dehydroepiandrosterone has been researched along with Inflammation in 78 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Excerpt | Relevance | Reference |
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"Previous studies have shown that chronic inflammation and oxidative stress may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS), and glutamine (Gln) have showed the anti-inflammatory and antioxidant properties." | 9.34 | The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats. ( Ding, J; Hu, X; Wu, G; Yang, J, 2020) |
"This study was implemented to address the role of Roflumilast in polycystic ovary syndrome (PCOS) as well as to discuss its reaction mechanism in vivo and in vitro." | 8.31 | PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro. ( Dong, X; Ji, X; Liu, S; Wang, L; Ye, Y, 2023) |
"Although nerolidol (NRL) is a naturally occurring sesquiterpene alcohol with many pharmacological activities, its role in dehydroepiandrosterone DHEA-induced polycystic ovary syndrome PCOS is unknown." | 8.31 | Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosis. ( Aydın, M; Çiftçi, O; Doğan, A; Hayal, TB; Özek, DA; Taşlıdere, A; Türkmen, NB; Ünüvar, S; Yaşar, Ş; Yüce, H, 2023) |
" The present research explores potentially advantageous BHF impacts and whereby BHF alleviates dehydroepiandrosterone (DHEA)-induced inflammation and endocrine disruption." | 8.12 | Inhibitory effect of bushen huoxue formula against dehydroepiandrosterone-induced inflammation in granulosa cells through TLR4/NF-κB signaling pathway. ( Chen, X; Cui, M; Fu, B; Jin, W; Sun, L; Wang, C; Wang, M, 2022) |
"Administration of dehydroepiandrosterone (DHEA) has been demonstrated to improve survival and cellular immune functions during systemic inflammation." | 7.76 | Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration. ( Hammes, F; Kobbe, P; Oberbeck, R; Schmitz, D; Wegner, A, 2010) |
"Dehydroepiandrosterone (DHEA) has beneficial effects in fat-reduction, anti-oxidation and anti-inflammation, and it was widely applied to alleviate multiple metabolic-related diseases; however, there are few reports on whether DHEA can prevent against metabolic-related diseases by modulating oxidative stress and inflammation, especially FLHS in laying hens." | 5.91 | Dehydroepiandrosterone protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in hepatocytes. ( Jiang, Z; Ma, H; Wang, H; Yang, Y; Yao, Y, 2023) |
"Inflammation is involved in the progression of polycystic ovary syndrome." | 5.91 | Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†. ( Ding, X; Li, G; Li, N; Lin, Y; Ma, Y; Wang, X; Xiong, C; Yang, Y; Yuan, Y; Zhang, Y; Zhang, Z, 2023) |
"Inflammation is likely to be a crucial contributor to the pathogenesis of PCOS." | 5.51 | Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome. ( Bulbul, A; Chen, S; Cui, X; Li, Y; Liu, S; Sun, D; Yan, Q; Zheng, Q, 2019) |
"The risk for atherosclerosis is increased in postmenopausal women." | 5.37 | Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells. ( Hao, Q; Li, DJ; Wang, L; Wang, WJ; Wang, YD, 2011) |
"Previous studies have shown that chronic inflammation and oxidative stress may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS), and glutamine (Gln) have showed the anti-inflammatory and antioxidant properties." | 5.34 | The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats. ( Ding, J; Hu, X; Wu, G; Yang, J, 2020) |
"Dehydroepiandrosterone (DHEA) was converted into androstenediol, androstenedione (ASD), 16alphaOH-DHEA, 7alphaOH-DHEA, testosterone, estrone (E1), estradiol (E2), estriol (E3), and 16alphaOH-testosterone (similar in OA and RA)." | 5.33 | Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. ( Anders, S; Naumann, H; Schmidt, M; Schölmerich, J; Straub, RH; Weidler, C, 2005) |
