Compounds > dehydroepiandrosterone
Page last updated: 2024-11-07

dehydroepiandrosterone and Hypopituitarism

dehydroepiandrosterone has been researched along with Hypopituitarism in 30 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Hypopituitarism: Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.

Research Excerpts

ExcerptRelevanceReference
"The efficacy of oral dehydroepiandrosterone (DHEA) in the treatment of atrichia pubis and psychological distress in young females with central adrenal insufficiency is unknown."9.14Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. ( Bettendorf, M; Binder, G; Doerr, HG; Ehrismann, M; Hartmann, MF; Heinrich, U; Keller, E; Maier, L; Meisner, C; Pfaeffle, RW; Ranke, MB; Weber, S; Wudy, SA; Zaiser, N, 2009)
"Panhypopituitarism is characterized by the absence of secretion of adrenal and gonadal steroids and thus the production of their metabolites."6.68Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans. ( Baulieu, EE; Brailly, S; Chanson, P; Couzinet, B; Nahoul, K; Schaison, G; Young, J, 1997)
"The efficacy of oral dehydroepiandrosterone (DHEA) in the treatment of atrichia pubis and psychological distress in young females with central adrenal insufficiency is unknown."5.14Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. ( Bettendorf, M; Binder, G; Doerr, HG; Ehrismann, M; Hartmann, MF; Heinrich, U; Keller, E; Maier, L; Meisner, C; Pfaeffle, RW; Ranke, MB; Weber, S; Wudy, SA; Zaiser, N, 2009)
"Aging is associated with diminished gonadal steroid and GH/IGF-I axis activity; whether these changes contribute to the parallel declines of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) production is unknown, as are the effects of sex steroid and/or GH administration on DHEA and DHEAS production."5.12Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men. ( Baldwin, HL; Bhasin, S; Blackman, MR; Harman, SM; Johnson, ML; Muniyappa, R; Sorkin, JD; Wong, KA, 2006)
"The aim of this study was to test the hypothesis that young women with androgen deficiency due to hypopituitarism would benefit from androgen replacement in the form of dehydroepiandrosterone (DHEA)."5.11Androgen replacement in adolescents and young women with hypopituitarism. ( Bilger, M; Hanna, CE; LaFranchi, SH; Speraw, S, 2005)
"Thirty-eight women, aged 25-65 yr, with androgen deficiency due to hypopituitarism were treated with oral dehydroepiandrosterone (DHEA; 30 mg/d if <45 yr of age and 20 mg if > or =45 yr of age) for 6 months in a randomized, placebo-controlled, double blind study, followed by a 6-month open treatment period."5.10Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial. ( Bengtsson, BA; Burman, P; Engström, BE; Johannsson, G; Jonsson, B; Karlsson, FA; Nilsson, AG; Ottosson, M; Wirén, L, 2002)
"The majority of women with Sheehan syndrome (SS) suffer from sexual dysfunction."3.11DHEA on Sexual Function in Sheehan Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial. ( Ghosh, S; Mandal, S; Mukhopadhyay, P, 2022)
"Patients with panhypopituitarism have impaired quality of life (QoL) despite GH replacement."2.72Dehydroepiandrosterone improves psychological well-being in male and female hypopituitary patients on maintenance growth hormone replacement. ( Brooke, AM; Camacho-Hübner, C; Hinson, JP; Kalingag, LA; Maher, KT; Miraki-Moud, F; Monson, JP; Walker, DM, 2006)
