dehydroepiandrosterone has been researched along with Klinefelter Syndrome in 14 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Klinefelter Syndrome: A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Measurements made in patients with Klinefelter's syndrome were compared to those obtained in age-matched normal male volunteers." | 1.28 | Osteoporosis and Klinefelter's syndrome. ( Horowitz, M; Morris, HA; Need, AG; Nordin, BE; O'Loughlin, PD; Wishart, JM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johannsen, TH | 1 |
| Main, KM | 1 |
| Ljubicic, ML | 1 |
| Jensen, TK | 1 |
| Andersen, HR | 1 |
| Andersen, MS | 1 |
| Petersen, JH | 1 |
| Andersson, AM | 1 |
| Juul, A | 1 |
| WELLER, O | 1 |
| Ozata, M | 1 |
| Yildirimkaya, M | 1 |
| Bulur, M | 1 |
| Yilmaz, K | 1 |
| Bolu, E | 1 |
| Corakci, A | 1 |
| Gundogan, MA | 1 |
| Smith, DA | 1 |
| Walker, MS | 1 |
| Serio, M | 1 |
| Horowitz, M | 1 |
| Wishart, JM | 1 |
| O'Loughlin, PD | 1 |
| Morris, HA | 1 |
| Need, AG | 1 |
| Nordin, BE | 1 |
| Nankin, HR | 1 |
| Talbott, JB | 1 |
| Oshima, H | 1 |
| Fan, DF | 1 |
| Pan, SF | 1 |
| Troen, P | 1 |
| Rivera, R | 1 |
| Dorfman, RI | 1 |
| Forchielli, E | 1 |
| Dufau, M | 1 |
| Weinstein, R | 1 |
| Kliman, B | 1 |
| Scurry, MT | 1 |
| Bruton, J | 1 |
| Barry, KG | 1 |
| Garmendia, F | 1 |
| Nicolis, GL | 1 |
| Gabrilove, JL | 1 |
| Froland, A | 1 |
| Frandsen, VA | 1 |
| Johnsen, SG | 1 |
| Schubert, K | 1 |
| Frankenberg, G | 1 |
| Gleispach, H | 1 |
| Glatzl, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Turner Syndrome Minipuberty Study A Prospective, Descriptive Cohortstudy[NCT04189406] | 30 participants (Anticipated) | Observational | 2020-02-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for dehydroepiandrosterone and Klinefelter Syndrome
| Article | Year |
|---|---|
Sex Differences in Reproductive Hormones During Mini-Puberty in Infants With Normal and Disordered Sex Development.
Topics: Androstenedione; Anti-Mullerian Hormone; Cross-Sectional Studies; Dehydroepiandrosterone; Dehydroepi | 2018 |
[Comparative studies on the metabolic effect of testosterone and 1-methyl-delta-androstenolone in cases with primary hypogonadism].
Topics: Androgens; Calcium; Dehydroepiandrosterone; Eunuchism; Humans; Hypogonadism; Klinefelter Syndrome; M | 1962 |
Effects of gonadotropin and testosterone treatments on Lipoprotein(a), high density lipoprotein particles, and other lipoprotein levels in male hypogonadism.
Topics: Adult; Apolipoprotein A-I; Apolipoprotein A-II; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehy | 1996 |
Changes in plasma steroids and bone density in Klinefelter's syndrome.
Topics: Adult; Age Factors; Aged; Androsterone; Bone and Bones; Dehydroepiandrosterone; Estradiol; Female; H | 1977 |
[Sex hormones in the male].
Topics: Adrenocorticotropic Hormone; Androgens; Androstenediols; Androstenedione; Dehydroepiandrosterone; Er | 1975 |
Osteoporosis and Klinefelter's syndrome.
Topics: Adult; Aged; Body Composition; Bone Density; Creatinine; Dehydroepiandrosterone; Humans; Hydroxyprol | 1992 |
Down and Klinefelter syndromes (48, XXY, G+) in a young man. Cytogenetic, endocrine, and testicular steroidogenesis studies.
Topics: 17-alpha-Hydroxypregnenolone; Adult; Androstenedione; Androstenols; Dehydroepiandrosterone; Down Syn | 1974 |
A modified method for the analysis of urinary 17-ketosteroids, pregnanediol and pregnanetriol by gas liquid chromatography in normal subjects and subjects with various endocrine disorders.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androsterone; Chromatography, Gas; Cushing Syndrom | 1967 |
Biochemical studies in a patient with chromatin-negative Klinefelter's syndrome.
Topics: 17-Hydroxycorticosteroids; Androstanes; Biopsy; Carbon Isotopes; Chorionic Gonadotropin; Dehydroepia | 1969 |
The effect of chorionic gonadotropin on steroid excretion.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adult; Androsterone; Chorionic G | 1971 |
The determination of urinary pregnanetriol and the neutral 17-ketosteroids by gas-liquid chromatography.
Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre | 1971 |
Adrenal and gonadal contribution to androgen and oestrogen excretion in Klinefelter's syndrome.
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adult; Androsterone; Dehydroepiandrosterone; D | 1973 |
[On the determination of testosterone and additional alpha, beta-unsaturated ketosteroids of the C19 series in urine].
Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Alopecia; Androstanes; Breast Disea | 1968 |
[Hormone examination in children with Klinefelter's syndrome].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Age Factors; An | 1969 |