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dehydroepiandrosterone and Lung Neoplasms

dehydroepiandrosterone has been researched along with Lung Neoplasms in 22 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"Cortisol production by hepatocellular carcinoma (HCC) has not been previously reported and dehydroepiandrosterone (DHEA) secretion by HCC is rare."3.81Possible ACTH-independent, cortisol-secreting and DHEA-secreting metastatic hepatocellular carcinoma causing Cushing's syndrome. ( Bahtiyar, G; Inoue, T; Sacerdote, A; Thomas, N, 2015)
"Gefitinib treatment significantly suppressed androgen levels, especially in women who had no smoking history."2.71Gefitinib treatment affects androgen levels in non-small-cell lung cancer patients. ( Horai, T; Horiike, A; Ishikawa, Y; Nakagawa, K; Nishio, K; Nishio, M; Ohyanagi, F; Okumura, S; Satoh, Y, 2005)
" In vitro, all compounds demonstrated growth inhibition at a dose-response manner; however, manumycin, gliotoxin, and DHEA demonstrated an initial increase in growth rate at lower doses."1.31Chemopreventive efficacy of promising farnesyltransferase inhibitors. ( Crist, KA; Hara, M; Lantry, LE; Lubet, RA; Wang, Y; You, M; Zeeck, A; Zhang, Z, 2000)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199013 (59.09)18.7374
1990's4 (18.18)18.2507
2000's3 (13.64)29.6817
2010's2 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sacerdote, A1
Inoue, T1
Thomas, N1
Bahtiyar, G1
Ali, M1
Heyob, K1
Jacob, NK1
Rogers, LK1
PIPINO, G1
Nishio, M1
Ohyanagi, F1
Horiike, A1
Ishikawa, Y1
Satoh, Y1
Okumura, S1
Nakagawa, K1
Nishio, K1
Horai, T1
Kent, S1
Gropp, C1
Havemann, K1
Scheuer, A1
Schwartz, AG2
Tannen, RH1
Forst, T1
Beyer, J1
Cordes, U1
Pfützner, A1
Küstner, E1
Moll, R1
Bockisch, A1
Lehnert, H1
Terzolo, M1
Osella, G1
Alì, A1
Reimondo, G1
Borretta, G1
Magro, GP1
Luceri, S1
Paccotti, P1
Angeli, A1
Taggart, DP1
Gray, CE1
Bowman, A1
Faichney, A1
Davidson, KG1
Pashko, LL1
Provost, PR1
Blomquist, CH1
Godin, C1
Huang, XF1
Flamand, N1
Luu-The, V1
Nadeau, D1
Tremblay, Y1
Lantry, LE1
Zhang, Z1
Crist, KA1
Wang, Y1
Hara, M1
Zeeck, A1
Lubet, RA1
You, M1
Miller, WR1
Shivas, AA1
Forrest, AP1
Moore, MA2
Thamavit, W1
Tsuda, H1
Sato, K1
Ichihara, A1
Ito, N1
Weber, E1
Thornton, M1
Bannasch, P1
Rao, LG1
Kenny, FM1
Hashida, Y1
Askari, HA1
Sieber, WH1
Fetterman, GH1
Detter, F1
Kollmeier, W1
Klingmüller, V1
Kirschner, MA2
Wider, JA1
Ross, GT1
Menzel, P1
Penzes, L1
Matzander, U1
Oertel, GW1
Cohen, FB1
Jespersen, D1

Reviews

1 review available for dehydroepiandrosterone and Lung Neoplasms

ArticleYear
Adrenal incidentaloma, a five year experience.
    Minerva endocrinologica, 1995, Volume: 20, Issue:1

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Aged; Algorithms; Carcinoma; C

1995

Trials

1 trial available for dehydroepiandrosterone and Lung Neoplasms

ArticleYear
Gefitinib treatment affects androgen levels in non-small-cell lung cancer patients.
    British journal of cancer, 2005, May-23, Volume: 92, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dehydroepiand

2005

Other Studies

20 other studies available for dehydroepiandrosterone and Lung Neoplasms

ArticleYear
Possible ACTH-independent, cortisol-secreting and DHEA-secreting metastatic hepatocellular carcinoma causing Cushing's syndrome.
    BMJ case reports, 2015, Dec-23, Volume: 2015

    Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Biopsy

2015
Alterative Expression and Localization of Profilin 1/VASPpS157 and Cofilin 1/VASPpS239 Regulates Metastatic Growth and Is Modified by DHA Supplementation.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:9

    Topics: Apoptosis; Biomarkers; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cofil

2016
[CLINICAL EVALUATION OF THE PROTEO-ANABOLIC ACTIVITY OF L-METHYL-DELTA ANDROSTENOLONE IN PATIENTS WITH MALIGNANT NEOPLASMS DURING ACTINOTHERAPY].
    Minerva medica, 1964, Aug-18, Volume: 55

