dehydroepiandrosterone has been researched along with Osteoarthritis in 15 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dehydroepiandrosterone (DHEA), a 19-carbon steroid hormone primarily synthesized in the adrenal gland, exerts a chondroprotective effect against osteoarthritis (OA) and has been considered an effective candidate of disease-modifying OA drugs (DMOADs) that slow disease progression." | 8.98 | Dehydroepiandrosterone: Molecular mechanisms and therapeutic implications in osteoarthritis. ( Huang, K; Wu, LD, 2018) |
| "We investigated conversion of the ubiquitous dehydroepiandrosterone sulfate (DHEAS), the biologically inactive precursor of DHEA, to the androgen DHEA in mixed synovial cells from patients with RA and patients with osteoarthritis (OA), making use of thin-layer chromatography and phosphorimaging." | 7.73 | Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency. ( Schmidt, M; Schölmerich, J; Straub, RH; Struharova, S; Ugele, B; Weidler, C, 2005) |
| "The aim of this study was to investigate the effects of intra-articular injection of dehydroepiandrosterone (DHEA) on cartilage and synovium of knee joints with osteoarthritis (OA) in rabbits and the underlying mechanism." | 7.73 | Effect of dehydroepiandrosterone on cartilage and synovium of knee joints with osteoarthritis in rabbits. ( Feng, J; Wu, LD; Xiong, Y; Yu, HC, 2006) |
| "Dehydroepiandrosterone (DHEA) was converted into androstenediol, androstenedione (ASD), 16alphaOH-DHEA, 7alphaOH-DHEA, testosterone, estrone (E1), estradiol (E2), estriol (E3), and 16alphaOH-testosterone (similar in OA and RA)." | 5.33 | Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. ( Anders, S; Naumann, H; Schmidt, M; Schölmerich, J; Straub, RH; Weidler, C, 2005) |
| "Dehydroepiandrosterone (DHEA), a 19-carbon steroid hormone primarily synthesized in the adrenal gland, exerts a chondroprotective effect against osteoarthritis (OA) and has been considered an effective candidate of disease-modifying OA drugs (DMOADs) that slow disease progression." | 4.98 | Dehydroepiandrosterone: Molecular mechanisms and therapeutic implications in osteoarthritis. ( Huang, K; Wu, LD, 2018) |
| "The sex hormone precursor dehydroepiandrosterone (DHEA), which can be converted into estradiol by the enzyme aromatase, has a protective role against osteoarthritis (OA)." | 3.79 | The chondroprotective effects of dehydroepiandrosterone probably exerted by its conversion to estradiol. ( Li, W; Tang, L; Wu, L; Xiong, Y; Zhou, X, 2013) |
| "We investigated conversion of the ubiquitous dehydroepiandrosterone sulfate (DHEAS), the biologically inactive precursor of DHEA, to the androgen DHEA in mixed synovial cells from patients with RA and patients with osteoarthritis (OA), making use of thin-layer chromatography and phosphorimaging." | 3.73 | Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency. ( Schmidt, M; Schölmerich, J; Straub, RH; Struharova, S; Ugele, B; Weidler, C, 2005) |
| "The aim of this study was to investigate the effects of intra-articular injection of dehydroepiandrosterone (DHEA) on cartilage and synovium of knee joints with osteoarthritis (OA) in rabbits and the underlying mechanism." | 3.73 | Effect of dehydroepiandrosterone on cartilage and synovium of knee joints with osteoarthritis in rabbits. ( Feng, J; Wu, LD; Xiong, Y; Yu, HC, 2006) |
| "Dehydroepiandrosterone (DHEA) was converted into androstenediol, androstenedione (ASD), 16alphaOH-DHEA, 7alphaOH-DHEA, testosterone, estrone (E1), estradiol (E2), estriol (E3), and 16alphaOH-testosterone (similar in OA and RA)." | 1.33 | Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. ( Anders, S; Naumann, H; Schmidt, M; Schölmerich, J; Straub, RH; Weidler, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, K | 7 |
| Wu, LD | 9 |
| Bao, JP | 4 |
| Cai, HL | 1 |
| Li, WJ | 1 |
| Tang, LP | 1 |
| Xiong, Y | 3 |
| Chen, WP | 2 |
| Zhou, XD | 1 |
| Ding, QH | 1 |
| Okamoto, K | 1 |
| Kiga, N | 1 |
| Shinohara, Y | 1 |
| Tojyo, I | 1 |
| Fujita, S | 1 |
| Jennings, GJ | 1 |
| Feng, J | 2 |
| Zhao, J | 1 |
| Shi, ZL | 1 |
| Zhang, C | 1 |
| Zhang, XW | 1 |
| Li, W | 1 |
| Tang, L | 1 |
| Zhou, X | 1 |
| Wu, L | 1 |
| Rovensky, J | 1 |
| Radikova, Z | 1 |
| Imrich, R | 1 |
| Greguska, O | 1 |
| Vigas, M | 1 |
| Macho, L | 1 |
| Weidler, C | 2 |
| Struharova, S | 1 |
| Schmidt, M | 2 |
| Ugele, B | 1 |
| Schölmerich, J | 2 |
| Straub, RH | 2 |
| Naumann, H | 1 |
| Anders, S | 1 |
| Yu, HC | 1 |
| Spector, TD | 1 |
| Perry, LA | 1 |
| Jubb, RW | 1 |
3 reviews available for dehydroepiandrosterone and Osteoarthritis
| Article | Year |
|---|---|
Dehydroepiandrosterone: Molecular mechanisms and therapeutic implications in osteoarthritis.
Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; Humans; Osteoarthritis; Signal Transduction | 2018 |
Potential of dehydroepiandrosterone in modulating osteoarthritis-related pain.
Topics: Animals; Dehydroepiandrosterone; Humans; Osteoarthritis; Pain | 2019 |
Suppression of aggrecanase: a novel protective mechanism of dehydroepiandrosterone in osteoarthritis?
Topics: ADAM Proteins; ADAMTS4 Protein; ADAMTS5 Protein; Cartilage; Dehydroepiandrosterone; Extracellular Ma | 2010 |
12 other studies available for dehydroepiandrosterone and Osteoarthritis
| Article | Year |
|---|---|
Dehydroepiandrosterone and Experimental Osteoarthritis.
Topics: Animals; Cartilage; Dehydroepiandrosterone; Drug Evaluation, Preclinical; Gene Expression Regulation | 2018 |
A possible mechanism in DHEA-mediated protection against osteoarthritis.
Topics: Animals; beta Catenin; Cartilage; Chondrocytes; Dehydroepiandrosterone; Gene Expression Regulation; | 2014 |
Effect of interleukin-1beta and dehydroepiandrosterone on the expression of lumican and fibromodulin in fibroblast-like synovial cells of the human temporomandibular joint.
Topics: Adjuvants, Immunologic; Adult; Aged; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Dehydroepia | 2015 |
The disease-modifying effect of dehydroepiandrosterone in different stages of experimentally induced osteoarthritis: a histomorphometric study.
Topics: Animals; Antirheumatic Agents; Dehydroepiandrosterone; Disease Models, Animal; Disease Progression; | 2015 |
Variation patterns of two degradation enzyme systems in articular cartilage in different stages of osteoarthritis: regulation by dehydroepiandrosterone.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Cystatins; Cysteine Proteases; Dehydroepi | 2009 |
Effect of dehydroepiandrosterone on aggrecanase expression in articular cartilage in a rabbit model of osteoarthritis.
Topics: Adjuvants, Immunologic; Animals; Anterior Cruciate Ligament; Cartilage, Articular; Dehydroepiandrost | 2011 |
The chondroprotective effects of dehydroepiandrosterone probably exerted by its conversion to estradiol.
Topics: Adjuvants, Immunologic; Animals; Aromatase Inhibitors; Cartilage; Cells, Cultured; Chondrocytes; Deh | 2013 |
Gonadal and adrenal steroid hormones in plasma and synovial fluid of patients with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aldosterone; Arthritis, Rheumatoid; Case-Control Studies; Dehy | 2004 |
Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency.
Topics: Aged; Arthritis, Rheumatoid; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; | 2005 |
Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Androstenedione; Aromatase; Arthritis, Rheumatoid; | 2005 |
Effect of dehydroepiandrosterone on cartilage and synovium of knee joints with osteoarthritis in rabbits.
Topics: Animals; Anterior Cruciate Ligament; Cartilage; Dehydroepiandrosterone; Disease Models, Animal; Dose | 2006 |
Endogenous sex steroid levels in women with generalised osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; F | 1991 |