dehydroepiandrosterone has been researched along with Insulin Sensitivity in 126 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia." | 9.41 | Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. ( Heshmati, J; Moini, A; Mojtahedi, MF; Morvaridzadeh, M; Palmowski, A; Salehi, M; Sepidarkish, M; Shidfar, F, 2021) |
| " Circulating testosterone, Δ-4-androstenedione and Hirsutism Score (HS) significantly decreased in both groups." | 9.19 | In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone. ( Belfiore, A; D'Orrico, B; Fava, A; Fruci, B; Guzzi, P; Malaguarnera, R; Mazza, A; Veltri, P, 2014) |
| "To demonstrate that calcium channel blockers can improve insulin resistance clinically, we investigated the effects of the calcium channel blockers, amlodipine, manidipine and cilnidipine on serum levels of steroid hormones and insulin." | 9.11 | Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients. ( Miyachi, Y; Ueshiba, H, 2004) |
| "Since hyperandrogenism in simple obesity is assumed to arise from hyperinsulinism and/or increased insulin-like growth factor I (IGF-I) or leptin levels, we examined how in patients with Prader-Willi syndrome (PWS), the most frequent form of syndromal obesity, the accelerated adrenarche can be explained despite hypothalamic-pituitary insufficiency with low levels of insulin and IGF-I." | 9.10 | Increased adrenal androgen levels in patients with Prader-Willi syndrome are associated with insulin, IGF-I, and leptin, but not with measures of obesity. ( Blum, W; Eiholzer, U; Gasser, T; Girard, J; L'Allemand, D; Rousson, V; Torresani, T, 2002) |
| " The present study was aimed at investigating whether early-onset androgenetic alopecia determines the impact of exogenous levothyroxine on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in young men with autoimmune hypothyroidism." | 8.02 | The impact of levothyroxine on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in men with autoimmune hypothyroidism and early-onset androgenetic alopecia. ( Kowalcze, K; Krysiak, R; Marek, B; Okopień, B, 2021) |
| " Blood samples were taken after overnight fasting at baseline and three months into the study to assess the levels of fasting glucose, insulin, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), free testosterone, dehydroepiandrosterone (DHEA), and the insulin resistance index (HOMA-IR)." | 7.91 | Effects of L-carnitine on Polycystic Ovary Syndrome. ( Gachkar, L; Hoseini, S; Moghaddam, PB; Nazari, L; Salehpour, S, 2019) |
| " Here, we found that 3 weeks of rutin (a novel compound for BAT activation) treatment increased BAT activation, thereby it improved thermogenesis and systemic insulin sensitivity in dehydroepiandrosterone (DHEA)-induced PCOS rat." | 7.85 | Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. ( Dong, M; Hu, T; Huang, Y; Jin, W; Lee, HJ; Lim, W; Lin, J; Liu, Q; Wei, G; Ye, R; Yuan, X; Zhang, C; Zhang, H; Zhou, H, 2017) |
| " Metformin has been introduced in the treatment of PCOS to manage insulin resistance and hyperglycemia." | 7.81 | Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model. ( Abramovich, D; Bas, D; Bianchi, MS; Di Pietro, M; Irusta, G; Parborell, F; Pascuali, N; Tesone, M, 2015) |
| "The authors evaluate the effects of 2 months of treatment with 250 mg flutamide daily on adrenal steroidogenesis (ACTH test) and metabolic parameters (lipids, insulin resistance) in 12 PCOS women aged 33." | 7.72 | Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome. ( Dvoráková, K; Hill, M; Stanická, S; Stárka, L; Vondra, K; Vrbíková, J, 2004) |
| " This study aimed to assess the ability of EM-652, alone or with dehydroepiandrosterone (DHEA), to prevent obesity and related metabolic abnormalities induced by an obesity-promoting diet and ovariectomy." | 7.72 | The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity. ( Deshaies, Y; Labrie, F; Lemieux, C; Picard, F; Richard, D, 2003) |
| "To evaluate whether dehydroepiandrosterone (DHEA) ameliorates the decreased insulin sensitivity in older rats, hyperinsulinemic euglycemic clamp studies were performed in rats of various age groups previously treated with DHEA." | 7.70 | Dehydroepiandrosterone (DHEA) ameliorates the insulin sensitivity in older rats. ( Aoki, K; Kanesiro, M; Mukasa, K; Okamura, J; Saito, T; Satoh, S; Sekihara, H, 1998) |
| "We examined the effects of an oral glucose load on plasma insulin, androgens, and beta-endorphin (beta EP) concentrations in patients carefully selected as having polycystic ovary syndrome (PCOS) and normal glucose tolerance." | 7.69 | Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome. ( Barini, A; Dell'Acqua, S; Liberale, I; Lucisano, A; Martino, G; Menini, E; Tropeano, G; Vuolo, IP, 1994) |
| "In hyperandrogenic females, the ratio of dehydroepiandrosterone (DHEA) to testosterone may be an important determinant of insulin sensitivity." | 7.68 | Case report: amelioration of insulin resistance in diabetes with dehydroepiandrosterone. ( Buffington, CK; Kitabchi, AE; Pourmotabbed, G, 1993) |
| "It has been hypothesized that the androgens testosterone and dehydroepiandrosterone (DHEA) may have opposing actions on insulin sensitivity." | 7.68 | Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females. ( Buffington, CK; Givens, JR; Kitabchi, AE, 1991) |
| "We hypothesize that dehydroepiandrosterone sulfate dampens the effect of insulin resistance, which in turn is reflected in apolipoprotein profiles in women with hirsutism/hyperandrogenism." | 7.68 | Lipoprotein abnormalities in hirsute women. II. Compensatory responses of insulin resistance and dehydroepiandrosterone sulfate with obesity. ( Alaupovic, P; Givens, JR; Parker, IJ; Wild, RA, 1992) |
| "Polycystic ovary syndrome is a complicated hormonal and metabolic disorder." | 5.91 | Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†. ( Ding, X; Li, G; Li, N; Lin, Y; Ma, Y; Wang, X; Xiong, C; Yang, Y; Yuan, Y; Zhang, Y; Zhang, Z, 2023) |
| " Baseline and end line assessment were performed for menstrual cycle regularity, ultrasonography scan for ovaries, total testosterone, dehydroepiandrosterone (DHEAS), insulin, luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio, fasting blood sugar (FBS), homeostatic model assessment-insulin resistance (HOMA-IR), weight reduction, waist-/hip circumference (WC, HC), waist to hip ratio (WHR), and body mass index (BMI)." | 5.51 | Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study. ( Ahire, J; Kaur, I; Medhi, B; Rana, SV; Sachdeva, N; Sahni, N; Singh, A; Suri, V, 2022) |
| "Hyperandrogenism is the hallmark of polycystic ovary syndrome (PCOS)." | 5.48 | The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome. ( Ho, LT; Huang, SW; Juan, CC; Seow, KM; Ting, CH, 2018) |
| "Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia." | 5.41 | Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. ( Heshmati, J; Moini, A; Mojtahedi, MF; Morvaridzadeh, M; Palmowski, A; Salehi, M; Sepidarkish, M; Shidfar, F, 2021) |
| "Treatment with metformin or rosiglitazone prevents excess adrenal androgen synthesis." | 5.34 | Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone. ( Bahtiyar, G; Sacerdote, AS; Weiss, K, 2007) |
| "In this study, the effects of DHEA treatment on insulin sensitivity were investigated in genetically obese Zucker rats, an animal model of insulin resistance, using the euglycemic clamp technique." | 5.30 | Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats. ( Kimura, M; Kiuchi, Y; Sekihara, H; Tanaka, S; Yamada, Y; Yamakawa, T, 1998) |
| "These results indicate that acute hyperinsulinemia of 12- to 16-h duration does not increase serum testosterone or DHEA-S concentrations and, indeed, can cause a decline in serum DHEA-S levels in both normal women and the single woman studied with hyperandrogenism, insulin resistance, and acanthosis nigricans." | 5.27 | The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. ( Blackard, WG; Clore, JN; Nestler, JE; Strauss, JF, 1987) |