"Airway inflammation was provoked in D." | 5.31 | Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice. ( Chen, CL; Liu, YH; Yu, CK, 2002) |
"The molar ratio of serum levels of DHEA/androstenedione (ASD) was increased in patients with an acute inflammatory stressful disease state and was decreased in patients with chronic inflammation." | 5.10 | Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor. ( Falk, W; Herfarth, H; Lehle, K; Preuner, J; Scholmerich, J; Straub, RH; Weber, M, 2002) |
"This study was implemented to address the role of Roflumilast in polycystic ovary syndrome (PCOS) as well as to discuss its reaction mechanism in vivo and in vitro." | 4.31 | PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro. ( Dong, X; Ji, X; Liu, S; Wang, L; Ye, Y, 2023) |
"Although nerolidol (NRL) is a naturally occurring sesquiterpene alcohol with many pharmacological activities, its role in dehydroepiandrosterone DHEA-induced polycystic ovary syndrome PCOS is unknown." | 4.31 | Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosis. ( Aydın, M; Çiftçi, O; Doğan, A; Hayal, TB; Özek, DA; Taşlıdere, A; Türkmen, NB; Ünüvar, S; Yaşar, Ş; Yüce, H, 2023) |
" Biomarkers of intestinal permeability (liposaccharide-binding protein [LBP]) and BBB permeability (S100 calcium-binding protein B [S100B]), stress (cortisol, dehydroepiandrosterone sulfate [DHEA-S] epinephrine, norepinephrine) and inflammation (interleukin-6 [IL-6], high-sensitivity C-reactive protein [hsCRP]) were measured in blood." | 4.12 | Stress and the gut-brain axis: Cognitive performance, mood state, and biomarkers of blood-brain barrier and intestinal permeability following severe physical and psychological stress. ( Berryman, CE; Farina, EK; Halagarda, CJ; Lieberman, HR; McClung, HL; McClung, JP; Pasiakos, SM; Philip Karl, J; Sepowitz, JJ; Varanoske, AN, 2022) |
" The present research explores potentially advantageous BHF impacts and whereby BHF alleviates dehydroepiandrosterone (DHEA)-induced inflammation and endocrine disruption." | 4.12 | Inhibitory effect of bushen huoxue formula against dehydroepiandrosterone-induced inflammation in granulosa cells through TLR4/NF-κB signaling pathway. ( Chen, X; Cui, M; Fu, B; Jin, W; Sun, L; Wang, C; Wang, M, 2022) |
"Administration of dehydroepiandrosterone (DHEA) has been demonstrated to improve survival and cellular immune functions during systemic inflammation." | 3.76 | Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration. ( Hammes, F; Kobbe, P; Oberbeck, R; Schmitz, D; Wegner, A, 2010) |
"Vaginitis is one of the most common causes of patient visits to gynecologists, primary care providers, and urgent care centers." | 2.66 | Noncandidal vaginitis: a comprehensive approach to diagnosis and management. ( Eckert, LO; Kus, LH; Neal, CM; Peipert, JF, 2020) |
"Dehydroepiandrosterone (DHEA) is a multifunctional steroid with a broad range of biological effects in humans and animals." | 2.48 | Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports. ( El Kihel, L, 2012) |
"Dehydroepiandrosterone (DHEA) has beneficial effects in fat-reduction, anti-oxidation and anti-inflammation, and it was widely applied to alleviate multiple metabolic-related diseases; however, there are few reports on whether DHEA can prevent against metabolic-related diseases by modulating oxidative stress and inflammation, especially FLHS in laying hens." | 1.91 | Dehydroepiandrosterone protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in hepatocytes. ( Jiang, Z; Ma, H; Wang, H; Yang, Y; Yao, Y, 2023) |
