Page last updated: 2024-11-07

dehydroepiandrosterone and Liver Diseases

dehydroepiandrosterone has been researched along with Liver Diseases in 16 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Liver Diseases: Pathological processes of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Both Dehydroepiandrosterone (DHEA) and letrozole (LET) treatments induced a PCOS phenotype and liver dysfunction."8.31Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid. ( Chen, S; Fan, Y; Gao, H; Li, T; Li, Y; Liu, R; Yin, C; Zhang, T, 2023)
"Both Dehydroepiandrosterone (DHEA) and letrozole (LET) treatments induced a PCOS phenotype and liver dysfunction."4.31Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid. ( Chen, S; Fan, Y; Gao, H; Li, T; Li, Y; Liu, R; Yin, C; Zhang, T, 2023)
"Diurnal variations of plasma testosterone and urinary excretion rates of testosterone-, androsterone-, aetiocholanolone-, and DHA-glucuronide, as well as DHA-sulphate were measured before and after selective Leydig-cell stimulation (with 3 X 5000 IU human gonadotrophin) in eight patients with alcoholic liver cirrhosis, ten with acute hepatitis and four with haemochromatosis."3.65[Androgen metabolism and Leydig-cell function in acute and chronic liver disease (author's transl)]. ( Gerdes, H; Littmann, KP; Martini, GA, 1975)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199010 (62.50)18.7374
1990's3 (18.75)18.2507
2000's1 (6.25)29.6817
2010's0 (0.00)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Kilanczyk, E1
Ruminkiewicz, D1
Banales, JM1
Milkiewicz, P1
Milkiewicz, M1
Zhang, T1
Gao, H1
Fan, Y1
Chen, S1
Li, Y1
Liu, R1
Li, T1
Yin, C1
Aoki, K1
Nakajima, A1
Mukasa, K1
Osawa, E1
Mori, Y1
Sekihara, H1
FIEGEL, G1
KELLING, HW1
Simile, M1
Pascale, RM1
De Miglio, MR1
Nufris, A1
Daino, L1
Seddaiu, MA1
Muroni, MR1
Rao, KN1
Feo, F1
Littmann, KP2
Gerdes, H1
Martini, GA1
Sonka, J3
Luppa, P1
Munker, R1
Nagel, D1
Weber, M1
Engelhardt, D1
Becker, U1
Gluud, C1
Farholt, S1
Bennett, P1
Micic, S1
Svenstrup, B1
Hardt, F1
Bannister, P1
Oakes, J1
Sheridan, P1
Losowsky, MS1
Gregorová, I2
Fassati, P2
Fassati, M2
Kappas, A2
Bradlow, HL2
Gillette, PN2
Gallagher, TF2
Holzmann, H1
Hoede, N1
Morsches, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Type and Severity of Liver Cirrhosis on Semen Parameters and Reproductive Hormones[NCT03167749]90 participants (Anticipated)Observational2018-01-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for dehydroepiandrosterone and Liver Diseases

ArticleYear
Prevention of diabetes, hepatic injury, and colon cancer with dehydroepiandrosterone.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 85, Issue:2-5

    Topics: Aging; Animals; Colonic Neoplasms; Dehydroepiandrosterone; Diabetes Mellitus; Gluconeogenesis; Human

2003
[Androgen metabolism in liver diseases].
    Der Internist, 1973, Volume: 14, Issue:6

    Topics: Androgens; Androsterone; Carbon Radioisotopes; Dehydroepiandrosterone; Etiocholanolone; Hepatitis; H

1973

Other Studies

14 other studies available for dehydroepiandrosterone and Liver Diseases

ArticleYear
DHEA Protects Human Cholangiocytes and Hepatocytes against Apoptosis and Oxidative Stress.
    Cells, 2022, 03-18, Volume: 11, Issue:6

    Topics: Apoptosis; Dehydroepiandrosterone; Estrogens; Female; Hepatocytes; Humans; Liver Diseases; Oxidative