| " Circulating testosterone, Δ-4-androstenedione and Hirsutism Score (HS) significantly decreased in both groups." | 5.19 | In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone. ( Belfiore, A; D'Orrico, B; Fava, A; Fruci, B; Guzzi, P; Malaguarnera, R; Mazza, A; Veltri, P, 2014) |
| "Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown." | 5.12 | DHEA in elderly women and DHEA or testosterone in elderly men. ( Basu, A; Basu, R; Cobelli, C; Dalla Man, C; Dhatariya, K; Jensen, MD; Khosla, S; Klee, GG; Melton, LJ; Nair, KS; Nehra, A; O'Brien, P; Rizza, RA; Short, KR; Smith, GE; Tindall, DJ; Toffolo, G; Vittone, JL, 2006) |
| "To demonstrate that calcium channel blockers can improve insulin resistance clinically, we investigated the effects of the calcium channel blockers, amlodipine, manidipine and cilnidipine on serum levels of steroid hormones and insulin." | 5.11 | Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients. ( Miyachi, Y; Ueshiba, H, 2004) |
| "Since hyperandrogenism in simple obesity is assumed to arise from hyperinsulinism and/or increased insulin-like growth factor I (IGF-I) or leptin levels, we examined how in patients with Prader-Willi syndrome (PWS), the most frequent form of syndromal obesity, the accelerated adrenarche can be explained despite hypothalamic-pituitary insufficiency with low levels of insulin and IGF-I." | 5.10 | Increased adrenal androgen levels in patients with Prader-Willi syndrome are associated with insulin, IGF-I, and leptin, but not with measures of obesity. ( Blum, W; Eiholzer, U; Gasser, T; Girard, J; L'Allemand, D; Rousson, V; Torresani, T, 2002) |
| "To investigate whether long-term treatment with dehydroepiandrosterone (DHEA) in postmenopausal women can modify insulin sensitivity and plasma lipid profile." | 5.09 | Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women. ( Basile, G; Cucinotta, D; Frisina, N; Gaudio, A; Lasco, A; Morabito, N; Morini, E; Nicita-Mauro, V; Trifiletti, A, 2001) |
| " In the present study, we aimed to explore how omega-3 PUFAs alleviate ovarian dysfunction and insulin resistance in mice with dehydroepiandrosterone (DHEA)-induced PCOS by modulating the gut microbiota." | 4.31 | Effects of gut microbiota on omega-3-mediated ovary and metabolic benefits in polycystic ovary syndrome mice. ( Cao, C; Chen, L; He, Z; Jing, J; Li, C; Li, Z; Ma, R; Ouyang, L; Qian, Z; Sun, S; Xu, R; Xue, M; Xue, T; Yao, B; Zhang, H; Zhang, K; Zheng, L, 2023) |
| "The aim of this study was to investigate the effects of berberine on polycystic ovary syndrome (PCOS) with insulin resistance (IR)." | 4.02 | Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites. ( Li, XL; Shen, HR; Xu, X; Ye, D, 2021) |
| " The present study was aimed at investigating whether early-onset androgenetic alopecia determines the impact of exogenous levothyroxine on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in young men with autoimmune hypothyroidism." | 4.02 | The impact of levothyroxine on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in men with autoimmune hypothyroidism and early-onset androgenetic alopecia. ( Kowalcze, K; Krysiak, R; Marek, B; Okopień, B, 2021) |
| "We used dehydroepiandrosterone (DHEA)-induced PCOS-like rat model to measure circadian clock genes and insulin resistance-related genes." | 3.96 | Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome. ( Di, F; Du, Y; Hu, M; Li, S; Liu, J; Zhai, J, 2020) |
| " Blood samples were taken after overnight fasting at baseline and three months into the study to assess the levels of fasting glucose, insulin, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), free testosterone, dehydroepiandrosterone (DHEA), and the insulin resistance index (HOMA-IR)." | 3.91 | Effects of L-carnitine on Polycystic Ovary Syndrome. ( Gachkar, L; Hoseini, S; Moghaddam, PB; Nazari, L; Salehpour, S, 2019) |
| " Here, we found that 3 weeks of rutin (a novel compound for BAT activation) treatment increased BAT activation, thereby it improved thermogenesis and systemic insulin sensitivity in dehydroepiandrosterone (DHEA)-induced PCOS rat." | 3.85 | Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. ( Dong, M; Hu, T; Huang, Y; Jin, W; Lee, HJ; Lim, W; Lin, J; Liu, Q; Wei, G; Ye, R; Yuan, X; Zhang, C; Zhang, H; Zhou, H, 2017) |
| "In view of antidiabetic and antiglucocorticoid effects of dehydroepiandrosterone (DHEA) both in vitro and in vivo studies were undertaken: (i) to elucidate the mechanism of action of both dexamethasone phosphate (dexP) and DHEA on glucose synthesis in primary cultured rabbit kidney-cortex tubules and (ii) to investigate the influence of DHEA on glucose synthesis, insulin sensitivity and plasma lipid profile in the control- and dexP-treated rabbits." | 3.83 | DHEA-induced modulation of renal gluconeogenesis, insulin sensitivity and plasma lipid profile in the control- and dexamethasone-treated rabbits. Metabolic studies. ( Jagielski, AK; Kiersztan, A; Nagalski, A; Nalepa, P; Tempes, A; Trojan, N; Usarek, M, 2016) |
| " Metformin has been introduced in the treatment of PCOS to manage insulin resistance and hyperglycemia." | 3.81 | Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model. ( Abramovich, D; Bas, D; Bianchi, MS; Di Pietro, M; Irusta, G; Parborell, F; Pascuali, N; Tesone, M, 2015) |
| "Dehydroepiandrosterone (DHEA) is believed to exert, besides others, positive effects on the insulin resistance or its secretion and glucose metabolism." | 3.78 | Dehydroepiandrosterone in the type 1 diabetes mellitus. ( Duskova, M; Hill, M; Hruskovicova, H; Starka, L, 2012) |
| "This study concentrated on the initial events triggering the development of nonalcoholic fatty liver disease induced by a high-fat plus fructose (HF-F) diet and on the possibility of delaying nonalcoholic fatty liver disease progression by adding dehydroepiandrosterone (DHEA) to the diet." | 3.75 | SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats. ( Aragno, M; Boccuzzi, G; Catalano, MG; Collino, M; Danni, O; Fantozzi, R; Tomasinelli, CE; Vercellinatto, I, 2009) |
| "The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet." | 3.74 | Adiponectin is involved in the protective effect of DHEA against metabolic risk in aged rats. ( Garaulet, M; Nicolás, F; Palou, A; Pérez-de-Heredia, F; Portillo, Mdel P; Priego, T; Sánchez, J; Zamora, S, 2008) |
| "Dehydroepiandrosterone (DHEA) is an adrenal steroid and nutritional supplement that may improve insulin sensitivity." | 3.73 | Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium. ( Chen, H; Consoli, A; Formoso, G; Kim, JA; Montagnani, M; Quon, MJ, 2006) |
| "The authors evaluate the effects of 2 months of treatment with 250 mg flutamide daily on adrenal steroidogenesis (ACTH test) and metabolic parameters (lipids, insulin resistance) in 12 PCOS women aged 33." | 3.72 | Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome. ( Dvoráková, K; Hill, M; Stanická, S; Stárka, L; Vondra, K; Vrbíková, J, 2004) |
| " This study aimed to assess the ability of EM-652, alone or with dehydroepiandrosterone (DHEA), to prevent obesity and related metabolic abnormalities induced by an obesity-promoting diet and ovariectomy." | 3.72 | The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity. ( Deshaies, Y; Labrie, F; Lemieux, C; Picard, F; Richard, D, 2003) |
| "Insulin-resistant muscle tissue contains low proportions of arachidonic acid (AA), and increased proportions of muscle AA correlate with improved insulin sensitivity." | 3.71 | Dehydroepiandrosterone alters phospholipid profiles in Zucker rat muscle tissue. ( Abadie, JM; Malcom, GT; Porter, JR; Svec, F, 2001) |