"Inflammation is involved in the progression of polycystic ovary syndrome." | 1.91 | Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†. ( Ding, X; Li, G; Li, N; Lin, Y; Ma, Y; Wang, X; Xiong, C; Yang, Y; Yuan, Y; Zhang, Y; Zhang, Z, 2023) |
"Endometritis is persistent inflammation caused by bacteria, which can lead to infertility." | 1.72 | Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites. ( Ding, H; Li, Q; Li, Z; Liu, H; Lu, W; Wang, J; Wang, Y; Zhao, J, 2022) |
"Inflammation is likely to be a crucial contributor to the pathogenesis of PCOS." | 1.51 | Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome. ( Bulbul, A; Chen, S; Cui, X; Li, Y; Liu, S; Sun, D; Yan, Q; Zheng, Q, 2019) |
"Dehydroepiandrosterone (DHEA) has anti-inflammatory, anti-oxidant and immune-regulating properties, while the mechanism of DHEA actions remains unclear." | 1.51 | Effect of dehydroepiandrosterone on the immune function of mice in vivo and in vitro. ( Cao, J; Ma, H; Yu, L; Zhao, J, 2019) |
"Dehydroepiandrosterone (DHEA) has been shown to have immunomodulatory effects after hemorrhage and sepsis." | 1.40 | Dehydroepiandrosterone modulates the inflammatory response in a bilateral femoral shaft fracture model. ( Ewers, P; Hildebrand, F; Kobbe, P; Lichte, P; Pape, HC; Pfeifer, R; Pufe, T; Tohidnezhad, M; Werner, BE, 2014) |
"The risk for atherosclerosis is increased in postmenopausal women." | 1.37 | Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells. ( Hao, Q; Li, DJ; Wang, L; Wang, WJ; Wang, YD, 2011) |
"Dehydroepiandrosterone (DHEA) was converted into androstenediol, androstenedione (ASD), 16alphaOH-DHEA, 7alphaOH-DHEA, testosterone, estrone (E1), estradiol (E2), estriol (E3), and 16alphaOH-testosterone (similar in OA and RA)." | 1.33 | Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. ( Anders, S; Naumann, H; Schmidt, M; Schölmerich, J; Straub, RH; Weidler, C, 2005) |
"Airway inflammation was provoked in D." | 1.31 | Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice. ( Chen, CL; Liu, YH; Yu, CK, 2002) |
"The etiology of rheumatoid arthritis has been elusive, but it finally seems to be explained by a combination of three factors: (i) a relatively mild deficiency of cortisol, the normal adrenocortical hormone that is essential for normal immunity but which has achieved a bad reputation because of the use of excessive dosages of it or its stronger derivatives, (ii) a deficiency of dehydro-epi-androsterone (DHEA), the chief androgen produced by the human adrenal cortex but which has been little studied, and (iii) infection by organisms such as mycoplasma, which have a relatively low virulence, are difficult to culture in the laboratory, and cause inflammation and destruction of tissue in periarticular and articular areas of immunocompromised hosts." | 1.30 | The etiology of rheumatoid arthritis. ( Jefferies, WM, 1998) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (7.69) | 18.7374 |
1990's | 3 (3.85) | 18.2507 |
2000's | 19 (24.36) | 29.6817 |
2010's | 30 (38.46) | 24.3611 |
2020's | 20 (25.64) | 2.80 |
Authors | Studies |
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Saunders, MJ | 1 |
Edwards, BS | 1 |
Zhu, J | 1 |
Sklar, LA | 1 |
Graves, SW | 1 |
Yang, YX | 1 |
Zheng, LT | 1 |
Shi, JJ | 1 |
Gao, B | 1 |
Chen, YK | 1 |
Yang, HC | 1 |
Chen, HL | 1 |
Li, YC | 1 |
Zhen, XC | 1 |
Koperniku, A | 1 |
Garcia, AA | 1 |
Mochly-Rosen, D | 1 |
Varanoske, AN | 1 |
McClung, HL | 1 |
Sepowitz, JJ | 1 |
Halagarda, CJ | 1 |
Farina, EK | 1 |
Berryman, CE | 1 |
Lieberman, HR | 1 |
McClung, JP | 1 |
Pasiakos, SM | 1 |
