Page last updated: 2024-11-07

dehydroepiandrosterone and Osteoporosis

dehydroepiandrosterone has been researched along with Osteoporosis in 57 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

Research Excerpts

ExcerptRelevanceReference
"Young women with anorexia nervosa (AN) have subnormal levels of dehydroepiandrosterone (DHEA) and estrogen that may be mechanistically linked to the bone loss seen in this disease."9.10Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial. ( Becker, KA; Emans, SJ; Feldman, HA; Goodman, E; Gordon, CM; Grace, E; Gundberg, CM; LeBoff, MS; Rosen, CJ, 2002)
"Postmenopausal women with sarcopenia were more likely to have lower DHEA levels and higher follistatin levels, and postmenopausal women with osteoporosis were more likely to have lower oxytocin levels."8.02Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community-dwelling postmenopausal women. ( Chen, M; Cheng, Q; Du, Y; Jiang, X; Li, H; Shi, H; Tang, W; Wu, X; Xu, C; Zhang, X, 2021)
"The current study aimed to evaluate the potential role of dehydroepiandrosterone (DHEA) in the protection and intervention of glucocorticoid-induced secondary osteoporosis in female rats."7.78Role of dehydroepiandrosterone in management of glucocorticoid-induced secondary osteoporosis in female rats. ( Ahmed, HH; Eskander, EF; Morcos, NY; Seoudi, DM; Shalby, AB, 2012)
" The objective of the following study was to induce osteoporosis in female rats by ovariectomy, followed by treatment with sustained delivery of Diosgenin (DG), dehydroepiandrosterone (DHEA), or estrogen (E) after clinical signs of osteoporosis."7.71The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model. ( Benghuzzi, H; Cason, Z; Higdon, K; Hughes, J; Puckett, A; Scott, A; Tsao, A; Tucci, M, 2001)
"Dehydroepiandrosterone (DHEA) levels decline dramatically with age, concurrent with the onset of osteoporosis, suggesting a role for DHEA supplementation in preventing age-related bone loss."5.13Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial. ( Bergstrom, J; Bettencourt, R; Kritz-Silverstein, D; Laughlin, GA; von Mühlen, D, 2008)
"Young women with anorexia nervosa (AN) have subnormal levels of dehydroepiandrosterone (DHEA) and estrogen that may be mechanistically linked to the bone loss seen in this disease."5.10Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial. ( Becker, KA; Emans, SJ; Feldman, HA; Goodman, E; Gordon, CM; Grace, E; Gundberg, CM; LeBoff, MS; Rosen, CJ, 2002)
"Dehydroepiandrosterone(DHEA), an adrenal androgen, has attracted much attention as an anti-aging hormone as well as a marker for senescence because of its unique change along with aging."4.93[Dehydroepiandrosterone(DHEA)and bone metabolism]. ( Ohnaka, K, 2016)
"The hypothalamic-pituitary-adrenal axis activity in the aging people is characterised by an unexplained reduction of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) secretion while ACTH and cortisol production remains relatively unchanged."4.84[Adrenopause]. ( Krysiak, R; Okopień, B; Szkróbka, W, 2008)
"Postmenopausal women with sarcopenia were more likely to have lower DHEA levels and higher follistatin levels, and postmenopausal women with osteoporosis were more likely to have lower oxytocin levels."4.02Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community-dwelling postmenopausal women. ( Chen, M; Cheng, Q; Du, Y; Jiang, X; Li, H; Shi, H; Tang, W; Wu, X; Xu, C; Zhang, X, 2021)
"The current study aimed to evaluate the potential role of dehydroepiandrosterone (DHEA) in the protection and intervention of glucocorticoid-induced secondary osteoporosis in female rats."3.78Role of dehydroepiandrosterone in management of glucocorticoid-induced secondary osteoporosis in female rats. ( Ahmed, HH; Eskander, EF; Morcos, NY; Seoudi, DM; Shalby, AB, 2012)
