dehydroepiandrosterone has been researched along with Osteoporosis, Postmenopausal in 27 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A major achievement from 500 million years of evolution is the establishment of a high secretion rate of dehydroepiandrosterone (DHEA) by the human adrenal glands coupled with the indroduction of menopause which stops secretion of estrogens by the ovary." | 3.76 | DHEA, important source of sex steroids in men and even more in women. ( Labrie, F, 2010) |
| "Approximately 70% of breast cancers are diagnosed in postmenopausal women." | 1.40 | The role of hormones and aromatase inhibitors on breast tumor growth and general health in a postmenopausal mouse model. ( Arumugam, A; Lakshmanaswamy, R; Lissner, EA, 2014) |
| "Prevention of postmenopausal osteoporosis is now possible with current therapy, if initiated soon after the menopause and continued for at least 10 years." | 1.28 | The relationship between sex steroids and bone mineral content in women soon after the menopause. ( Edwards, AC; McGarrigle, HH; Perry, LA; Spector, TD; Thompson, PW, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 11 (40.74) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marques, MAA | 1 |
| Lourenço, BHLB | 1 |
| Reis, MP | 1 |
| Pauli, KB | 1 |
| Soares, AL | 1 |
| Belettini, ST | 1 |
| Donadel, G | 1 |
| Palozi, RAC | 1 |
| Froehlich, DL | 1 |
| Lívero, FADR | 1 |
| Gasparotto Junior, A | 1 |
| Lourenço, ELB | 1 |
| Arumugam, A | 1 |
| Lissner, EA | 1 |
| Lakshmanaswamy, R | 1 |
| Gui, Y | 2 |
| Qiu, X | 2 |
| Xu, Y | 1 |
| Li, D | 2 |
| Wang, L | 4 |
| Zhang, N | 1 |
| Tang, W | 1 |
| Li, L | 1 |
| Gober, HJ | 1 |
| Wang, YD | 3 |
| Wang, WJ | 2 |
| Li, DJ | 2 |
| Labrie, F | 2 |
| Lang, X | 1 |
| Tao, MF | 1 |
| Cheng, WW | 1 |
| Marcelli, C | 1 |
| Perry, CG | 1 |
| Connell, JM | 1 |
| Bassotti, G | 1 |
| Di Sarra, D | 1 |
| Pietrobono, D | 1 |
| Schiaffini, R | 1 |
| Battocletti, T | 1 |
| D'Amico, T | 1 |
| Gargiulo, P | 1 |
| Bácsi, K | 1 |
| Kósa, J | 1 |
| Lazáry, A | 1 |
| Horváth, H | 1 |
| Balla, B | 1 |
| Lakatos, P | 1 |
| Speer, G | 1 |
| Raven, PW | 1 |
| Hinson, JP | 1 |
| Rozenberg, S | 1 |
| Gevers, R | 1 |
| Peretz, A | 1 |
| Vandromme, J | 1 |
| Robyn, C | 1 |
| Ham, H | 1 |
| Tremollieres, FA | 1 |
| Pouilles, JM | 1 |
| Ribot, C | 1 |
| Szathmári, M | 1 |
| Holló, I | 1 |
| McCarty, MF | 1 |
| Miklós, S | 1 |
| Fingerová, H | 1 |
| Matlochová, J | 1 |
| Castelo-Branco, C | 1 |
| Vicente, JJ | 1 |
| Figueras, F | 1 |
| Sanjuan, A | 1 |
| Martínez de Osaba, MJ | 1 |
| Casals, E | 1 |
| Pons, F | 1 |
| Balasch, J | 1 |
| Vanrell, JA | 1 |
| Garnero, P | 2 |
| Sornay-Rendu, E | 2 |
| Claustrat, B | 2 |
| Delmas, PD | 2 |
| Chapurlat, RD | 1 |
| Arlot, ME | 1 |
| Cormier, C | 1 |
| Souberbielle, JC | 1 |
| Kahan, A | 1 |
| Sambrook, P | 1 |
| Birmingham, J | 1 |
| Champion, D | 1 |
| Kelly, P | 1 |
| Kempler, S | 1 |
| Freund, J | 1 |
| Eisman, J | 1 |
| Spector, TD | 1 |
| Thompson, PW | 1 |
| Perry, LA | 1 |
| McGarrigle, HH | 1 |
| Edwards, AC | 1 |
| Enzelsberger, H | 1 |
| Heytmanek, G | 1 |
| Kurz, C | 1 |
| Metka, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DHEA + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women (Placebo Controlled, Double Blind and Randomized Phase III Study to Evaluate the Effects of 12-Week Treatment With DHEA (Prasterone) and Acolbifene on Vasomotor Symptoms (H[NCT01452373] | Phase 3 | 238 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Effects of DHEA/Exercise on Bone, Muscle and Balance[NCT00664053] | Phase 4 | 99 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| The Effects of Testosterone and Nutritional Supplementation, Alone and Combined, on the Adverse Effects of Under-Nutrition in the Elderly[NCT00117000] | Phase 3 | 200 participants | Interventional | 2003-07-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for dehydroepiandrosterone and Osteoporosis, Postmenopausal
| Article | Year |
|---|---|
Can DHEA be used to prevent bone loss and osteoporosis?
Topics: Aged; Bone Density; Bone Remodeling; Dehydroepiandrosterone; Female; Fractures, Spontaneous; Humans; | 2003 |
Key developments in endocrinology.
Topics: Addison Disease; Adjuvants, Immunologic; Dehydroepiandrosterone; Endocrine System Diseases; Female; | 2003 |
[Significance of dehydroepiandrosterone and dehydroepiandrosterone sulfate in different diseases].
