dehydroepiandrosterone has been researched along with Metastase in 38 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-five patients with actively progressing advanced breast cancer were treated with aminoglutethimide, a drug which inhibits adrenal steroid synthesis and decreases peripheral conversion of androgens to oestrogens." | 7.66 | Medical adrenalectomy with aminoglutethimide in the management of advanced breast cancer. ( Jerums, G; Murray, RM; Pitt, P, 1981) |
| "40), but not for MPA and estrone, indicating better adrenal suppression by higher MPA dosage and plasma levels." | 6.66 | Endocrine effects of medroxyprogesterone acetate: relation between plasma levels and suppression of adrenal steroids in patients with breast cancer. ( Doorenbos, H; Sleijfer, DT; Sluiter, WJ; van Veelen, H; Willemse, PH, 1985) |
| " While this regimen effectively blocked adrenal function, it was complicated by a drug interaction in which aminoglutethimide accelerated the metabolism and reduced the bioavailability of dexamethasone." | 6.36 | Kinetic, hormonal and clinical studies with aminoglutethimide in breast cancer. ( Harvey, H; Kendall, J; Lipton, A; Ruby, EB; Samojlik, E; Santen, RJ; Wells, SA, 1977) |
| "Sixty-five patients with actively progressing advanced breast cancer were treated with aminoglutethimide, a drug which inhibits adrenal steroid synthesis and decreases peripheral conversion of androgens to oestrogens." | 3.66 | Medical adrenalectomy with aminoglutethimide in the management of advanced breast cancer. ( Jerums, G; Murray, RM; Pitt, P, 1981) |
| "40), but not for MPA and estrone, indicating better adrenal suppression by higher MPA dosage and plasma levels." | 2.66 | Endocrine effects of medroxyprogesterone acetate: relation between plasma levels and suppression of adrenal steroids in patients with breast cancer. ( Doorenbos, H; Sleijfer, DT; Sluiter, WJ; van Veelen, H; Willemse, PH, 1985) |
| " While this regimen effectively blocked adrenal function, it was complicated by a drug interaction in which aminoglutethimide accelerated the metabolism and reduced the bioavailability of dexamethasone." | 2.36 | Kinetic, hormonal and clinical studies with aminoglutethimide in breast cancer. ( Harvey, H; Kendall, J; Lipton, A; Ruby, EB; Samojlik, E; Santen, RJ; Wells, SA, 1977) |
| "Cell invasion and metastasis were measured by cell invasion assays." | 1.56 | Relationship between CYP17A1-Mediated DNA Demethylation and Proliferation, Invasion and Metastasis of Glioma Cells. ( Lv, W; Meng, L; Zhou, Y, 2020) |
| "Ketoconazole can suppress androgen production and has a beneficial role in the hormonal therapy of patients with prostate cancer who have not undergone orchiectomy." | 1.27 | High-dose ketoconazole therapy in patients with metastatic prostate cancer. ( Al-Sarraf, M; Decker, DA; Kresge, C; Subramanian, MG; Tapazoglou, E, 1986) |
| "There months following surgery, liver metastases were documented associated with elevated levels of serum androgens." | 1.26 | Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens. ( Korth-Schutz, S; Levine, LS; New, MI; Roth, JA; Saenger, P, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (78.95) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 4 (10.53) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Meng, L | 1 |
