Page last updated: 2024-11-07

dehydroepiandrosterone and Hypogonadism

dehydroepiandrosterone has been researched along with Hypogonadism in 71 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).

Research Excerpts

ExcerptRelevanceReference
"The endocrine system of aging males reveals changes of more or less unknown significance for estrogens, dehydroepiandrosterone (DHEA), melatonin and growth hormone."8.82[Hormone therapy in the aging male. Estrogen, DHEA, melatonin, somatotropin]. ( Kliesch, S, 2004)
"It has previously been shown that increased nocturnal melatonin (MT) secretion exists in male patients with hypogonadotropic hypogonadism."7.69Daytime plasma melatonin levels in male hypogonadism. ( Beyhan, Z; Bingol, N; Bolu, E; Bulur, M; Corakci, A; Gundogan, MA; Ozata, M, 1996)
"The purpose of this study was to evaluate, without using radioisotopes, the peripheral contribution of dehydroepiandrosterone (D) to estrogens and to androstenedione (A) in patients with hypogonadotropic hypogonadism associated with weight loss (HH) and in normal menstruating women (N)."7.67Reduced conversion of dehydroepiandrosterone into estrogens in women having hypogonadotropic hypogonadism associated with weight loss. ( Bolelli, G; Bonavia, M; Bulletti, C; Ferraretti, AP; Flamigni, C; Franceschetti, F; Jasonni, VM, 1986)
"The endocrine system of aging males reveals changes of more or less unknown significance for estrogens, dehydroepiandrosterone (DHEA), melatonin and growth hormone."4.82[Hormone therapy in the aging male. Estrogen, DHEA, melatonin, somatotropin]. ( Kliesch, S, 2004)
"It has previously been shown that increased nocturnal melatonin (MT) secretion exists in male patients with hypogonadotropic hypogonadism."3.69Daytime plasma melatonin levels in male hypogonadism. ( Beyhan, Z; Bingol, N; Bolu, E; Bulur, M; Corakci, A; Gundogan, MA; Ozata, M, 1996)
"The purpose of this study was to evaluate, without using radioisotopes, the peripheral contribution of dehydroepiandrosterone (D) to estrogens and to androstenedione (A) in patients with hypogonadotropic hypogonadism associated with weight loss (HH) and in normal menstruating women (N)."3.67Reduced conversion of dehydroepiandrosterone into estrogens in women having hypogonadotropic hypogonadism associated with weight loss. ( Bolelli, G; Bonavia, M; Bulletti, C; Ferraretti, AP; Flamigni, C; Franceschetti, F; Jasonni, VM, 1986)
" The transectional or longitudinal study of the plasma levels of dehydroepiandrosterone, its sulfate (DHAS), delta 4-androstenedione, testosterone, and 170H-progesterone in 121 children with a variety of clinical disorders in which adrenarchal and gonadal maturations are dissociated (precocious adrenarche, precocious or delayed puberty, adrenal insufficiency, gonadal dysgenesis, hypogonadotropism hypogonadotrophic) is presented."3.66[Does adrenarche really play a determining role in pubertal development? A study of the dissociations between adrenarche and gonadarche. The failure of dehydroepiandrosterone sulfate treatment in delayed adrenarche]. ( David, M; de Peretti, E; Forest, MG; Sempe, M, 1982)
"Obesity is an issue that is increasingly affecting ageing men."2.41Impact of obesity on hypogonadism in the andropause. ( Pu, SJ; Tan, RS, 2002)
"Hypogonadism was associated with decreased levels of a number of testosterone precursors."1.72[Features of steroidogenesis in men with hypogonadism and type 2 diabetes]. ( Chernova, MO; Ioutsi, VA; Mel'nichenko, GA; Mokrysheva, NG; Rozhivanov, RV; Shestakova, MV, 2022)
"The classification of hereditary ataxias of unknown etiology is difficult because of the heterogeneity of these diseases."1.29Primary hypogonadism in females with infantile onset spinocerebellar ataxia. ( Koskinen, T; Pihko, H; Voutilainen, R, 1995)
"Besides marked bone loss, hypogonadotropic hypogonadism was found in 3 male patients, while normal LH, FSH concentration values were measured in 3 female patients."1.28Is dehydroepiandrosterone-sulphate a possible pathogenetic factor in osteopenia of patients with iron overload? ( Czink, E; Horváth, C; Malek, AA; Siklósi, G, 1991)
"Polycystic ovarian syndrome and hypogonadotropic hypogonadism occurred significantly more often in women with TLE than in the general female population."1.27Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. ( Geschwind, N; Herzog, AG; Schomer, DL; Seibel, MM; Vaitukaitis, JL, 1986)
"Children with Turner's syndrome and hypergonadotrophic males had the response in elevated DHA levels while ACTH-induced DHA response related to bone-age matched controls."1.26Responsiveness of cortisol and dehydroepiandrosterone to ACTH in children. ( Gupta, D; Ranke, MB; Rosendahl, W, 1982)