Topics: Androgens; Cardiovascular Diseases; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabetes | 2007 |
Dehydroepiandrosterone (DHEA) and the menopause: an update.
Topics: Adjuvants, Immunologic; Breast Neoplasms; Cardiovascular Diseases; Cognition Disorders; Dehydroepian | 2007 |
DHEA as physiological replacement therapy at menopause.
Topics: Animals; Bone Density; Dehydroepiandrosterone; Female; Humans; Male; Middle Aged; Osteoporosis, Post | 1998 |
DHEA in bone and joint diseases.
Topics: Administration, Oral; Aged; Animals; Bone Density; Dehydroepiandrosterone; Female; Hormone Replaceme | 2001 |
1 trial available for dehydroepiandrosterone and Osteoporosis, Postmenopausal
| Article | Year |
|---|---|
Comparative effects of estrogens plus androgens and tibolone on bone, lipid pattern and sexuality in postmenopausal women.
Topics: Administration, Cutaneous; Anabolic Agents; Apolipoprotein A-I; Apolipoproteins B; Bone and Bones; B | 2000 |
20 other studies available for dehydroepiandrosterone and Osteoporosis, Postmenopausal
| Article | Year |
|---|---|
Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca
Topics: Animals; Bone Density; Calcium; Dehydroepiandrosterone; Female; Humans; Osteoporosis, Postmenopausal | 2019 |
The role of hormones and aromatase inhibitors on breast tumor growth and general health in a postmenopausal mouse model.
Topics: Aging; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Dehydroepiandrosterone; Disease M | 2014 |
Bu-Shen-Ning-Xin decoction suppresses osteoclastogenesis via increasing dehydroepiandrosterone to prevent postmenopausal osteoporosis.
Topics: Animals; Cell Survival; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Disease Models, Anim | 2015 |
DHEA prevents bone loss by suppressing the expansion of CD4(+) T cells and TNFa production in the OVX-mouse model for postmenopausal osteoporosis.
Topics: Animals; Bone Density; CD4-Positive T-Lymphocytes; Dehydroepiandrosterone; Estradiol; Female; Humans | 2016 |
Differential regulation of dehydroepiandrosterone and estrogen on bone and uterus in ovariectomized mice.
Topics: Absorptiometry, Photon; Animals; Aromatase; Bone Density; Cells, Cultured; Dehydroepiandrosterone; E | 2009 |
DHEA, important source of sex steroids in men and even more in women.
Topics: Adrenal Glands; Age Factors; Aging; Anticarcinogenic Agents; Brain; Breast; Cardiovascular Diseases; | 2010 |
[Selective ERβ action of dehydroepiandrosterone for osteoblast cell line].
Topics: Apoptosis; Butadienes; Cell Line; Cell Proliferation; Dehydroepiandrosterone; Estrogen Receptor alph | 2011 |
Dehydroepiandrosterone inhibited the bone resorption through the upregulation of OPG/RANKL.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Bone Resorption; Carrier Proteins; Cells, Culture | 2006 |
Polyglandular autoimmune endocrine insufficiency complicated by severe osteoporosis.
Topics: Addison Disease; Adult; Asthenia; Bone Density; Dehydroepiandrosterone; Female; Gonadal Steroid Horm | 2006 |
Decrease of bone mineral density during estrogen substitution therapy.
Topics: Alkaline Phosphatase; Bone Density; Creatine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate | 1993 |
Vertebral postmenopausal bone loss is reduced in overweight women: a longitudinal study in 155 early postmenopausal women.
Topics: Body Mass Index; Body Weight; Bone Density; Calcium; Creatinine; Dehydroepiandrosterone; Dehydroepia | 1993 |
[Androgens and bone metabolism].
Topics: Bone Density; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Middle Aged; O | 1993 |
Anabolic effects of insulin on bone suggest a role for chromium picolinate in preservation of bone density.
Topics: Animals; Bone Density; Bone Resorption; Calcium; Collagen; Dehydroepiandrosterone; Dehydroepiandrost | 1995 |
Dehydroepiandrosterone sulphate in the diagnosis of osteoporosis.
Topics: Absorptiometry, Photon; Aged; Aging; Biomarkers; Bone Density; Dehydroepiandrosterone; Dehydroepiand | 1995 |
[Reduced serum dehydroepiandrosterone levels in postmenopausal osteoporosis].
Topics: Biomarkers; Bone Density; Dehydroepiandrosterone; Female; Humans; Middle Aged; Osteoporosis, Postmen | 1998 |
Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study.
Topics: Alkaline Phosphatase; Biomarkers; Bone Density; Collagen; Collagen Type I; Dehydroepiandrosterone; E | 2000 |
Longitudinal study of bone loss in pre- and perimenopausal women: evidence for bone loss in perimenopausal women.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Androstenedione; Bone Density; Collagen; Dehydr | 2000 |
Postmenopausal bone loss in rheumatoid arthritis: effect of estrogens and androgens.
Topics: Androgens; Arthritis, Rheumatoid; Bone Density; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfa | 1992 |
The relationship between sex steroids and bone mineral content in women soon after the menopause.
Topics: Absorptiometry, Photon; Biomarkers; Bone Density; Dehydroepiandrosterone; Dehydroepiandrosterone Sul | 1991 |
[The effects of smoking on estrogen level and bone mass].
Topics: Adult; Androstenedione; Bone Density; Dehydroepiandrosterone; Estradiol; Estrogens; Female; Humans; | 1989 |