" The objective of the following study was to induce osteoporosis in female rats by ovariectomy, followed by treatment with sustained delivery of Diosgenin (DG), dehydroepiandrosterone (DHEA), or estrogen (E) after clinical signs of osteoporosis."3.71The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model. ( Benghuzzi, H; Cason, Z; Higdon, K; Hughes, J; Puckett, A; Scott, A; Tsao, A; Tucci, M, 2001)
" This loss, combined with the low plasma concentrations of androstenedione, dehydroepiandrosterone, and testosterone (and low concentrations of oestrone of adrenal origin), indicates that adrenal androgens may be essential for the maintenance of bone mass in postmenopausal women with Addison's disease."3.67Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass. ( Crabbé, J; Devogelaer, JP; Nagant de Deuxchaisnes, C, 1987)
"To investigate the effects of dehydroepiandrosterone (DHEA) combined with exercise on bone mass, strength, and physical function in older, frail women."2.75Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women. ( Boxer, RS; Brindisi, J; Burleson, JA; Feinn, R; Kenny, AM; Kleppinger, A, 2010)
"Dehydroepiandrosterone (DHEA) is a metabolic intermediate in the biosynthesis of estrogens and androgens with a past clouded in controversy and bold claims."2.66DHEA in bone: the role in osteoporosis and fracture healing. ( Anil, U; Buchalter, DB; Kirby, DJ; Leucht, P, 2020)
"Dehydroepiandrosterone (DHEA) is a multifunctional steroid with a broad range of biological effects in humans and animals."2.48Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports. ( El Kihel, L, 2012)
"The pharmacology, pharmacokinetics, clinical efficacy, adverse effects and toxicities, drug interactions, dosage and administration, and safety issues related to the use of prasterone are discussed."2.43Prasterone. ( Kocis, P, 2006)
" Therefore, the deleterious side-effects of chronic administration of GC emerges from both their direct catabolic activity and the suppression of DHEA production."2.40Should dehydroepiandrosterone replacement therapy be provided with glucocorticoids? ( Cutolo, M; Robinzon, B, 1999)
" In conclusion, the steroid substitution in Addison's disease requires individually tailored dosage and adequate monitoring."1.37[Metabolic assessment of hydrocortisone replacement therapy in patients with primary adrenocortical insufficiency]. ( Fichna, M; Gryczyńska, M; Sowińska, A; Sowiński, J, 2011)
"0052), which was significantly correlated with steroid dosage (r = -0."1.31Low circulating estradiol and adrenal androgens concentrations in men on glucocorticoids: a potential contributory factor in steroid-induced osteoporosis. ( Bhargava, N; Cheung, J; Fogelman, I; Hampson, G; Seed, PT; Vaja, S, 2002)
"Measurements made in patients with Klinefelter's syndrome were compared to those obtained in age-matched normal male volunteers."1.28Osteoporosis and Klinefelter's syndrome. ( Horowitz, M; Morris, HA; Need, AG; Nordin, BE; O'Loughlin, PD; Wishart, JM, 1992)
" Prednisolone therapy in 22 patients (mean dosage 8 mg/day) was associated with reductions in estrone and testosterone levels; however, DHEAS and femoral BMD were also decreased in RA patients who were not receiving corticosteroids."1.27Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis. ( Champion, GD; Eisman, JA; Pocock, NA; Sambrook, PN, 1988)
"The severity of the osteoporosis is directly related to the severity of the calcium malabsorption."1.27The relation between calcium absorption, serum dehydroepiandrosterone, and vertebral mineral density in postmenopausal women. ( Bridges, A; Deam, S; Horowitz, M; Morris, HA; Need, AG; Nordin, BE; Philcox, JC; Robertson, A; Seamark, RF, 1985)

Research

Studies (57)

TimeframeStudies, this research(%)All Research%
pre-199018 (31.58)18.7374
1990's6 (10.53)18.2507
2000's20 (35.09)29.6817
2010's10 (17.54)24.3611
2020's3 (5.26)2.80