"Panhypopituitarism is characterized by the absence of secretion of adrenal and gonadal steroids and thus the production of their metabolites."2.68Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans. ( Baulieu, EE; Brailly, S; Chanson, P; Couzinet, B; Nahoul, K; Schaison, G; Young, J, 1997)
"Hypopituitarism is a rare disorder, but its prevalence has increased as a result of an increase in secondary causes of hypopituitarism such as traumatic brain injury and cranial irradiation."2.44Androgen replacement therapy in androgen-deficient women with hypopituitarism. ( Davis, SR; Zang, H, 2008)
"Dehydroepiandrosterone (DHEA) is an abundant circulating androgen precursor preferentially produced by the adrenal glands."2.43Dehydroepiandrosterone therapy as female androgen replacement. ( Guay, A; Saltzman, E, 2006)
"Children with Turner's syndrome and hypergonadotrophic males had the response in elevated DHA levels while ACTH-induced DHA response related to bone-age matched controls."1.26Responsiveness of cortisol and dehydroepiandrosterone to ACTH in children. ( Gupta, D; Ranke, MB; Rosendahl, W, 1982)
"In addition, 53 boys with idiopathic delayed puberty (IDP) were studied."1.26Hypopituitarism and idiopathic delayed puberty: a longitudinal study in an attempt to diagnose gonadotropin deficiency before puberty. ( Bourguignon, JP; Craen, M; Du Caju, MV; Ernould, C; Franchimont, P; Malvaux, P; Vanderschueren-Lodeweyckx, M; Wolter, R, 1982)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199014 (46.67)18.7374
1990's1 (3.33)18.2507
2000's12 (40.00)29.6817
2010's2 (6.67)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Mandal, S1
Mukhopadhyay, P1
Ghosh, S1
Boettcher, C1
Hartmann, MF2
de Laffolie, J1
Zimmer, KP1
Wudy, SA2
Giton, F1
Trabado, S1
Maione, L1
Sarfati, J1
Le Bouc, Y1
Brailly-Tabard, S1
Fiet, J1
Young, J2
Zang, H1
Davis, SR1
Binder, G1
Weber, S1
Ehrismann, M1
Zaiser, N1
Meisner, C1
Ranke, MB2
Maier, L1
Heinrich, U1
Bettendorf, M1
Doerr, HG1
Pfaeffle, RW1
Keller, E1
Aimaretti, G1
Baffoni, C1
Di Vito, L1
Grottoli, S1
Gaia, D1
Gasco, V1
Giordano, R1
Zadik, Z1
Camanni, F1
Ghigo, E1
Arvat, E1
ROSNER, JM1
CONTE, NF1
BRIGGS, JH1
CHAO, PY1
SUDMAN, EM1
FORSHAM, PH1
IACONO, G1
BRANCACCIO, A1
D ALESSANDRO, B1
DELUCA, R1
REPOLE, R1
Cameron, DR1
Braunstein, GD1
Bilger, M1
Speraw, S1
LaFranchi, SH1
Hanna, CE1
Saltzman, E1
Guay, A1
Brooke, AM2
Kalingag, LA2
Miraki-Moud, F2
Camacho-Hübner, C2
Maher, KT2
Walker, DM2
Hinson, JP2
Monson, JP2
Muniyappa, R1
Wong, KA1
Baldwin, HL1
Sorkin, JD1
Johnson, ML1
Bhasin, S1
Harman, SM1
Blackman, MR1
Basson, R1
Brückel, J1
Rosendahl, W1
Gupta, D1
Ilondo, MM1
Vanderschueren-Lodeweyckx, M2
Vlietinck, R1
Pizarro, M1
Malvaux, P2
Eggermont, E1
Eeckels, R1
Bourguignon, JP1
Wolter, R1
Craen, M1
Du Caju, MV1
Ernould, C1
Franchimont, P1
Couzinet, B1
Nahoul, K1
Brailly, S1
Chanson, P1
Baulieu, EE1
Schaison, G1
Johannsson, G1
Burman, P1
Wirén, L1
Engström, BE1
Nilsson, AG1
Ottosson, M1
Jonsson, B1
Bengtsson, BA1
Karlsson, FA1
Reiter, EO1
Fuldauer, VG1
Root, AW1
Gács, G1
Sólyom, J1
Jakabfi, P1
Fehér, T1
Oesterling, JE1
Epstein, JI1
Walsh, PC1
Scurry, MT1
Bruton, J1
Barry, KG1
Crook, D1
Sekihara, H1
Osawa, N1
Adadevoh, BK1
Mellinger, RC1
Morrow, LB1
Petermann, FL1
Wolf, CB1
Kratz, F1
Graef, V1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dehydroepiandrosterone(DHEA) Substitution in Adolescent and Young Women With Central Adrenal Insufficiency. A Multicenter, Randomised Double Blind Trial[NCT00575341]Phase 323 participants (Actual)Interventional2003-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for dehydroepiandrosterone and Hypopituitarism