| "To evaluate whether dehydroepiandrosterone (DHEA) ameliorates the decreased insulin sensitivity in older rats, hyperinsulinemic euglycemic clamp studies were performed in rats of various age groups previously treated with DHEA." | 3.70 | Dehydroepiandrosterone (DHEA) ameliorates the insulin sensitivity in older rats. ( Aoki, K; Kanesiro, M; Mukasa, K; Okamura, J; Saito, T; Satoh, S; Sekihara, H, 1998) |
| "The purpose of this study was to determine whether administration of dehydroepiandrosterone (DHEA) protects male rats against the accumulation of body fat the development of insulin resistance with advancing age." | 3.70 | DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats. ( Chen, MM; Han, DH; Hansen, PA; Holloszy, JO, 1998) |
| "We examined the effects of an oral glucose load on plasma insulin, androgens, and beta-endorphin (beta EP) concentrations in patients carefully selected as having polycystic ovary syndrome (PCOS) and normal glucose tolerance." | 3.69 | Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome. ( Barini, A; Dell'Acqua, S; Liberale, I; Lucisano, A; Martino, G; Menini, E; Tropeano, G; Vuolo, IP, 1994) |
| "To evaluate the relative or discriminatory usefulness of sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and insulin like growth factor binding protein 1 (IGFBP-1) as markers of insulin resistance and to estimate the tissue sensitivity to insulin by means of the insulin tolerance test (ITT) and the frequently sampled i." | 3.69 | [Biochemical markers and methods to assess insulin resistance in normal, obese and hyperandrogenic women]. ( Calvillán, M; Castillo, T; Durruty, P; López, G; Muñoz, S; Sir, T, 1997) |
| " We examined the possible associations of sex hormone-binding globulin, total and free testosterone, estradiol, and dehydroepiandrosterone sulfate to Lp(a) concentrations in men in two population-based studies (San Antonio Heart Study [n = 178] and a Finnish study on the association between insulin resistance and atherosclerosis [n = 87])." | 3.69 | Lack of association between sex hormones and Lp(a) concentrations in American and Finnish men. ( Gruber, KK; Haffner, SM; Laakso, M; Mykkanen, L; Rainwater, DL, 1994) |
| "In hyperandrogenic females, the ratio of dehydroepiandrosterone (DHEA) to testosterone may be an important determinant of insulin sensitivity." | 3.68 | Case report: amelioration of insulin resistance in diabetes with dehydroepiandrosterone. ( Buffington, CK; Kitabchi, AE; Pourmotabbed, G, 1993) |
| "We hypothesize that dehydroepiandrosterone sulfate dampens the effect of insulin resistance, which in turn is reflected in apolipoprotein profiles in women with hirsutism/hyperandrogenism." | 3.68 | Lipoprotein abnormalities in hirsute women. II. Compensatory responses of insulin resistance and dehydroepiandrosterone sulfate with obesity. ( Alaupovic, P; Givens, JR; Parker, IJ; Wild, RA, 1992) |
| "It has been hypothesized that the androgens testosterone and dehydroepiandrosterone (DHEA) may have opposing actions on insulin sensitivity." | 3.68 | Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females. ( Buffington, CK; Givens, JR; Kitabchi, AE, 1991) |
| "In a previous report we found extreme hyperinsulinemia associated with high testosterone levels in patients with polycystic ovarian syndrome (PCO) and normal insulin levels in a small group of patients with elevated dehydroepiandrosterone (DHEA)." | 3.68 | Role of adrenal and gonadal androgens in insulin action and metabolism. ( Buffington, CK; Givens, J; Inouye, H; Kitabchi, AE, 1991) |
| "Insulin sensitivity was estimated using the insulin sensitivity index and the quantitative insulin sensitivity check index, whereas insulin resistance was estimated using the homeostatic model for insulin resistance." | 2.79 | Association between circulating endogenous androgens and insulin sensitivity changes with exercise training in midlife women. ( Campbell, C; Gaikwad, NW; Gustafson, MB; Keim, NL; Krishnan, S, 2014) |
| " The pattern of breakthrough bleeding did not substantially differ between the DHEA and PL groups and no significant adverse endometrial effects were apparent." | 2.74 | The safety of 52 weeks of oral DHEA therapy for postmenopausal women. ( Adams, J; Bell, RJ; Davis, SR; Jane, F; Morrow, C; Panjari, M, 2009) |
| "Amlodipine treatment 1) lowered fasting serum insulin (from 273 +/- 19 to 200 +/- 17 pmol/L; P < 0." | 2.67 | The calcium channel blocker amlodipine raises serum dehydroepiandrosterone sulfate and androstenedione, but lowers serum cortisol, in insulin-resistant obese and hypertensive men. ( Beer, NA; Beer, RM; Jakubowicz, DJ; Nestler, JE, 1993) |
| "Nitrendipine treatment 1) lowered fasting serum insulin from 265 +/- 24 to 194 +/- 22 pmol/L (P < 0." | 2.67 | Effects of nitrendipine on glucose tolerance and serum insulin and dehydroepiandrosterone sulfate levels in insulin-resistant obese and hypertensive men. ( Arocha, IR; Beer, NA; Beer, RM; Jakubowicz, DJ; Nestler, JE, 1993) |
| "Type 2 diabetes mellitus is increasing globally and is an established risk factor for the development of atherosclerotic vascular disease." | 2.43 | Androgens, insulin resistance and vascular disease in men. ( Channer, KS; Jones, TH; Kapoor, D; Malkin, CJ, 2005) |
| "As insulin resistance is an underlying feature of premature adrenarche, it seems rational to assess the efficacy and safety of using insulin-sensitizing agents to treat these individuals." | 2.41 | Premature adrenarche. ( Dimartino-Nardi, J; Saenger, P, 2001) |
| "In some breast cancer cell lines in a low oestrogen milieu DHEA has an oestradiol-like effect, stimulating tumour growth, whereas in oestradiol abundance DHEA antagonises the growth-stimulating effect of oestradiol." | 2.39 | Physiological importance of dehydroepiandrosterone. ( Ebeling, P; Koivisto, VA, 1994) |
| "Polycystic ovary syndrome is a complicated hormonal and metabolic disorder." | 1.91 | Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†. ( Ding, X; Li, G; Li, N; Lin, Y; Ma, Y; Wang, X; Xiong, C; Yang, Y; Yuan, Y; Zhang, Y; Zhang, Z, 2023) |
| " The former was combined with hyperinsulinemia and IR, while the latter was combined with glucolipid metabolic disorders, extremely heterogeneous hyperinsulinemia and IR." | 1.72 | Effects of dehydroepiandrosterone alone or in combination with a high-fat diet and antibiotic cocktail on the heterogeneous phenotypes of PCOS mouse models by regulating gut microbiota. ( Ding, X; Gu, L; Peng, Y; Wang, X; Xiong, C; Zhang, Y, 2022) |
| "Hyperandrogenism is the hallmark of polycystic ovary syndrome (PCOS)." | 1.48 | The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome. ( Ho, LT; Huang, SW; Juan, CC; Seow, KM; Ting, CH, 2018) |
| "Dehydroepiandrosterone (DHEA) is an adrenal steroid hormone that is a precursor of sexual hormones." | 1.48 | Dehydroepiandrosterone supplementation is not beneficial in the late postmenopausal period in diet-induced obese rats. ( Curi, R; da Cunha Araujo, LC; de Oliveira Carvalho, CR; Ribeiro, LM; Teixeira, CJ; Veras, K, 2018) |
| "The study included 20 women with gestational diabetes mellitus and 27 controls tested using a 120 min." | 1.39 | Androgens in the maternal and fetal circulation: association with insulin resistance. ( Drolet, R; Dubé, MC; John Weisnagel, S; Labrie, F; Luu-The, V; Morisset, AS; Pelletier, M; Robitaille, J; Tchernof, A; Tremblay, Y, 2013) |
| " Randomized trials in elderly subjects with an age-dependent decrease in DHEA have provided little or no evidence for enhanced physical performance after long-term administration of DHEA, 50 mg/d, and smaller short-term studies in healthy male athletes using higher doses were completely negative." | 1.36 | Dehydroepiandrosterone to enhance physical performance: myth and reality. ( Allolio, B; Hahner, S, 2010) |