Authors

AuthorsStudies
Du, Y1
Xu, C1
Shi, H1
Jiang, X1
Tang, W1
Wu, X1
Chen, M1
Li, H1
Zhang, X1
Cheng, Q1
Kirby, DJ1
Buchalter, DB1
Anil, U1
Leucht, P1
Huang, K1
Cai, HL1
Bao, JP1
Wu, LD1
Ohlsson, C2
Nethander, M2
Karlsson, MK2
Rosengren, BE2
Ribom, E1
Mellström, D2
Vandenput, L2
Zhou, S1
Glowacki, J1
Ohnaka, K1
Kindmark, A1
Ljunggren, Ö1
Lorentzon, M1
Sánchez-Guerrero, J1
Fragoso-Loyo, HE1
Neuwelt, CM1
Wallace, DJ1
Ginzler, EM1
Sherrer, YR1
McIlwain, HH1
Freeman, PG1
Aranow, C1
Petri, MA1
Deodhar, AA1
Blanton, E1
Manzi, S1
Kavanaugh, A1
Lisse, JR1
Ramsey-Goldman, R1
McKay, JD1
Kivitz, AJ1
Mease, PJ1
Winkler, AE1
Kahl, LE1
Lee, AH1
Furie, RA1
Strand, CV1
Lou, L1
Ahmed, M1
Quarles, B1
Schwartz, KE1
Szkróbka, W1
Krysiak, R1
Okopień, B1
Herman, WA1
Seńko, A1
Korczowska, I1
Łacka, K1
Marder, W1
Somers, EC1
Kaplan, MJ1
Anderson, MR1
Lewis, EE1
McCune, WJ1
Kenny, AM1
Boxer, RS1
Kleppinger, A1
Brindisi, J1
Feinn, R1
Burleson, JA1
Ahmed, HH1
Morcos, NY1
Eskander, EF1
Seoudi, DM1
Shalby, AB1
Fichna, M1
Gryczyńska, M1
Sowińska, A1
Sowiński, J1
El Kihel, L1
Papierska, L1
Rabijewski, M1
Kasperlik-Załuska, A1
Zgliczyński, W1
Burd, ID1
Bachmann, GA1
Hampson, G1
Bhargava, N1
Cheung, J1
Vaja, S1
Seed, PT1
Fogelman, I1
Gordon, CM1
Grace, E1
Emans, SJ1
Feldman, HA1
Goodman, E1
Becker, KA1
Rosen, CJ1
Gundberg, CM1
LeBoff, MS1
Oncken, C1
Prestwood, K1
Cooney, JL1
Unson, C1
Fall, P1
Kulldorff, M1
Raisz, LG1
ZARA, M1
LUMBROSO, A1
INTINI, L1
Yamada, Y1
Sekihara, H1
Villareal, DT1
Kocis, P1
McCormick, RK1
von Mühlen, D1
Laughlin, GA1
Kritz-Silverstein, D2
Bergstrom, J1
Bettencourt, R1
Brückel, J1
Davidson, BJ1
Riggs, BL1
Wahner, HW1
Judd, HL1
Brody, S1
Carlström, K1
Lagrelius, A1
Lunell, NO1
Rosenborg, L1
Crilly, RG2
Francis, RM1
Nordin, BE4
Nawata, H2
Tanaka, S3
Takayanagi, R2
Sakai, Y1
Yanase, T1
Ikuyama, S1
Haji, M2
Barrett-Connor, E1
Edelstein, SL1
Kuritzky, L1
Robinzon, B1
Cutolo, M1
Kwak, CS1
Kang, CM1
Kang, HS1
Song, KY1
Lee, MS1
Seong, SC1
Park, SC1
Kamel, HK1
Perry, HM1
Morley, JE1
Scott, A2
Higdon, K2
Tucci, M2
Benghuzzi, H2
Puckett, A2
Tsao, A2
Cason, Z2
Hughes, J2
Rigaud, AS1
Pellerin, J1
Manolagas, SC1
Anderson, DC1
Lindsay, R1
Breckwoldt, M1
Holló, I2
Szalay, F1
Steczek, K1
Szücs, J2
Marshall, DH1
Horowitz, M2
Wishart, JM1
O'Loughlin, PD1
Morris, HA2
Need, AG2
Fabbri, G1
Petraglia, F1
Segre, A1
Maietta-Latessa, A1
Galassi, MC1
Cellini, M1
Sardelli, S1
Massolo, F1
Genazzani, A1
Genazzani, AR1
Taelman, P1
Kaufman, JM1
Janssens, X1
Vermeulen, A1
Devogelaer, JP1
Crabbé, J1
Nagant de Deuxchaisnes, C1
Ribot, C1
Tremollieres, F1
Pouilles, JM1
Bonneu, M1
Germain, F1
Louvet, JP1
Sambrook, PN1
Eisman, JA1
Champion, GD1
Pocock, NA1
Robertson, A1
Seamark, RF1
Bridges, A1
Philcox, JC1
Deam, S1
Nishida, E1
Fehér, T1
Morii, H1
Tanae, A1
Ibayashi, H1
Nakao, K1
Staub, JJ1
Philbert, M1
Luton, JP1
Bricaire, H1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Multi-Center, Placebo- Controlled Study to Assess Prevention of Bone Loss by Treatment With GL701 (Prestara) in Women With Systemic Lupus Erythematosus Receiving Treatment With Glucocorticoids[NCT00053560]Phase 3155 participants Interventional2002-12-31Active, not recruiting
A Multi-Center, Open-Label Study to Assess the Durability and Safety of the Prevention of Bone Loss by Treatment With GL701 (Prestara™) in Women With Systemic Lupus Erythematosus Receiving Treatment With Glucocorticoids[NCT00082511]Phase 3114 participants (Actual)Interventional2003-07-31Completed
Effects of DHEA/Exercise on Bone, Muscle and Balance[NCT00664053]Phase 499 participants (Actual)Interventional2004-10-31Completed
DHEA+Exercise-Effect on Sarcopenia and Osteopenia of Aging[NCT00205686]Phase 364 participants Interventional2001-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