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-199046 (64.79)18.7374
1990's7 (9.86)18.2507
2000's9 (12.68)29.6817
2010's8 (11.27)24.3611
2020's1 (1.41)2.80

Authors

AuthorsStudies
Rozhivanov, RV1
Chernova, MO1
Ioutsi, VA1
Mel'nichenko, GA1
Shestakova, MV1
Mokrysheva, NG1
Savkovic, S1
Lim, S1
Jayadev, V1
Conway, A1
Turner, L1
Curtis, D1
Goebel, C1
Handelsman, DJ1
Pluchino, N1
Carmignani, A1
Cubeddu, A1
Santoro, A1
Cela, V1
Errasti, T1
Alcalà, TE1
Giton, F1
Trabado, S1
Maione, L1
Sarfati, J1
Le Bouc, Y1
Brailly-Tabard, S1
Fiet, J1
Young, J1
Zimmerman, Y2
Foidart, JM2
Pintiaux, A2
Minon, JM2
Fauser, BC2
Cobey, K2
Coelingh Bennink, HJ2
Kovac, JR1
Pan, M1
Arent, S1
Lipshultz, LI1
Diamanti-Kandarakis, E1
Dattilo, M1
Macut, D1
Duntas, L1
Gonos, ES1
Goulis, DG1
Gantenbein, CK1
Kapetanou, M1
Koukkou, E1
Lambrinoudaki, I1
Michalaki, M1
Eftekhari-Nader, S1
Pasquali, R1
Peppa, M1
Tzanela, M1
Vassilatou, E1
Vryonidou, A1
Shibayama, Y1
Higashi, T1
Shimada, K1
Odani, A1
Mizokami, A1
Konaka, H1
Koh, E1
Namiki, M1
Colameco, S1
Coren, JS1
Kim, NN1
Schaaf, L1
Stalla, GK1
Araujo, AB1
Wittert, GA1
Tan, RS1
Pu, SJ1
INADA, T1
EBISUTA, K1
WELLER, O1
ROSNER, JM1
CONTE, NF1
BRIGGS, JH1
CHAO, PY1
SUDMAN, EM1
FORSHAM, PH1
VILLEE, DB1
MACGILLIVRAY, M1
CRAWFORD, JD1
SCULLY, RE1
KLIMAN, B1
DENEVE, L1
VERMEULEN, A3
Cuzin, B1
Giuliano, F1
Jamin, Ch1
Legros, JJ1
Lejeune, H1
Rigot, JM1
Roger, M1
Kliesch, S1
Kaufman, JM1
Cohen, HN1
Hay, ID1
Beastall, GH1
Thomson, JA1
D'Agata, R1
Vicari, E1
Aliffi, A1
Maugeri, G1
Mongioì, A1
Gulizia, S1
Forest, MG1
de Peretti, E1
David, M1
Sempe, M1
Berg, R1
Berg, G1
Edman, G1
Svensson, J1
Aström, G1
Ranke, MB1
Rosendahl, W1
Gupta, D1
Reiter, EO1
Duckett, GE1
Root, AW1
Bahnsen, M1
Gluud, C1
Johnsen, SG1
Bennett, P1
Svenstrup, S1
Micic, S1
Dietrichson, O1
Svendsen, LB1
Brodthagen, UA1
Luboshitzky, R1
Lavi, S1
Thuma, I1
Lavie, P1
Koskinen, T1
Pihko, H1
Voutilainen, R1
Ozata, M2
Bulur, M2
Bingol, N1
Beyhan, Z1
Corakci, A2
Bolu, E2
Gundogan, MA2
Yildirimkaya, M1
Yilmaz, K1
Medraś, M1
Jankowska, E1
Weinstein, RL1
Reitz, RE1
Harris, E1
Mahendra, P1
McGarrigle, HH1
Linch, DC1
Chatterjee, R1
Christiansen, P1
Sizonenko, PC4
Paunier, L2
Stahl, F1
Copeland, KC1
Boyar, RM1
Czink, E1
Horváth, C1
Malek, AA1
Siklósi, G1
Frank-Raue, K1
Raue, F1
Korth-Schütz, S1
Vecsei, P1
Ziegler, R1
Herzog, AG1
Seibel, MM1
Schomer, DL1
Vaitukaitis, JL1
Geschwind, N1
Bulletti, C1
Jasonni, VM1
Bolelli, G1
Franceschetti, F1
Ferraretti, AP1
Bonavia, M1
Flamigni, C1
Oesterling, JE1
Epstein, JI1
Walsh, PC1
Schwarz, HP1
Zimmermann, A1
Carasso, A1
Zuppinger, K1
Kaufman, FR1
Donnell, GN1
Lobo, RA1
Yanaihara, T1
Hirato, K1
Nakayama, T1
Schmidt, H1
Starcevic, Z1
Teller, WM1
Krese, A1
Teller, W1
Horký, K2
Küchel, O2
Gregorvá, I1
Stárka, L2
Zimprich, H1
Conti, C1
Sciarra, F1
Cathro, DM2
Jänne, O1
Perheentupa, J1
Vihko, R1
Gregorová, I1
Saez, JM1
Bertrand, J1
Scurry, MT1
Bruton, J1
Barry, KG1
Kelch, RP1
Jenner, MR1
Weinstein, R1
Kaplan, SL1
Grumbach, MM1
Drucker, WD1
Blumberg, JM1
Gandy, HM1
David, RR1
Verde, AL1
Boon, DA1
Keenan, RE1
Salunwhite, WR1
Aceto, T1
Crook, D1
Thomas, JP1
Oake, RJ1
Takahara, J1
Hashimoto, K1
Ofuji, T1
Drobnjak, P1
Grizelj, V1
Stanetti, P1
Longhino, N1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Antioxidants vs.Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve[NCT03621683]78 participants (Actual)Interventional2016-01-06Completed
Pharmacokinetics of a Novel Oral Testosterone Undecanoate Formulation With Concomitant Inhibition of 5alpha-Reductase by Finasteride[NCT00842751]Phase 211 participants (Actual)Interventional2009-07-31Completed
Pharmacokinetics of Modified Slow-Release Oral Testosterone Over 10 Days in Normal Men With Experimental Hypogonadism[NCT01167829]Phase 114 participants (Actual)Interventional2010-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Maximum Testosterone Concentration