| "The insulin resistance was calculated by the measurement of fasting serum glucose and insulin levels, serum insulin response to an oral glucose tolerance test and homeostasis model assessment." | 1.35 | Oxidative stress in nonobese women with polycystic ovary syndrome: correlations with endocrine and screening parameters. ( Erel, O; Verit, FF, 2008) |
| "Treatment with metformin or rosiglitazone prevents excess adrenal androgen synthesis." | 1.34 | Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone. ( Bahtiyar, G; Sacerdote, AS; Weiss, K, 2007) |
| "Insulin resistance was estimated by fasting insulin level, fasting glucose/insulin ratio and 75 g 2 h glucose tolerance test." | 1.33 | The association of serum androgens and insulin resistance with fat distribution in polycystic ovary syndrome. ( Noyan, V; Sagsoz, N; Yucel, A, 2006) |
| "On the other hand, hyperandrogenism is associated with certain insulin-resistant conditions with hyperinsulinaemia, including the polycystic ovary syndrome (PCO)." | 1.31 | Two hyperandrogenic adolescent girls with congenital portosystemic shunt. ( Fujisawa, T; Hachiya, M; Hachiya, Y; Hoshino, K; Saji, T; Satoh, M; Yokoya, S, 2001) |
| "In this study, the effects of DHEA treatment on insulin sensitivity were investigated in genetically obese Zucker rats, an animal model of insulin resistance, using the euglycemic clamp technique." | 1.30 | Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats. ( Kimura, M; Kiuchi, Y; Sekihara, H; Tanaka, S; Yamada, Y; Yamakawa, T, 1998) |
| "Dehydroepiandrosterone (DHEA) has been reported to protect against the development of obesity." | 1.30 | DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet. ( Chen, M; Han, DH; Hansen, PA; Holloszy, JO; Nolte, LA, 1997) |
| "The acute effects of hyperinsulinemia on androgen homeostasis and a possible association of androgens to insulin sensitivity, serum lipids and lipoproteins and to lipid oxidation were examined in 19 healthy males (27 +/- 1 yrs, body mass index 24 +/- 1 kg/m2)." | 1.29 | Acute hyperinsulinemia, androgen homeostasis and insulin sensitivity in healthy man. ( Ebeling, P; Koivisto, VA; Seppälä, M; Stenman, UH, 1995) |
| "However, PCO patients with NIDDM differed from those without diabetes in that they had elevated basal and corticotropin-stimulated adrenal steroids (cortisol, dehydroepiandrosterone [DHEA], dehydroepiandrosterone sulfate [DHEAS])." | 1.29 | Enhanced adrenocortical activity as a contributing factor to diabetes in hyperandrogenic women. ( Buffington, CK; Givens, JR; Kitabchi, AE, 1994) |
| "Dehydroepiandrosterone (DHEA) was fed at 0." | 1.27 | Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice. ( Coleman, DL; Leiter, EH; Schwizer, RW, 1984) |
| "Their insulin resistance was significantly greater than that in a control group with comparable obesity." | 1.27 | Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: pediatric perspective and natural history. ( Cavallo, A; Meyer, WJ; Peters, EJ; Prince, MJ; Richards, GE; Smith, ER; Stuart, CA, 1985) |
| "These results indicate that acute hyperinsulinemia of 12- to 16-h duration does not increase serum testosterone or DHEA-S concentrations and, indeed, can cause a decline in serum DHEA-S levels in both normal women and the single woman studied with hyperandrogenism, insulin resistance, and acanthosis nigricans." | 1.27 | The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. ( Blackard, WG; Clore, JN; Nestler, JE; Strauss, JF, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (8.73) | 18.7374 |
| 1990's | 32 (25.40) | 18.2507 |
| 2000's | 37 (29.37) | 29.6817 |
| 2010's | 30 (23.81) | 24.3611 |
| 2020's | 16 (12.70) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, HR | 1 |
| Xu, X | 1 |
| Ye, D | 1 |
| Li, XL | 1 |
| Zheng, Y | 2 |
| He, J | 1 |
| Yang, D | 1 |
| Yuan, M | 1 |
| Liu, S | 2 |
| Dai, F | 1 |
| Jia, Y | 1 |
| Cheng, Y | 1 |
| Kaur, I | 1 |
| Suri, V | 1 |
| Sachdeva, N | 1 |
| Rana, SV | 1 |
| Medhi, B | 1 |
| Sahni, N | 1 |
| Ahire, J | 1 |
| Singh, A | 1 |
| Yao, Q | 1 |
| Zou, X | 1 |
| Wu, H | 1 |
| Shen, Q | 1 |
| Kang, J | 1 |
| Wang, X | 3 |
| Gu, L | 1 |
| Zhang, Y | 3 |
| Xiong, C | 2 |
| Peng, Y | 2 |
| Ding, X | 2 |
| Lin, Y | 1 |
| Li, G | 1 |
| Yuan, Y | 1 |
| Li, N | 1 |
| Yang, Y | 1 |
| Ma, Y | 1 |
| Zhang, Z | 1 |
| Zhang, H | 4 |
| Zheng, L | 1 |
| Li, C | 1 |
| Jing, J | 1 |
| Li, Z | 1 |
| Sun, S | 1 |
| Xue, T | 1 |
| Zhang, K | 1 |
| Xue, M | 1 |
| Cao, C | 1 |
| Ouyang, L | 1 |
| Qian, Z | 1 |
| Xu, R | 1 |
| He, Z | 1 |
| Ma, R | 1 |
| Chen, L | 1 |
| Yao, B | 1 |
| Teixeira, CJ | 2 |
| Veras, K | 2 |
| de Oliveira Carvalho, CR | 2 |
| Li, L | 2 |
| Yao, Y | 1 |
| Zhao, J | 2 |
| Cao, J | 1 |
| Ma, H | 1 |
| Zhai, J | 1 |
| Li, S | 1 |
| Hu, M | 1 |
| Di, F | 1 |
| Liu, J | 1 |
| Du, Y | 1 |
| Doretto-Silva, L | 1 |
| Steiner, ML | 1 |
| Veridiano, JM | 1 |
| Petri, G | 1 |
| Luz, MCB | 1 |
| Neofiti-Papi, B | 1 |
| Bianco, B | 1 |
| Fonseca, FLA | 1 |
| Toledo, OMS | 1 |
| Fernandes, CE | 1 |
| Pompei, LM | 1 |
| Yang, X | 1 |
| Luo, X | 1 |
| Liu, C | 1 |
| Cao, X | 1 |
| Wang, H | 2 |
| Guo, L | 1 |
| Heshmati, J | 1 |
| Moini, A | 1 |
| Sepidarkish, M | 1 |
| Morvaridzadeh, M | 1 |
| Salehi, M | 1 |
| Palmowski, A | 1 |
| Mojtahedi, MF | 1 |
| Shidfar, F | 1 |
| Feng, H | 1 |
| Fan, D | 1 |
| Zou, G | 1 |
| Han, Y | 1 |
| Liu, L | 1 |
| Wu, LM | 1 |
| Wang, YX | 2 |
| Zhan, Y | 1 |
| Liu, AH | 1 |
| Shen, HF | 1 |
| Wang, YF | 1 |
| Wang, LY | 1 |
| Tao, ZB | 1 |
| Wang, YQ | 1 |
| Krysiak, R | 1 |
| Kowalcze, K | 1 |
| Marek, B | 1 |
| Okopień, B | 1 |
| Hu, T | 2 |
| Yuan, X | 2 |
| Ye, R | 2 |
| Zhou, H | 2 |
| Lin, J | 2 |
| Zhang, C | 2 |
| Wei, G | 2 |
| Dong, M | 2 |
| Huang, Y | 3 |
| Lim, W | 1 |
| Liu, Q | 2 |
| Lee, HJ | 2 |
| Jin, W | 2 |
| O'Reilly, MW | 2 |
| Kempegowda, P | 2 |
| Walsh, M | 1 |
| Taylor, AE | 2 |
| Manolopoulos, KN | 1 |
| Allwood, JW | 1 |
| Semple, RK | 1 |
| Hebenstreit, D | 1 |
| Dunn, WB | 1 |
| Tomlinson, JW | 1 |
| Arlt, W | 2 |
| Ara, J | 1 |
| Nuwormegbe, SA | 1 |
| Sajo, MEJ | 1 |
| Kim, SK | 1 |
| Shim, KY | 1 |
| Lee, KJ | 1 |
| Zhao, H | 2 |
| Zhou, D | 1 |
| Chen, Y | 2 |
| Liu, D | 1 |
| Chu, S | 1 |
| Zhang, S | 1 |
| Ribeiro, LM | 1 |
| da Cunha Araujo, LC | 1 |
| Curi, R | 1 |
| Blaslov, K | 1 |
| Kruljac, I | 1 |
| Mirošević, G | 1 |
| Kirigin Biloš, LS | 1 |
| Vrkljan, M | 1 |
| Neisy, A | 1 |
| Zal, F | 1 |
| Seghatoleslam, A | 1 |
| Alaee, S | 1 |
| Dou, L | 1 |
| Gui, X | 1 |
| Yu, M | 1 |
| Guo, Y | 1 |
| Zhou, DN | 1 |
| Li, SJ | 1 |
| Ding, JL | 1 |
| Yin, TL | 1 |
| Yang, J | 2 |
| Ye, H | 1 |
| Seow, KM | 1 |
| Ting, CH | 1 |
| Huang, SW | 1 |
| Ho, LT | 1 |
| Juan, CC | 1 |
| Salehpour, S | 1 |
| Nazari, L | 1 |
| Hoseini, S | 1 |
| Moghaddam, PB | 1 |
| Gachkar, L | 1 |
| Reading, CL | 1 |
| Stickney, DR | 1 |
| Flores-Riveros, J | 3 |
| Destiche, DA | 1 |
| Ahlem, CN | 1 |
| Cefalu, WT | 1 |
| Frincke, JM | 3 |
| Mazza, A | 1 |
| Fruci, B | 1 |
| Guzzi, P | 1 |
| D'Orrico, B | 1 |
| Malaguarnera, R | 1 |
| Veltri, P | 1 |
| Fava, A | 1 |
| Belfiore, A | 1 |
| Krishnan, S | 1 |
| Gustafson, MB | 1 |
| Campbell, C | 1 |
| Gaikwad, NW | 1 |
| Keim, NL | 1 |
| Fichna, M | 1 |
| Fichna, P | 1 |
| Gryczyńska, M | 1 |
| Czarnywojtek, A | 1 |
| Żurawek, M | 1 |
| Ruchała, M | 1 |
| Karbowska, J | 1 |
| Kochan, Z | 1 |
| Di Pietro, M | 1 |
| Parborell, F | 1 |
| Irusta, G | 1 |
| Pascuali, N | 1 |
| Bas, D | 1 |
| Bianchi, MS | 1 |
| Tesone, M | 1 |
| Abramovich, D | 1 |
| Kiersztan, A | 1 |
| Nagalski, A | 1 |
| Nalepa, P | 1 |
| Tempes, A | 1 |
| Trojan, N | 1 |
| Usarek, M | 1 |
| Jagielski, AK | 1 |
| Yi, M | 1 |
| Jin, H | 1 |
| Zhang, W | 1 |
| Yan, L | 1 |
| Li, R | 1 |
| Zhao, Y | 1 |
| Qiao, J | 1 |
| Chen, ZJ | 1 |
| Aoki, K | 4 |
| Tajima, K | 1 |
| Taguri, M | 1 |
| Terauchi, Y | 1 |
| Sato, K | 1 |
| Fujita, S | 1 |
| Iemitsu, M | 1 |