Philip Karl, J | 1 |
Ullah, A | 1 |
Wang, MJ | 1 |
Yang, JP | 1 |
Adu-Gyamfi, EA | 1 |
Czika, A | 1 |
Sah, SK | 1 |
Feng, Q | 1 |
Wang, YX | 1 |
Jin, W | 1 |
Wang, C | 1 |
Cui, M | 1 |
Wang, M | 1 |
Fu, B | 1 |
Sun, L | 1 |
Chen, X | 1 |
Ding, H | 2 |
Wang, Y | 11 |
Li, Z | 1 |
Li, Q | 2 |
Liu, H | 1 |
Zhao, J | 4 |
Lu, W | 1 |
Wang, J | 1 |
Xia, J | 1 |
Wu, S | 1 |
Wu, G | 2 |
Yang, J | 5 |
Chen, Y | 3 |
Kuang, H | 3 |
Feng, X | 3 |
Ji, X | 1 |
Ye, Y | 1 |
Wang, L | 2 |
Liu, S | 3 |
Dong, X | 2 |
Türkmen, NB | 1 |
Yüce, H | 1 |
Aydın, M | 1 |
Taşlıdere, A | 1 |
Doğan, A | 1 |
Özek, DA | 1 |
Hayal, TB | 1 |
Yaşar, Ş | 1 |
Çiftçi, O | 1 |
Ünüvar, S | 1 |
Yao, Q | 1 |
Li, X | 2 |
Wu, H | 2 |
Sun, C | 1 |
Bai, W | 1 |
Kang, J | 1 |
Yao, Y | 2 |
Wang, H | 4 |
Yang, Y | 2 |
Jiang, Z | 1 |
Ma, H | 5 |
Zhang, Y | 2 |
Lin, Y | 1 |
Li, G | 1 |
Yuan, Y | 1 |
Wang, X | 1 |
Li, N | 1 |
Xiong, C | 1 |
Ma, Y | 1 |
Zhang, Z | 1 |
Ding, X | 1 |
Weng, Y | 1 |
Wang, D | 1 |
Wang, R | 1 |
Xiang, Z | 1 |
Shen, S | 1 |
Wu, X | 1 |
Wen, Y | 1 |
Xiang, Y | 1 |
Xu, T | 1 |
Liu, X | 1 |
Huang, Z | 1 |
Ge, H | 1 |
Neal, CM | 1 |
Kus, LH | 1 |
Eckert, LO | 1 |
Peipert, JF | 1 |
Cao, J | 4 |
Yu, L | 3 |
Hu, X | 1 |
Ding, J | 1 |
D Prabhu, Y | 1 |
Valsala Gopalakrishnan, A | 1 |
Scarola, SJ | 1 |
Bardi, M | 1 |
Shen, X | 1 |
Li, L | 1 |
Chen, CY | 1 |
Liao, YH | 1 |
Chou, CC | 1 |
Sung, YC | 1 |
Tsai, SC | 1 |
Alexaki, VI | 1 |
Fodelianaki, G | 1 |
Neuwirth, A | 1 |
Mund, C | 1 |
Kourgiantaki, A | 1 |
Ieronimaki, E | 1 |
Lyroni, K | 1 |
Troullinaki, M | 1 |
Fujii, C | 1 |
Kanczkowski, W | 1 |
Ziogas, A | 1 |
Peitzsch, M | 1 |
Grossklaus, S | 1 |
Sönnichsen, B | 1 |
Gravanis, A | 1 |
Bornstein, SR | 2 |
Charalampopoulos, I | 1 |
Tsatsanis, C | 1 |
Chavakis, T | 1 |
Maciel-Barón, LÁ | 1 |
Morales-Rosales, SL | 1 |
Silva-Palacios, A | 1 |
Rodríguez-Barrera, RH | 1 |
García-Álvarez, JA | 1 |
Luna-López, A | 1 |
Pérez, VI | 1 |
Torres, C | 1 |
Königsberg, M | 1 |
Collomp, K | 1 |
Gravisse, N | 1 |
Vibarel-Rebot, N | 1 |
Asselin, M | 1 |
Do, MC | 1 |
Gagey, O | 1 |
Le-Tiec, C | 1 |
Dufay, S | 1 |
Buisson, C | 1 |
Audran, M | 1 |
Li, Y | 1 |
Zheng, Q | 1 |
Sun, D | 1 |
Cui, X | 1 |
Chen, S | 1 |
Bulbul, A | 1 |
Yan, Q | 1 |
Xue, J | 1 |
Liu, P | 1 |
Li, K | 1 |
Sha, L | 1 |
Yang, X | 1 |
Zhu, L | 1 |
Wang, Z | 1 |
Dong, Y | 1 |
Zhang, L | 1 |
Lei, H | 1 |
Zhang, X | 1 |
Huerta-García, E | 1 |
Montiél-Dávalos, A | 1 |
Alfaro-Moreno, E | 1 |
Gutiérrez-Iglesias, G | 1 |
López-Marure, R | 1 |
Reading, CL | 3 |
Stickney, DR | 1 |
Flores-Riveros, J | 2 |
Destiche, DA | 1 |
Ahlem, CN | 1 |
Cefalu, WT | 1 |
Frincke, JM | 4 |
Chan, CC | 1 |
Liou, CJ | 1 |
Xu, PY | 1 |
Shen, JJ | 1 |
Kuo, ML | 1 |
Len, WB | 1 |
Chang, LE | 1 |
Huang, WC | 1 |
Chen, J | 1 |
Xu, L | 1 |
Huang, C | 1 |
González, F | 2 |
Sia, CL | 1 |
Bearson, DM | 2 |
Blair, HE | 2 |
Lichte, P | 1 |
Pfeifer, R | 1 |
Werner, BE | 1 |
Ewers, P | 1 |
Tohidnezhad, M | 1 |
Pufe, T | 1 |
Hildebrand, F | 1 |
Pape, HC | 1 |
Kobbe, P | 2 |
Sreekumaran Nair, K | 1 |
Basal, E | 1 |
Schimke, JM | 1 |
Lettieri-Barbato, D | 1 |
Giovannetti, E | 1 |
Aquilano, K | 1 |
Boström, EA | 1 |
d'Elia, HF | 1 |
Dahlgren, U | 1 |
Simark-Mattsson, C | 1 |
Hasséus, B | 1 |
Carlsten, H | 1 |
Tarkowski, A | 1 |
Bokarewa, M | 1 |
Bauer, ME | 1 |
Pérez, AR | 1 |
Bottasso, O | 2 |
Savino, W | 1 |
Lu, M | 1 |
Patsouris, D | 1 |
Li, P | 1 |
Watkins, S | 1 |
Schenk, S | 1 |
Olefsky, JM | 1 |
Pugh, ME | 1 |
Hemnes, AR | 1 |
Thierer, J | 1 |
Acosta, A | 1 |
Vainstein, N | 1 |
Sultan, M | 1 |
Francesia, A | 1 |
Marino, J | 1 |
Prado, AH | 1 |
Guglielmone, R | 1 |
Trivi, M | 1 |
Boero, L | 1 |
