression Reg | 2014 |
Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats.
Topics: Animals; Blood Glucose; Body Weight; Dehydroepiandrosterone; Disease Models, Animal; Drugs, Chinese | 2014 |
Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse.
Topics: Animals; Caveolin 1; Dehydroepiandrosterone; Disease Models, Animal; Down-Regulation; Estradiol; Fem | 2014 |
Long-term treatment with dehydroepiandrosterone may lead to follicular atresia through interaction with anti-Mullerian hormone.
Topics: Animals; Anti-Mullerian Hormone; Dehydroepiandrosterone; Female; Follicular Atresia; Hyperandrogenis | 2014 |
Induction of hyperandrogenism in lean reproductive-age women stimulates proatherogenic inflammation.
Topics: Adult; Androgens; C-Reactive Protein; Dehydroepiandrosterone; Female; Humans; Hyperandrogenism; Infl | 2015 |
Comparison of steroidogenic pathways among normoandrogenic and hyperandrogenic polycystic ovary syndrome patients and normal cycling women.
Topics: Adult; Androgens; Androstenedione; Case-Control Studies; Dehydroepiandrosterone; Estradiol; Female; | 2015 |
Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model.
Topics: Angiogenesis Modulating Agents; Angiopoietin-1; Angiopoietin-2; Animals; Dehydroepiandrosterone; Fem | 2015 |
Alternative splicing of the androgen receptor in polycystic ovary syndrome.
Topics: Adult; Alternative Splicing; Base Sequence; Cells, Cultured; Dehydroepiandrosterone; Female; Gene Ex | 2015 |
Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Exenatide; Female; Gene Expression Regulati | 2015 |
Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome.
Topics: Adjuvants, Immunologic; Administration, Oral; Analysis of Variance; Animals; Aromatase; Dehydroepian | 2015 |
Mass spectrometry methods measured androgen and estrogen concentrations during pregnancy and in newborns of mothers with polycystic ovary syndrome.
Topics: Adult; Androgens; Androstenedione; Case-Control Studies; Chromatography, Liquid; Dehydroepiandroster | 2016 |
Increased anti-Mullerian hormone levels and ovarian size in a subgroup of women with functional hypothalamic amenorrhea: further identification of the link between polycystic ovary syndrome and functional hypothalamic amenorrhea.
Topics: Adult; Amenorrhea; Androstenedione; Anti-Mullerian Hormone; Case-Control Studies; Dehydroepiandroste | 2016 |
High-fat diets exaggerate endocrine and metabolic phenotypes in a rat model of DHEA-induced PCOS.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Diet, High-Fat; Estrous Cycle; Female; Glucose Toleran | 2016 |
Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats.
Topics: Animals; Apoptosis; CD4-Positive T-Lymphocytes; Dehydroepiandrosterone; Disease Models, Animal; Drug | 2016 |
Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.
Topics: Adiponectin; Adipose Tissue, Brown; Adult; Analysis of Variance; Animals; Blood Glucose; Dehydroepia | 2016 |
Effects of Exenatide on Metabolic Changes, Sexual Hormones, Inflammatory Cytokines, Adipokines, and Weight Change in a DHEA-Treated Rat Model.
Topics: Adipokines; Animals; Body Weight; Cytokines; Dehydroepiandrosterone; Disease Models, Animal; Exenati | 2016 |
Effects of gonadotropin-releasing hormone agonist and antagonist on ovarian activity in a mouse model for polycystic ovary.
Topics: Animals; Corpus Luteum; Dehydroepiandrosterone; Disease Models, Animal; Estradiol; Female; Gene Expr | 2016 |
Steroidogenic enzymes of adipose tissue in modulation of trivalent chromium in a mouse model of PCOS.
Topics: 17-Hydroxysteroid Dehydrogenases; Adipose Tissue; Animals; Aromatase; Chromium; Dehydroepiandrostero | 2017 |
Depression-Like Behavior in a Dehydroepiandrosterone-Induced Mouse Model of Polycystic Ovary Syndrome.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Brain; Dehydroepiandrosterone; Depression; Diet, Hig | 2016 |
RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model.
Topics: Animals; Cell Line; Dehydroepiandrosterone; Disease Models, Animal; Estrous Cycle; Female; GTP Phosp | 2017 |
Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults.
Topics: Animals; Blood Pressure; Dehydroepiandrosterone; Female; Gene Expression Regulation; Glucose Toleran | 2016 |
11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome.
Topics: Adult; Androgens; Androstenedione; Androstenes; Blood Glucose; Case-Control Studies; Chromatography, | 2017 |
Impaired receptivity and decidualization in DHEA-induced PCOS mice.
Topics: Abortion, Spontaneous; Animals; Blastocyst; Dehydroepiandrosterone; Embryo Implantation; Embryo Tran | 2016 |
Dehydroepiandrosterone and metformin regulate proliferation of murine T lymphocytes.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Dehydroepiandr | 2008 |
Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; | 2009 |
Impact of glycemic variations on the regulation of androgen metabolism in obese women with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxyprogesterone; Adult; Androgens; Androstenedione; Blood Glucose; C-Peptide; Dehydroep | 2009 |
Detrimental effects of hyperandrogenism on uterine functions.
Topics: Adjuvants, Immunologic; Animals; Catalase; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; C | 2008 |
In polycystic ovary syndrome, adrenal steroids are regulated differently in the morning versus in response to nutrient intake.
Topics: Adrenal Glands; Adult; Blood Glucose; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrostero | 2010 |
Inactivating PAPSS2 mutations in a patient with premature pubarche.
Topics: Androgens; Androstenedione; Child; Dehydroepiandrosterone; Diagnosis, Differential; Female; Heterozy | 2009 |
The effects of metformin on uterine tissue of hyperandrogenized BALB/c mice.
Topics: Animals; Blotting, Western; Catalase; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cycloo | 2009 |
Demethylation of LHR in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; DNA Methylation; Female; Mice; Polycystic O | 2010 |
Ovarian morphology and prevalence of polycystic ovary syndrome in reproductive aged women with or without mild acne.