ArticleYear
Androgen replacement therapy in androgen-deficient women with hypopituitarism.
    Drugs, 2008, Volume: 68, Issue:15

    Topics: Androgens; Dehydroepiandrosterone; Female; Hormone Replacement Therapy; Humans; Hypopituitarism; Tes

2008
The use of dehydroepiandrosterone therapy in clinical practice.
    Treatments in endocrinology, 2005, Volume: 4, Issue:2

    Topics: Adrenal Insufficiency; Aging; Alzheimer Disease; Bone Density; Cardiovascular Diseases; Dehydroepian

2005
Dehydroepiandrosterone therapy as female androgen replacement.
    Seminars in reproductive medicine, 2006, Volume: 24, Issue:2

    Topics: Adrenal Insufficiency; Aging; Androgens; Dehydroepiandrosterone; Female; Hormone Replacement Therapy

2006
[Replacement and supplementation of DHEA--is it a wellness hormone?].
    MMW Fortschritte der Medizin, 2005, Feb-17, Volume: 147, Issue:7

    Topics: Addison Disease; Adjuvants, Immunologic; Administration, Oral; Adult; Age Factors; Aged; Aged, 80 an

2005
Endocrine patterns in the African. Clinico-biochemical assessment.
    Tropical and geographical medicine, 1970, Volume: 22, Issue:2

    Topics: Acromegaly; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Africa; Andr

1970

Trials

9 trials available for dehydroepiandrosterone and Hypopituitarism

ArticleYear
DHEA on Sexual Function in Sheehan Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial.
    The Journal of clinical endocrinology and metabolism, 2022, 07-14, Volume: 107, Issue:8

    Topics: Adult; Androgens; Cross-Over Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Double

2022
Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:4

    Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Blood Pressure; Brain Neoplas

2009
Androgen replacement in adolescents and young women with hypopituitarism.
    Journal of pediatric endocrinology & metabolism : JPEM, 2005, Volume: 18, Issue:4

    Topics: Adipose Tissue; Adolescent; Adrenal Insufficiency; Adult; Androgens; Body Composition; Cross-Over St

2005
Dehydroepiandrosterone improves psychological well-being in male and female hypopituitary patients on maintenance growth hormone replacement.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:10

    Topics: Dehydroepiandrosterone; Double-Blind Method; Female; Growth Hormone; Health Status Indicators; Hormo

2006
Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Body Mass Index; Circadian Rhythm; Dehydroepiandrosterone; Dehydroep

2006
Dehydroepiandrosterone (DHEA) replacement reduces growth hormone (GH) dose requirement in female hypopituitary patients on GH replacement.
    Clinical endocrinology, 2006, Volume: 65, Issue:5

    Topics: Adult; Chi-Square Distribution; Cholesterol; Cholesterol, HDL; Dehydroepiandrosterone; Double-Blind

2006
Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:8

    Topics: Adult; Aged; Androstane-3,17-diol; Androstenediol; Androstenedione; Androsterone; Dehydroepiandroste

1997
Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:5

    Topics: Adult; Androgens; Behavior; Body Composition; Bone and Bones; Dehydroepiandrosterone; Double-Blind M

2002
Effect of growth hormone on urinary 17-ketosteroids in childhood.
    Metabolism: clinical and experimental, 1972, Volume: 21, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Age Factors

1972

Other Studies

16 other studies available for dehydroepiandrosterone and Hypopituitarism

ArticleYear
Absent adrenarche in children with hypopituitarism: a study based on urinary steroid metabolomics.
    Hormone research in paediatrics, 2013, Volume: 79, Issue:6