Brites, F | 1 |
Anker, S | 1 |
Schmitz, D | 1 |
Wegner, A | 1 |
Hammes, F | 1 |
Oberbeck, R | 1 |
Hao, Q | 1 |
Wang, YD | 1 |
Wang, WJ | 1 |
Li, DJ | 1 |
Pizza, V | 1 |
Agresta, A | 1 |
D'Acunto, CW | 1 |
Festa, M | 1 |
Capasso, A | 1 |
Kosiewicz, MM | 1 |
Auci, DL | 1 |
Fagone, P | 1 |
Mangano, K | 1 |
Caponnetto, S | 1 |
Tucker, CF | 1 |
Azeem, N | 1 |
White, SK | 2 |
Nicoletti, F | 1 |
Weiss, EP | 1 |
Villareal, DT | 1 |
Fontana, L | 1 |
Han, DH | 1 |
Holloszy, JO | 1 |
Traish, AM | 1 |
Kang, HP | 1 |
Saad, F | 1 |
Guay, AT | 1 |
El Kihel, L | 1 |
Bay, ML | 1 |
Besedovsky, H | 1 |
Del Rey, A | 1 |
Cutolo, M | 1 |
Sulli, A | 1 |
Pizzorni, C | 1 |
Craviotto, C | 1 |
Prete, C | 1 |
Foppiani, L | 1 |
Salvarani, C | 1 |
Straub, RH | 4 |
Seriolo, B | 1 |
Yu, CK | 1 |
Liu, YH | 1 |
Chen, CL | 1 |
Peña, L | 1 |
Silván, G | 1 |
Pérez-Alenza, MD | 1 |
Nieto, A | 1 |
Illera, JC | 1 |
Marx, C | 1 |
Petros, S | 1 |
Weise, M | 1 |
Wendt, M | 1 |
Menschikowski, M | 1 |
Engelmann, L | 1 |
Höffken, G | 1 |
Kirk-Bayley, J | 1 |
Venn, R | 1 |
RUBENS-DUVAL, A | 1 |
VILLIAUMEY, J | 1 |
Hinson, JP | 1 |
Brooke, A | 1 |
Raven, PW | 1 |
Dillon, JS | 1 |
Matsuda, A | 1 |
Furukawa, K | 1 |
Suzuki, H | 1 |
Matsutani, T | 1 |
Tajiri, T | 1 |
Chaudry, IH | 1 |
Schmidt, M | 2 |
Weidler, C | 2 |
Naumann, H | 2 |
Anders, S | 2 |
Schölmerich, J | 2 |
Schellenberg, M | 1 |
Park, J | 1 |
Choe, SS | 1 |
Choi, AH | 1 |
Kim, KH | 1 |
Yoon, MJ | 1 |
Suganami, T | 1 |
Ogawa, Y | 1 |
Kim, JB | 1 |
Simm, A | 1 |
Nass, N | 1 |
Bartling, B | 1 |
Hofmann, B | 1 |
Silber, RE | 1 |
Navarrete Santos, A | 1 |
Hennebold, JD | 1 |
Daynes, RA | 1 |
Jefferies, WM | 1 |
Bradlow, HL | 1 |
Murphy, J | 1 |
Byrne, JJ | 1 |
Kanik, KS | 1 |
Chrousos, GP | 1 |
Schumacher, HR | 1 |
Crane, ML | 1 |
Yarboro, CH | 1 |
Wilder, RL | 1 |
Schwartz, AG | 1 |
Pashko, LL | 1 |
Leowattana, W | 1 |
Lehle, K | 1 |
Herfarth, H | 1 |
Weber, M | 1 |
Falk, W | 1 |
Preuner, J | 1 |
Harrison, BJ | 1 |
Kumar, S | 1 |
Read, GF | 1 |
Edwards, CA | 1 |
Scanlon, MF | 1 |
Hughes, LE | 1 |
Mortimer, PS | 1 |
Dawber, RP | 1 |
Gales, MA | 1 |
Moore, RA | 1 |
Pal'chik, DA | 1 |
Meshcherskaia, KA | 1 |
Suglobova, VM | 1 |
Aleksandrov, ID | 1 |
Efimtseva, AF | 1 |
Sparagana, M | 1 |
Phillips, G | 1 |
Bodel, P | 1 |
Dillard, GM | 1 |
Kaplan, SS | 1 |
Malawista, SE | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Evaluation of the Relationship Between Right Atrial Volume Index, Functional Capacity and Inflammatory Biomarkers in Patients With Chronic Obstructive Lung Disease and Right Heart Affection.[NCT05366400] | 151 participants (Actual) | Observational | 2022-01-19 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
15 reviews available for dehydroepiandrosterone and Inflammation
Article | Year |
---|---|
Boosting the Discovery of Small Molecule Inhibitors of Glucose-6-Phosphate Dehydrogenase for the Treatment of Cancer, Infectious Diseases, and Inflammation.
Topics: Communicable Diseases; Drug Discovery; Glucosephosphate Dehydrogenase; High-Throughput Screening Ass | 2022 |
Noncandidal vaginitis: a comprehensive approach to diagnosis and management.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Infective Agents; Anti-Inflammatory Agents; | 2020 |
Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human.
Topics: Adipokines; Adipose Tissue; Aging; Biomarkers; Caloric Restriction; Cytokines; Dehydroepiandrosteron | 2016 |
Chronic stress and immunosenescence: a review.
Topics: Aged; Aged, 80 and over; Aging; Aging, Premature; Caregivers; Chronic Disease; Circadian Rhythm; Cyt | 2008 |
The impact of infectious diseases upon neuroendocrine circuits.