| Lv, W | 1 |
| Zhou, Y | 1 |
| Qin, S | 1 |
| Liu, D | 1 |
| Kohli, M | 1 |
| Wang, L | 2 |
| Vedell, PT | 1 |
| Hillman, DW | 1 |
| Niu, N | 1 |
| Yu, J | 1 |
| Weinshilboum, RM | 1 |
| Labrie, F | 1 |
| López-Marure, R | 1 |
| Zapata-Gómez, E | 1 |
| Rocha-Zavaleta, L | 1 |
| Aguilar, MC | 1 |
| Espinosa Castilla, M | 1 |
| Meléndez Zajgla, J | 1 |
| Meraz-Cruz, N | 1 |
| Huesca-Gómez, C | 1 |
| Gamboa-Ávila, R | 1 |
| Gómez-González, EO | 1 |
| Ali, M | 1 |
| Heyob, K | 1 |
| Jacob, NK | 1 |
| Rogers, LK | 1 |
| GALLAGHER, TF | 1 |
| SPENCER, H | 1 |
| BRADLOW, HL | 2 |
| ALLEN, L | 1 |
| HELLMAN, L | 2 |
| KHATTAB, AA | 1 |
| BARON, DN | 1 |
| ADAMS, JB | 1 |
| Spiegel, D | 1 |
| Giese-Davis, J | 1 |
| Taylor, CB | 1 |
| Kraemer, H | 1 |
| Stuart-Harris, RC | 1 |
| Smith, IE | 1 |
| Gropp, C | 1 |
| Havemann, K | 1 |
| Scheuer, A | 1 |
| Murray, RM | 1 |
| Pitt, P | 1 |
| Jerums, G | 1 |
| Bencsik, Z | 1 |
| Szabolcs, I | 1 |
| Kovács, Z | 1 |
| Ferencz, A | 1 |
| Vörös, A | 1 |
| Kaszás, I | 1 |
| Bor, K | 1 |
| Gönczi, J | 1 |
| Góth, M | 1 |
| Kovács, L | 1 |
| Dohán, O | 1 |
| Szilágyi, G | 1 |
| Maeyama, M | 1 |
| Ifuku, M | 1 |
| Nakahara, K | 1 |
| Walsh, PC | 1 |
| Siiteri, PK | 1 |
| Deshpande, N | 3 |
| Görlich, M | 1 |
| Heise, E | 1 |
| O'Higgins, NJ | 1 |
| Carson, P | 1 |
| Mitchell, I | 1 |
| Korth-Schutz, S | 1 |
| Levine, LS | 1 |
| Roth, JA | 1 |
| Saenger, P | 1 |
| New, MI | 1 |
| Wang, DY | 1 |
| Bulbrook, RD | 2 |
| Hayward, JL | 1 |
| Santen, RJ | 1 |
| Samojlik, E | 1 |
| Lipton, A | 1 |
| Harvey, H | 1 |
| Ruby, EB | 1 |
| Wells, SA | 1 |
| Kendall, J | 1 |
| Meikle, AW | 1 |
| Cardoso de Sousa, JC | 1 |
| Ward, JH | 1 |
| Woodward, M | 1 |
| Samlowski, WE | 1 |
| Geller, J | 1 |
| Albert, JD | 1 |
| Tapazoglou, E | 1 |
| Subramanian, MG | 1 |
| Al-Sarraf, M | 1 |
| Kresge, C | 1 |
| Decker, DA | 1 |
| van Veelen, H | 1 |
| Willemse, PH | 1 |
| Sleijfer, DT | 1 |
| Sluiter, WJ | 1 |
| Doorenbos, H | 1 |
| Argüelles, AE | 1 |
| Poggi, UL | 1 |
| Saborida, C | 1 |
| Hoffman, C | 1 |
| Chekherdemian, M | 1 |
| Blanchard, O | 1 |
| Uemura, J | 1 |
| Okamura, T | 1 |
| Noto, S | 1 |
| Kida, R | 1 |
| Kenny, FM | 1 |
| Hashida, Y | 1 |
| Askari, HA | 1 |
| Sieber, WH | 1 |
| Fetterman, GH | 1 |
| Dao, TL | 3 |
| Libby, PR | 3 |
| Kirschner, MA | 1 |
| Wider, JA | 1 |
| Ross, GT | 1 |
| Morii, H | 1 |
| Tanae, A | 1 |
| Ibayashi, H | 1 |
| Nakao, K | 1 |
| Zumoff, B | 1 |
| Bordiushkov, IuN | 1 |
| Mindlin, SS | 1 |
| Verkhovtseva, AI | 1 |
| Leung, BS | 1 |
| Jack, W | 1 |
| Wood, DC | 1 |
| Morimoto, Y | 1 |
| Hiwada, K | 1 |
| Nanahoshi, M | 1 |
| Yano, S | 1 |
| Kumagai, A | 1 |
| Yamamura, Y | 1 |
| Koto, K | 1 |
| Uda, H | 1 |
| Okano, K | 1 |
| Yamane, G | 1 |
| Jensen, V | 1 |
| Doouss, TW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PROstate Cancer Medically Optimized Genome Enhanced ThErapy (PROMOTE)[NCT01953640] | 92 participants (Actual) | Observational | 2013-05-28 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for dehydroepiandrosterone and Metastase
| Article | Year |
|---|---|
Combined blockade of testicular and locally made androgens in prostate cancer: a highly significant medical progress based upon intracrinology.