| Jenkinson, C | 1 |
| Quanson, JL | 1 |
| Storbeck, KH | 1 |
| Pérez-de-Heredia, F | 1 |
| Sánchez, J | 1 |
| Priego, T | 1 |
| Nicolás, F | 1 |
| Portillo, Mdel P | 1 |
| Palou, A | 1 |
| Zamora, S | 1 |
| Garaulet, M | 1 |
| Manco, M | 1 |
| Bottazzo, G | 1 |
| Geer, EB | 1 |
| Shen, W | 1 |
| Panjari, M | 1 |
| Bell, RJ | 1 |
| Jane, F | 1 |
| Adams, J | 1 |
| Morrow, C | 1 |
| Davis, SR | 1 |
| Aragno, M | 1 |
| Tomasinelli, CE | 1 |
| Vercellinatto, I | 1 |
| Catalano, MG | 1 |
| Collino, M | 1 |
| Fantozzi, R | 1 |
| Danni, O | 1 |
| Boccuzzi, G | 1 |
| Wang, T | 1 |
| Villegas, S | 1 |
| White, SK | 1 |
| Ahlem, C | 1 |
| Lu, M | 2 |
| Olefsky, JM | 2 |
| Reading, C | 1 |
| Alleva, D | 1 |
| Hahner, S | 1 |
| Allolio, B | 1 |
| Patsouris, D | 1 |
| Li, P | 1 |
| Watkins, S | 1 |
| Schenk, S | 1 |
| Weiss, EP | 1 |
| Villareal, DT | 1 |
| Fontana, L | 1 |
| Han, DH | 3 |
| Holloszy, JO | 3 |
| Carmina, E | 1 |
| Campagna, AM | 1 |
| Lobo, RA | 3 |
| Duskova, M | 1 |
| Hruskovicova, H | 1 |
| Hill, M | 4 |
| Starka, L | 4 |
| Morisset, AS | 1 |
| Dubé, MC | 1 |
| Drolet, R | 1 |
| Pelletier, M | 1 |
| Labrie, F | 2 |
| Luu-The, V | 1 |
| Tremblay, Y | 1 |
| Robitaille, J | 1 |
| John Weisnagel, S | 1 |
| Tchernof, A | 1 |
| L'Allemand, D | 1 |
| Eiholzer, U | 1 |
| Rousson, V | 1 |
| Girard, J | 1 |
| Blum, W | 1 |
| Torresani, T | 1 |
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| Lemieux, C | 1 |
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| Kawano, H | 1 |
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| Kitagawa, A | 1 |
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| Yoshida, T | 1 |
| Soejima, H | 1 |
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| Farah-Eways, L | 1 |
| Reyna, R | 1 |
| Knochenhauer, ES | 1 |
| Bartolucci, AA | 1 |
| Azziz, R | 1 |
| Vrbíková, J | 2 |
| Dvoráková, K | 2 |
| Stanická, S | 1 |
| Vondra, K | 3 |
| Ueshiba, H | 2 |
| Miyachi, Y | 2 |
| Wang, Y | 1 |
| Sun, Y | 1 |
| Qiu, H | 1 |
| Yang, SC | 1 |
| Chen, CY | 1 |
| Liao, YH | 1 |
| Lin, FC | 1 |
| Lee, WC | 2 |
| Cho, YM | 1 |
| Chen, MT | 1 |
| Chous, CH | 1 |
| Kuo, CH | 2 |
| Kapoor, D | 1 |
| Malkin, CJ | 1 |
| Channer, KS | 1 |
| Jones, TH | 1 |
| Yucel, A | 1 |
| Noyan, V | 1 |
| Sagsoz, N | 1 |
| Formoso, G | 1 |
| Chen, H | 1 |
| Kim, JA | 1 |
| Montagnani, M | 1 |
| Consoli, A | 1 |
| Quon, MJ | 1 |
| Mai, K | 1 |
| Bobbert, T | 1 |
| Kullmann, V | 1 |
| Andres, J | 1 |
| Rochlitz, H | 1 |
| Osterhoff, M | 1 |
| Weickert, MO | 1 |
| Bähr, V | 1 |
| Möhlig, M | 1 |
| Pfeiffer, AF | 1 |
| Diederich, S | 1 |
| Spranger, J | 1 |
| Zhang, YF | 1 |
| Yang, YS | 1 |
| Hong, J | 1 |
| Gu, WQ | 1 |
| Shen, CF | 1 |
| Xu, M | 1 |
| Du, PF | 1 |
| Li, XY | 1 |
| Ning, G | 1 |
| Chen, SM | 1 |
| Wu, MC | 1 |
| Hou, CW | 1 |
| Lai, YC | 1 |
| Laio, YH | 1 |
| Lin, CH | 1 |
| Nair, KS | 2 |
| Rizza, RA | 2 |
| O'Brien, P | 1 |
| Dhatariya, K | 1 |
| Short, KR | 2 |
| Nehra, A | 1 |
| Vittone, JL | 1 |
| Klee, GG | 1 |
| Basu, A | 1 |
| Basu, R | 1 |
| Cobelli, C | 1 |
| Toffolo, G | 1 |
| Dalla Man, C | 1 |
| Tindall, DJ | 1 |
| Melton, LJ | 1 |
| Smith, GE | 1 |
| Khosla, S | 1 |
| Jensen, MD | 1 |
| Stewart, PM | 1 |
| Yamada, Y | 2 |
| Sekihara, H | 5 |
| Omura, M | 1 |
| Yanase, T | 1 |
| Takayanagi, R | 1 |
| Mune, T | 1 |
| Yasuda, K | 2 |
| Ishizuka, T | 2 |
| Iwasaki, T | 1 |
| Nakajima, A | 2 |
| Nawata, H | 1 |
| Bahtiyar, G | 1 |
| Weiss, K | 1 |
| Sacerdote, AS | 1 |
| Igwebuike, A | 1 |
| Irving, BA | 1 |
| Bigelow, ML | 1 |
| McConnell, JP | 1 |
| Verit, FF | 1 |
| Erel, O | 1 |
| Bendlová, B | 2 |
| Vaňková, M | 1 |
| Lukášová, P | 1 |
| Včelák, J | 1 |
| Vejražková, D | 1 |
| Hampl, R | 2 |
| Chang, RJ | 1 |
| Nakamura, RM | 1 |
| Judd, HL | 1 |
| Kaplan, SA | 1 |
| Shoupe, D | 2 |
| Kumar, DD | 1 |
| Coleman, DL | 1 |
| Schwizer, RW | 1 |
| Leiter, EH | 1 |
| Ebeling, P | 3 |
| Stenman, UH | 2 |
| Seppälä, M | 2 |
| Koivisto, VA | 3 |
| Wild, RA | 2 |
| Tropeano, G | 1 |
| Lucisano, A | 1 |
| Liberale, I | 1 |
| Barini, A | 1 |
| Vuolo, IP | 1 |
| Martino, G | 1 |
| Menini, E | 1 |
| Dell'Acqua, S | 1 |
| Buffington, CK | 4 |
| Givens, JR | 3 |
| Kitabchi, AE | 4 |
| Pourmotabbed, G | 1 |
| Haffner, SM | 2 |
| Mykkanen, L | 2 |
| Gruber, KK | 1 |
| Rainwater, DL | 1 |
| Laakso, M | 2 |
| Karhapää, P | 1 |
| Beer, NA | 2 |
| Jakubowicz, DJ | 2 |
| Beer, RM | 2 |
| Arocha, IR | 1 |
| Nestler, JE | 3 |
| Lasco, A | 2 |
| Cucinotta, D | 2 |
| Gigante, A | 1 |
| Denuzzo, G | 1 |
| Pedulla, M | 1 |
| Trifiletti, A | 2 |
| Frisina, N | 2 |
| McCarty, MF | 1 |
| Vogiatzi, MG | 1 |
| Boeck, MA | 1 |
| Vlachopapadopoulou, E | 1 |
| el-Rashid, R | 1 |
| New, MI | 1 |
| Dunaif, A | 1 |
| Scott, D | 1 |
| Finegood, D | 1 |
| Quintana, B | 1 |
| Whitcomb, R | 1 |
| Casson, PR | 1 |
| Hornsby, PJ | 1 |
| Buster, JE | 1 |
| Yamauchi, A | 1 |
| Takei, I | 1 |
| Nakamoto, S | 1 |
| Ohashi, N | 1 |
| Kitamura, Y | 1 |
| Tokui, M | 1 |
| Nakano, S | 1 |
| Takayama, S | 1 |
| Kasuga, A | 1 |
| Katsukawa, F | 1 |
| Saruta, T | 1 |
| Skolnick, AA | 1 |
| Hansen, PA | 2 |
| Nolte, LA | 1 |
| Chen, M | 1 |
| Chen, MM | 1 |
| Sir, T | 1 |
| López, G | 1 |
| Castillo, T | 1 |
| Muñoz, S | 1 |
| Durruty, P | 1 |
| Calvillán, M | 1 |
| Kimura, M | 1 |
| Tanaka, S | 1 |
| Kiuchi, Y | 1 |
| Yamakawa, T | 1 |
| Katz, S | 1 |
| Morales, AJ | 1 |
| Mukasa, K | 3 |
| Kanesiro, M | 1 |
| Okamura, J | 1 |
| Saito, T | 2 |
| Satoh, S | 3 |
| Kaneshiro, M | 1 |
| Kawasaki, S | 1 |
| Okamura, A | 2 |
| Goodfriend, TL | 1 |
| Kelley, DE | 1 |
| Goodpaster, BH | 1 |
| Winters, SJ | 1 |
| Paolisso, G | 1 |
| Tagliamonte, MR | 1 |
| Rizzo, MR | 1 |
| Scheen, A | 1 |
| D'Onofrio, F | 1 |
| Lefèbvre, P | 1 |
| Nedĕlníková, K | 1 |
| Svacina, S | 2 |
| Matoulek, M | 2 |
| Sonka, J | 1 |
| Kajita, K | 1 |
| Miura, A | 1 |
| Ishizawa, M | 1 |
| Kanoh, Y | 1 |
| Vrbíklová, J | 1 |
| Sulcová, J | 2 |
| Snajderová, M | 1 |
| Cibula, D | 1 |
| Pobisová, Z | 1 |
| Kikuchi, T | 1 |
| Ito, S | 1 |
| Haas, T | 1 |
| Satoh, M | 1 |
| Yokoya, S | 1 |
| Hachiya, Y | 1 |
| Hachiya, M | 1 |
| Fujisawa, T | 1 |
| Hoshino, K | 1 |
| Saji, T | 1 |
| Morabito, N | 1 |
| Gaudio, A | 1 |
| Morini, E | 1 |
| Basile, G | 1 |
| Nicita-Mauro, V | 1 |
| Saenger, P | 1 |
| Dimartino-Nardi, J | 1 |
| Abadie, JM | 1 |
| Malcom, GT | 1 |
| Porter, JR | 1 |
| Svec, F | 1 |
| Zdrojewicz, Z | 1 |
| Kesik, S | 1 |
| Alaupovic, P | 1 |
| Parker, IJ | 1 |
| Givens, J | 1 |
| Inouye, H | 1 |
| Lindgren, F | 1 |
| Dahlquist, G | 1 |
| Efendić, S | 1 |
| Persson, B | 1 |
| Skottner, A | 1 |
| Falcone, T | 1 |
| Finegood, DT | 1 |
| Fantus, IG | 1 |
| Morris, D | 1 |
| Caprio, S | 1 |
| Plewe, G | 1 |
| Diamond, MP | 1 |
| Simonson, DC | 1 |
| Boulware, SD | 1 |
| Sherwin, RS | 1 |
| Tamborlane, WV | 1 |
| Richards, GE | 1 |
| Cavallo, A | 1 |
| Meyer, WJ | 1 |
| Prince, MJ | 1 |
| Peters, EJ | 1 |
| Stuart, CA | 1 |
| Smith, ER | 1 |
| Bruno, B | 1 |
| Poccia, G | 1 |
| Fabbrini, A | 1 |
| Clore, JN | 1 |
| Strauss, JF | 1 |
| Blackard, WG | 1 |
| Alper, MM | 1 |
| Garner, PR | 1 |
| Jialal, I | 1 |
| Naiker, P | 1 |
| Reddi, K | 1 |
| Moodley, J | 1 |
| Joubert, SM | 1 |
| Micic, D | 1 |
| Popovic, V | 1 |
| Nesovic, M | 1 |
| Sumarac, M | 1 |
| Dragasevic, M | 1 |
| Kendereski, A | 1 |
| Markovic, D | 1 |
| Djordjevic, P | 1 |
| Manojlovic, D | 1 |
| Micic, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Trial of Bicalutamide Versus Placebo in Reproductive-Aged Women With Nonalcoholic Fatty Liver Disease (NAFLD) and Polycystic Ovary Syndrome (PCOS)[NCT05979389] | Phase 1 | 50 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| The Effects of Acetyl L--Carnitine and Myo/Chiro-Inositol on Improving Ovulation, Pregnancy Rate, Ovarian Function and Perceived Stress Response in Patients With PCOS[NCT05767515] | 120 participants (Anticipated) | Interventional | 2023-04-15 | Not yet recruiting | |||
