dehydroepiandrosterone has been researched along with Neurodegenerative Diseases in 9 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since chronic hyperglycemia is central to diabetic complications, and poorly differentiated cells are oxidatively more vulnerable, we currently investigated the effect of glycemic status on MG-induced apoptosis in naïve (nPC12) cells focusing on glutathione-to-glutathione disulfide (GSH/GSSG) redox signaling." | 3.73 | Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: relationship to cellular redox and activator protease factor-1 expression. ( Aw, TY; Okayama, N; Okouchi, M, 2005) |
| "Dehydroepiandrosterone (DHEA) is a multifunctional steroid with a broad range of biological effects in humans and animals." | 2.48 | Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports. ( El Kihel, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arbo, BD | 1 |
| Ribeiro, FS | 1 |
| Ribeiro, MF | 1 |
| Powrie, YSL | 1 |
| Smith, C | 1 |
| Grimm, A | 1 |
| Schmitt, K | 1 |
| Lang, UE | 1 |
| Mensah-Nyagan, AG | 1 |
| Eckert, A | 1 |
| Charalampopoulos, I | 1 |
| Remboutsika, E | 1 |
| Margioris, AN | 1 |
| Gravanis, A | 1 |
| El Kihel, L | 1 |
| Okouchi, M | 1 |
| Okayama, N | 1 |
| Aw, TY | 1 |
| Xie, L | 1 |
| Sun, HY | 1 |
| Gao, J | 1 |
| Liao, H | 1 |
| Bastianetto, S | 1 |
| Quirion, R | 1 |
| Lapchak, PA | 1 |
| Araujo, DM | 1 |
7 reviews available for dehydroepiandrosterone and Neurodegenerative Diseases
| Article | Year |
|---|---|
Astrocyte Neuroprotection and Dehydroepiandrosterone.
Topics: Animals; Astrocytes; Brain Injuries, Traumatic; Dehydroepiandrosterone; Humans; Neurodegenerative Di | 2018 |
Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?
Topics: Aging; Animals; Dehydroepiandrosterone; Encephalitis; Humans; Neurodegenerative Diseases | 2018 |
Neurosteroids as modulators of neurogenesis and neuronal survival.
Topics: Animals; Cell Proliferation; Cell Survival; Dehydroepiandrosterone; Humans; Models, Biological; Myel | 2008 |
Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports.
Topics: Androsterone; Animals; Brain; Cardiovascular Diseases; Dehydroepiandrosterone; Female; Humans; Hydro | 2012 |
[Functions and mechanisms of dehydroepiandrosterone in nervous system].
Topics: Animals; Apoptosis; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Neurodegenerativ | 2006 |
Any facts behind the DHEA hype?
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfa | 1997 |
Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases.
Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Neurodegenerative Diseases; | 2001 |
2 other studies available for dehydroepiandrosterone and Neurodegenerative Diseases
| Article | Year |
|---|---|
Improvement of neuronal bioenergetics by neurosteroids: implications for age-related neurodegenerative disorders.
Topics: Adenosine Triphosphate; Aging; Androstane-3,17-diol; Animals; Cell Line, Tumor; Cell Proliferation; | 2014 |
Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: relationship to cellular redox and activator protease factor-1 expression.
Topics: Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Brain; Cell Respiration; Dehydroepiandro | 2005 |