Area under the curve of serum testosterone Pharmacokinetic measures time-weighted mean concentration calculated as area under the concentration curve (AUC) divided by time from initiation of dosing for the morning dose and corrected for differences in baseline hormone concentration. (NCT00842751)
Timeframe: 0,1,2,4,8,and 12-hour post dose

Interventionng*hr/dL (Geometric Mean)
Acyline +Testosterone Undecanoate + Placebo471
Acyline +Testosterone Undecanoate + 0.5mg Finasteride444
Acyline +Testosterone Undecanoate + 1mg Finasteride543

Serum Dihydrotestosterone Concentration

Area under the curve of serum dihydrotestosterone (NCT00842751)
Timeframe: 0,1,2,4,8,and 12-hour post dose

Interventionng*hr/dL (Geometric Mean)
Acyline +Testosterone Undecanoate + Placebo154
Acyline + Testosterone Undecanoate + 0.5mg Finasteride118
Acyline + Testosterone Undecanoate + 1mg Finasteride125

Serum Estradiol Concentration

Area under the curve of serum estradiol (NCT00842751)
Timeframe: 0,1,2,4,8,and 12-hour post dose

Interventionng*hr/dL (Geometric Mean)
Acyline +Testosterone Undecanoate + Placebo7.9
Acyline + Testosterone Undecanoate + 0.5mg Finasteride6.5
Acyline +Testosterone Undecanoate + 1mg Finasteride7.2