| Metformin Versus Metfotmin Plus Low-dose Spironolactone in the Treatment of Overweight/Obese Patients With Polycystic Ovary Syndrome: a Randomized Study[NCT01526616] | 56 participants (Actual) | Interventional | 2010-05-31 | Completed | |||
| Pathogenesis of Sarcopenia and Metabolic Changes in Aging[NCT00254371] | 150 participants | Interventional | 1998-07-31 | Completed | |||
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| Incidence of Diabetes and Cardiovascular Disease in Mexican Americans[NCT00005205] | 0 participants | Observational | 1987-08-31 | Completed | |||
| Biologic Effects of DHEA in Humans[NCT00099697] | 56 participants | Interventional | 2001-06-30 | Completed | |||
| Is DHEA Replacement Beneficial?[NCT00182975] | Phase 3 | 142 participants (Actual) | Interventional | 2002-09-30 | Completed | ||
| BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects[NCT01977859] | Phase 1 | 4 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects[NCT03234751] | Phase 1 | 6 participants (Actual) | Interventional | 2017-07-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for dehydroepiandrosterone and Insulin Sensitivity
| Article | Year |
|---|---|
Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period.
Topics: Aged; Aged, 80 and over; Aging; Animals; Cardiovascular Diseases; Cardiovascular System; Dehydroepia | 2020 |
The influence of dehydroepiandrosterone (DHEA) on fasting plasma glucose, insulin levels and insulin resistance (HOMA-IR) index: A systematic review and dose response meta-analysis of randomized controlled trials.
Topics: Adjuvants, Immunologic; Blood Glucose; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Hum | 2020 |
Effects of DHEA on metabolic and endocrine functions of adipose tissue.
Topics: Adipogenesis; Adipokines; Adipose Tissue; Animals; Cell Proliferation; Dehydroepiandrosterone; Gluco | 2013 |
Gender differences in insulin resistance, body composition, and energy balance.
Topics: Body Composition; Dehydroepiandrosterone; Energy Intake; Energy Metabolism; Estrogens; Female; Human | 2009 |
Androgens, insulin resistance and vascular disease in men.
Topics: Aged; Aging; Arteriosclerosis; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Humans; Insulin Re | 2005 |
Physiological importance of dehydroepiandrosterone.
Topics: Breast Neoplasms; Cardiovascular Diseases; Dehydroepiandrosterone; Female; Humans; Insulin Resistanc | 1994 |
Role of endogenous estrogen in the hirsutism paradigm.
Topics: Adrenal Glands; Androgens; Apolipoproteins; Dehydroepiandrosterone; Estrogens; Female; Hirsutism; Hu | 1994 |
Adrenal androgens, insulin resistance, and cardiovascular disease.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Androgens; Cardiovascular Diseases; Dehydroepiandr | 1996 |
Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DS) as therapeutic options in menopause.
Topics: Adult; Aging; Animals; Bone Remodeling; Cardiovascular System; Dehydroepiandrosterone; Estrogen Repl | 1998 |
[Is aging associated with a diminution of insulin sensitivity? Roles of IGF1 and dehydroepiandrosterone].
Topics: Aged; Aging; Body Composition; Body Mass Index; Dehydroepiandrosterone; Diet; Exercise; Humans; Insu | 1999 |
Androgen effect on insulin action and glucose metabolism.
Topics: Androgens; Animals; Dehydroepiandrosterone; Disease Models, Animal; Drug Evaluation, Preclinical; Gl | 2000 |
Premature adrenarche.
Topics: Adrenal Glands; Androgens; Blood Glucose; Child; Dehydroepiandrosterone; Female; Humans; Hyperandrog | 2001 |
[Dehydroepiandrosterone (DHEA)--youth hormone?].
Topics: Aging; Arteriosclerosis; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabetes | 2001 |
21 trials available for dehydroepiandrosterone and Insulin Sensitivity
| Article | Year |
|---|---|
Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study.
Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; Dehydroepiandrosterone; Diet; Female; Follicle St | 2022 |
Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Androgens; Blood Glucose; Curcumin; Dehydroepiandrosterone; Dietary Supplements; | 2021 |
A synthetic anti-inflammatory sterol improves insulin sensitivity in insulin-resistant obese impaired glucose tolerance subjects.
Topics: Adiponectin; Adult; Anti-Inflammatory Agents; Blood Glucose; Body Mass Index; C-Reactive Protein; Ch | 2013 |
In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Female; Hirsutism; | 2014 |
Association between circulating endogenous androgens and insulin sensitivity changes with exercise training in midlife women.
Topics: Adult; Androgens; Blood Glucose; Body Composition; Cardiovascular Diseases; Cholesterol; Dehydroepia | 2014 |
The safety of 52 weeks of oral DHEA therapy for postmenopausal women.
Topics: Administration, Oral; Blood Glucose; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Doubl | 2009 |
A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats.
Topics: Adult; Analysis of Variance; Animals; Blood Glucose; Blotting, Western; Cell Movement; Chemokines; C | 2010 |
Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans.
Topics: Aged; Aging; Animals; Blood Chemical Analysis; Cytokines; Dehydroepiandrosterone; Energy Intake; Exe | 2011 |
Increased adrenal androgen levels in patients with Prader-Willi syndrome are associated with insulin, IGF-I, and leptin, but not with measures of obesity.
Topics: Adolescent; Adrenal Glands; Analysis of Variance; Androgens; Androstenedione; Anthropometry; Body Co | 2002 |
Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men.
Topics: Adjuvants, Immunologic; Brachial Artery; Dehydroepiandrosterone; Endothelium, Vascular; Humans; Hype | 2003 |
Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients.
Topics: Aged; Amlodipine; Analysis of Variance; Body Mass Index; Calcium Channel Blockers; Dehydroepiandrost | 2004 |
Interactive effect of an acute bout of resistance exercise and dehydroepiandrosterone administration on glucose tolerance and serum lipids in middle-aged women.
Topics: Adult; Blood Glucose; Creatine Kinase; Dehydroepiandrosterone; Exercise; Glucose Tolerance Test; Hum | 2005 |
Free fatty acids increase androgen precursors in vivo.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adult; Androgens; Androstenedione; Blood Glucose; Cros | 2006 |
DHEA in elderly women and DHEA or testosterone in elderly men.
Topics: Adult; Aged; Aging; Body Composition; Bone Density; Dehydroepiandrosterone; Double-Blind Method; Est | 2006 |
Changes in serum sex hormone profiles after short-term low-dose administration of dehydroepiandrosterone (DHEA) to young and elderly persons.
Topics: Adult; Aging; Cell Adhesion Molecules; Cytokines; Dehydroepiandrosterone; Dose-Response Relationship | 2007 |
Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women.
Topics: Aged; Blood Glucose; Body Composition; Cholesterol; Dehydroepiandrosterone; Dehydroepiandrosterone S | 2008 |
Effects of nitrendipine on glucose tolerance and serum insulin and dehydroepiandrosterone sulfate levels in insulin-resistant obese and hypertensive men.
Topics: Adult; Analysis of Variance; Blood Glucose; Blood Pressure; Dehydroepiandrosterone; Dehydroepiandros | 1993 |
The calcium channel blocker amlodipine raises serum dehydroepiandrosterone sulfate and androstenedione, but lowers serum cortisol, in insulin-resistant obese and hypertensive men.
Topics: Adult; Amlodipine; Androgens; Androstenedione; Calcium Channel Blockers; Dehydroepiandrosterone; Deh | 1993 |
Dehydroepiandrosterone in morbidly obese adolescents: effects on weight, body composition, lipids, and insulin resistance.
Topics: Adolescent; Adult; Androgens; Body Weight; Dehydroepiandrosterone; Double-Blind Method; Female; Huma | 1996 |
The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.