19 reviews available for dehydroepiandrosterone and Osteoporosis

ArticleYear
DHEA in bone: the role in osteoporosis and fracture healing.
    Archives of osteoporosis, 2020, 06-05, Volume: 15, Issue:1

    Topics: Dehydroepiandrosterone; Fracture Healing; Humans; Osteoporosis; Testosterone

2020
Dehydroepiandrosterone and age-related musculoskeletal diseases: Connections and therapeutic implications.
    Ageing research reviews, 2020, Volume: 62

    Topics: Aged; Aging; Dehydroepiandrosterone; Humans; Musculoskeletal Diseases; Osteoporosis; Sarcopenia

2020
[Dehydroepiandrosterone(DHEA)and bone metabolism].
    Clinical calcium, 2016, Volume: 26, Issue:7

    Topics: Aging; Bone and Bones; Bone Density; Dehydroepiandrosterone; Hormone Replacement Therapy; Humans; Os

2016
[Adrenopause].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2008, Volume: 25, Issue:145

    Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Aging; Androgens; Ather

2008
Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports.
    Steroids, 2012, Volume: 77, Issue:1-2

    Topics: Androsterone; Animals; Brain; Cardiovascular Diseases; Dehydroepiandrosterone; Female; Humans; Hydro

2012
Androgen replacement in menopause.
    Current women's health reports, 2001, Volume: 1, Issue:3

    Topics: Androgens; Androstenedione; Bone Density; Dehydroepiandrosterone; Female; Hormone Replacement Therap

2001
[DHEA: hormone as antiaging remedies].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2003, Volume: 40, Issue:5