Topics: 17-alpha-Hydroxyprogesterone; Acne Vulgaris; Adolescent; Adult; Age of Onset; Cross-Sectional Studie | 2010 |
The conversion of dehydroepiandrosterone into androst-5-ene-3beta,17beta-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome.
Topics: 3-Hydroxysteroid Dehydrogenases; Adult; Androstenediol; Dehydroepiandrosterone; Endometrium; Female; | 2010 |
[DHEA, DHEA-S].
Topics: Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Cushing Syndrome; Dehydroepiandrosterone; | 2010 |
Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats.
Topics: Animals; bcl-2-Associated X Protein; Dehydroepiandrosterone; Female; Gene Expression Regulation; Ova | 2011 |
Ovarian morphology and endocrine function in polycystic ovary syndrome.
Topics: Adult; Anthropometry; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Dehydroepiandr | 2011 |
Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS).
Topics: Analysis of Variance; Androstenedione; Case-Control Studies; Dehydroepiandrosterone; Female; Follicl | 2011 |
Systemic inflammation, cellular influx and up-regulation of ovarian VCAM-1 expression in a mouse model of polycystic ovary syndrome (PCOS).
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; Cytokines; Dehydroepiandrostero | 2011 |
A 20-year follow-up of young women with polycystic ovary syndrome.
Topics: Adult; Anovulation; Body Mass Index; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; F | 2012 |
Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome.
Topics: Adjuvants, Immunologic; Angiopoietins; Animals; Dehydroepiandrosterone; Disease Models, Animal; Endo | 2012 |
Steroid studies in a case of Stein-Leventhal syndrome with hirsutism.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anatomy; Dehydroepiandrostero | 1963 |
[The demonstration of dehyroepiandrosterone in human sclerocystic ovaries].
Topics: Anatomy; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrome | 1962 |
[AN ALTERATION IN HORMONAL BIOSYNTHESIS IN THE OVARY, A POSSIBLE CAUSE OF HYPERANDROGENISM IN THE STEIN-LEVENTHAL SYNDROME].
Topics: Androgens; Dehydroepiandrosterone; Estrogens; Female; Humans; Hydroxyprogesterones; Hyperandrogenism | 1963 |
[STUDIES OF SO-CALLED "SIMPLE" HIRSUTISM. VI. HORMONAL RESEARCH IN DYNAMIC CONDITIONS: REDUCTION WITH DEXAMETHASONE].
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Dehydroepiandros | 1963 |
THE DETERMINATION OF STEROIDS IN CYST FLUID FROM HUMAN POLYCYSTIC OVARIES.
Topics: Androgens; Chromatography; Cyst Fluid; Cysts; Dehydroepiandrosterone; Endometriosis; Estradiol; Estr | 1963 |
PLASMA ANDROGENS IN WOMEN. II. PATIENTS WITH POLYCYSTIC OVARIES AND HIRSUTISM.
Topics: Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Androgens; Androsterone; Blood Chemical Ana | 1964 |
VIRILIZATION AND THE HUMAN OVARY: INCLUDING OBSERVATION ON THE STEIN-LEVENTHAL SYNDROME.
Topics: Androgens; Castration; Dehydroepiandrosterone; Estrogens; Female; Gonadotropins; Humans; Hydrazines; | 1964 |
STEROID SYNTHESIS IN ABNORMAL OVARIES. 3. POLYCYSTIC OVARIES.
Topics: Androgens; Biochemical Phenomena; Biochemistry; Cysts; Dehydroepiandrosterone; Estradiol; Estrone; F | 1964 |
SIGNIFICANCE OF PLASMA DEHYDROISOANDROSTERONE AND ANDROSTERONE SULFATES IN THE DIAGNOSIS OF VIRILIZING DISORDERS.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Amenorrhea; Androsterone; Blood C | 1965 |
Isolation of dehydroepiandrosterone and 17alpha-hydroxy-delta5-pregenolone from the polycystic ovaries of the Stein-Leventhal syndrome.
Topics: Androgens; Cysts; Dehydroepiandrosterone; Female; Gonadotropins; Gonadotropins, Pituitary; Humans; M | 1962 |
Dehydroisoandrosterone synthesis by the human ovary.
Topics: Androgens; Biochemical Phenomena; Biological Assay; Dehydroepiandrosterone; Female; Humans; Lipid Me | 1962 |
Valproate potentiates androgen biosynthesis in human ovarian theca cells.
Topics: 17-alpha-Hydroxyprogesterone; Acetylation; Adult; Androgens; Androstenedione; Cholesterol Side-Chain | 2004 |
Glucose action and adrenocortical biosynthesis in women with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenal Cortex Hormones; | 2004 |
Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgen Antag | 2004 |
Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dehydroepiandrosterone; Epilepsy; Female; Growth; | 2004 |
Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome.
Topics: Adenoviridae; Androgens; Animals; Blotting, Western; Cell Line; Cells, Cultured; Dehydroepiandroster | 2005 |
Expression of resistin mRNA in adipose tissue of rat model with polycystic ovarian syndrome and its implication.
Topics: Adipose Tissue; Animals; Animals, Newborn; Dehydroepiandrosterone; Estradiol; Female; Insulin Resist | 2004 |
Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome.
Topics: Alitretinoin; Antineoplastic Agents; Cholesterol Side-Chain Cleavage Enzyme; Dehydroepiandrosterone; | 2005 |
Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Animals; Area Under Curve; Dehydroepiandrost | 2005 |
The association of serum androgens and insulin resistance with fat distribution in polycystic ovary syndrome.
Topics: Absorptiometry, Photon; Adult; Androgens; Blood Glucose; Body Fat Distribution; Body Mass Index; Cas | 2006 |
Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats.
Topics: 17-Hydroxysteroid Dehydrogenases; Adjuvants, Immunologic; Animals; Chromans; Dehydroepiandrosterone; | 2006 |
Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone.
Topics: Androgens; Animals; Blood Glucose; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dehydroep | 2006 |
The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice.