Topics: Androgen Antagonists; Androgens; Androstenes; Androstenols; Animals; Antineoplastic Agents; Benzamid | 2015 |
Aminoglutethimide in the treatment of advanced breast cancer.
Topics: Adrenalectomy; Aged; Aminoglutethimide; Androstenedione; Breast Neoplasms; Clinical Trials as Topic; | 1984 |
Kinetic, hormonal and clinical studies with aminoglutethimide in breast cancer.
Topics: Adrenocorticotropic Hormone; Aldosterone; Aminoglutethimide; Androstenedione; Breast Neoplasms; Dehy | 1977 |
Adrenal androgen blockade in relapsed prostate cancer.
Topics: Adrenalectomy; Aminoglutethimide; Androgen Antagonists; Castration; Combined Modality Therapy; Cypro | 1985 |
3 trials available for dehydroepiandrosterone and Metastase
| Article | Year |
|---|---|
Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function.
Topics: Adrenocorticotropic Hormone; Adult; Arousal; Breast Neoplasms; Circadian Rhythm; Dehydroepiandroster | 2006 |
Aminoglutethimide in the treatment of advanced breast cancer.
Topics: Adrenalectomy; Aged; Aminoglutethimide; Androstenedione; Breast Neoplasms; Clinical Trials as Topic; | 1984 |
Endocrine effects of medroxyprogesterone acetate: relation between plasma levels and suppression of adrenal steroids in patients with breast cancer.
Topics: Adrenal Glands; Aged; Androstenedione; Breast Neoplasms; Clinical Trials as Topic; Dehydroepiandrost | 1985 |
32 other studies available for dehydroepiandrosterone and Metastase
| Article | Year |
|---|---|
Relationship between CYP17A1-Mediated DNA Demethylation and Proliferation, Invasion and Metastasis of Glioma Cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dehydroepiandrosterone; DNA Demethyl | 2020 |
TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer.
Topics: Abiraterone Acetate; Cell Cycle Proteins; Cell Proliferation; Cytochrome P-450 CYP3A; Cytochrome P-4 | 2018 |
Dehydroepiandrosterone inhibits events related with the metastatic process in breast tumor cell lines.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Growth Processes; Cell Line, Tumor; Cell Movement; | 2016 |
Alterative Expression and Localization of Profilin 1/VASPpS157 and Cofilin 1/VASPpS239 Regulates Metastatic Growth and Is Modified by DHA Supplementation.
Topics: Apoptosis; Biomarkers; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cofil | 2016 |
Steroid production and metabolism in metastatic arrhenoblastoma.
Topics: Adrenocorticotropic Hormone; Dehydroepiandrosterone; Diethylstilbestrol; Female; Humans; Male; Methy | 1962 |
DIFFERENTIAL 17-OXOSTEROID EXCRETION IN WOMEN WITH CANCER OF THE BREAST FOLLOWING HYPOPHYSECTOMY.
Topics: 17-Ketosteroids; Androsterone; Breast; Breast Neoplasms; Chromatography; Dehydroepiandrosterone; Eti | 1964 |
ENZYMIC SYNTHESIS OF STEROID SULFATES. II.
Topics: Adenine Nucleotides; Androsterone; Breast Neoplasms; Cortisone; Dehydroepiandrosterone; Drug Therapy | 1964 |
Ectopic hormones in lung cancer patients at diagnosis and during therapy.
Topics: Adrenocorticotropic Hormone; Calcitonin; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, | 1980 |
Medical adrenalectomy with aminoglutethimide in the management of advanced breast cancer.
Topics: Adrenal Glands; Aminoglutethimide; Breast Neoplasms; Dehydroepiandrosterone; Dehydroepiandrosterone | 1981 |
Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors.
Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and ov | 1996 |
Steroidogenesis in cerebral metastatic chorionepithelioma tissue in vitro.