Topics: Adult; Body Mass Index; Chromans; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Double-Bli | 1996 |
Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose Intolerance; Hormone Replace | 2001 |
92 other studies available for dehydroepiandrosterone and Insulin Sensitivity
| Article | Year |
|---|---|
Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites.
Topics: Animals; Berberine; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Female; Gastrointestinal Micr | 2021 |
Irisin reduces the abnormal reproductive and metabolic phenotypes of PCOS by regulating the activity of brown adipose tissue in mice†.
Topics: Adipose Tissue, Brown; Animals; Dehydroepiandrosterone; Female; Fibronectins; Humans; Insulin Resist | 2022 |
Oxidative Stress as a Contributor to Insulin Resistance in the Skeletal Muscles of Mice with Polycystic Ovary Syndrome.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Dehydroepiandrosterone; Female; Humans; Insulin R | 2022 |
Effects of dehydroepiandrosterone alone or in combination with a high-fat diet and antibiotic cocktail on the heterogeneous phenotypes of PCOS mouse models by regulating gut microbiota.
Topics: Animals; Dehydroepiandrosterone; Diet, High-Fat; Female; Gastrointestinal Microbiome; Humans; Hypera | 2022 |
Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†.
Topics: Adipose Tissue, White; Animals; Dehydroepiandrosterone; Female; Glucagon-Like Peptide-1 Receptor; Hu | 2023 |
Effects of gut microbiota on omega-3-mediated ovary and metabolic benefits in polycystic ovary syndrome mice.
Topics: Animals; Dehydroepiandrosterone; Dietary Supplements; Fatty Acids, Omega-3; Female; Gastrointestinal | 2023 |
Dehydroepiandrosterone protects against hepatic glycolipid metabolic disorder and insulin resistance induced by high fat via activation of AMPK-PGC-1α-NRF-1 and IRS1-AKT-GLUT2 signaling pathways.
Topics: AMP-Activated Protein Kinases; Animals; Dehydroepiandrosterone; Fatty Liver; Glucose Transporter Typ | 2020 |
Decreased brain and muscle ARNT-like protein 1 expression mediated the contribution of hyperandrogenism to insulin resistance in polycystic ovary syndrome.
Topics: 3T3-L1 Cells; Adipocytes; Animals; ARNTL Transcription Factors; Brain; Circadian Clocks; Dehydroepia | 2020 |
White, brown, and bone marrow adipose tissue behavior in DHEA-induced PCOS mice.
Topics: Adipose Tissue; Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Insulin Resistance; | 2021 |
Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress.
Topics: Animals; Dehydroepiandrosterone; Electroacupuncture; Female; Insulin Resistance; Mitochondria; Oxida | 2020 |
Dulaglutide, a long-acting GLP-1 receptor agonist, can improve hyperandrogenemia and ovarian function in DHEA-induced PCOS rats.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Disease Models, Animal; Female; Gene Expression Regula | 2021 |
The impact of levothyroxine on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in men with autoimmune hypothyroidism and early-onset androgenetic alopecia.
Topics: Adolescent; Adult; Alopecia; Autoimmunity; Dehydroepiandrosterone; Hashimoto Disease; Humans; Hypoth | 2021 |
Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat.
Topics: Adipose Tissue, Brown; Animals; Anovulation; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity A | 2017 |
AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome.
Topics: 3-Hydroxysteroid Dehydrogenases; Adipocytes; Adolescent; Adult; Aldo-Keto Reductase Family 1 Member | 2017 |
Potential therapeutic effect of alkaline reduced water in polycystic ovarian syndrome.
Topics: Animals; Dehydroepiandrosterone; Female; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydr | 2017 |
Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; DNA-Binding Proteins; Drugs, Chinese Herbal | 2017 |
Dehydroepiandrosterone supplementation is not beneficial in the late postmenopausal period in diet-induced obese rats.
Topics: Adiposity; Animals; Dehydroepiandrosterone; Diet, High-Fat; Dietary Supplements; Eating; Female; Glu | 2018 |
The possible role of stress induced hormonal disbalance in the patophysiology of insulin resistane in lean individuals.
Topics: Adiposity; alpha 1-Antitrypsin; Blood Glucose; Body Weight; Cardiovascular Diseases; Dehydroepiandro | 2018 |
Amelioration by quercetin of insulin resistance and uterine GLUT4 and ERα gene expression in rats with polycystic ovary syndrome (PCOS).
Topics: Animals; Antioxidants; Dehydroepiandrosterone; Disease Models, Animal; Estrogen Receptor alpha; Fema | 2019 |
The effect of cinnamon on polycystic ovary syndrome in a mouse model.
Topics: Animals; Cinnamomum zeylanicum; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Insu | 2018 |
MIF May Participate in Pathogenesis of Polycystic Ovary Syndrome in Rats through MAPK Signalling Pathway.
Topics: Animals; Dehydroepiandrosterone; Diet, High-Fat; Disease Models, Animal; Fasting; Female; Humans; In | 2018 |
The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome.
Topics: Adiposity; Animals; Blood Glucose; Dehydroepiandrosterone; Disease Models, Animal; Estrous Cycle; Fa | 2018 |
Effects of L-carnitine on Polycystic Ovary Syndrome.
Topics: Adult; Blood Glucose; Body Mass Index; Carnitine; Dehydroepiandrosterone; Female; Humans; Insulin; I | 2019 |
Steroid replacement in primary adrenal failure does not appear to affect circulating adipokines.
Topics: Addison Disease; Adiponectin; Adrenal Cortex Hormones; Adult; Body Composition; Body Mass Index; Deh | 2015 |
Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model.
Topics: Angiogenesis Modulating Agents; Angiopoietin-1; Angiopoietin-2; Animals; Dehydroepiandrosterone; Fem | 2015 |
DHEA-induced modulation of renal gluconeogenesis, insulin sensitivity and plasma lipid profile in the control- and dexamethasone-treated rabbits. Metabolic studies.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Dehydroepiandrosterone; Gluconeogenesis; Glucose T | 2016 |
High-fat diets exaggerate endocrine and metabolic phenotypes in a rat model of DHEA-induced PCOS.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Diet, High-Fat; Estrous Cycle; Female; Glucose Toleran | 2016 |
Brown adipose tissue transplantation ameliorates polycystic ovary syndrome.
Topics: Adiponectin; Adipose Tissue, Brown; Adult; Analysis of Variance; Animals; Blood Glucose; Dehydroepia | 2016 |
Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet.
Topics: Androstenedione; Animals; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Diet, High-Fat; Insulin | 2016 |
Dioscorea esculenta-induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model.
Topics: Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dioscor | 2017 |
11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome.
Topics: Adult; Androgens; Androstenedione; Androstenes; Blood Glucose; Case-Control Studies; Chromatography, | 2017 |
Adiponectin is involved in the protective effect of DHEA against metabolic risk in aged rats.
Topics: Adiponectin; Adipose Tissue; Aging; Animals; Blood Glucose; Body Weight; Cholesterol; Dehydroepiandr | 2008 |
Does the hormone of eternal youth protect against nonalcoholic steatohepatitis?
Topics: Adiponectin; Dehydroepiandrosterone; Disease Progression; Fatty Acids, Nonesterified; Fatty Liver; H | 2008 |
SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats.
Topics: Animals; Cell Death; Dehydroepiandrosterone; Dietary Fats; Fatty Liver; Fructose; Hyperlipidemias; I | 2009 |
Amelioration of glucose intolerance by the synthetic androstene HE3286: link to inflammatory pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Dehydroepiandrosterone; Gene Expression Profiling; Glu | 2010 |
Dehydroepiandrosterone to enhance physical performance: myth and reality.
Topics: Adrenal Insufficiency; Aged; Aged, 80 and over; Aging; Anabolic Agents; Athletic Performance; Body C | 2010 |
A 20-year follow-up of young women with polycystic ovary syndrome.
Topics: Adult; Anovulation; Body Mass Index; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; F | 2012 |
Dehydroepiandrosterone in the type 1 diabetes mellitus.
Topics: Adolescent; Adult; Age Factors; Aging; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone | 2012 |
Androgens in the maternal and fetal circulation: association with insulin resistance.
Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Androgens; Aromatase; Dehydroepiandrosterone; Diabetes, Ges | 2013 |
The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity.
Topics: Adipose Tissue; Animals; Body Composition; Body Weight; Cholesterol; Dehydroepiandrosterone; Diet; D | 2003 |
Glucose action and adrenocortical biosynthesis in women with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenal Cortex Hormones; | 2004 |
Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgen Antag | 2004 |
Expression of resistin mRNA in adipose tissue of rat model with polycystic ovarian syndrome and its implication.
Topics: Adipose Tissue; Animals; Animals, Newborn; Dehydroepiandrosterone; Estradiol; Female; Insulin Resist | 2004 |
The association of serum androgens and insulin resistance with fat distribution in polycystic ovary syndrome.
Topics: Absorptiometry, Photon; Adult; Androgens; Blood Glucose; Body Fat Distribution; Body Mass Index; Cas | 2006 |
Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.
Topics: Animals; Cattle; Cells, Cultured; Dehydroepiandrosterone; Endothelin-1; Endothelium, Vascular; Enzym | 2006 |
Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome.
Topics: Blood Glucose; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Dehydroepiandrosterone; Diabetes | 2006 |
The role of dehydroepiandrosterone levels on physiologic acclimatization to chronic mountaineering activity.
Topics: Acclimatization; Adult; Dehydroepiandrosterone; Erythropoietin; Glucose Tolerance Test; Hematologic | 2006 |
Aging and fountain-of-youth hormones.