    Topics: Adolescent; Adrenarche; Adrenocorticotropic Hormone; Child; Dehydroepiandrosterone; Female; Gas Chro

2013
Sex steroids, precursors, and metabolite deficiencies in men with isolated hypogonadotropic hypogonadism and panhypopituitarism: a GCMS-based comparative study.
    The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:2

    Topics: Adult; Androstenedione; Chromatography, Gas; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol;

2015
Hypopituitaric patients with corticotropin insufficiency show marked impairment of the cortisol response to ACTH (1-24) independently of the duration of the disease.
    Journal of endocrinological investigation, 2003, Volume: 26, Issue:1

    Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aldosterone; Area Under Curve; Cosyntropi

2003
DETERMINATION OF URINARY TESTOSTERONE BY CHROMATOGRAPHY AND COLORIMETRY: FINDINGS IN NORMAL SUBJECTS AND IN PATIENTS WITH ENDOCRINE DISEASES.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Androg

1965
[STUDY OF ADRENAL CORTEX FUNCTION AFTER ADMINISTRATION OF HYDROCHLOROTHIAZIDE IN NORMAL SUBJECTS AND PATIENTS WITH ADRENAL GLAND DISEASES].
    Folia endocrinologica, 1964, Volume: 17

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Cortex; Adrenal Gland Diseases;

1964
Female sexual dysfunction in hypopituitarism.
    Lancet (London, England), 2007, Sep-01, Volume: 370, Issue:9589

    Topics: Dehydroepiandrosterone; Female; Humans; Hypopituitarism; Libido; Postmenopause; Sexual Dysfunction,

2007
Responsiveness of cortisol and dehydroepiandrosterone to ACTH in children.
    Hormone research, 1982, Volume: 16, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Child; Child, Preschool; Dehydroepiandrosterone; Humans; Hy

1982
Plasma androgens in children and adolescents. Part II. A longitudinal study in patients with hypopituitarism.
    Hormone research, 1982, Volume: 16, Issue:2

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Androgens; Androstenedione; Child; Child, Preschool;

1982
Hypopituitarism and idiopathic delayed puberty: a longitudinal study in an attempt to diagnose gonadotropin deficiency before puberty.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:4

    Topics: Adolescent; Age Determination by Skeleton; Child; Dehydroepiandrosterone; Dehydroepiandrosterone Sul

1982
Secretion of the adrenal androgen, dehydroepiandrosterone sulfate, during normal infancy, childhood, and adolescence, in sick infants, and in children with endocrinologic abnormalities.
    The Journal of pediatrics, 1977, Volume: 90, Issue:5

    Topics: Adolescent; Adrenal Cortex; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Child; Chil

1977
Does hypoprolactinaemia affect adrenal androgen levels in children with hypopituitarism?
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1989, Volume: 21, Issue:9

    Topics: Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgens; Child; Dehydroepiandroste

1989
The inability of adrenal androgens to stimulate the adult human prostate: an autopsy evaluation of men with hypogonadotropic hypogonadism and panhypopituitarism.
    The Journal of urology, 1986, Volume: 136, Issue:5

    Topics: Adrenal Glands; Aged; Aged, 80 and over; Androstenedione; Dehydroepiandrosterone; Dehydroepiandroste

1986
The effect of chorionic gonadotropin on steroid excretion.
    Archives of internal medicine, 1971, Volume: 128, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adult; Androsterone; Chorionic G

1971
The routine measurement of urinary 17-oxosteroids and 17-oxogenic steroids using gas-liquid chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 40, Issue:1

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Androgens; Androsterone; Chromat

1972
A radioimmunoassay for serum 11-deoxy-17-ketosteroids.
    Steroids, 1974, Volume: 23, Issue:2

    Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Ammonium Sulfate; Androsterone; Animals; Cattle; Child; Ch

1974
[Coexistent pregnancy and isolated ACTH deficiency: case report (author's transl)].
    Klinische Wochenschrift, 1973, Volume: 21, Issue:1

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adul

1973