2022
Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid.
    Life sciences, 2023, Oct-01, Volume: 330

    Topics: Animals; Dehydroepiandrosterone; Female; Gastrointestinal Microbiome; Humans; Letrozole; Liver Disea

2023
[Behavior of nor-androstenolone phenyl propionate in severe liver damage; comparative studies with early results with testosterone propionate].
    Arztliche Forschung, 1959, Apr-10, Volume: 13, Issue:4

    Topics: Abdominal Injuries; Dehydroepiandrosterone; Liver Cirrhosis; Liver Diseases; Organic Chemicals; Prop

1959
Inhibition by dehydroepiandrosterone of growth and progression of persistent liver nodules in experimental rat liver carcinogenesis.
    International journal of cancer, 1995, Jul-17, Volume: 62, Issue:2

    Topics: Animals; Body Weight; Dehydroepiandrosterone; Glucosephosphate Dehydrogenase; Liver; Liver Diseases;

1995
[Androgen metabolism and Leydig-cell function in acute and chronic liver disease (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38

    Topics: Acute Disease; Adult; Aged; Androgens; Androsterone; Chorionic Gonadotropin; Chronic Disease; Circad

1975
Dehydroepiandrosterone. Metabolic effects.
    Acta Universitatis Carolinae. Medica. Monographia, 1976, Volume: 71

    Topics: Adolescent; Adult; Androgens; Animals; Cell Division; Cell Membrane Permeability; Chemical Phenomena

1976
Serum androgens in intensive-care patients: correlations with clinical findings.
    Clinical endocrinology, 1991, Volume: 34, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adult; Androgens; Andros

1991
Menopausal age and sex hormones in postmenopausal women with alcoholic and non-alcoholic liver disease.
    Journal of hepatology, 1991, Volume: 13, Issue:1

    Topics: Aged; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone;

1991
Sex hormone changes in chronic liver disease: a matched study of alcoholic versus non-alcoholic liver disease.
    The Quarterly journal of medicine, 1987, Volume: 63, Issue:240

    Topics: Adult; Aged; Androstenedione; Dehydroepiandrosterone; Estradiol; Gonadal Steroid Hormones; Humans; L

1987
[Dehydroepiandrosterone in chronic hepatopathies].
    Casopis lekaru ceskych, 1966, Aug-15, Volume: 105, Issue:32

    Topics: Dehydroepiandrosterone; Glucosephosphate Dehydrogenase; Humans; Liver; Liver Diseases

1966
Dehydroepiandrosterone deficiency in hepatopathies-therapeutic aspects.
    Tijdschrift voor gastro-enterologie, 1968, Volume: 11, Issue:2

    Topics: 17-Ketosteroids; Chronic Disease; Dehydroepiandrosterone; Female; Humans; Liver Diseases; Male

1968
Studies in porphyria. I. A defect in the reductive transformation of natural steroid hormones in the hereditary liver disease, acute intermittent porphyria.
    The Journal of experimental medicine, 1972, Nov-01, Volume: 136, Issue:5

    Topics: 5-Aminolevulinate Synthetase; Adult; Androsterone; Carbon Isotopes; Dehydroepiandrosterone; Enzyme I

1972
[Organ findings in psoriasis].
    Deutsche medizinische Wochenschrift (1946), 1973, Aug-11, Volume: 98, Issue:33

    Topics: Dehydroepiandrosterone; Erythrocytes; Female; Gout; Humans; Intestinal Diseases; Joint Diseases; Liv

1973
Studies in porphyria. II. Evidence for a deficiency of steroid delta-4-5-alpha-reductase activity in acute intermittent porphyria.
    The Journal of experimental medicine, 1973, Oct-01, Volume: 138, Issue:4

    Topics: Androstenols; Carbon Radioisotopes; Dehydroepiandrosterone; Enzyme Induction; Humans; Liver; Liver D

1973