    Topics: Anabolic Agents; Blood Protein Electrophoresis; Breast Neoplasms; Carcinoma, Bronchogenic; Cobalt Is

1964
DHEA: "miracle" drug?
    Geriatrics, 1982, Volume: 37, Issue:9

    Topics: Adrenal Glands; Adult; Aged; Aging; Animals; Breast Neoplasms; Colonic Neoplasms; Dehydroepiandroste

1982
Ectopic hormones in lung cancer patients at diagnosis and during therapy.
    Cancer, 1980, Jul-15, Volume: 46, Issue:2

    Topics: Adrenocorticotropic Hormone; Calcitonin; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma,

1980
Inhibition of 7,12-dimethylbenz[a]anthracene- and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone.
    Carcinogenesis, 1981, Volume: 2, Issue:12

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Body Weight; Dehydroepiandrosterone;

1981
Gynaecomastia in a patient with a hCG producing giant cell carcinoma of the lung. Case report.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1995, Volume: 103, Issue:1

    Topics: Adult; Carcinoma, Giant Cell; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehydroepiandrosterone

1995
Serum androgens and gonadotrophins in bronchial carcinoma.
    Respiratory medicine, 1993, Volume: 87, Issue:6

    Topics: Adult; Androgens; Androstenedione; Carcinoma, Bronchogenic; Dehydroepiandrosterone; Discriminant Ana

1993
Inhibition of 7,12-dimethylbenz[a]anthracene-induced lung tumorigenesis in A/J mice by food restriction is reversed by adrenalectomy.
    Carcinogenesis, 1996, Volume: 17, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenalectomy; Animals; Carcinogens; Corticosterone; Dehydroepiand

1996
Androgen formation and metabolism in the pulmonary epithelial cell line A549: expression of 17beta-hydroxysteroid dehydrogenase type 5 and 3alpha-hydroxysteroid dehydrogenase type 3.
    Endocrinology, 2000, Volume: 141, Issue:8

    Topics: 17-Hydroxysteroid Dehydrogenases; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroi

2000
Chemopreventive efficacy of promising farnesyltransferase inhibitors.
    Experimental lung research, 2000, Volume: 26, Issue:8

    Topics: 3T3 Cells; Adenoma; Alkyl and Aryl Transferases; Animals; Apoptosis; Chemoprevention; Dehydroepiandr

2000
Steroid interconversions by metastatic deposits of a human bronchogenic carcinoma.
    Clinical oncology, 1976, Volume: 2, Issue:2

    Topics: Adrenal Cortex Hormones; Aged; Androstane-3,17-diol; Androstenediol; Androstenedione; Carcinoma, Bro

1976
Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats.
    Carcinogenesis, 1986, Volume: 7, Issue:2

    Topics: Animals; Body Weight; Carcinogens; Dehydroepiandrosterone; gamma-Glutamyltransferase; Glucosephospha

1986
Sex-dependent, tissue-specific opposing effects of dehydroepiandrosterone on initiation and modulation stages of liver and lung carcinogenesis induced by dihydroxy-di-n-propylnitrosamine in F344 rats.
    Carcinogenesis, 1988, Volume: 9, Issue:8

    Topics: Animals; Dehydroepiandrosterone; Female; Glucosephosphate Dehydrogenase; Glutathione Transferase; Li

1988
Discriminant function based on steroid abnormalities in patients with lung cancer.
    Lancet (London, England), 1970, Aug-29, Volume: 2, Issue:7670

    Topics: 17-Hydroxycorticosteroids; Adult; Aged; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Human

1970
Virilizing tumors of the adrenal cortex.
    American journal of diseases of children (1960), 1968, Volume: 115, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adenoma; Adrenal Gland Neoplasms; Adrenal

1968
[Pattern of urinary neutral 17-ketosteroids on the basis of thin layer chromatography].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1967, Volume: 5, Issue:4

    Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adult; Androstan

1967
Leydig cell function in men with gonadotrophin-producing testicular tumors.
    The Journal of clinical endocrinology and metabolism, 1970, Volume: 30, Issue:4

    Topics: Adult; Choriocarcinoma; Chorionic Gonadotropin; Chromatography, Gas; Dehydroepiandrosterone; Electro

1970
In vivo perfusion of human lung tissue with 7 alpha-3H-dehydroepiandrosterone 35S-sulfate. Metabolism of steroid conjugates. IV.
    Experientia, 1970, Jun-15, Volume: 26, Issue:6

    Topics: 17-Ketosteroids; Androstanes; Androsterone; Dehydroepiandrosterone; Estradiol; Estrone; Etiocholanol

1970
Estrogen production and its origin in men with gonadotropin-producing neoplasms.
    The Journal of clinical endocrinology and metabolism, 1974, Volume: 39, Issue:1

    Topics: Adult; Aged; Choriocarcinoma; Dehydroepiandrosterone; Estradiol; Estrone; Hormones, Ectopic; Humans;

1974