dehydroepiandrosterone has been researched along with Malaria, Falciparum in 3 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the behavior of cortisol and dehydroepiandrosterone (DHEA) in 24 patients with uncomplicated Plasmodium falciparum malaria of the Evandro Chagas Institute, Belém, Pará, Brazil." | 7.73 | Some aspects of the behavior of the hypothalamus-pituitary-adrenal axis in patients with uncomplicated Plasmodium falciparum malaria: Cortisol and dehydroepiandrosterone levels. ( de Mendonça, BB; de Souza, JM; Libonati, RM; Maués, JA; Quaresma, JA, 2006) |
| "We studied the behavior of cortisol and dehydroepiandrosterone (DHEA) in 24 patients with uncomplicated Plasmodium falciparum malaria of the Evandro Chagas Institute, Belém, Pará, Brazil." | 3.73 | Some aspects of the behavior of the hypothalamus-pituitary-adrenal axis in patients with uncomplicated Plasmodium falciparum malaria: Cortisol and dehydroepiandrosterone levels. ( de Mendonça, BB; de Souza, JM; Libonati, RM; Maués, JA; Quaresma, JA, 2006) |
| "Dehydroepiandrosterone (DHEA) was utilised for inhibiting the G6PD activity of erythrocytes." | 1.46 | The effect and mechanism of inhibiting glucose-6-phosphate dehydrogenase activity on the proliferation of Plasmodium falciparum. ( Chen, X; Fang, Z; Feng, Y; Jiang, C; Jiang, W; Zhang, Z, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Z | 1 |
| Chen, X | 1 |
| Jiang, C | 1 |
| Fang, Z | 1 |
| Feng, Y | 1 |
| Jiang, W | 1 |
| Ayi, K | 1 |
| Giribaldi, G | 1 |
| Skorokhod, A | 1 |
| Schwarzer, E | 1 |
| Prendergast, PT | 1 |
| Arese, P | 1 |
| Libonati, RM | 1 |
| de Mendonça, BB | 1 |
| Maués, JA | 1 |
| Quaresma, JA | 1 |
| de Souza, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Etude de l'Activite (Efficacite et Tolerance) de l'Association de la Chloroquine Avec la Dehydroepiandrosterone-Sulfate (Dheas) Dans le Traitement de l'Acces Palustre Simple A Plasmodium Falciparum[NCT00442403] | Phase 3 | 200 participants | Interventional | 2002-04-30 | Suspended (stopped due to At the end of the year 2002, Cameroon switched from chloroquine to amodiaquine as first-line therapy for of uncomplicated malaria.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for dehydroepiandrosterone and Malaria, Falciparum
| Article | Year |
|---|---|
The effect and mechanism of inhibiting glucose-6-phosphate dehydrogenase activity on the proliferation of Plasmodium falciparum.
Topics: Antimalarials; Cells, Cultured; Dehydroepiandrosterone; Erythrocyte Membrane; Erythrocytes; Glucosep | 2017 |
16alpha-bromoepiandrosterone, an antimalarial analogue of the hormone dehydroepiandrosterone, enhances phagocytosis of ring stage parasitized erythrocytes: a novel mechanism for antimalarial activity.
Topics: Adult; Androsterone; Animals; Antimalarials; Cell Membrane; Dehydroepiandrosterone; Dehydroepiandros | 2002 |
Some aspects of the behavior of the hypothalamus-pituitary-adrenal axis in patients with uncomplicated Plasmodium falciparum malaria: Cortisol and dehydroepiandrosterone levels.
Topics: Adolescent; Adult; Animals; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Hypothalamo-Hypo | 2006 |