Free T Maximum Concentration

Free T normal range 4.7-18 ng/dL (NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1-2Day 9-10
300 mg Oral Testosterone2421

Free Testosterone Mean Concentration

Free T normal range 4.7-18 ng/dL (NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1-2Day 9-10
300 mg Oral Testosterone8.78.3

Maximum Dihydrotestosterone (DHT) Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone233142

Maximum Estradiol Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone149

Maximum Sex Hormone-Binding Globulin (SHGB)Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone3122

Maximum Testosterone Concentration

initial pharmacokinetics [PK] (day 1) of oral testosterone dosed 3 times daily and the PK after 9 days of treatment (NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
Acyline and 300 mg Oral Testosterone924741

Mean Dihydrotestosterone (DHT) Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
Acyline and 300 mg Oral Testosterone9669

Mean Estradiol Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone117

Mean SHGB Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone2719

Mean Testosterone Concentration

initial 24-hour pharmacokinetics (PK) of oral testosterone dosed 3 times daily and post 24-hour PK after 9 days of treatment (NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
Acyine and 300 mg Oral Testosterone378315

Reviews

15 reviews available for dehydroepiandrosterone and Hypogonadism

ArticleYear
Androgen therapy in women: for whom and when.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:4

    Topics: Aging; Androgens; Dehydroepiandrosterone; Female; Hormone Replacement Therapy; Humans; Hypogonadism;

2013
Dietary Adjuncts for Improving Testosterone Levels in Hypogonadal Males.
    American journal of men's health, 2016, Volume: 10, Issue:6

    Topics: Androstenediol; Androstenedione; Dehydroepiandrosterone; Dietary Supplements; Hormone Replacement Th

2016
MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview.
    European journal of endocrinology, 2017, Volume: 176, Issue:6

    Topics: Adjuvants, Immunologic; Aging; Androgens; Antioxidants; Circadian Rhythm; Dehydroepiandrosterone; Di

2017
Opioid-induced endocrinopathy.
    The Journal of the American Osteopathic Association, 2009, Volume: 109, Issue:1

    Topics: Adrenal Glands; Analgesics, Opioid; Dehydroepiandrosterone; Endocrine System Diseases; Humans; Hypog

2009
Sex steroid hormones in diabetes-induced sexual dysfunction: focus on the female gender.
    The journal of sexual medicine, 2009, Volume: 6 Suppl 3

    Topics: Clitoris; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Estrogens; Female; Glucose Intolerance;

2009
Endocrinology of the aging male.
    Best practice & research. Clinical endocrinology & metabolism, 2011, Volume: 25, Issue:2

    Topics: Aging; Animals; Dehydroepiandrosterone; Dihydrotestosterone; Follicle Stimulating Hormone; Humans; H

2011
Impact of obesity on hypogonadism in the andropause.
    International journal of andrology, 2002, Volume: 25, Issue:4

    Topics: Aged; Aging; Body Composition; Climacteric; Dehydroepiandrosterone; Diabetes Mellitus; Humans; Hypog

2002
[Hormone therapy in the aging male. Estrogen, DHEA, melatonin, somatotropin].
    Der Urologe. Ausg. A, 2004, Volume: 43, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Dehydroepiandrosterone; Estrogens; Growth Hormone; Hormone Replaceme

2004
The decline of androgen levels in elderly men and its clinical and therapeutic implications.
    Endocrine reviews, 2005, Volume: 26, Issue:6

    Topics: Aged; Aging; Androgens; Atherosclerosis; Clinical Trials as Topic; Coronary Disease; Dehydroepiandro

2005
Decreased androgen levels and obesity in men.
    Annals of medicine, 1996, Volume: 28, Issue:1

    Topics: Dehydroepiandrosterone; Humans; Hypogonadism; Leydig Cells; Male; Obesity; Sex Hormone-Binding Globu

1996
[On the healthy male aging: hormonal aspects].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 1999, Volume: 6, Issue:34

    Topics: Aged; Aging; Climacteric; Dehydroepiandrosterone; Health Status; Human Growth Hormone; Humans; Hypog