    Topics: Aged; Aging; Animals; Anti-Inflammatory Agents; Brain; Dehydroepiandrosterone; Dementia; Female; Hum

2003
Effects of dehydroepiandrosterone on bone mineral density: what implications for therapy?
    Treatments in endocrinology, 2002, Volume: 1, Issue:6

    Topics: Adjuvants, Immunologic; Bone Density; Dehydroepiandrosterone; Humans; Osteoporosis

2002
Prasterone.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Nov-15, Volume: 63, Issue:22

    Topics: Adjuvants, Immunologic; Adult; Biological Availability; Bone Density; Dehydroepiandrosterone; Drug A

2006
Osteoporosis: integrating biomarkers and other diagnostic correlates into the management of bone fragility.
    Alternative medicine review : a journal of clinical therapeutic, 2007, Volume: 12, Issue:2

    Topics: Absorptiometry, Photon; Acidosis; Biomarkers; Bone Density; Bone Remodeling; C-Reactive Protein; Cal

2007
[Replacement and supplementation of DHEA--is it a wellness hormone?].
    MMW Fortschritte der Medizin, 2005, Feb-17, Volume: 147, Issue:7

    Topics: Addison Disease; Adjuvants, Immunologic; Administration, Oral; Adult; Age Factors; Aged; Aged, 80 an

2005
Steroid hormones, ageing and bone.
    Clinics in endocrinology and metabolism, 1981, Volume: 10, Issue:1

    Topics: Adult; Aged; Aging; Androstenedione; Bone and Bones; Calcium; Castration; Dehydroepiandrosterone; Es

1981
Aromatase in bone cell: association with osteoporosis in postmenopausal women.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 53, Issue:1-6

    Topics: Aged; Androstenedione; Animals; Aromatase; Base Sequence; Bone and Bones; Bone Density; Calcitriol;

1995
DHEA: science or wishful thinking?
    Hospital practice (1995), 1998, May-15, Volume: 33, Issue:5

    Topics: Adult; Aged; Aging; Dehydroepiandrosterone; Female; Humans; Male; Middle Aged; Obesity; Osteoporosis

1998
Should dehydroepiandrosterone replacement therapy be provided with glucocorticoids?
    Rheumatology (Oxford, England), 1999, Volume: 38, Issue:6

    Topics: Adjuvants, Immunologic; Atrophy; Autoimmunity; Dehydroepiandrosterone; Diabetes Mellitus; Female; Gl

1999
Hormone replacement therapy and fractures in older adults.
    Journal of the American Geriatrics Society, 2001, Volume: 49, Issue:2

    Topics: Age Distribution; Age Factors; Aged; Chemistry, Pharmaceutical; Dehydroepiandrosterone; Estrogen Rep

2001
[Neuropsychic effects of dehydroepiandrosterone].
    Annales de medecine interne, 2001, Volume: 152 Suppl 3

    Topics: Affect; Aging; Animals; Attention; Cardiovascular Diseases; Dehydroepiandrosterone; Dehydroepiandros

2001
[Androgen in the treatment of osteoporosis ].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 3

    Topics: Androgens; Animals; Aromatase; Bone Density; Dehydroepiandrosterone; Estrogens; Fractures, Stress; H

2002
[Clinical findings and laboratory diagnosis in Cushing's syndrome].
    Praxis, 1968, Oct-15, Volume: 57, Issue:41

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic

1968

Trials

8 trials available for dehydroepiandrosterone and Osteoporosis

ArticleYear
Low Serum DHEAS Predicts Increased Fracture Risk in Older Men: The MrOS Sweden Study.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017, Volume: 32, Issue:8

    Topics: Aged; Aged, 80 and over; Aging; Dehydroepiandrosterone; Fractures, Bone; Humans; Incidence; Male; Os