Topics: Animals; Cattle; Communicable Diseases; Cytokines; Dehydroepiandrosterone; Extracellular Matrix Prot | 2009 |
Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Estrogens; Female; Gonadal Steroid Hormones | 2010 |
Neuroinflammation and ageing: current theories and an overview of the data.
Topics: Aging; Alzheimer Disease; Apoptosis; Atherosclerosis; Biological Evolution; Brain; Cellular Senescen | 2011 |
Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology.
Topics: Aging; Animals; Body Composition; Bone and Bones; Cardiovascular Diseases; Dehydroepiandrosterone; D | 2011 |
Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports.
Topics: Androsterone; Animals; Brain; Cardiovascular Diseases; Dehydroepiandrosterone; Female; Humans; Hydro | 2012 |
Recently published papers: inflammation, elucidation, manipulation?
Topics: Biomarkers; Dehydroepiandrosterone; Humans; Hydrocortisone; Inflammation; Respiration, Artificial; S | 2003 |
Therapeutic uses of dehydroepiandrosterone.
Topics: Adrenal Insufficiency; Aging; Animals; Bone Density; Chronic Disease; Dehydroepiandrosterone; Humans | 2003 |
Dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders.
Topics: Aging; Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cytokines; Dehydroepiandrosterone; De | 2005 |
Inflammation and sex hormone metabolism.
Topics: Androgens; Animals; Arthritis, Rheumatoid; Dehydroepiandrosterone; Estrogens; Humans; Inflammation; | 2006 |
Potential biomarkers of ageing.
Topics: Aging; Animals; Biomarkers; Cellular Senescence; Dehydroepiandrosterone; Estrogens; Growth Hormone; | 2008 |
DHEA(S): the fountain of youth.
Topics: Aging; Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Inflammation | 2001 |
7 trials available for dehydroepiandrosterone and Inflammation
Article | Year |
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The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.
Topics: Animals; Dehydroepiandrosterone; Female; Glutamine; Humans; Inflammation; Oxidative Stress; Polycyst | 2020 |
A synthetic anti-inflammatory sterol improves insulin sensitivity in insulin-resistant obese impaired glucose tolerance subjects.
Topics: Adiponectin; Adult; Anti-Inflammatory Agents; Blood Glucose; Body Mass Index; C-Reactive Protein; Ch | 2013 |
Hyperandrogenism induces a proinflammatory TNFα response to glucose ingestion in a receptor-dependent fashion.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Double-Blind Method; | 2014 |
Salivary resistin reflects local inflammation in Sjögren's syndrome.
Topics: Adjuvants, Immunologic; Adult; Aged; Biomarkers; Case-Control Studies; Dehydroepiandrosterone; Femal | 2008 |
A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats.
Topics: Adult; Analysis of Variance; Animals; Blood Glucose; Blotting, Western; Cell Movement; Chemokines; C | 2010 |
Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans.
Topics: Aged; Aging; Animals; Blood Chemical Analysis; Cytokines; Dehydroepiandrosterone; Energy Intake; Exe | 2011 |
Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Androstenedione; Cardiac Surgical Procedures; Chronic | 2002 |
56 other studies available for dehydroepiandrosterone and Inflammation
Article | Year |
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Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: discovery of a novel neuroinflammation inhibitor.
Topics: Animals; Cell Line; Cell Survival; Cholestanones; Crystallography, X-Ray; Disease Models, Animal; Do | 2014 |
Stress and the gut-brain axis: Cognitive performance, mood state, and biomarkers of blood-brain barrier and intestinal permeability following severe physical and psychological stress.
Topics: Affect; Biomarkers; Blood-Brain Barrier; Brain-Gut Axis; Cognition; Dehydroepiandrosterone; Epinephr | 2022 |
Ovarian inflammatory mRNA profiles of a dehydroepiandrosterone plus high-fat diet-induced polycystic ovary syndrome mouse model.
Topics: Animals; Dehydroepiandrosterone; Diet, High-Fat; Disease Models, Animal; Female; Humans; Inflammatio | 2022 |
Inhibitory effect of bushen huoxue formula against dehydroepiandrosterone-induced inflammation in granulosa cells through TLR4/NF-κB signaling pathway.
Topics: Androgens; Cytokines; Dehydroepiandrosterone; Drugs, Chinese Herbal; Female; Granulosa Cells; Humans | 2022 |
Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites.
Topics: Animals; Dehydroepiandrosterone; Endometritis; Escherichia coli; Female; Humans; Inflammation; Mice; | 2022 |
Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway.
Topics: Animals; Benzimidazoles; Dehydroepiandrosterone; DNA Glycosylases; Female; Guanine; Humans; Inflamma | 2022 |
Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome.
Topics: Animals; Carrier Proteins; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammasomes; I | 2023 |
Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome.
Topics: Animals; Carrier Proteins; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammasomes; I | 2023 |
Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome.
Topics: Animals; Carrier Proteins; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammasomes; I | 2023 |
Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome.
Topics: Animals; Carrier Proteins; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammasomes; I | 2023 |
PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro.