1999
Endocrine laboratory findings in pubertal distrubances.
    Clinics in endocrinology and metabolism, 1975, Volume: 4, Issue:1

    Topics: Adolescent; Adrenal Glands; Adult; Age Factors; Androstenedione; Child; Child, Preschool; Clomiphene

1975
Preadolescent and adolescent endocrinology: physiology and physiopathology. II. Hormonal changes during abnormal pubertal development.
    American journal of diseases of children (1960), 1978, Volume: 132, Issue:8

    Topics: Adolescent; Adrenocortical Hyperfunction; Androgen Antagonists; Child; Dehydroepiandrosterone; Estra

1978
[The determination, secretion and plasma concentration of androgens].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1979, Oct-15, Volume: 34, Issue:20

    Topics: Adolescent; Adult; Age Factors; Androgen Antagonists; Androgen-Binding Protein; Androgens; Androstan

1979
Control of the onset of puberty.
    Annual review of medicine, 1978, Volume: 29

    Topics: Adolescent; Adrenocorticotropic Hormone; Androstenedione; Anorexia Nervosa; Dehydroepiandrosterone;

1978

Trials

4 trials available for dehydroepiandrosterone and Hypogonadism

ArticleYear
Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: II. Clinical effects.
    Contraception, 2015, Volume: 91, Issue:2

    Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Androstenes; Belgium; Contraceptives, Oral,

2015
Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I. Endocrine effects.
    Contraception, 2015, Volume: 91, Issue:2

    Topics: Adolescent; Adult; Androgen Antagonists; Androstane-3,17-diol; Androstenedione; Androstenes; Belgium

2015
Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC-MS/MS: Method development and evaluation of applicability for diagnosis and medication for late-onset hypogonadism.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Sep-01, Volume: 877, Issue:25

    Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Chromatography, Liquid; Dehydroepiandrosterone; Humans

2009
Qualitative alterations in urinary 17-ketosteroid excretion during aminoglutethimide administration.
    The Journal of clinical endocrinology and metabolism, 1969, Volume: 29, Issue:2

    Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Aminoglutethimide; Androsterone; Aniline Compounds; A

1969

Other Studies

52 other studies available for dehydroepiandrosterone and Hypogonadism

ArticleYear
[Features of steroidogenesis in men with hypogonadism and type 2 diabetes].
    Problemy endokrinologii, 2022, 06-16, Volume: 68, Issue:3

    Topics: 17-alpha-Hydroxyprogesterone; Androgens; Cross-Sectional Studies; Dehydroepiandrosterone; Diabetes M

2022
Urine and Serum Sex Steroid Profile in Testosterone-Treated Transgender and Hypogonadal and Healthy Control Men.
    The Journal of clinical endocrinology and metabolism, 2018, 06-01, Volume: 103, Issue:6

    Topics: Adolescent; Adult; Androgens; Androsterone; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol;

2018
Sex steroids, precursors, and metabolite deficiencies in men with isolated hypogonadotropic hypogonadism and panhypopituitarism: a GCMS-based comparative study.
    The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:2

    Topics: Adult; Androstenedione; Chromatography, Gas; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol;

2015
[Endocrine changes with advancing age].
    MMW Fortschritte der Medizin, 2009, Oct-15, Volume: 151, Issue:42

    Topics: Aged; Dehydroepiandrosterone; Erectile Dysfunction; Female; Humans; Hypogonadism; Insulin-Like Growt

2009
[A mixed agent of testosterone, dehydroepiandrosterone, mare serum gonadotropin and human chorionic gonadotropin (Gonasteron) in the treatment of male hypogonadism].
    Hinyokika kiyo. Acta urologica Japonica, 1963, Volume: 9

    Topics: Animals; Chorionic Gonadotropin; Dehydroepiandrosterone; Female; Gonadotropins; Gonadotropins, Equin

1963
[Comparative studies on the metabolic effect of testosterone and 1-methyl-delta-androstenolone in cases with primary hypogonadism].
    Endokrinologie, 1962, Volume: 42

    Topics: Androgens; Calcium; Dehydroepiandrosterone; Eunuchism; Humans; Hypogonadism; Klinefelter Syndrome; M

