dehydroepiandrosterone has been researched along with Multiple Sclerosis in 6 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, little is known about the bioavailability of endogenous steroids in the central nervous system (CNS) of MS patients." | 1.36 | Reduced cortisol levels in cerebrospinal fluid and differential distribution of 11beta-hydroxysteroid dehydrogenases in multiple sclerosis: implications for lesion pathogenesis. ( Buck, D; Buttmann, M; Häusler, SF; Heidbrink, C; Keller, A; Krockenberger, M; Laman, JD; Mehling, M; Mittelbronn, M; Ossadnik, M; Strik, HM; van Meurs, M; Verbraak, E; Wiendl, H; Wischhusen, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Amato, A | 1 |
| Ragonese, P | 1 |
| Ingoglia, S | 1 |
| Schiera, G | 1 |
| Schirò, G | 1 |
| Di Liegro, CM | 1 |
| Salemi, G | 1 |
| Di Liegro, I | 1 |
| Proia, P | 1 |
| Boghozian, R | 1 |
| McKenzie, BA | 1 |
| Saito, LB | 1 |
| Mehta, N | 1 |
| Branton, WG | 1 |
| Lu, J | 1 |
| Baker, GB | 1 |
| Noorbakhsh, F | 1 |
| Power, C | 1 |
| Aggelakopoulou, M | 1 |
| Kourepini, E | 1 |
| Paschalidis, N | 1 |
| Simoes, DC | 1 |
| Kalavrizioti, D | 1 |
| Dimisianos, N | 1 |
| Papathanasopoulos, P | 1 |
| Mouzaki, A | 1 |
| Panoutsakopoulou, V | 1 |
| Heidbrink, C | 1 |
| Häusler, SF | 1 |
| Buttmann, M | 1 |
| Ossadnik, M | 1 |
| Strik, HM | 1 |
| Keller, A | 1 |
| Buck, D | 1 |
| Verbraak, E | 1 |
| van Meurs, M | 1 |
| Krockenberger, M | 1 |
| Mehling, M | 1 |
| Mittelbronn, M | 1 |
| Laman, JD | 1 |
| Wiendl, H | 1 |
| Wischhusen, J | 1 |
| Ramsaransing, GS | 1 |
| Heersema, DJ | 1 |
| De Keyser, J | 1 |
| Dougados, M | 1 |
| Nahoul, K | 1 |
| Benhamou, L | 1 |
| Jungers, P | 1 |
| Laplane, D | 1 |
| Amor, B | 1 |
1 trial available for dehydroepiandrosterone and Multiple Sclerosis
| Article | Year |
|---|---|
Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach.
Topics: Adult; Biomarkers; Brain-Derived Neurotrophic Factor; Dehydroepiandrosterone; Exercise; Exercise The | 2021 |
5 other studies available for dehydroepiandrosterone and Multiple Sclerosis
| Article | Year |
|---|---|
Suppressed oligodendrocyte steroidogenesis in multiple sclerosis: Implications for regulation of neuroinflammation.
Topics: Animals; Astrocytes; Case-Control Studies; Cells, Cultured; Central Nervous System; Cytokines; Dehyd | 2017 |
ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.
Topics: Animals; Autoimmunity; Cell Proliferation; Cells, Cultured; Central Nervous System; Dehydroepiandros | 2016 |
Reduced cortisol levels in cerebrospinal fluid and differential distribution of 11beta-hydroxysteroid dehydrogenases in multiple sclerosis: implications for lesion pathogenesis.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; 11-beta-Hy | 2010 |
Serum uric acid, dehydroepiandrosterone sulphate, and apolipoprotein E genotype in benign vs. progressive multiple sclerosis.
Topics: Adult; Apolipoproteins E; Dehydroepiandrosterone; Disease Progression; Female; Genotype; Humans; Mal | 2005 |
[Study of plasma androgens in women with autoimmune diseases].
Topics: Adolescent; Adult; Androgens; Androstenedione; Arthritis, Rheumatoid; Autoimmune Diseases; Dehydroep | 1984 |