dehydroepiandrosterone has been researched along with Oligomenorrhea in 24 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Oligomenorrhea: Abnormally infrequent menstruation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of epimestrol (5 mg every 6 hours for 5 days) on basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (Prl), estradiol, progesterone, and dehydroepiandrosterone sulfate, and on the response to LH-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) stimulation, were studied in 18 cases of secondary amenorrhea and oligomenorrhea of hypothalamic-pituitary origin, in three cases of anorexia nervosa, in two cases of long-lasting progestin-induced amenorrhea, and in one case of precocious menopause." | 7.66 | Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea. ( de Leo, V; Facchinetti, F; Franchi, F; Genazzani, AR; Kicovic, PM; Parrini, D; Picciolini, E, 1978) |
| " Compared with the non-PCO group, the PCO subgroup without hirsutism (n = 31) had statistically significantly higher median values of LH, testosterone, androstenedione, and dehydroepiandrosterone sulphate concentrations, and free androgen index." | 3.68 | Oestrogen and androgen states in oligo-amenorrhoeic women with polycystic ovaries. ( Corrigan, E; Fox, R; Hull, MG; Thomas, PG, 1991) |
| "Low-dose spironolactone improves hirsutism in a majority of hirsute women, irrespective of age, severity or duration of hirsutism, menstrual status, or serum hormone levels." | 3.68 | Predictors of clinical response in hirsute women treated with spironolactone. ( Crosby, PD; Rittmaster, RS, 1991) |
| "Thirty-six women with acne vulgaris who consulted gynecologist with complaints of hirsutism, infertility, menorrhagia, or oligomenorrhea were evaluated for an androgen abnormality with assays for testosterone (T), androstenedione (A), and dehydro-epi-androsterone (DHEA)." | 3.66 | Androgen abnormalities in acne vulgaris. ( Birnbaum, MD; Ginsberg, GS; Rose, LI, 1981) |
| "Serum dehydroepiandrosterone sulfate (DHEAS) was measured in 32 infertility patients who were found to be ovulatory, in 37 women with oligomenorrhea, and in 52 hirsute patients under basal conditions." | 3.66 | Serum levels of DHEAS in gynecologic endocrinopathy and infertility. ( Goebelsmann, U; Lobo, RA; Paul, WL, 1981) |
| "The effects of epimestrol (5 mg every 6 hours for 5 days) on basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (Prl), estradiol, progesterone, and dehydroepiandrosterone sulfate, and on the response to LH-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) stimulation, were studied in 18 cases of secondary amenorrhea and oligomenorrhea of hypothalamic-pituitary origin, in three cases of anorexia nervosa, in two cases of long-lasting progestin-induced amenorrhea, and in one case of precocious menopause." | 3.66 | Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea. ( de Leo, V; Facchinetti, F; Franchi, F; Genazzani, AR; Kicovic, PM; Parrini, D; Picciolini, E, 1978) |
| "For dose-response studies, blood samples were obtained before and at 0." | 2.76 | Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome. ( Chang, RJ; Coffler, MS; Donohue, MC; Duke, KB; Haggan, A; Rosencrantz, MA; Shayya, RF; Su, HI, 2011) |
| " In contradistinction to other low dosage combination oral contraceptives this new oral contraceptive has a good control of the menstrual cycle." | 2.65 | [Clinical and biochemical results during the treatment with marvelon, a new oral contraceptive (author's transl)]. ( Huber, P; Mall-Haefeli, M; Weijers, MJ; Werner-Zodrow, I, 1982) |