Topics: Animals; Apoptosis; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Inflammation; Lipids; M | 2023 |
Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosis.
Topics: Animals; Apoptosis; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Inflammation; Ox | 2023 |
Effects of a ketogenic diet on reproductive and metabolic phenotypes in mice with polycystic ovary syndrome†.
Topics: Animals; Dehydroepiandrosterone; Diet, Ketogenic; Disease Models, Animal; Female; Humans; Inflammati | 2023 |
Dehydroepiandrosterone protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in hepatocytes.
Topics: AMP-Activated Protein Kinases; Animals; Chickens; Dehydroepiandrosterone; Female; Hepatocytes; Human | 2023 |
Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†.
Topics: Adipose Tissue, White; Animals; Dehydroepiandrosterone; Female; Glucagon-Like Peptide-1 Receptor; Hu | 2023 |
Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS.
Topics: Animals; Carrier Proteins; Cell Cycle Proteins; Dehydroepiandrosterone; Endoribonucleases; Female; F | 2023 |
Hyperandrogenism drives ovarian inflammation and pyroptosis: A possible pathogenesis of PCOS follicular dysplasia.
Topics: Animals; Dehydroepiandrosterone; Female; Humans; Hyperandrogenism; Inflammation; Mice; Polycystic Ov | 2023 |
Dehydroepiandrosterone resisted E. Coli O157:H7-induced inflammation via blocking the activation of p38 MAPK and NF-κB pathways in mice.
Topics: Animals; Cytokines; Dehydroepiandrosterone; Down-Regulation; Escherichia coli; Inflammation; Male; M | 2020 |
γ-Linolenic acid ameliorates DHEA induced pro-inflammatory response in polycystic ovary syndrome via PPAR-γ signaling in rats.
Topics: Animals; Dehydroepiandrosterone; Female; gamma-Linolenic Acid; Gene Expression; Inflammation; Peroxi | 2020 |
Environmental enrichment modulates inflammation during development in long-evans rats (Rattus norvegicus).
Topics: Animals; Cytokines; Dehydroepiandrosterone; Environment; Hypothalamo-Hypophyseal System; Inflammatio | 2021 |
Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Dehydroepiandrosterone; Inflammation; Infla | 2021 |
Initial systemic inflammatory state perturbs exercise training adaptations in elite Taekwondo athletes.
Topics: Adaptation, Physiological; Athletes; Body Fat Distribution; Dehydroepiandrosterone; Exercise; Female | 2017 |
DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway.
Topics: Animals; CREB-Binding Protein; Dehydroepiandrosterone; Inflammation; Jumonji Domain-Containing Histo | 2018 |
The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on neuronal mitochondrial potential.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Astrocytes; Cellular Senescence; Central Nervou | 2018 |
Neuroendocrine and inflammatory responses to DHEA administration in young healthy women.
Topics: Dehydroepiandrosterone; Double-Blind Method; Female; Humans; Inflammation; Neurosecretory Systems; S | 2018 |
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
Topics: Animals; Apoptosis; Cell Line; Dehydroepiandrosterone; Disease Models, Animal; Down-Regulation; Fema | 2019 |
Effect of dehydroepiandrosterone on the immune function of mice in vivo and in vitro.
Topics: Animals; Antioxidants; Cytokines; Dehydroepiandrosterone; Inflammation; Lipopolysaccharides; Macroph | 2019 |
Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents; Bacteria; Biomarkers; Cytokines; Dehydroepiandrosterone; Diet, Hi | 2019 |
Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dehydroepiandrosterone; Escherichia coli; Inflammation | 2019 |
Dehydroepiandrosterone protects endothelial cells against inflammatory events induced by urban particulate matter and titanium dioxide nanoparticles.
Topics: Adjuvants, Immunologic; Cell Adhesion; Cell Proliferation; Coculture Techniques; Dehydroepiandroster | 2013 |
Effect of dehydroepiandrosterone on atopic dermatitis-like skin lesions induced by 1-chloro-2,4-dinitrobenzene in mouse.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Chemokines; Cytokines; Dehydroepiandroste | 2013 |
DHEA inhibits vascular remodeling following arterial injury: a possible role in suppression of inflammation and oxidative stress derived from vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Carotid Artery Injuries; Cell Movement; Cell Proliferation | 2014 |
Dehydroepiandrosterone modulates the inflammatory response in a bilateral femoral shaft fracture model.
Topics: Adjuvants, Immunologic; Animals; Cytokines; Dehydroepiandrosterone; Disease Models, Animal; Femoral | 2014 |
Induction of hyperandrogenism in lean reproductive-age women stimulates proatherogenic inflammation.
Topics: Adult; Androgens; C-Reactive Protein; Dehydroepiandrosterone; Female; Humans; Hyperandrogenism; Infl | 2015 |
Relation of left ventricular ejection fraction and functional capacity with metabolism and inflammation in chronic heart failure with reduced ejection fraction (from the MIMICA Study).