Topics: Adjuvants, Immunologic; Administration, Oral; AMP-Activated Protein Kinases; Animals; Catalase; Cycl | 2006 |
Altered expression of Fas/Fas ligand/caspase 8 and membrane type 1-matrix metalloproteinase in atretic follicles within dehydroepiandrosterone-induced polycystic ovaries in rats.
Topics: Animals; Apoptosis; Caspase 8; Dehydroepiandrosterone; Disease Models, Animal; Fas Ligand Protein; f | 2006 |
Polycystic ovary syndrome in bulimic women--an evaluation based on the new diagnostic criteria.
Topics: Adult; Bulimia; Case-Control Studies; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; | 2006 |
Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome.
Topics: Blood Glucose; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Dehydroepiandrosterone; Diabetes | 2006 |
Comparison of fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome and women with simple obesity.
Topics: Adult; Blood Glucose; Case-Control Studies; Cholesterol; Dehydroepiandrosterone; Estradiol; Female; | 2006 |
Relation of nutrients and hormones in polycystic ovary syndrome.
Topics: Adult; Androstenedione; Blood Glucose; Body Mass Index; Dehydroepiandrosterone; Female; Food; Ghreli | 2007 |
Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Body Mass Index; Cohort Studies; Dehydroepiandroster | 2007 |
Helpful diagnostic markers of steroidogenesis for defining hyperandrogenemia in hirsute women.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Aged; Androstenedione; Biomarkers; Cortodoxone; Deh | 2008 |
Oxidative stress in nonobese women with polycystic ovary syndrome: correlations with endocrine and screening parameters.
Topics: Adult; Antioxidants; Body Mass Index; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulatin | 2008 |
Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Androgens; Androstenedione; Dehydroepiandrosterone; | 2008 |
Lipoprotein(a) levels in girls with premature adrenarche.
Topics: Adolescent; Adrenarche; Blood Glucose; Cardiovascular Diseases; Child; Dehydroepiandrosterone; Femal | 2008 |
Prevalence of nonclassic adrenal hyperplasia (NCAH) in hyperandrogenic women.
Topics: 17-alpha-Hydroxyprogesterone; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Ho | 2008 |
Insulin resistance in patients with polycystic ovaries: its relationship to body weight and androgen levels.
Topics: Adult; Androstenedione; Blood Glucose; C-Peptide; Dehydroepiandrosterone; Dehydroepiandrosterone Sul | 1983 |
An extended regimen of clomiphene citrate in women unresponsive to standard therapy.
Topics: Chorionic Gonadotropin; Clomiphene; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradio | 1982 |
[The succession of precocious puberty and Stein-Leventhal syndrome].
Topics: Androstenedione; Child, Preschool; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Medroxypr | 1982 |
Hirsutism and weight gain in a woman with normal plasma testosterone.
Topics: Adult; Body Weight; Contraceptives, Oral, Combined; Dehydroepiandrosterone; Dexamethasone; Female; H | 1982 |
Clomiphene and dexamethasone in women unresponsive to clomiphene alone.
Topics: Anovulation; Clomiphene; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Drug | 1982 |
Elevated bioactive luteinizing hormone in women with the polycystic ovary syndrome.
Topics: Adolescent; Adult; Androgens; Anovulation; Chronic Disease; Dehydroepiandrosterone; Dehydroepiandros | 1983 |
Effect of celioscopic ovarian resection in patients with polycystic ovaries.
Topics: Body Temperature; Chorionic Gonadotropin; Clomiphene; Dehydroepiandrosterone; Endoscopy; Estradiol; | 1983 |
Evidence for the importance of peripheral tissue events in the development of hirsutism in polycystic ovary syndrome.
Topics: Adolescent; Adult; Androgens; Androstane-3,17-diol; Androstanols; Androstenediol; Androstenedione; D | 1983 |
Insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose; Humans; In | 1983 |
Insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose; Humans; In | 1983 |
Insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose; Humans; In | 1983 |
Insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose; Humans; In | 1983 |
Effect of human pituitary luteinizing hormone administration on plasma levels of dehydroepiandrosterone, androstenediol and their sulphates and testosterone in women with secondary amenorrhoea.
Topics: Amenorrhea; Androgens; Androstenediol; Anorexia Nervosa; Chromatography, Gas; Dehydroepiandrosterone | 1983 |
Obesity, serum steroid levels, and pulsatile gonadotropin secretion in polycystic ovarian disease.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Estrone; | 1983 |
The origin of androgen synthesis in polycystic ovary syndrome.
Topics: Adrenal Glands; Adult; Androgens; Androstenedione; Chorionic Gonadotropin; Dehydroepiandrosterone; D | 1983 |
Insulin resistance in polycystic ovary syndrome.
Topics: Adult; Anovulation; Dehydroepiandrosterone; Estradiol; Female; Hirsutism; Humans; Insulin; Insulin R | 1983 |
Plasma dehydroepiandrosterone sulfate and other androgens in normo- and hyperprolactinemic women with polycystic ovary disease.
Topics: Adult; Androgens; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; H | 1983 |
Prolactin secretion in polycystic ovary syndrome (PCO): correlation with the steroid pattern.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Dehydroepiandrosterone; Estradiol; Estrone; Female; | 1984 |
The influence of androgens on insulin resistance.
Topics: Adult; Androgens; Androstane-3,17-diol; Dehydroepiandrosterone; Dihydrotestosterone; Female; Hirsuti | 1984 |
Prolactin levels in the polycystic ovary syndrome.
Topics: Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estrogen | 1984 |
Bromocriptine response in normoprolactinemic patients with polycystic ovary disease: a preliminary report.
Topics: Adult; Anovulation; Bromocriptine; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Hum | 1984 |
Clinical and biochemical evaluation of patients with hirsutism.
Topics: 17-Ketosteroids; Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone | 1984 |
Chronic anovulation.
Topics: Adrenocortical Hyperfunction; Amenorrhea; Anorexia Nervosa; Anovulation; Breast Neoplasms; Chronic D | 1984 |
Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome.
