dehydroepiandrosterone has been researched along with Nerve Degeneration in 7 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results suggest that memory deficits in AD may be improved by sominone independently of reducing amyloid plaques and neuroinflammation." | 1.37 | Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD. ( Joyashiki, E; Matsuya, Y; Tohda, C, 2011) |
| "Pregnenolone was recently shown to potentiate the neuronal damage induced by excessive glutamate in cell culture models, whereas dehydroepiandrosterone was reported to present some neuroprotective activity." | 1.31 | Differential effect of dehydroepiandrosterone and its steroid precursor pregnenolone against the behavioural deficits in CO-exposed mice. ( Maurice, T; Phan, V; Sandillon, F; Urani, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, YK | 1 |
| Yoon, IY | 1 |
| Kim, JM | 1 |
| Jeong, SH | 1 |
| Kim, KW | 1 |
| Shin, YK | 1 |
| Kim, BS | 1 |
| Kim, SE | 1 |
| Joyashiki, E | 1 |
| Matsuya, Y | 1 |
| Tohda, C | 1 |
| Dudas, B | 1 |
| Hanin, I | 1 |
| Rose, M | 1 |
| Wülfert, E | 1 |
| Leskiewicz, M | 1 |
| Regulska, M | 1 |
| Budziszewska, B | 1 |
| Jantas, D | 1 |
| Jaworska-Feil, L | 1 |
| Basta-Kaim, A | 1 |
| Kubera, M | 1 |
| Jagla, G | 1 |
| Nowak, W | 1 |
| Lason, W | 1 |
| García-Nogales, P | 1 |
| Almeida, A | 1 |
| Fernández, E | 1 |
| Medina, JM | 1 |
| Bolaños, JP | 1 |
| Maurice, T | 1 |
| Phan, V | 1 |
| Sandillon, F | 1 |
| Urani, A | 1 |
| Näsman, B | 1 |
| Olsson, T | 1 |
| Bäckström, T | 1 |
| Eriksson, S | 1 |
| Grankvist, K | 1 |
| Viitanen, M | 1 |
| Bucht, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Establishing Alpha-synuclein Real Time - Quaking Induced Conversion (RT-QuIC) Assay as a Diagnostic Technique in Rapid Eye Movement (REM) Sleep Behaviour Disorder (RBD)[NCT04266457] | 0 participants (Actual) | Observational | 2021-09-01 | Withdrawn (stopped due to Study stopped after ethical approval but before first patient gave consent due to pandemic) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for dehydroepiandrosterone and Nerve Degeneration
| Article | Year |
|---|---|
The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder.
Topics: Aged; Ascorbic Acid; Caudate Nucleus; Chin; Cholecalciferol; Corpus Striatum; Dehydroepiandrosterone | 2010 |
Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD.
Topics: Alzheimer Disease; Animals; Axons; Cell Count; Cells, Cultured; Cerebral Cortex; Dehydroepiandroster | 2011 |
Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aziridines; Cell Death; Choline; Choline O-Acetyl | 2004 |
Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Brain; Cell Line, Tumor; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme I | 2008 |
Induction of glucose-6-phosphate dehydrogenase by lipopolysaccharide contributes to preventing nitric oxide-mediated glutathione depletion in cultured rat astrocytes.
Topics: Adjuvants, Immunologic; Animals; Astrocytes; Blotting, Northern; Cells, Cultured; Dehydroepiandroste | 1999 |
Differential effect of dehydroepiandrosterone and its steroid precursor pregnenolone against the behavioural deficits in CO-exposed mice.
Topics: Animals; Anisoles; Antipsychotic Agents; Behavior, Animal; Carbon Monoxide Poisoning; Dehydroepiandr | 2000 |
Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood-Brain Barrier; Dehydroepiandrosterone; Dehydroepia | 1991 |