| "Hirsutism was present in 64." | 1.29 | Endocrinological, ultrasonographic and clinical findings in adolescent and adult polycystic ovary patients: a comparative study. ( Gökmen, O; Gülekli, B; Kükner, S; Oral, H; Senöz, S; Turhan, NO, 1993) |
| "Body weight was significantly negatively correlated with DHEAS and TeBG-BC in those women with a normal DHEAS level but not in those with an elevated level." | 1.27 | Androgen parameters and their correlation with body weight in one hundred thirty-eight women thought to have hyperandrogenism. ( Andersen, RN; Givens, JR; Ranney, GB; Umstot, ES; Wild, RA, 1983) |
| "Dehydroepiandrosterone-sulfate was the only steroid which showed significantly different mean levels between the two groups of hirsute women, being higher in the H-OA patients." | 1.25 | Ovarian and adrenal contributions to peripheral androgens in hirsute women. ( Abraham, GE; Buster, JE; Chakmakjian, ZH; Marshall, JR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (50.00) | 18.7374 |
| 1990's | 9 (37.50) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosencrantz, MA | 1 |
| Coffler, MS | 1 |
| Haggan, A | 1 |
| Duke, KB | 1 |
| Donohue, MC | 1 |
| Shayya, RF | 1 |
| Su, HI | 1 |
| Chang, RJ | 1 |
| Naessén, S | 1 |
| Carlström, K | 1 |
| Garoff, L | 1 |
| Glant, R | 1 |
| Hirschberg, AL | 1 |
| Ginsberg, GS | 1 |
| Birnbaum, MD | 1 |
| Rose, LI | 2 |
| Mall-Haefeli, M | 1 |
| Werner-Zodrow, I | 1 |
| Huber, P | 1 |
| Weijers, MJ | 1 |
| Lobo, RA | 4 |
| Granger, LR | 1 |
| Davajan, V | 1 |
| Mishell, DR | 1 |
| Kletzky, OA | 1 |
| Campeau, JD | 1 |
| diZerega, GS | 1 |
| Wild, RA | 1 |
| Umstot, ES | 1 |
| Andersen, RN | 1 |
| Ranney, GB | 1 |
| Givens, JR | 1 |
| Siegberg, R | 1 |
| Nilsson, CG | 1 |
| Stenman, UH | 1 |
| Widholm, O | 1 |
| McKenna, TJ | 1 |
| Cunningham, S | 1 |
| Culliton, M | 1 |
| Daly, L | 1 |
| Moore, A | 1 |
| Magee, F | 1 |
| Smyth, PP | 1 |
| Paul, WL | 1 |
| Goebelsmann, U | 2 |
| Gülekli, B | 1 |
| Turhan, NO | 1 |
| Senöz, S | 1 |
| Kükner, S | 1 |
| Oral, H | 1 |
| Gökmen, O | 1 |
| McArthur, JW | 1 |
| Turnbull, BA | 1 |
| Pehrson, J | 1 |
| Bauman, M | 1 |
| Henley, K | 1 |
| Turner, A | 1 |
| Evans, WJ | 1 |
| Bullen, BA | 1 |
| Skrinar, GS | 1 |
| Bili, H | 1 |
| Laven, J | 1 |
| Imani, B | 1 |
| Eijkemans, MJ | 1 |
| Fauser, BC | 1 |
| Abraham, GE | 1 |
| Chakmakjian, ZH | 1 |
| Buster, JE | 1 |
| Marshall, JR | 1 |
| Genazzani, AR | 1 |
| Facchinetti, F | 1 |
| de Leo, V | 1 |
| Picciolini, E | 1 |
| Franchi, F | 1 |
| Parrini, D | 1 |
| Kicovic, PM | 1 |
| Hawkins, LA | 1 |
| Chasalow, FI | 1 |
| Blethen, SL | 1 |
| Snead, DB | 1 |
| Weltman, A | 1 |
| Weltman, JY | 1 |
| Evans, WS | 1 |
| Veldhuis, JD | 1 |
| Varma, MM | 1 |
| Teates, CD | 1 |
| Dowling, EA | 1 |
| Rogol, AD | 1 |
| Vogt, C | 1 |
| Dericks-Tan, JS | 1 |
| Kuhl, H | 1 |
| Taubert, HD | 1 |
| Fox, R | 1 |
| Corrigan, E | 1 |
| Thomas, PG | 1 |
| Hull, MG | 1 |
| Crosby, PD | 1 |
| Rittmaster, RS | 1 |
| Redmond, GP | 1 |
| Bergfeld, W | 1 |
| Gupta, M | 1 |
| Bedocs, NM | 1 |
| Skibinski, C | 1 |
| Gidwani, G | 1 |
| Helfer, EL | 1 |
| Miller, JL | 1 |
| Weise, HC | 1 |
| Moltz, L | 1 |
| Bispink, G | 1 |
