dehydroepiandrosterone has been researched along with Metabolic Syndrome in 16 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dehydroepiandrosterone (DHEA) administration has been shown to reduce accumulation of abdominal visceral fat and protect against insulin resistance in laboratory animals, but it is not known whether DHEA decreases abdominal obesity in humans." | 5.11 | Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. ( Holloszy, JO; Villareal, DT, 2004) |
| " Dehydroepiandrosterone (DHEA), a major circulating adrenal steroid and dietary supplement, demonstrates antiobesity, anti-inflammatory, GC-opposing and immune-modulating activity when administered to rodents." | 3.77 | A potential role for 5-androstene-3β,7β,17β-triol in obesity and metabolic syndrome. ( Ahlem, CN; Auci, DL; Frincke, JM; Kennedy, MR; Page, TM; Reading, CL, 2011) |
| "The aim of our study was to assess selected negative (transferrin) and positive (alpha1-antichymotrypsin [alpha1-ACT], C-reactive protein [CRP]) acute phase proteins, and to investigate associations between these proteins and serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels, as well as anthropometrical and biochemical indices of metabolic syndrome (MS) in men over 40 years of age." | 3.75 | Assessment of selected serum inflammatory markers of acute phase response and their correlations with adrenal androgens and metabolic syndrome in a population of men over the age of 40. ( Herman, WA; Korczowska, I; Lacka, K; Seńko, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| El-Zawawy, HT | 1 |
| El-Aghoury, AA | 1 |
| Katri, KM | 1 |
| El-Sharkawy, EM | 1 |
| Gad, SMS | 1 |
| Pereira, A | 1 |
| Merino, PM | 1 |
| Santos, JL | 1 |
| Iñiguez, G | 1 |
| Cutler, GB | 1 |
| Corvalan, C | 1 |
| Mericq, V | 1 |
| Teixeira, CJ | 1 |
| Veras, K | 1 |
| de Oliveira Carvalho, CR | 1 |
| Grzesiak, K | 1 |
| Rył, A | 1 |
| Ratajczak, W | 1 |
| Stachowska, E | 1 |
| Rotter, I | 1 |
| Słojewski, M | 1 |
| Sipak, O | 1 |
| Walczakiewicz, K | 1 |
| Laszczyńska, M | 1 |
| Kim, C | 1 |
| Halter, JB | 1 |
| Vuksan-Ćusa, B | 1 |
| Sagud, M | 1 |
| Mihaljević-Peleš, A | 1 |
| Jakšić, N | 1 |
| Jakovljević, M | 1 |
| Manco, M | 1 |
| Bottazzo, G | 1 |
| Herman, WA | 3 |
| Seńko, A | 2 |
| Korczowska, I | 2 |
| Łacka, K | 1 |
| Lacka, K | 2 |
| Auci, DL | 1 |
| Ahlem, CN | 1 |
| Kennedy, MR | 1 |
| Page, TM | 1 |
| Reading, CL | 1 |
| Frincke, JM | 1 |
| Rasmusson, AM | 1 |
| Schnurr, PP | 1 |
| Zukowska, Z | 1 |
| Scioli, E | 1 |
| Forman, DE | 1 |
| Kaufman, E | 1 |
| Wójcicka, M | 1 |
| Kramer, L | 1 |
| Losy, J | 1 |
| Mieczkowska, J | 1 |
| Mosiewicz, J | 1 |
| Sak, J | 1 |
| Grzybowski, A | 1 |
| Terlecki, P | 1 |
| Barud, W | 1 |
| Kwaśniewski, W | 1 |
| Tutka, P | 1 |
| Cicero, AF | 1 |
| Magni, P | 1 |
| Moré, M | 1 |
| Ruscica, M | 1 |
| Borghi, C | 1 |
| Strollo, F | 1 |
| Villareal, DT | 1 |
| Holloszy, JO | 1 |
| Howard, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biologic Effects of DHEA in Humans[NCT00099697] | 56 participants | Interventional | 2001-06-30 | Completed | |||
| Biological Effects of DHEA in the Elderly[NCT00111930] | 144 participants | Interventional | 2000-08-31 | Completed | |||
| DHEA+Exercise-Effect on Sarcopenia and Osteopenia of Aging[NCT00205686] | Phase 3 | 64 participants | Interventional | 2001-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dehydroepiandrosterone and Metabolic Syndrome
| Article | Year |
|---|---|
Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period.