Topics: Adult; Aged; Aging; Body Composition; Dehydroepiandrosterone; Female; Hormone Replacement Therapy; H | 2006 |
Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Glands; Adult; Aged; Antipsychotic Agents; Cortodo | 2007 |
Oxidative stress in nonobese women with polycystic ovary syndrome: correlations with endocrine and screening parameters.
Topics: Adult; Antioxidants; Body Mass Index; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulatin | 2008 |
Dehydroepiandrosterone in relation to adiposity, glucose tolerance and lipid spectra in Czech non-diabetic population.
Topics: Adipose Tissue; Adult; Blood Glucose; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Contracep | 2008 |
Insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose; Humans; In | 1983 |
Insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose; Humans; In | 1983 |
Insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose; Humans; In | 1983 |
Insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucose; Humans; In | 1983 |
Insulin resistance in polycystic ovary syndrome.
Topics: Adult; Anovulation; Dehydroepiandrosterone; Estradiol; Female; Hirsutism; Humans; Insulin; Insulin R | 1983 |
Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice.
Topics: Aging; Animals; Blood Glucose; Body Weight; Dehydroepiandrosterone; Diabetes Mellitus; Female; Gluco | 1984 |
The influence of androgens on insulin resistance.
Topics: Adult; Androgens; Androstane-3,17-diol; Dehydroepiandrosterone; Dihydrotestosterone; Female; Hirsuti | 1984 |
Acute hyperinsulinemia, androgen homeostasis and insulin sensitivity in healthy man.
Topics: Acute Disease; Adult; Androgens; C-Peptide; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; | 1995 |
Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome.
Topics: Administration, Oral; Adult; Androgens; Androstenedione; beta-Endorphin; C-Peptide; Dehydroepiandros | 1994 |
Enhanced adrenocortical activity as a contributing factor to diabetes in hyperandrogenic women.
Topics: Adrenal Cortex; Adult; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Female; Glucose Tolerance | 1994 |
Case report: amelioration of insulin resistance in diabetes with dehydroepiandrosterone.
Topics: Adolescent; Blood Glucose; Dehydroepiandrosterone; Dexamethasone; Diabetes Mellitus, Type 2; Drug Th | 1993 |
Lack of association between sex hormones and Lp(a) concentrations in American and Finnish men.
Topics: Adult; Arteriosclerosis; Cardiovascular Diseases; Dehydroepiandrosterone; Dehydroepiandrosterone Sul | 1994 |
Insulin resistance, body fat distribution, and sex hormones in men.
Topics: Adipose Tissue; Blood Glucose; Body Composition; Body Mass Index; C-Peptide; Dehydroepiandrosterone; | 1994 |
No changes of peripheral insulin resistance in polycystic ovary syndrome after long-term reduction of endogenous androgens with leuprolide.
Topics: Adult; Androgens; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; F | 1995 |
Androgens and insulin resistance in type 1 diabetic men.
Topics: Adult; Calorimetry, Indirect; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabetes Melli | 1995 |
Anabolic effects of insulin on bone suggest a role for chromium picolinate in preservation of bone density.
Topics: Animals; Bone Density; Bone Resorption; Calcium; Collagen; Dehydroepiandrosterone; Dehydroepiandrost | 1995 |
Hyperglycemia decreases dehydroepiandrosterone in Japanese male with impaired glucose tolerance and low insulin response.
Topics: Dehydroepiandrosterone; Diabetes Mellitus; Glucose Intolerance; Glucose Tolerance Test; Humans; Hype | 1996 |
Scientific verdict still out on DHEA.
Topics: Aging; Animals; Cardiovascular System; Dehydroepiandrosterone; Food, Fortified; Humans; Immune Syste | 1996 |
DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet.
Topics: Animals; Biological Transport; Body Weight; Dehydroepiandrosterone; Deoxyglucose; Dietary Fats; Insu | 1997 |
DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet.
Topics: Animals; Biological Transport; Body Weight; Dehydroepiandrosterone; Deoxyglucose; Dietary Fats; Insu | 1997 |
DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet.
Topics: Animals; Biological Transport; Body Weight; Dehydroepiandrosterone; Deoxyglucose; Dietary Fats; Insu | 1997 |
DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet.
Topics: Animals; Biological Transport; Body Weight; Dehydroepiandrosterone; Deoxyglucose; Dietary Fats; Insu | 1997 |
DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Mass Index; Body Weight; Dehydroepiandrostero | 1998 |
DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Mass Index; Body Weight; Dehydroepiandrostero | 1998 |
DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Mass Index; Body Weight; Dehydroepiandrostero | 1998 |
DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Mass Index; Body Weight; Dehydroepiandrostero | 1998 |
[Biochemical markers and methods to assess insulin resistance in normal, obese and hyperandrogenic women].
Topics: Adult; Biomarkers; Blood Glucose; Dehydroepiandrosterone; Female; Glucose Tolerance Test; Humans; Hy | 1997 |
Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Eating; Female; Glucos | 1998 |
Dehydroepiandrosterone (DHEA) ameliorates the insulin sensitivity in older rats.
Topics: Aging; Animals; Body Weight; Dehydroepiandrosterone; Feeding Behavior; Insulin; Insulin Resistance; | 1998 |
Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone.
Topics: Androstenedione; Animals; Blood Glucose; Body Composition; Chromans; Dehydroepiandrosterone; Diabete | 1999 |
Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women.
Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Aldosterone; Blood Glucose; Blood Pressure; Body Mass | 1999 |
Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women.
Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Aldosterone; Blood Glucose; Blood Pressure; Body Mass | 1999 |
Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women.
Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Aldosterone; Blood Glucose; Blood Pressure; Body Mass | 1999 |
Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women.
Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Aldosterone; Blood Glucose; Blood Pressure; Body Mass | 1999 |
[Metabolic and hormonal links in obese individuals with and without symptoms of syndrome X].
Topics: Arteriosclerosis; Dehydroepiandrosterone; Diabetes Mellitus; Humans; Insulin Resistance; Lipids; Obe | 2000 |
The role of atypical and conventional PKC in dehydroepiandrosterone-induced glucose uptake and dexamethasone-induced insulin resistance.
Topics: Adipocytes; Adjuvants, Immunologic; Androstadienes; Animals; Antimetabolites; Carbazoles; Cells, Cul | 2000 |
An analysis of the relationship between insulin resistance and the activity of steroid C17,20-lyase and 3beta-hydroxysteroid dehydrogenase in ovaries and adrenals in women with polycystic ovary syndrome.
Topics: 17-alpha-Hydroxyprogesterone; 3-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenocorticotropic H | 2000 |
Dehydroepiandrosterone suppresses elevated hepatic glucose-6-phosphatase mRNA level in C57BL/KsJ-db/db mice: comparison with troglitazone.
Topics: Animals; Blood Glucose; Blotting, Northern; Body Weight; Chromans; Dehydroepiandrosterone; Diabetes | 2000 |
[Derivatives of dehydroepiandrosterone and their changes during a one-day starvation test].
Topics: Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Insulin Resistance; M | 2000 |
Two hyperandrogenic adolescent girls with congenital portosystemic shunt.
Topics: Adolescent; Adrenocorticotropic Hormone; Androstenedione; Dehydroepiandrosterone; Female; Glucose To | 2001 |
Dehydroepiandrosterone alters phospholipid profiles in Zucker rat muscle tissue.
Topics: Animals; Arachidonic Acid; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Fatty Acids; Heart; In | 2001 |
Lipoprotein abnormalities in hirsute women. II. Compensatory responses of insulin resistance and dehydroepiandrosterone sulfate with obesity.
Topics: Adaptation, Physiological; Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Hi | 1992 |
Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females.
Topics: Adrenocortical Hyperfunction; Blood Glucose; C-Peptide; Dehydroepiandrosterone; Female; Glucose Tole | 1991 |
Role of adrenal and gonadal androgens in insulin action and metabolism.
Topics: Adrenal Glands; Dehydroepiandrosterone; Erythrocytes; Female; Glucose Tolerance Test; Humans; Hyperp | 1991 |
Insulin sensitivity and glucose-induced insulin response changes during adolescence.
Topics: Adolescent; Age Factors; Androgens; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone Su | 1990 |
Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women.
Topics: Adult; Androgens; Androstenedione; Blood Glucose; Dehydroepiandrosterone; Female; Glucose Tolerance | 1990 |
Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity.
Topics: Adolescent; Adult; Blood Glucose; C-Peptide; Child; Dehydroepiandrosterone; Dehydroepiandrosterone S | 1989 |
Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: pediatric perspective and natural history.
Topics: Acanthosis Nigricans; Adolescent; Androstenedione; Body Weight; Child; Dehydroepiandrosterone; Femal | 1985 |
Insulin resistance and secretion in polycystic ovarian disease.
Topics: Adolescent; Adult; Androgens; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; | 1985 |
The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans.
Topics: Acanthosis Nigricans; Adult; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Fema | 1987 |
Elevated serum dehydroepiandrosterone sulfate levels in patients with insulin resistance, hirsutism, and acanthosis nigricans.
Topics: Acanthosis Nigricans; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Follicle Stimu | 1987 |
Evidence for insulin resistance in nonobese patients with polycystic ovarian disease.
Topics: Adult; Androstenedione; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Eryth | 1987 |
Androgen levels during sequential insulin euglycemic clamp studies in patients with polycystic ovary disease.
Topics: Adult; Blood Glucose; C-Peptide; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glu | 1988 |