Topics: 17-alpha-Hydroxypregnenolone; Androstenedione; Brain Neoplasms; Choriocarcinoma; Dehydroepiandroster | 1975 |
Suppression of plasma androgens by spironolactone in castrated men with carcinoma of the prostate.
Topics: Aged; Androgens; Androstenedione; Castration; Dehydroepiandrosterone; Depression, Chemical; Humans; | 1975 |
Hormonal imbalance in breast cancer.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Androgens; Androstenedione; Breast Neoplasms; Cholesterol; | 1975 |
Urinary excretion of 17-ketosteroids in patients suffering from mammary cancer.
Topics: 17-Ketosteroids; Aged; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Me | 1975 |
Adrenal function in breast cancer: the metabolism of pregnenolone in breast cancer patients.
Topics: Adrenal Cortex Function Tests; Adult; Aged; Breast Neoplasms; Dehydroepiandrosterone; Female; Humans | 1976 |
Virilizing adrenal tumor in a child suppressed with dexamethasone for three years. Effect of o,p'-DDD on serum and urinary androgens.
Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Androgens; Child, Preschool; | 1977 |
Plasma androstenedione levels in women with breast cancer.
Topics: 17-Ketosteroids; Aged; Androstenedione; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Fema | 1977 |
Reduction of testosterone synthesis after high dose interleukin-2 therapy of metastatic cancer.
Topics: Adult; Carcinoma, Renal Cell; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Fol | 1991 |
High-dose ketoconazole therapy in patients with metastatic prostate cancer.
Topics: Adenocarcinoma; Aged; Androstenedione; Combined Modality Therapy; Dehydroepiandrosterone; Dexamethas | 1986 |
Endocrine profiles and breast cancer.
Topics: 11-Hydroxycorticosteroids; Adult; Aged; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estriol | 1973 |
[Clinical trial of dehydroisoandrosterone for terminal cases of malignant tumors].
Topics: Adult; Aged; Antineoplastic Agents; Dehydroepiandrosterone; Female; Humans; Male; Middle Aged; Neopl | 1966 |
Virilizing tumors of the adrenal cortex.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adenoma; Adrenal Gland Neoplasms; Adrenal | 1968 |
Conjugation of steroid hormones by normal and neoplastic tissues.
Topics: Adult; Aged; Breast; Breast Neoplasms; Chromatography, Paper; Dehydroepiandrosterone; Desoxycorticos | 1968 |
Conjugation of steroid hormones by breast cancer tissue and selection of patients for adrenalectomy.
Topics: Adrenalectomy; Aged; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estrone; Humans; Liver; Li | 1969 |
Leydig cell function in men with gonadotrophin-producing testicular tumors.
Topics: Adult; Choriocarcinoma; Chorionic Gonadotropin; Chromatography, Gas; Dehydroepiandrosterone; Electro | 1970 |
Effects of calcitonin in metastatic bone carcinoma, osteoporosis, polyostotic fibrous dysplasia and hypercalcemia.
Topics: Adenocarcinoma; Adult; Aged; Alkaline Phosphatase; Bone Neoplasms; Calcitonin; Calcium; Child, Presc | 1971 |
Decreased conversion of androgens to normal 17-ketosteroid metabolites as a result of treatment with o,p'-DDD.
Topics: Adrenal Gland Neoplasms; Androsterone; Anemia, Pernicious; Carbon Isotopes; Dehydroepiandrosterone; | 1973 |
[The mechanism of action of hydrocortisone administered by lumbar puncture in breast cancer].
Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Br | 1973 |
Steroid sulfurylation in normal tissues and mammary tumors: a micro method.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Adult; Aged; Animals; Binding Sites; Breast Neoplas | 1972 |
Conjugation of steroid hormones by breast-cancer tissue and selection of patients for adrenalectomy.
Topics: Adrenalectomy; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estrogens, Conjugated (USP); Fem | 1969 |
Cushing's syndrome caused by malignant tumor in the scrotum: clinical, pathologic and biochemical studies.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Rest Tumor; Adrenocorticotropic Hormone; Androst | 1971 |
The effect of NADPH on steroidogenesis by the human adrenal gland in vivo.
Topics: Adrenal Glands; Adrenalectomy; Breast Neoplasms; Castration; Dehydroepiandrosterone; Female; Humans; | 1969 |