Topics: 17-alpha-Hydroxypregnenolone; 3-Hydroxysteroid Dehydrogenases; Adrenocorticotropic Hormone; Adult; A | 1981 |
Circulating levels of plasma adrenocorticotropin in polycystic ovary disease.
Topics: Adrenocorticotropic Hormone; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate | 1982 |
Acth function in women with the polycystic ovarian syndrome.
Topics: Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; And | 1983 |
Testosterone free index correlates best with dehydroepiandrosterone sulfate.
Topics: Amenorrhea; Dehydroepiandrosterone; Female; Humans; Infertility, Female; Luteal Phase; Menotropins; | 1981 |
Effect of androgen excess on inappropriate gonadotropin secretion as found in the polycystic ovary syndrome.
Topics: Androgens; Androstenediols; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; | 1982 |
Clinical, ultrasound and hormonal markers of androgenicity in acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Adult; Androgens; Androstenedione; Biomarkers; Dehydroepiandrosterone; De | 1995 |
Early polycystic ovary-like syndrome in girls with central precocious puberty and exaggerated adrenal response.
Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenocorticotropic Horm | 1995 |
Reassessment of adrenal androgen secretion in women with polycystic ovary syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Androstenedione; Case-Control Studies; Dehydroepiandrosterone; D | 1995 |
The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women.
Topics: Adult; Androstenedione; Body Composition; Body Mass Index; Cross-Sectional Studies; Dehydroepiandros | 1994 |
Lipid profiles in women with hirsutism and polycystic ovaries.
Topics: Adult; Androgens; Androstenedione; Cholesterol; Dehydroepiandrosterone; Female; Follicle Stimulating | 1994 |
Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome.
Topics: Administration, Oral; Adult; Androgens; Androstenedione; beta-Endorphin; C-Peptide; Dehydroepiandros | 1994 |
Endocrinological, ultrasonographic and clinical findings in adolescent and adult polycystic ovary patients: a comparative study.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Amenorrhea; Androstenedione; Dehydroepiandrosterone | 1993 |
Enhanced adrenocortical activity as a contributing factor to diabetes in hyperandrogenic women.
Topics: Adrenal Cortex; Adult; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Female; Glucose Tolerance | 1994 |
[A possible role of ultrasound-guided follicular aspiration in induction of ovulation in patients with polycystic ovaries].
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Estradiol; Estrone; Female; Follicle Stimulating Hor | 1994 |
Elevated serum LH and androgens in affective disorder related to the menstrual cycle: with reference to polycystic ovary syndrome.
Topics: Adolescent; Adult; Androgens; Androstenedione; Bipolar Disorder; Dehydroepiandrosterone; Dehydroepia | 1993 |
24-hour serum cortisol profiles in women with polycystic ovary syndrome.
Topics: Adult; Androstenedione; Body Mass Index; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrost | 1993 |
[Differential diagnosis of hirsutism in girls between 15-19 years old].
Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult; Dehydroepiandro | 1993 |
The hypothalamo-pituitary-adrenal axis across the normal menstrual cycle and in polycystic ovary syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; | 1993 |
Pulsatile luteinizing hormone secretion pattern in hyperandrogenemic women.
Topics: Adolescent; Adult; Androgens; Anovulation; Chronic Disease; Dehydroepiandrosterone; Female; Humans; | 1993 |
Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome.
Topics: Adult; Androgen Antagonists; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Flutami | 1995 |
The impact of obesity on hormonal parameters in hirsute and nonhirsute women.
Topics: Adolescent; Adult; Androstenedione; Body Mass Index; Dehydroepiandrosterone; Dehydroepiandrosterone | 1996 |
No changes of peripheral insulin resistance in polycystic ovary syndrome after long-term reduction of endogenous androgens with leuprolide.
Topics: Adult; Androgens; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; F | 1995 |
Obesity and endocrine disorders in women taking valproate for epilepsy.
Topics: Adult; Body Weight; Carbamazepine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Endocrine | 1996 |
Laparoscopic ovarian treatment in infertile patients with polycystic ovarian syndrome (PCOS): endocrine changes and clinical outcome.
Topics: Adult; Androstenedione; Androstenols; Body Weight; Cohort Studies; Dehydroepiandrosterone; Electroco | 1996 |
[Polycystic ovary and diazoxide. In vivo study].
Topics: Adolescent; Androgens; Dehydroepiandrosterone; Diazoxide; Female; Hirsutism; Humans; Hyperinsulinism | 1996 |
The number of follicles and ovarian volume in the assessment of response to clomiphene citrate treatment in polycystic ovarian syndrome.
Topics: Adult; Androstenedione; Clomiphene; Dehydroepiandrosterone; Female; Fertility Agents, Female; Follic | 1996 |
The polycystic ovarian (PCO) condition: apoptosis and epithelialization of the ovarian antral follicles are aspects of cystogenesis in the dehydroepiandrosterone (DHEA)-treated rat model.
Topics: Androgens; Animals; Apoptosis; Cytoskeleton; Dehydroepiandrosterone; Disease Models, Animal; Epithel | 1997 |
Impact of overnight dexamethasone suppression on the adrenal androgen response to an oral glucose tolerance test in women with and without polycystic ovary syndrome.
Topics: Adrenal Cortex; Adult; Androgens; Blood Glucose; Case-Control Studies; Dehydroepiandrosterone; Dehyd | 1997 |
Different dysregulations in adrenal steroid biosynthesis as a prevalent cause of hyperandrogenism in women from southern Italy.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adul | 1997 |
Polycystic ovarian condition in the dehydroepiandrosterone-treated rat model: hyperandrogenism and the resumption of meiosis are major initial events associated with cystogenesis of antral follicles.
Topics: Androstenedione; Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Follicle Stimulati | 1997 |
Multidrug resistance gene expression correlates with progesterone production in dehydroepiandrosterone-induced polycystic and equine chorionic gonadotropin-stimulated ovaries of prepubertal rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Chorionic Gona | 1998 |
Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families.