| Leidenberger, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS)[NCT02145247] | 39 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| Theca Cell Function in Women With Polycystic Ovary Syndrome[NCT00747617] | Phase 3 | 25 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Evaluation of Vitamin D With and Without Hormonal Contraception on Sexual Function in Women With Polycystic Ovary Syndrome[NCT02865187] | 47 participants (Actual) | Interventional | 2017-02-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"On study day one, recombinant-hCG (r-hCG) will be administered intravenously at a dose of 25 micrograms.~Blood samples will be obtained before and after r-hCG adminstration" (NCT02145247)
Timeframe: before and 24 hours after adminisration of r-hCG
| Intervention | percent change (Mean) |
|---|---|
| Normal Adult Women | 67 |
| Women With PCOS | 140 |
Mean serum testosterone levels before and after hCG injection. Serum testosterone levels before (-0.5 and 0 hrs) were averaged to achieve a single value (NCT00747617)
Timeframe: -0.5, 0, 24 hrs
| Intervention | ng/ml (Mean) |
|---|---|
| PCOS | 0.6 |
| Normal | 0.3 |
Assess serum 17OHP levels following each dose of hCG adminstration in PCOS and normal subjects (NCT00747617)
Timeframe: 24 hrs post dose
| Intervention | ng/ml (Mean) | ||||
|---|---|---|---|---|---|
| 17OHP post 10 micrograms | 17OHP level post 1 micrograms | 17OHP level post 25 micrograms | 17OHP level post 100 micrograms | 17OHP level post 250 micrograms | |
| Normal | 1.2 | 1.0 | 1.7 | 2.2 | 2.1 |
| PCOS | 2.0 | 1.1 | 2.7 | 3.3 | 4.0 |
Prevalence rate of women with PCOS defined by scores of the FSFI (total scores range from 2-36; scores less than 26.55 represent presence/degree of sexual dysfunction) - For this outcome, total scores were converted, using the cutoff score of 26.55, into a dichotomous variable for presence or absence of sexual dysfunction. (NCT02865187)
Timeframe: Baseline
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin D + Hormonal Contraception | 26 |
| Vit D + Non-hormonal Contraception | 11 |
Female Sexual Function Index (FSFI) scores at Month 6 (Total score ranges from 2 - 36; scores less than 26.55 represent presence/degree of sexual dysfunction) (NCT02865187)
Timeframe: Month 6
| Intervention | score on a scale (Mean) |
|---|---|
| Vitamin D + Hormonal Contraception | 24.8 |
| Vit D + Non-hormonal Contraception | 26.0 |
3 trials available for dehydroepiandrosterone and Oligomenorrhea
| Article | Year |
|---|---|
Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone; Dose-Response Re | 2011 |
Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone; Dose-Response Re | 2011 |
Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone; Dose-Response Re | 2011 |
Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone; Dose-Response Re | 2011 |
[Clinical and biochemical results during the treatment with marvelon, a new oral contraceptive (author's transl)].
Topics: Adolescent; Adult; Androstane-3,17-diol; Clinical Trials as Topic; Contraceptives, Oral; Contracepti | 1982 |
Nalmefene enhances LH secretion in a proportion of oligo-amenorrheic athletes.
Topics: Adult; Amenorrhea; Analysis of Variance; Androstenedione; Dehydroepiandrosterone; Estradiol; Female; | 1993 |
21 other studies available for dehydroepiandrosterone and Oligomenorrhea
| Article | Year |
|---|---|
Polycystic ovary syndrome in bulimic women--an evaluation based on the new diagnostic criteria.
Topics: Adult; Bulimia; Case-Control Studies; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; | 2006 |
Androgen abnormalities in acne vulgaris.