2017
Effects of prasterone on bone mineral density in women with active systemic lupus erythematosus receiving chronic glucocorticoid therapy.
    The Journal of rheumatology, 2008, Volume: 35, Issue:8

    Topics: Adult; Bone Density; Bone Density Conservation Agents; Dehydroepiandrosterone; Dose-Response Relatio

2008
Effects of prasterone on bone mineral density in women with active systemic lupus erythematosus receiving chronic glucocorticoid therapy.
    The Journal of rheumatology, 2008, Volume: 35, Issue:8

    Topics: Adult; Bone Density; Bone Density Conservation Agents; Dehydroepiandrosterone; Dose-Response Relatio

2008
Effects of prasterone on bone mineral density in women with active systemic lupus erythematosus receiving chronic glucocorticoid therapy.
    The Journal of rheumatology, 2008, Volume: 35, Issue:8

    Topics: Adult; Bone Density; Bone Density Conservation Agents; Dehydroepiandrosterone; Dose-Response Relatio

2008
Effects of prasterone on bone mineral density in women with active systemic lupus erythematosus receiving chronic glucocorticoid therapy.
    The Journal of rheumatology, 2008, Volume: 35, Issue:8

    Topics: Adult; Bone Density; Bone Density Conservation Agents; Dehydroepiandrosterone; Dose-Response Relatio

2008
Effects of prasterone (dehydroepiandrosterone) on markers of cardiovascular risk and bone turnover in premenopausal women with systemic lupus erythematosus: a pilot study.
    Lupus, 2010, Volume: 19, Issue:10

    Topics: Adjuvants, Immunologic; Adult; Atherosclerosis; Bone Density; Cholesterol, HDL; Cross-Over Studies;

2010
Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women.
    Journal of the American Geriatrics Society, 2010, Volume: 58, Issue:9

    Topics: Adjuvants, Immunologic; Administration, Oral; Aged; Bone Density; Dehydroepiandrosterone; Dose-Respo

2010
Effect of DHEA supplementation on serum IGF-1, osteocalcin, and bone mineral density in postmenopausal, glucocorticoid-treated women.
    Advances in medical sciences, 2012, Jun-01, Volume: 57, Issue:1

    Topics: Aged; Bone Density; Dehydroepiandrosterone; Female; Glucocorticoids; Humans; Insulin-Like Growth Fac

2012
Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:11

    Topics: Adipose Tissue; Adolescent; Adult; Alkaline Phosphatase; Anorexia Nervosa; Body Composition; Body Im

2002
Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal women.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2002, Volume: 4, Issue:4

    Topics: Dehydroepiandrosterone; Estradiol; Estrogen Replacement Therapy; Estrone; Female; Humans; Middle Age

2002
Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008, Volume: 19, Issue:5

    Topics: Aged; Aged, 80 and over; Biomarkers; Body Composition; Bone Density; Bone Density Conservation Agent

2008

Other Studies

30 other studies available for dehydroepiandrosterone and Osteoporosis

ArticleYear
Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community-dwelling postmenopausal women.
    BMC geriatrics, 2021, 10-12, Volume: 21, Issue:1

    Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Dehydroepiandrosterone; Female; Follistatin; Human

2021
Serum DHEA and Its Sulfate Are Associated With Incident Fall Risk in Older Men: The MrOS Sweden Study.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018, Volume: 33, Issue:7

    Topics: Accidental Falls; Aged; Aged, 80 and over; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; F

2018
Dehydroepiandrosterone and Bone.
    Vitamins and hormones, 2018, Volume: 108

    Topics: Animals; Bone Density; Dehydroepiandrosterone; Gene Expression Regulation, Developmental; Humans; In

2018
[Could serum DHEA and DHEAS levels be good risk predictors of metabolic syndrome and osteoporosis in the population of ageing men?].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2009, Volume: 27, Issue:159

    Topics: Adult; Aged; Aged, 80 and over; Aging; Comorbidity; Dehydroepiandrosterone; Dementia; Humans; Hypert