Topics: Adult; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Genes, Dominant; Humans; Lutein | 1999 |
Circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome.
Topics: Adolescent; Adult; Amenorrhea; Androstenedione; beta-Endorphin; Body Mass Index; Dehydroepiandroster | 1999 |
Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries.
Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Androgens; Cells, Cultured; Cholesterol Side-Chain Cleavage | 1999 |
The molecular basis of premature adrenarche: an hypothesis.
Topics: Adrenal Glands; Child; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Female; Humans; Phosp | 1999 |
An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxyprogesterone; 3-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenocorticotropic H | 2000 |
Lysyl oxidase and MMP-2 expression in dehydroepiandrosterone-induced polycystic ovary in rats.
Topics: Androstenedione; Animals; Blotting, Northern; Blotting, Western; Collagen; Dehydroepiandrosterone; D | 2001 |
Multiple ovarian biopsy in the treatment of women with polycystic ovary syndrome (PCOS).
Topics: 17-alpha-Hydroxyprogesterone; Adrenocorticotropic Hormone; Biopsy; Dehydroepiandrosterone; Female; F | 2000 |
[Correlations between acne and polycystic ovary. A study of 60 cases].
Topics: Acne Vulgaris; Adult; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Human | 2001 |
Two hyperandrogenic adolescent girls with congenital portosystemic shunt.
Topics: Adolescent; Adrenocorticotropic Hormone; Androstenedione; Dehydroepiandrosterone; Female; Glucose To | 2001 |
Increase in calcitonin gene related peptide (CGRP) and decrease in mast cells in dihydroepiandrosterone (DHEA)-induced polycystic rat ovaries.
Topics: Animals; Calcitonin Gene-Related Peptide; Dehydroepiandrosterone; Female; Immunoenzyme Techniques; M | 2001 |
Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy.
Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Comorbidity; Dehydroepiandrosterone; Epileps | 2001 |
Uterine perfusion and hormonal pattern in patients with polycystic ovary syndrome.
Topics: Adult; Androgens; Arteries; Body Weight; Case-Control Studies; Dehydroepiandrosterone; Estradiol; Fe | 2001 |
Hypoglycemia, but not insulin, acutely decreases LH and T secretion in men.
Topics: Adrenocorticotropic Hormone; Adult; Blood Glucose; Dehydroepiandrosterone; Female; Follicle Stimulat | 2001 |
Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years.
Topics: Adolescent; Adult; Aging; Amenorrhea; Androstenedione; Body Constitution; Body Mass Index; Cross-Sec | 2001 |
Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin.
Topics: Adult; Androstenedione; Blood Glucose; Body Constitution; Body Mass Index; Contraceptives, Oral, Com | 2002 |
Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adult; Blood Glucose; Body Constitution; Body Mass Index; | 2002 |
[Androgens in the plasma of women with hirsutism (author's transl)].
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Androgens; Androstenediols; Carcinoma; Dehydroe | 1975 |
24-Hour secretory pattern of dehydroisoandrosterone and dehydroisoandrosterone sulfate.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aged; Circadian Rhythm; Dehydroepiandrosterone; Female; Hu | 1975 |
Circulating gonadotropins, estrogens, and androgens in polycystic ovarian disease.
Topics: Adolescent; Adult; Androgens; Androstenedione; Dehydroepiandrosterone; Estradiol; Estrogens; Estrone | 1975 |
Gas chromatographic determination of unconjugated dehydroepiandrosterone, androstenedione, testosterone, pregnenolone and progesterone in human ovarian tissue.
Topics: Androgens; Androstenedione; Carbon Radioisotopes; Chromatography, Gas; Dehydroepiandrosterone; Femal | 1975 |
Concentration of unconjugated adrenogenic hormones and their precursors in normal and polycystic ovaries.
Topics: 17-Ketosteroids; Adolescent; Adult; Androgens; Androstenedione; Chromatography, Gas; Dehydroepiandro | 1975 |
Editorial: Endocrine function in hirsute women.
Topics: 17-Ketosteroids; Adrenal Glands; Androstenedione; Dehydroepiandrosterone; Estrogens; Female; Hirsuti | 1976 |
Biochemical and Clinical Effect of Ovarian Wedge Resection in the Polycystic Ovary Syndrome.
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Function Tests; Adult; Androgens; Androsterone; Dehydroe | 1976 |
Polycystic ovarian disease.
Topics: Androstenedione; Clomiphene; Dehydroepiandrosterone; Depression, Chemical; Dexamethasone; Estradiol; | 1976 |
The influence of combined cyproterone acetate-ethinyl oestradiol therapy on serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women.
Topics: Adolescent; Adult; Androstenedione; Cyproterone; Dehydroepiandrosterone; Drug Therapy, Combination; | 1977 |
Correlation of the effects of dexamethasone administration on urinary 17-ketosteroid and serum androgen levels in patients with hirsutism.
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex; Adult; Androgens; Androstenedione; Dehydroepiandrostero | 1977 |
Hormone levels following wedge resection in polycystic ovary syndrome.
Topics: Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; Female; | 1978 |
The induction of polycystic ovaries in mature cycling rats by the administration of dehydroepiandrosterone (DHA).
Topics: Animals; Castration; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Estrus; Female; Folli | 1978 |
Saliva as a matrix for measuring free androgens: comparison with serum androgens in polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dihydrotestosterone; Female; Humans; Polycystic Ovary Syndr | 1979 |
Endocrine studies of normal and polycystic ovarian tissues in vitro.
Topics: Adrenocorticotropic Hormone; Adult; Androstenedione; Bucladesine; Culture Techniques; Dehydroepiandr | 1979 |
Variability of serum gonadotropin and dehydroepiandrosterone sulfate concentrations in women with polycystic ovary syndrome.
Topics: Adult; Case-Control Studies; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Follicula | 1992 |
Differential androgen response to adrenocorticotropic hormone stimulation in polycystic ovarian syndrome: relationship with insulin secretion.