Topics: Adiponectin; Aged; C-Reactive Protein; Chronic Disease; Dehydroepiandrosterone; Female; Heart Failur | 2010 |
Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration.
Topics: Animals; Apoptosis; Cell Proliferation; Cytokines; Dehydroepiandrosterone; Disease Models, Animal; D | 2010 |
Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells.
Topics: Animals; Atherosclerosis; Chemokine CCL2; Dehydroepiandrosterone; E-Selectin; Endothelial Cells; Fem | 2011 |
HE3286, an orally bioavailable synthetic analogue of an active DHEA metabolite suppresses spontaneous autoimmune diabetes in the non-obese diabetic (NOD) mouse.
Topics: Administration, Oral; Animals; Biological Availability; CD4 Antigens; Dehydroepiandrosterone; Diabet | 2011 |
Molecular targets for 17α-ethynyl-5-androstene-3β,7β,17β-triol, an anti-inflammatory agent derived from the human metabolome.
Topics: Adipocytes; Androstenols; Animals; Anti-Inflammatory Agents; Autoimmunity; Cell Line; Dehydroepiandr | 2012 |
Adverse neuro-immune-endocrine interactions in patients with active tuberculosis.
Topics: Cytokines; Dehydroepiandrosterone; Humans; Inflammation; Neuroimmunomodulation; Stress, Psychologica | 2013 |
Cortisol, dehydroepiandrosterone sulfate, and androstenedione levels in patients with polymyalgia rheumatica during twelve months of glucocorticoid therapy.
Topics: Adrenal Cortex; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Aged; Aging; Androsten | 2002 |
Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice.
Topics: Animals; Antigens, Dermatophagoides; Bronchial Hyperreactivity; Dehydroepiandrosterone; Female; Immu | 2002 |
Steroid hormone profile of canine inflammatory mammary carcinoma: a preliminary study.
Topics: Androstenedione; Animals; Carcinoma; Dehydroepiandrosterone; Dogs; Estradiol; Estrone; Female; Immun | 2003 |
Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol.
Topics: Adrenocorticotropic Hormone; Age Factors; Aged; APACHE; C-Reactive Protein; Calcitonin; Dehydroepian | 2003 |
[Comparative study of local changes in connective tissue induced by testosterone propionate, dehydroepiandrosterone, methylandrostenediol and cholesterol].
Topics: Androgens; Cholesterol; Connective Tissue; Dehydroepiandrosterone; Inflammation; Methandriol; Testos | 1956 |
Dehydroepiandrosterone modulates toll-like receptor expression on splenic macrophages of mice after severe polymicrobial sepsis.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Cell Membrane; Dehydroepiandrosterone; DN | 2005 |
Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Androstenedione; Aromatase; Arthritis, Rheumatoid; | 2005 |
Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals.
Topics: 3T3 Cells; Adipocytes; Adipose Tissue; Animals; Dehydroepiandrosterone; Gene Expression Regulation; | 2006 |
Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cytokines; Dehydroepiandrosterone; Dehydro | 1994 |
The etiology of rheumatoid arthritis.
Topics: Adrenal Cortex; Arthritis, Rheumatoid; Cartilage, Articular; Dehydroepiandrosterone; Humans; Hydroco | 1998 |
Immunological properties of dehydroepiandrosterone, its conjugates, and metabolites.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Dehydroepiandrosterone; Dexamethasone; Di | 1999 |
Adrenocorticotropin, glucocorticoid, and androgen secretion in patients with new onset synovitis/rheumatoid arthritis: relations with indices of inflammation.
Topics: Adrenocorticotropic Hormone; Adult; Androgens; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactiv | 2000 |
Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia and inflammation by the dehydroepiandrosterone analog 16alpha-fluoro-5-androsten-17-one and its reversal by NADPH liposomes.
Topics: Androstenes; Animals; Antineoplastic Agents; Binding, Competitive; Capillary Permeability; Carcinoge | 2001 |
Hidradenitis suppurativa: evidence for an endocrine abnormality.
Topics: Adult; Dehydroepiandrosterone; Estradiol; Female; Gonadotropins; Humans; Inflammation; Progesterone; | 1985 |
Mediation of hidradenitis suppurativa by androgens.
Topics: Adolescent; Adult; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Fem | 1986 |
[Function of the ovaries and adrenal glands in aseptic inflammation of the ovaries (experimental data)].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Animals; Dehydroepiandrosterone; Estrus; | 1969 |
Dehydroepiandrosterone (3 -hydroxy-5-androsten-17-one) metabolism in gout.
Topics: 17-Ketosteroids; Administration, Oral; Androstanes; Androsterone; Carbon Isotopes; Chromatography, G | 1972 |
Anti-inflammatory effects of estradiol on human blood leukocytes.
Topics: Acid Phosphatase; Carbon Isotopes; Culture Media; Dehydroepiandrosterone; Diethylstilbestrol; Estrad | 1972 |