Topics: Aged; Aged, 80 and over; Aging; Animals; Cardiovascular Diseases; Cardiovascular System; Dehydroepia | 2020 |
Endogenous sex hormones, metabolic syndrome, and diabetes in men and women.
Topics: Age Factors; Androgens; Biomarkers; Blood Glucose; Cross-Sectional Studies; Dehydroepiandrosterone; | 2014 |
Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome.
Topics: Adaptation, Physiological; Animals; Dehydroepiandrosterone; Female; Glucocorticoids; Humans; Hydroco | 2010 |
2 trials available for dehydroepiandrosterone and Metabolic Syndrome
| Article | Year |
|---|---|
The associations between iL-18 serum levels and the prevalence of metabolic syndrome in Polish men over the age of 40 according to other selected inflammatory indices and androgens: comparison of NCEP with IDF criteria.
Topics: Adult; Age Factors; Aged; Dehydroepiandrosterone; Humans; Inflammation Mediators; Interleukin-18; Ma | 2011 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
Topics: Abdomen; Adipose Tissue; Aged; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Female; G | 2004 |
11 other studies available for dehydroepiandrosterone and Metabolic Syndrome
| Article | Year |
|---|---|
Cortisol/DHEA ratio in morbidly obese patients before and after bariatric surgery: Relation to metabolic parameters and cardiovascular performance.
Topics: Adult; Bariatric Surgery; Dehydroepiandrosterone; Echocardiography; Female; Humans; Hydrocortisone; | 2022 |
High DHEAS in girls and metabolic features throughout pubertal maturation.
Topics: Adolescent; Adrenarche; Body Mass Index; Child; Cohort Studies; Dehydroepiandrosterone; Dehydroepian | 2022 |
Influence of metabolic syndrome on the relationship between fatty acids and the selected parameters in men with benign prostatic hyperplasia.
Topics: Aged; Aged, 80 and over; Dehydroepiandrosterone; Fatty Acids; Female; Humans; Insulin; Insulin-Like | 2019 |
Metabolic syndrome and cortisol/DHEAS ratio in patients with bipolar disorder and schizophrenia.
Topics: Adult; Bipolar Disorder; Blood Pressure; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Mal | 2014 |
Does the hormone of eternal youth protect against nonalcoholic steatohepatitis?
Topics: Adiponectin; Dehydroepiandrosterone; Disease Progression; Fatty Acids, Nonesterified; Fatty Liver; H | 2008 |
[Could serum DHEA and DHEAS levels be good risk predictors of metabolic syndrome and osteoporosis in the population of ageing men?].
Topics: Adult; Aged; Aged, 80 and over; Aging; Comorbidity; Dehydroepiandrosterone; Dementia; Humans; Hypert | 2009 |
Assessment of selected serum inflammatory markers of acute phase response and their correlations with adrenal androgens and metabolic syndrome in a population of men over the age of 40.
Topics: Acute-Phase Proteins; Adult; Age Factors; Aged; Aged, 80 and over; Aging; alpha 1-Antichymotrypsin; | 2009 |
A potential role for 5-androstene-3β,7β,17β-triol in obesity and metabolic syndrome.
Topics: Adult; Aged; Aged, 80 and over; Androstenols; Anti-Inflammatory Agents; Anti-Obesity Agents; Body Ma | 2011 |
Effects of cigarette smoking, metabolic syndrome and dehydroepiandrosterone deficiency on intima-media thickness and endothelial function in hypertensive postmenopausal women.
Topics: Anthropometry; Biomarkers; Blood Pressure; Carotid Intima-Media Thickness; Dehydroepiandrosterone; D | 2012 |
Metabolic syndrome, adipokines and hormonal factors in pharmacologically untreated adult elderly subjects from the Brisighella Heart Study historical cohort.
Topics: Adiponectin; Aged; Biomarkers; Case-Control Studies; Cohort Studies; Dehydroepiandrosterone; Estrone | 2012 |
Common factor of cancer and the metabolic syndrome may be low DHEA.
Topics: Dehydroepiandrosterone; Humans; Metabolic Syndrome; Neoplasms; United States | 2007 |