Topics: 17-alpha-Hydroxyprogesterone; Adrenocorticotropic Hormone; Androgens; Androstenedione; Blood Glucose | 1992 |
Investigation of adrenal function in women with oligomenorrhoea and hirsutism (clinical PCOS) from the north-east of England using an adrenal stimulation test.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex Function Tests; Adrenal Glands; Adrenal Hyperplasia, | 1992 |
The ovarian contribution to peripherally derived serum C19 conjugates.
Topics: Adult; Androgens; Androstenedione; Biomarkers; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfat | 1992 |
Implications of ultrasonically diagnosed polycystic ovaries. II. Studies of dynamic and pulsatile hormonal patterns.
Topics: Adrenal Glands; Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Fo | 1992 |
Endocrinological environment with regard to the number of microcysts in patients with polycystic ovary syndrome.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Estradiol; Estrone; Female; Follicle Stimulating Hor | 1992 |
Long-term administration of gonadotropin-releasing hormone agonist and dexamethasone: assessment of the adrenal role in ovarian dysfunction.
Topics: Adrenal Glands; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dela | 1992 |
Treatment of hirsutism in women with flutamide.
Topics: Adult; Analysis of Variance; Androstane-3,17-diol; Androstenedione; Dehydroepiandrosterone; Dehydroe | 1992 |
Lack of linear relationship between hyperinsulinaemia and hyperandrogenism.
Topics: Adolescent; Adult; Androgens; Androstenedione; Dehydroepiandrosterone; Female; Follicle Stimulating | 1992 |
An abnormality of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovary syndrome due to coexistent obesity.
Topics: 17-alpha-Hydroxyprogesterone; Adult; Analysis of Variance; Blood Glucose; Dehydroepiandrosterone; De | 1992 |
Assessment of the adrenal-ovarian contribution by short-term dexamethasone and ACTH tests in hyperandrogenized patients.
Topics: Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgens; Androstenedione; Circadia | 1991 |
Plasma levels of insulin-like growth factor-I and its binding protein in polycystic ovary syndrome.
Topics: Adult; Androstenedione; Carrier Proteins; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Es | 1990 |
Androgen responses to acutely increased endogenous insulin levels in hyperandrogenic and normal cycling women.
Topics: Adrenal Glands; Adult; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Fo | 1991 |
Oestrogen and androgen states in oligo-amenorrhoeic women with polycystic ovaries.
Topics: Amenorrhea; Androgens; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estr | 1991 |
Sex steroids, adiposity and smoking in the pathogenesis of idiopathic hirsutism and polycystic ovary syndrome.
Topics: Adrenal Glands; Adult; Androgens; Androstenedione; Body Mass Index; Body Weight; Dehydroepiandroster | 1991 |
Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females.
Topics: Adrenocortical Hyperfunction; Blood Glucose; C-Peptide; Dehydroepiandrosterone; Female; Glucose Tole | 1991 |
Role of adrenal and gonadal androgens in insulin action and metabolism.
Topics: Adrenal Glands; Dehydroepiandrosterone; Erythrocytes; Female; Glucose Tolerance Test; Humans; Hyperp | 1991 |
Adrenal and ovarian steroid hormone responses to gonadotropin-releasing hormone agonist treatment in polycystic ovary syndrome.
Topics: 3-Hydroxysteroid Dehydrogenases; Adolescent; Adrenal Glands; Adult; Androgens; Dehydroepiandrosteron | 1991 |
[Endocrine and ultrasound examination of hirsutism].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Amenorrhea; Dehy | 1991 |
No acute effect of physiological insulin increase on dehydroepiandrosterone sulfate in women with obesity and/or polycystic ovarian disease.
Topics: Administration, Oral; Adult; Body Mass Index; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate | 1991 |
[Results of treatment with surface cauterization of polycystic ovaries in sterility patients].
Topics: Adult; Combined Modality Therapy; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Electrocoa | 1991 |
Ovarian enlargement as a possible marker of androgen activity in polycystic ovary syndrome.
Topics: Adult; Androgens; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; H | 1991 |
Pituitary-adrenal responses to ovine corticotropin-releasing factor in polycystic ovary syndrome and in other hyperandrogenic patients.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Androstenedione; Anovulation; Corticotropin-Releasin | 1990 |
Laparoscopic ovarian diathermy in the management of anovulatory infertility in women with polycystic ovaries: endocrine changes and clinical outcome.
Topics: Adult; Androstenedione; Anovulation; Dehydroepiandrosterone; Electrocoagulation; Female; Follicle St | 1990 |
On the origin of the elevated 17-hydroxyprogesterone levels after adrenal stimulation in hyperandrogenism.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenal Hyperplasia, Congenital; Adult; Androgens; And | 1990 |
Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans.
Topics: Acanthosis Nigricans; Adolescent; Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Fas | 1990 |
Hormonal studies on women with polycystic ovaries diagnosed by ultrasound.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Dehydroepiandrosterone; Female; Follicle Stimulatin | 1990 |
[Polycystic ovary syndrome with excess of prolactin].
Topics: Adult; Bromocriptine; Clomiphene; Dehydroepiandrosterone; Dexamethasone; Estrogens; Female; Follicle | 1990 |
[Significance of sex hormone binding globulin and free androgen index in the estimation of androgenic cases].
Topics: Androgens; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Hirsutis | 1990 |
Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women.
Topics: Adult; Androgens; Androstenedione; Blood Glucose; Dehydroepiandrosterone; Female; Glucose Tolerance | 1990 |
Glucagon in women with polycystic ovary syndrome (PCO): relationship to abnormalities of insulin and androgens.
Topics: Adult; Androgens; Androstenedione; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone Sul | 1990 |
Ovarian response patterns to human menopausal gonadotropin in mixed hyperandrogenemia.
Topics: Adult; Androgens; Androstenedione; Anovulation; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfa | 1990 |
Long-term treatment with the combination ethinylestradiol and cyproterone acetate in polycystic ovary syndrome.