1962
DETERMINATION OF URINARY TESTOSTERONE BY CHROMATOGRAPHY AND COLORIMETRY: FINDINGS IN NORMAL SUBJECTS AND IN PATIENTS WITH ENDOCRINE DISEASES.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Androg

1965
ANDROGEN SYNTHESIS BY TESTICULAR TISSUE FROM A PATIENT WITH GONADAL INSUFFICIENCY.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Androgens; Biopsy; Chromatography; Dehydroepiandrosterone;

1965
THE DETERMINATION OF 17-OXOSTEROID SULPHATES IN HUMAN PLASMA.
    The Journal of endocrinology, 1965, Volume: 32

    Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenalectomy; Androsterone; Blood Chemical Analysis;

1965
[Investigation, treatment and monitoring of late-onset hypogonadism in males: the official guidelines of the International Society for the Study of the Study of the Aging Male (ISSAM) with comments].
    Annales d'endocrinologie, 2003, Volume: 64, Issue:4

    Topics: Aging; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; France; Hormones; Human Gr

2003
Failure of adrenal androgen to induce puberty in familial cytomegalic adrenocortical hypoplasia.
    Lancet (London, England), 1982, Dec-25, Volume: 2, Issue:8313

    Topics: Adrenal Cortex Diseases; Adrenal Insufficiency; Adult; Dehydroepiandrosterone; Dehydroepiandrosteron

1982
Testicular responsiveness to chronic human chorionic gonadotropin administration in hypogonadotropic hypogonadism.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 55, Issue:1

    Topics: Adolescent; Adult; Androstenedione; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Human

1982
[Does adrenarche really play a determining role in pubertal development? A study of the dissociations between adrenarche and gonadarche. The failure of dehydroepiandrosterone sulfate treatment in delayed adrenarche].
    Annales d'endocrinologie, 1982, Volume: 43, Issue:6

    Topics: Adolescent; Adrenal Cortex; Adrenal Cortex Diseases; Androgens; Child; Dehydroepiandrosterone; Dehyd

1982
Androgens and personality in normal men and men operated for hypospadias in childhood.
    Acta psychiatrica Scandinavica, 1983, Volume: 68, Issue:3

    Topics: Adult; Androgens; Child; Child, Preschool; Dehydroepiandrosterone; Follicle Stimulating Hormone; Fol

1983
Responsiveness of cortisol and dehydroepiandrosterone to ACTH in children.
    Hormone research, 1982, Volume: 16, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Child; Child, Preschool; Dehydroepiandrosterone; Humans; Hy

1982
Responses to constant infusion of LH-RH in girls with primary hypogonadism.
    Obstetrics and gynecology, 1980, Volume: 56, Issue:3

    Topics: Adolescent; Adult; Androstenedione; Child; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; E

1980
Pituitary-testicular function in patients with alcoholic cirrhosis of the liver.
    European journal of clinical investigation, 1981, Volume: 11, Issue:6

    Topics: Adult; Aged; Dehydroepiandrosterone; Estradiol; Estrone; Gonadotropins; Gynecomastia; Humans; Hypogo

1981
Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:7

    Topics: Activity Cycles; Adolescent; Cohort Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate;

1995
Primary hypogonadism in females with infantile onset spinocerebellar ataxia.
    Neuropediatrics, 1995, Volume: 26, Issue:5

    Topics: Adolescent; Adult; Age of Onset; Brain; Child; Child, Preschool; Dehydroepiandrosterone; Dehydroepia

1995
Daytime plasma melatonin levels in male hypogonadism.
    The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:5

    Topics: Adult; Chorionic Gonadotropin; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrosterone Sulf

1996
Effects of gonadotropin and testosterone treatments on Lipoprotein(a), high density lipoprotein particles, and other lipoprotein levels in male hypogonadism.
    The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:9

    Topics: Adult; Apolipoprotein A-I; Apolipoprotein A-II; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehy

1996
Pituitary-testicular responsiveness in male hypogonadotropic hypogonadism.
    The Journal of clinical investigation, 1974, Volume: 53, Issue:2

    Topics: Adult; Chorionic Gonadotropin; Clomiphene; Dehydroepiandrosterone; Estrogen Antagonists; Follicle St

1974
Gynaecomastia with hypergonadotrophic hypogonadism and Leydig cell insufficiency in recipients of high-dose chemotherapy or chemo-radiotherapy.
    Bone marrow transplantation, 2001, Volume: 28, Issue:12