2009
Role of dehydroepiandrosterone in management of glucocorticoid-induced secondary osteoporosis in female rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:6

    Topics: Animals; Bone and Bones; Dehydroepiandrosterone; Female; Glucocorticoids; Osteoporosis; Prednisolone

2012
[Metabolic assessment of hydrocortisone replacement therapy in patients with primary adrenocortical insufficiency].
    Przeglad lekarski, 2011, Volume: 68, Issue:2

    Topics: Addison Disease; Adolescent; Adult; Aged; Dehydroepiandrosterone; Drug Therapy, Combination; Female;

2011
Low circulating estradiol and adrenal androgens concentrations in men on glucocorticoids: a potential contributory factor in steroid-induced osteoporosis.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:11

    Topics: Adult; Aged; Bone Density; Calcium; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Estrad

2002
[Therapeutic study of a new anabolic drug: nor-androstenolone phenylpropionate].
    La Semaine des hopitaux: therapeutique, 1960, Volume: 36

    Topics: Body Weight; Body Weights and Measures; Bone and Bones; Dehydroepiandrosterone; Neoplasms; Osteoporo

1960
[USE OF AN ANABOLIZING AGENT (1-METHYL-DELTA-ANDROSTENOLONE) AS A PREVENTIVE OF OSTEOPOROSIS IN PATIENTS SUBJECTED TO PLASTER CAST IMMOBILIZATION].
    La Clinica terapeutica, 1965, May-15, Volume: 33

    Topics: Anabolic Agents; Casts, Surgical; Dehydroepiandrosterone; Humans; Immobilization; Osteoporosis; Ster

1965
Endogenous cortisol and sex steroids in patients with osteoporotic spinal fractures.
    Obstetrics and gynecology, 1983, Volume: 61, Issue:3

    Topics: Androgens; Androstenedione; Bone and Bones; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate;

1983
Adrenal steroids, bone mineral content and endometrial pathology in postmenopausal women.
    Acta obstetricia et gynecologica Scandinavica, 1981, Volume: 60, Issue:3

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Bone and Bones; Dehydroepiandrosterone; Dehydr

1981
A prospective study of dehydroepiandrosterone sulfate (DHEAS) and bone mineral density in older men and women.
    American journal of epidemiology, 1993, Jan-15, Volume: 137, Issue:2

    Topics: Absorptiometry, Photon; Age Factors; Aged; Antihypertensive Agents; Bone Density; California; Dehydr

1993
Dehydroepiandrosterone-dependent induction of peroxisomal proliferation can be reduced by aspartyl esterification without attenuation of inhibitory bone loss in ovariectomy animal model.
    Journal of Korean medical science, 2000, Volume: 15, Issue:5

    Topics: Acyl-CoA Dehydrogenase; Adjuvants, Immunologic; Animals; Aspartic Acid; Biomarkers; Calcium; Cholest

2000
The prevention of osteoporotic progression by means of steroid loaded TCPL drug delivery systems.
    Biomedical sciences instrumentation, 2001, Volume: 37

    Topics: Animals; Bone Resorption; Calcium Phosphates; Dehydroepiandrosterone; Diosgenin; Disease Progression

2001
The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model.
    Biomedical sciences instrumentation, 2001, Volume: 37

    Topics: Animals; Calcium Phosphates; Capsules; Ceramics; Dehydroepiandrosterone; Diosgenin; Drug Delivery Sy

2001
[DHEA, osteoporosis, nuclear receptor and aging].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2001, Volume: 38, Issue:6

    Topics: Administration, Oral; Aged; Aging; Bone and Bones; Dehydroepiandrosterone; Female; Humans; Male; Mid

2001
Adrenal steroids and the development of osteoporosis in oophorectomised women.
    Lancet (London, England), 1979, Sep-22, Volume: 2, Issue:8143

    Topics: 17-Ketosteroids; Adult; Androgens; Androstenediols; Androstenedione; Castration; Dehydroepiandroster