Topics: Acne Vulgaris; Adult; Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Androgen Ant | 1990 |
Hormonal and clinical effects of multifollicular puncture and resection on the ovaries of polycystic ovary syndrome.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Estrone; Female; | 1990 |
Hormonal evaluation of female infertility and reproductive disorders.
Topics: Adult; Amenorrhea; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; E | 1989 |
Recovery of hormone secretion after chronic gonadotropin-releasing hormone agonist administration in women with polycystic ovarian disease.
Topics: Adult; Dehydroepiandrosterone; Delayed-Action Preparations; Estradiol; Estrone; Female; Follicle Sti | 1989 |
Aggravation of inappropriate luteinizing hormone secretion by bromocriptine in polycystic ovary syndrome with elevated serum dehydroepiandrosterone sulfate.
Topics: Adult; Bromocriptine; Clomiphene; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Drug Resis | 1989 |
Steroid responses to ACTH in women with polycystic ovaries.
Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Adult; | 1989 |
Androgen sulfate and glucuronide conjugates in nonhirsute and hirsute women with polycystic ovarian syndrome.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androgens; Androstenedione; Androsterone; Biomarkers; | 1989 |
Adrenal steroid responses to naloxone in polycystic ovarian disease.
Topics: Adrenal Glands; Androstenedione; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Naloxone; P | 1987 |
Insulin resistance and secretion in polycystic ovarian disease.
Topics: Adolescent; Adult; Androgens; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; | 1985 |
The effect of bromocriptine on gonadotropin and steroid secretion in polycystic ovarian disease.
Topics: Androstenedione; Bromocriptine; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Gonado | 1986 |
[Dehydroepiandrosterone sulfate in the differential diagnosis of adrenal and ovarian dysfunction in women with hirsutism and anovulation].
Topics: Adrenal Gland Diseases; Androgens; Anovulation; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfa | 1986 |
The hormonal response of patients with polycystic ovarian disease to subcutaneous low frequency pulsatile administration of luteinizing hormone-releasing hormone.
Topics: Adult; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Follicl | 1986 |
[Polycystic ovary--classification and treatment by bromocriptine].
Topics: Adolescent; Adult; Androstenedione; Bromocriptine; Clomiphene; Dehydroepiandrosterone; Dehydroepiand | 1986 |
[Value of laboratory parameters in androgenization in the female with special reference to the "free androgen index"].
Topics: Adrenal Hyperplasia, Congenital; Adult; Alopecia; Amenorrhea; Androgens; Dehydroepiandrosterone; Fem | 1986 |
Evidence for insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Adult; Androstenedione; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Eryth | 1987 |
Plasma prolactin and dehydroepiandrosterone sulfate levels in polycystic ovarian disease.
Topics: Adolescent; Adult; Dehydroepiandrosterone; Female; Humans; Hyperprolactinemia; Polycystic Ovary Synd | 1987 |
Effects of combined desogestrel-ethinylestradiol treatment on lipid profiles in women with polycystic ovarian disease.
Topics: Adolescent; Adult; Cholesterol, HDL; Cholesterol, LDL; Dehydroepiandrosterone; Dehydroepiandrosteron | 1987 |
The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome.
Topics: Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradio | 1988 |
Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization.
Topics: Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Estrone; Female; Follicle | 1988 |
Free testosterone and testosterone/SHBG index in hirsute women: a comparison of diagnostic accuracy.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Female; Hirsutism; Humans; Menstrual Cycle; Polycyst | 1987 |
[Combined therapy with bromocriptine, clomiphene and gonadotropin for polycystic ovary syndrome patients failing to respond to clomiphene alone].
Topics: Adolescent; Adult; Bromocriptine; Clomiphene; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate | 1988 |
Conventional dose intravenous pulsatile GnRH therapy does not induce ovulation in polycystic ovarian disease.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Follicle Sti | 1988 |
Bromocriptine treatment in anovulation with decreased ratio of follicle stimulating hormone to luteinizing hormone and with hyperandrogenism.
Topics: Adult; Androgens; Androstenedione; Anovulation; Bromocriptine; Dehydroepiandrosterone; Dehydroepiand | 1988 |
The influence of body weight on lipoprotein lipids in patients with polycystic ovary syndrome.
Topics: Adult; Age Factors; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, VLDL; Dehydroepiandrost | 1988 |
The effect of laparoscopic multiple punch resection of the ovary on hypothalamo-pituitary axis in polycystic ovary syndrome.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Follicle Sti | 1988 |
[Relations between polycystic ovary and idiopathic hirsutism].
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Androstenedione; Child; Dehydroepiandrosterone; Deh | 1988 |
Androgen levels during sequential insulin euglycemic clamp studies in patients with polycystic ovary disease.
Topics: Adult; Blood Glucose; C-Peptide; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glu | 1988 |
Inhibition of gonadotropic and ovarian function by intranasal administration of D-Ser (TBU)6-EA10-LHRH in normo-ovulatory women and patients with polycystic ovary disease.
Topics: Administration, Intranasal; Buserelin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estra | 1988 |
Androstenedione concentrations following dexamethasone suppression: correlation with clomiphene responsiveness in women with polycystic ovary syndrome.
Topics: Amenorrhea; Androstenedione; Clomiphene; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dex | 1988 |
Increased DHEAs levels in PCO syndrome: evidence for the existence of two subgroups of patients.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amenorrhea; Dehydroepiandrosterone; Dehydroepiandros | 1986 |
Prevalence of and markers for the attenuated form of congenital adrenal hyperplasia and hyperprolactinemia masquerading as polycystic ovarian disease.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Dehydroe | 1986 |
Normal ovarian function in a mild form of late-onset 3 beta-hydroxysteroid dehydrogenase deficiency.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenocorticotropic Hormone; Adult; Age Factors; Androstenedione; D | 1986 |
Increased 5 alpha-reductase activity in idiopathic hirsutism.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstane-3,17-diol; Androstenedione; Dehydroepiandro | 1985 |
Role of dehydroepiandrosterone sulfate as a prehormone for ovarian steroidogenesis.
