Page last updated: 2024-11-07

dehydroepiandrosterone and Hypoglycemia

dehydroepiandrosterone has been researched along with Hypoglycemia in 10 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.

Research Excerpts

ExcerptRelevanceReference
"We tested the hypothesis that acute administration of oral dehydroepiandrosterone (DHEA) during episodes of repeated hypoglycemia can prevent the development of hypoglycemia-associated neuroendocrine and autonomic failure in healthy humans."9.22Acute Effects of Oral Dehydroepiandrosterone on Counterregulatory Responses During Repeated Hypoglycemia in Healthy Humans. ( Davis, I; Davis, SN; Hedrington, MS; Joy, N; Mikeladze, M; Tate, DB; Younk, LM, 2016)
"We tested the hypothesis that acute administration of oral dehydroepiandrosterone (DHEA) during episodes of repeated hypoglycemia can prevent the development of hypoglycemia-associated neuroendocrine and autonomic failure in healthy humans."5.22Acute Effects of Oral Dehydroepiandrosterone on Counterregulatory Responses During Repeated Hypoglycemia in Healthy Humans. ( Davis, I; Davis, SN; Hedrington, MS; Joy, N; Mikeladze, M; Tate, DB; Younk, LM, 2016)
"The interrelations among adrenal steroids: cortisol (CORT), 17alpha-hydroxyprogesterone (17-OHP), androstenedione (ASD), dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) were evaluated in 15 glucocorticoid-naïve premenopausal females with RA and in 14 age- and body mass index- matched healthy females at basal and during insulin-induced hypoglycemia states."3.75Adrenal plasma steroid relations in glucocorticoid-naïve premenopausal rheumatoid arthritis patients during insulin-induced hypoglycemia test compared to matched normal control females. ( Aldag, JC; Imrich, R; Masi, AT; Rovensky, J; Vigas, M, 2009)
"Over 80% of Addison's disease is of the autoimmune type, though almost any systemic destructive process can cause similar steroid insufficiency."2.37Adrenocortical insufficiency. ( Burke, CW, 1985)
"Patients with fibromyalgia have an impaired ability to activate the hypothalamic-pituitary portion of the hypothalamic-pituitary-adrenal axis as well as the sympathoadrenal system, leading to reduced ACTH and epinephrine responses to hypoglycemia."1.30Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. ( Adler, GK; Goldenberg, DL; Hurwitz, S; Kinsley, BT; Mossey, CJ, 1999)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19903 (30.00)18.7374
1990's1 (10.00)18.2507
2000's4 (40.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Novakovic, A1
Zukic, E1
Gazibera, B1
Gojak, R1
Mikeladze, M1
Hedrington, MS1
Joy, N1
Tate, DB1
Younk, LM1
Davis, I1
Davis, SN1
Khoury, K1
Barbar, E1
Ainmelk, Y1
Ouellet, A1
Lehoux, JG1
Imrich, R2
Vigas, M2
Rovensky, J2
Aldag, JC1
Masi, AT1
Lukac, J1
Radikova, Z1
Penesova, A1
Kvetnansky, R1
Huckova, M1
Macho, L1
Koska, J1
Adler, GK1
Kinsley, BT1
Hurwitz, S1
Mossey, CJ1
Goldenberg, DL1
Oltmanns, KM1
Fruehwald-Schultes, B1
Kern, W1
Born, J1
Fehm, HL1
Peters, A1
Vermeulen, A1
Deslypere, JP1
Burke, CW1
Gordon, ES1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Spa Therapy in the Treatment of Fibromyalgia : a Randomized, Controlled, Open Multicenter Study[NCT02265029]220 participants (Actual)Interventional2014-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for dehydroepiandrosterone and Hypoglycemia

ArticleYear
Adrenocortical insufficiency.
    Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:4

    Topics: Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aldosterone; Androstenedione; A

1985
Metabolic aspects of obesity.
    Advances in metabolic disorders, 1970, Volume: 4

    Topics: Acidosis; Adenosine Triphosphate; Adipose Tissue; Adrenal Cortex Hormones; Alcoholism; Animals; Body

1970

Trials

1 trial available for dehydroepiandrosterone and Hypoglycemia

ArticleYear
Acute Effects of Oral Dehydroepiandrosterone on Counterregulatory Responses During Repeated Hypoglycemia in Healthy Humans.
    Diabetes, 2016, Volume: 65, Issue:10

    Topics: Administration, Oral; Adult; Blood Glucose; Dehydroepiandrosterone; Drug Administration Schedule; Fe

2016

Other Studies

7 other studies available for dehydroepiandrosterone and Hypoglycemia

ArticleYear
Hypoglycemia in Non-diabetics During Development of Acute Coronary Ischemia.
    Medical archives (Sarajevo, Bosnia and Herzegovina), 2015, Volume: 69, Issue:4

    Topics: Acute Disease; Age Factors; Ascorbic Acid; Cholecalciferol; Dehydroepiandrosterone; Female; Humans;

2015
Gonadal function, first cases of pregnancy, and child delivery in a woman with lipoid congenital adrenal hyperplasia.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:4

    Topics: Adrenal Hyperplasia, Congenital; Androgens; Dehydroepiandrosterone; Estradiol; Female; Fetal Death;

2009
Adrenal plasma steroid relations in glucocorticoid-naïve premenopausal rheumatoid arthritis patients during insulin-induced hypoglycemia test compared to matched normal control females.
    Endocrine regulations, 2009, Volume: 43, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex Hormones; Adult; Androstenedione; Arthritis, Rheumatoid

2009
Lower adrenocortical and adrenomedullary responses to hypoglycemia in premenopausal women with systemic sclerosis.
    The Journal of rheumatology, 2006, Volume: 33, Issue:11

    Topics: Adrenal Cortex; Adrenal Medulla; Adrenocorticotropic Hormone; Adult; Androgens; Androstenedione; Deh

2006
Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome.
    The American journal of medicine, 1999, Volume: 106, Issue:5

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Case-Control Studies; Dehydroepiandrosterone; Ep

1999
Hypoglycemia, but not insulin, acutely decreases LH and T secretion in men.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:10

    Topics: Adrenocorticotropic Hormone; Adult; Blood Glucose; Dehydroepiandrosterone; Female; Follicle Stimulat

2001
Testicular endocrine function in the ageing male.
    Maturitas, 1985, Volume: 7, Issue:3

    Topics: Adult; Aged; Aging; Circadian Rhythm; Dehydroepiandrosterone; Diet; Dihydrotestosterone; Estradiol;

1985