    Topics: Adult; Antineoplastic Agents; Bone Marrow Transplantation; Combined Modality Therapy; Dehydroepiandr

2001
Urinary gonadotrophins in the Sertoli-Cell-only syndrome.
    Acta endocrinologica, 1975, Volume: 78, Issue:1

    Topics: Adult; Androgens; Androsterone; Biological Assay; Biopsy; Castration; Dehydroepiandrosterone; Dexame

1975
Hormonal changes in puberty III: Correlation of plasma dehydroepiandrosterone, testosterone, FSH, and LH with stages of puberty and bone age in normal boys and girls and in patients with Addison's disease or hypogonadism or with premature or late adrenarc
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 41, Issue:5

    Topics: Addison Disease; Adolescent; Bone Development; Child; Dehydroepiandrosterone; Female; Follicle Stimu

1975
The secretion of adrenal androgens and growth patterns of patients with hypogonadotropic hypogonadism and isiopathic delayed puberty.
    The Journal of pediatrics, 1977, Volume: 91, Issue:6

    Topics: Adolescent; Adrenal Cortex; Adrenal Glands; Adult; Age Determination by Skeleton; Androgens; Dehydro

1977
Is dehydroepiandrosterone-sulphate a possible pathogenetic factor in osteopenia of patients with iron overload?
    Haematologia, 1991, Volume: 24, Issue:1

    Topics: Adult; Bone Density; Bone Diseases, Metabolic; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfat

1991
[Clinical features and diagnosis of mild 3-beta-hydroxysteroid dehydrogenase deficiency in men].
    Deutsche medizinische Wochenschrift (1946), 1989, Mar-03, Volume: 114, Issue:9

    Topics: 17-alpha-Hydroxypregnenolone; 3-Hydroxysteroid Dehydrogenases; Adolescent; Adult; Body Height; Dehyd

1989
Reproductive endocrine disorders in women with partial seizures of temporal lobe origin.
    Archives of neurology, 1986, Volume: 43, Issue:4

    Topics: Adult; Dehydroepiandrosterone; Endocrine System Diseases; Epilepsy, Temporal Lobe; Estradiol; Female

1986
Reduced conversion of dehydroepiandrosterone into estrogens in women having hypogonadotropic hypogonadism associated with weight loss.
    Journal of steroid biochemistry, 1986, Volume: 24, Issue:6

    Topics: Adult; Amenorrhea; Androstenedione; Body Weight; Dehydroepiandrosterone; Dehydroepiandrosterone Sulf

1986
The inability of adrenal androgens to stimulate the adult human prostate: an autopsy evaluation of men with hypogonadotropic hypogonadism and panhypopituitarism.
    The Journal of urology, 1986, Volume: 136, Issue:5

    Topics: Adrenal Glands; Aged; Aged, 80 and over; Androstenedione; Dehydroepiandrosterone; Dehydroepiandroste

1986
Feminization in a galactosemic girl in the presence of hypergonadotropic hypogonadism.
    Acta endocrinologica. Supplementum, 1986, Volume: 279

    Topics: Adult; Amenorrhea; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Estrone; Femal

1986
Ovarian androgen secretion in patients with galactosemia and premature ovarian failure.
    Fertility and sterility, 1987, Volume: 47, Issue:6

    Topics: Adolescent; Adult; Androgens; Androstenedione; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehyd

1987
[Placental sulfatase deficiency in Japan].
    Nihon Sanka Fujinka Gakkai zasshi, 1987, Volume: 39, Issue:5

    Topics: Adult; Cesarean Section; Dehydroepiandrosterone; Estriol; Estrogens; Female; Humans; Hypogonadism; I

1987
[The diagnostic significance of testosterone, 17-ketosteroids and estrogen secretion in male hypogonadism].
    Klinische Wochenschrift, 1965, Dec-01, Volume: 43, Issue:23

    Topics: Adult; Androsterone; Animals; Castration; Chromatography; Dehydroepiandrosterone; Estradiol; Estriol

1965
[Excretion of C-19 and C21 steroids in the urine under normal and pathological conditions of development and maturation].
    Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimentelle Chirurgie, 1967, Volume: 142, Issue:3

    Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Androsterone; Carbon Isotopes; Child; Child, Presch

1967
[Steroid spectrum of diabetic men in relationship to their potency].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1966, Oct-01, Volume: 21, Issue:19

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androsterone; Cortisone; Dehydroepiandrosterone;

1966
[Adolescence. I. C-19 and C21 steroid metabolism during puberty].
    Der Internist, 1967, Volume: 8, Issue:8

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Age Factors; Androgens; Carbon Isotop

1967
[Clinical and biochemical studies in a female patient with mixed gonadal dysgenesis].
    Wiener klinische Wochenschrift, 1969, Jun-20, Volume: 81, Issue:25

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Androsterone; Body

1969
Two cases of germinal aplasia: plasma concentration and in vitro biosynthesis of androgens.
    Folia endocrinologica, 1968, Volume: 21, Issue:4

    Topics: 17-Ketosteroids; Adult; Androgens; Carbon Isotopes; Dehydroepiandrosterone; Eczema; Estradiol; Estro

1968
The effect of clomiphene on the androgen production of pubertal and prepubertal boys.
    The Journal of endocrinology, 1969, Volume: 45, Issue:1

    Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Gland Diseases; Androgens; Child; Child, Presc

1969
Plasma and urinary steroids in an eight-year-old boy with 3-beta-hydxysteroid dehydrogenase deficiency.
    The Journal of clinical endocrinology and metabolism, 1970, Volume: 31, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aldosterone; Androsterone; Child; Dehydroepiandro

1970
Effect of aminoglutethimide on extraglandular metabolism of exogenous testosterone.
    Metabolism: clinical and experimental, 1971, Volume: 20, Issue:3

    Topics: 17-Ketosteroids; Adult; Aminoglutethimide; Androsterone; Aniline Compounds; Anticonvulsants; Dehydro

1971
The effect of clomiphene on the plasma androgens of prepubertal and pubertal boys.
    The Journal of endocrinology, 1971, Volume: 50, Issue:3

    Topics: 17-Ketosteroids; Adolescent; Adrenal Insufficiency; Androgens; Androstanes; Child; Child, Preschool;

1971
The effect of chorionic gonadotropin on steroid excretion.
    Archives of internal medicine, 1971, Volume: 128, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adult; Androsterone; Chorionic G

1971
Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Androgen-Insensitivity Syndrome; Animals; Chorionic Gonadotropin; Chromatography, Thin Layer;

1972
Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Androgen-Insensitivity Syndrome; Animals; Chorionic Gonadotropin; Chromatography, Thin Layer;

1972
Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Androgen-Insensitivity Syndrome; Animals; Chorionic Gonadotropin; Chromatography, Thin Layer;

1972
Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Androgen-Insensitivity Syndrome; Animals; Chorionic Gonadotropin; Chromatography, Thin Layer;

1972
Biologic activity of dehydroepiandrosterone sulfate in man.
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Dehydroepiandrosterone; Down Syndrome; Female; Humans; Hydroxyproline; Hypogonadi

1972
Conjugated and unconjugated plasma androgens in normal children.
    Pediatric research, 1972, Volume: 6, Issue:2

    Topics: 17-Ketosteroids; Adolescent; Adult; Age Factors; Androgens; Androstanes; Androsterone; Bromine; Carb

1972
The routine measurement of urinary 17-oxosteroids and 17-oxogenic steroids using gas-liquid chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 40, Issue:1

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Androgens; Androsterone; Chromat

1972
Androgen metabolism in the skin of hirsute women.
    The Journal of clinical endocrinology and metabolism, 1974, Volume: 38, Issue:1

    Topics: 17-Ketosteroids; Adult; Androstanes; Chromatography, Paper; Chromatography, Thin Layer; Dehydroepian

1974
[Gas liquid chromatography analysis of urinary neutral steroid fractions in normal persons and patients with various diseases].
    Nihon Naibunpi Gakkai zasshi, 1970, Jun-20, Volume: 46, Issue:3

    Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormon

1970
Primary hypogonadotrophic hypogonadism in women.
    The Journal of obstetrics and gynaecology of the British Commonwealth, 1969, Volume: 76, Issue:10

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Dehy

1969