Topics: Adrenal Glands; Amenorrhea; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; E | 1985 |
Polycystic ovary syndrome.
Topics: Androgens; Clomiphene; Contraceptives, Oral; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; | 1985 |
[Diagnosis and treatment of patients with an atypical form of the polycystic ovary syndrome].
Topics: Adult; Dehydroepiandrosterone; Estrogens; Female; Gonadotropins, Pituitary; Humans; Polycystic Ovary | 1985 |
Unilateral ovariectomy restores ovulatory cyclicity in rats with a polycystic ovarian condition.
Topics: Animals; Castration; Dehydroepiandrosterone; Estrus; Female; Gonadotropin-Releasing Hormone; Luteini | 1985 |
Spironolactone in combination drug therapy for unresponsive hirsutism.
Topics: Contraceptives, Oral; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Drug Th | 1985 |
Morphological studies of polycystic mouse ovaries induced by dehydroepiandrosterone.
Topics: Animals; Dehydroepiandrosterone; Female; Freeze Fracturing; Granulosa Cells; Intercellular Junctions | 1985 |
Acute effects of bromocriptine on gonadotropin secretion in polycystic ovary syndrome.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Animals; Bromocriptine; Dehydroepiandrosterone; Deh | 1985 |
[Simple method for the determination of androstenolone in urine].
Topics: Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adult; Child; Child, Preschool; Dehydro | 1967 |
Studies on testosterone metabolism. IV. Urinary 5-alpha- and beta-androstanediols and testosterone glucuronide from testosterone and dehydrolsoandrosterone sulfate in normal people and hirsute women.
Topics: Adult; Androgens; Androsterone; Dehydroepiandrosterone; Female; Glucuronates; Hirsutism; Humans; Mal | 1965 |
[The biosynthesis of androgens in normal and Stein-Leventhal ovaries from dehydroepiandrosterone-4-C-14].
Topics: Adult; Androgens; Dehydroepiandrosterone; Female; Humans; In Vitro Techniques; Ovary; Polycystic Ova | 1965 |
[In vivo studies on metabolism of androgens following administration of steroidal inhibitors of ovulation. II. Metabolism of radioactive testosterone and dehydroepiandrosterone sulfate in subjects treated with lynestrenol, synthetic estrogens and their co
Topics: Adolescent; Adult; Androsterone; Chromatography, Paper; Dehydroepiandrosterone; Ethinyl Estradiol; E | 1966 |
A modified method for the analysis of urinary 17-ketosteroids, pregnanediol and pregnanetriol by gas liquid chromatography in normal subjects and subjects with various endocrine disorders.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androsterone; Chromatography, Gas; Cushing Syndrom | 1967 |
[Influence of dehydroepiandrosterone on the secretion of corticoids].
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adult; Androsterone; Cholesterol; Circadia | 1964 |
Routine assay of 11-deoxy-17-ketosteroids in human urinary gas-liquid chromatography with a standardized column.
Topics: 17-Ketosteroids; Adrenal Gland Diseases; Androsterone; Chromatography, Gas; Dehydroepiandrosterone; | 1967 |
[Changes of dehydroepiandrosterone following the administration of progesterone in some endocrine disorders in gynecology].
Topics: 17-Ketosteroids; Adult; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrome; Progester | 1967 |
Urinary testosterone fractions. Studies on the origin in certain diseases associated with elevated testosterone excretion.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Cushing Syndrome; Dehydroepiandr | 1967 |
A method for the simultaneous determination of progesterone, androstenedione, testosterone and dehydroepiandrosterone sulphate in biological fluids. Its application in the analysis of venous plasma and cyst fluid from human ovaries in situ.
Topics: 17-Ketosteroids; Adult; Amenorrhea; Androgens; Chromatography, Gas; Dehydroepiandrosterone; Endometr | 1968 |
[On the differential diagnosis of hirsutism].
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Chiari-Frommel Syndrome; Chromatography; De | 1968 |
Stein-Leventhal syndrome. A report of seventeen cases.
Topics: Adult; Amenorrhea; Dehydroepiandrosterone; Female; Fertility; Humans; Ovary; Polycystic Ovary Syndro | 1968 |
The conversion, in vivo, of dehydroepiandrosterone sulfate to testosterone and testosterone glucuronide as reflected in urinary testosterone glucuronide.
Topics: Carbon Isotopes; Castration; Crystallization; Dehydroepiandrosterone; Female; Glucuronates; Humans; | 1969 |
Secretion of C19-steroids and oestrogens in the polycystic ovary syndrome. Ovarian studies in vivo and in vitro (including studies in vitro on a coincidental granulosa cell tumour).
Topics: 17-Ketosteroids; Adolescent; Adult; Dehydroepiandrosterone; Estradiol; Estrogens; Female; Follicle S | 1968 |
Neutral steroid sulfates in human ovarlian vein blood.
Topics: Adult; Androstanes; Androsterone; Chromatography, Gas; Dehydroepiandrosterone; Female; Humans; Middl | 1970 |
The determination of urinary pregnanetriol and the neutral 17-ketosteroids by gas-liquid chromatography.
Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre | 1971 |
A single method for determination of urine steroids. I. Levels of testosterone, epitestosterone and 17-ketosteroid fractions. II. Specific activities of testosterone, androsterone and etiocholanolone and production rate of testosterone following administr
Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Androsterone; Breast Neoplasms; Carbon Isotopes; Carcinoma | 1970 |
Adrenocortical function in Stein-Leventhal syndrome.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Androstanes; Chemistry, Clin | 1968 |
Arrhenoblastomas and associated ovarian pathology.
Topics: 17-Ketosteroids; Adolescent; Amenorrhea; Androstenedione; Cystadenoma; Dehydroepiandrosterone; Epith | 1974 |
An unusual case of Cushing's syndrome, hilus cell tumor and polycystic ovaries.
Topics: Adolescent; Adrenalectomy; Adrenocorticotropic Hormone; Child; Cushing Syndrome; Dehydroepiandroster | 1974 |