1979
[Diseases in the climacteric, with poor or without any organic findings].
    Zeitschrift fur Allgemeinmedizin, 1975, Nov-10, Volume: 51, Issue:31

    Topics: Cardiovascular Diseases; Climacteric; Dehydroepiandrosterone; Estradiol; Estrogens; Female; Humans;

1975
Effect of intravenous calcium load on the serum calcium level in postmenopausal osteoporosis (a study of the pathogenesis, and diagnostic use of the test).
    Acta medica Academiae Scientiarum Hungaricae, 1978, Volume: 35, Issue:1

    Topics: Calcium; Decanoates; Dehydroepiandrosterone; Female; Humans; Menopause; Nandrolone; Osteoporosis

1978
Metabolic effects of corticosteroid therapy in post-menopausal women.
    Journal of steroid biochemistry, 1979, Volume: 11, Issue:1B

    Topics: Androstenedione; Bone and Bones; Calcium; Creatinine; Dehydroepiandrosterone; Estradiol; Estrone; Fe

1979
Osteoporosis and Klinefelter's syndrome.
    Clinical endocrinology, 1992, Volume: 36, Issue:1

    Topics: Adult; Aged; Body Composition; Bone Density; Creatinine; Dehydroepiandrosterone; Humans; Hydroxyprol

1992
Reduced spinal bone density in young women with amenorrhoea.
    European journal of obstetrics, gynecology, and reproductive biology, 1991, Sep-13, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Amenorrhea; Bone Density; Dehydroepiandrosterone; Estradiol; Female; Humans; Hydr

1991
Persistence of increased bone resorption and possible role of dehydroepiandrosterone as a bone metabolism determinant in osteoporotic women in late post-menopause.
    Maturitas, 1989, Volume: 11, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Bone and Bones; Bone Resorption; Dehydroepiandrosterone; Femal

1989
Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass.
    British medical journal (Clinical research ed.), 1987, Mar-28, Volume: 294, Issue:6575

    Topics: Addison Disease; Adult; Aged; Androgens; Androstenedione; Bone and Bones; Dehydroepiandrosterone; Es

1987
Obesity and postmenopausal bone loss: the influence of obesity on vertebral density and bone turnover in postmenopausal women.
    Bone, 1987, Volume: 8, Issue:6

    Topics: Aged; Bone and Bones; Calcium; Calcium-Binding Proteins; Dehydroepiandrosterone; Estradiol; Female;

1987
Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis.
    Arthritis and rheumatism, 1988, Volume: 31, Issue:8

    Topics: Arthritis, Rheumatoid; Bone and Bones; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Femal

1988
The relation between calcium absorption, serum dehydroepiandrosterone, and vertebral mineral density in postmenopausal women.
    The Journal of clinical endocrinology and metabolism, 1985, Volume: 60, Issue:4

    Topics: Aged; Bone and Bones; Calcium; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Intestinal Ab

1985
[Effect of dehydroepiandrosterone and cortisol on the bones of bilaterally adrenalectomized female rats].
    Nihon Sanka Fujinka Gakkai zasshi, 1966, Volume: 18, Issue:11

    Topics: Adrenalectomy; Animals; Bone and Bones; Dehydroepiandrosterone; Desoxycorticosterone; Female; Femur;

1966
Serum dehydroepiandrosterone, androsterone and cortisol level in primary postmenopausal and other type osteoporosis.
    Acta medica Academiae Scientiarum Hungaricae, 1970, Volume: 27, Issue:2

    Topics: Adrenal Cortex Hormones; Androsterone; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Menop

1970
Effects of calcitonin in metastatic bone carcinoma, osteoporosis, polyostotic fibrous dysplasia and hypercalcemia.
    Endocrinologia japonica, 1971, Volume: 17, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Alkaline Phosphatase; Bone Neoplasms; Calcitonin; Calcium; Child, Presc

1971