Topics: Acne Vulgaris; Adolescent; Adult; Amenorrhea; Androstenedione; Dehydroepiandrosterone; Female; Hirsu | 1981 |
An extended regimen of clomiphene citrate in women unresponsive to standard therapy.
Topics: Chorionic Gonadotropin; Clomiphene; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradio | 1982 |
Elevated bioactive luteinizing hormone in women with the polycystic ovary syndrome.
Topics: Adolescent; Adult; Androgens; Anovulation; Chronic Disease; Dehydroepiandrosterone; Dehydroepiandros | 1983 |
Androgen parameters and their correlation with body weight in one hundred thirty-eight women thought to have hyperandrogenism.
Topics: Acne Vulgaris; Adolescent; Adult; Androgens; Androstenedione; Body Weight; Dehydroepiandrosterone; E | 1983 |
Sex hormone profiles in oligomenorrheic adolescent girls and the effect of oral contraceptives.
Topics: Adolescent; Adult; Androstenedione; Contraceptives, Oral; Contraceptives, Oral, Combined; Dehydroepi | 1984 |
Prolactin in hirsute women: possible roles for androgens in suppressing basal levels, and for oestrogens in enhancing TRH-induced responses.
Topics: Adrenal Glands; Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estrone; Female; Hirs | 1984 |
Serum levels of DHEAS in gynecologic endocrinopathy and infertility.
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androstenedione; Dehydroepiandrosterone; Dehydroepiand | 1981 |
Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome.
Topics: 17-alpha-Hydroxypregnenolone; 3-Hydroxysteroid Dehydrogenases; Adrenocorticotropic Hormone; Adult; A | 1981 |
Endocrinological, ultrasonographic and clinical findings in adolescent and adult polycystic ovary patients: a comparative study.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Amenorrhea; Androstenedione; Dehydroepiandrosterone | 1993 |
Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years.
Topics: Adolescent; Adult; Aging; Amenorrhea; Androstenedione; Body Constitution; Body Mass Index; Cross-Sec | 2001 |
Ovarian and adrenal contributions to peripheral androgens in hirsute women.
Topics: Adrenal Glands; Adult; Amenorrhea; Androgens; Androstenedione; Chorionic Gonadotropin; Dehydroepiand | 1975 |
Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea.
Topics: Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Dehydroepiandrosterone; Epimestrol; Estradiol; Estr | 1978 |
The role of adrenocorticotropin testing in evaluating girls with premature adrenarche and hirsutism/oligomenorrhea.
Topics: 17-alpha-Hydroxyprogesterone; Acne Vulgaris; Adolescent; Adrenal Cortex; Adrenal Cortex Diseases; Ad | 1992 |
Reproductive hormones and bone mineral density in women runners.
Topics: Adolescent; Adult; Amenorrhea; Bone Density; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; | 1992 |
Is 3 alpha, 17 beta-androstanediol-glucuronide a diagnostic marker in women with androgenic manifestations?
Topics: Acne Vulgaris; Adolescent; Adult; Alopecia; Androgens; Androstane-3,17-diol; Biomarkers; Dehydroepia | 1992 |
Oestrogen and androgen states in oligo-amenorrhoeic women with polycystic ovaries.
Topics: Amenorrhea; Androgens; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estr | 1991 |
Predictors of clinical response in hirsute women treated with spironolactone.
Topics: Adolescent; Adult; Age Factors; Body Mass Index; Child; Contraceptives, Oral; Dehydroepiandrosterone | 1991 |
Menstrual dysfunction in hirsute women.
Topics: Adult; Androstenedione; Body Weight; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; | 1990 |
Cost effectiveness of routine gonadotropin and androgen measurements in hirsute women.
Topics: Adult; Androstenedione; Cost-Benefit Analysis; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfat | 1990 |
[Rational hormonal diagnosis of oligomenorrhea].
Topics: Adolescent; Adult; Amenorrhea; Body Weight; Dehydroepiandrosterone; Diagnosis, Differential; Female; | 1989 |