dehydroepiandrosterone has been researched along with Hyperplasia in 44 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a previous report we found extreme hyperinsulinemia associated with high testosterone levels in patients with polycystic ovarian syndrome (PCO) and normal insulin levels in a small group of patients with elevated dehydroepiandrosterone (DHEA)." | 3.68 | Role of adrenal and gonadal androgens in insulin action and metabolism. ( Buffington, CK; Givens, J; Inouye, H; Kitabchi, AE, 1991) |
| "A plasma testosterone/androstenedione (T/A) ratio was calculated in 15 women with possible ovarian neoplasms and androgen excess and whose mean plasma concentration of testosterone approached or was greater than a twofold elevation." | 3.66 | Testosterone/androstenedione ratio in the evaluation of women with ovarian androgen excess. ( Morris, CV; Wiebe, RH, 1983) |
| "The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats." | 1.28 | Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone. ( Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (68.18) | 18.7374 |
| 1990's | 7 (15.91) | 18.2507 |
| 2000's | 6 (13.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Jing, H | 1 |
| Ding, Y | 1 |
| Jiang, X | 1 |
| Liu, G | 1 |
| Sha, Y | 1 |
| Dumont, T | 1 |
| Black, AY | 1 |
| Ahmet, A | 1 |
| Fleming, NA | 1 |
| Suárez, C | 1 |
| García Tornadú, I | 1 |
| Khalil, W | 1 |
| Becu-Villalobos, D | 1 |
| SORCINI, G | 1 |
| SCIARRA, F | 1 |
| CONCOLINO, G | 1 |
| RASCIO, L | 1 |
| GOLDMAN, AS | 1 |
| BONGIOVANNI, AM | 1 |
| YAKOVAC, WC | 1 |
| PRADER, A | 1 |
| Raff, H | 1 |
| Bruder, ED | 1 |
| Kopplow, K | 1 |
| Wayss, K | 1 |
| Enzmann, H | 1 |
| Mayer, D | 1 |
| Wiebe, RH | 1 |
| Morris, CV | 1 |
| Raj, SG | 1 |
| Shibata, M | 1 |
| Hasegawa, R | 1 |
| Imaida, K | 1 |
| Hagiwara, A | 1 |
| Ogawa, K | 1 |
| Hirose, M | 2 |
| Ito, N | 1 |
| Shirai, T | 2 |
| Baron, JJ | 1 |
| Baron, J | 1 |
| Shibata, MA | 1 |
| Asakawa, E | 1 |
| Fukushima, S | 1 |
| Goudas, VT | 1 |
| Wasty, F | 1 |
| Pardanani, B | 1 |
| Ying, YK | 1 |
| Sourla, A | 1 |
| Richard, V | 1 |
| Labrie, F | 1 |
| Labrie, C | 1 |
| Schwartz, AG | 1 |
| Pashko, LL | 1 |
| Halmy, L | 1 |
| Nagy, I | 1 |
| Kurcz, M | 1 |
| Givens, JR | 1 |
| New, MI | 2 |
| Lorenzen, F | 1 |
| Pang, S | 1 |
| Gunczler, P | 1 |
| Dupont, B | 1 |
| Levine, LS | 2 |
| Rao, MS | 1 |
| Subbarao, V | 1 |
| Yeldandi, AV | 1 |
| Reddy, JK | 1 |
| Kleiber, H | 1 |
| Rey, F | 1 |
| Temler, E | 1 |
| Gomez, F | 1 |
| Kitabchi, AE | 1 |
| Buffington, CK | 1 |
| Givens, J | 1 |
| Inouye, H | 1 |
| Jackson, JA | 1 |
| Fachnie, JD | 1 |
| Mellinger, RC | 1 |
| Gansler, TS | 1 |
| Muller, S | 1 |
| Cleary, MP | 1 |
| el Etreby, MF | 1 |
| Günzel, P | 1 |
| Rosner, JM | 1 |
| Charreau, E | 1 |
| Houssay, AB | 1 |
| Epper, C | 1 |
| Wieland, RG | 1 |
| Vorys, N | 1 |
| Folk, RL | 1 |
| Hamwi, GJ | 2 |
| Göbel, P | 3 |
| Horký, K | 1 |
| Küchel, O | 1 |
| Gregorvá, I | 1 |
| Stárka, L | 1 |
| Green, OC | 2 |
| Miller, RR | 1 |
| Garcia, O | 1 |
| Mahesh, VG | 1 |
| McDonough, PG | 1 |
| Bardin, CW | 1 |
| Rosen, S | 1 |
| LeMaire, WJ | 1 |
| Tjio, JH | 1 |
| Gallup, J | 1 |
| Marshall, J | 1 |
| Savard, K | 1 |
| Völlmin, JA | 1 |
| Kenny, FM | 1 |
| Reynolds, JW | 1 |
| Garmendia, F | 1 |
| Nicolis, GL | 1 |
| Gabrilove, JL | 1 |
| Pal, SB | 1 |
| Teller, WM | 1 |
| Schaeppi, U | 1 |
| Heyman, IA | 1 |
| Fleischman, RW | 1 |
| Rosenkrantz, H | 1 |
| Ilievski, V | 1 |
| Phelan, R | 1 |
| Cooney, DA | 1 |
| Davis, RD | 1 |
| Mizutani, S | 1 |
| Sonoda, T | 1 |
| Seki, T | 1 |
| Matsumoto, K | 1 |
| Lederer, J | 1 |
| Saez, JM | 1 |
| Migeon, CJ | 1 |
| Yamaji, T | 1 |
| Ibayashi, H | 1 |
| Cruikshank, DP | 1 |
| Yannone, ME | 1 |
| Chapler, FK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of DHEA on Skin Aging - Placebo-Controlled and Randomized Phase III Study in Postmenopausal Women.[NCT00248989] | Phase 3 | 150 participants (Actual) | Interventional | 2004-11-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dehydroepiandrosterone and Hyperplasia
| Article | Year |
|---|---|
Hirsutism and hyperandrogenism.
Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Glands; Adult; Androgens; Androstenedio | 1976 |
Sex hormones--effects on prolactin cells.
Topics: Adenoma; Adult; Animals; Dehydroepiandrosterone; Diethylstilbestrol; Dogs; Estradiol; Female; Gonada | 1974 |
Congenital adrenal hyperplasia.
Topics: Adrenal Gland Diseases; Adrenal Glands; Androstenedione; Body Height; Dehydroepiandrosterone; Diagno | 1973 |
2 trials available for dehydroepiandrosterone and Hyperplasia
| Article | Year |
|---|---|
Qualitative alterations in urinary 17-ketosteroid excretion during aminoglutethimide administration.
Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Aminoglutethimide; Androsterone; Aniline Compounds; A | 1969 |
Plasma dehydroepiandrosterone sulfate in normal and pathological conditions.
Topics: Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; | 1969 |
39 other studies available for dehydroepiandrosterone and Hyperplasia
| Article | Year |
|---|---|
RNA-Seq reveals ACTH-induced steroid hormone pathway participating in goat adrenal gland response to castration.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Androgens; Animals; De | 2023 |
Isolated transient neonatal clitoromegaly with hyperandrogenism of unknown etiology.
Topics: Clitoris; Dehydroepiandrosterone; Female; Humans; Hyperandrogenism; Hyperplasia; Infant, Newborn; In | 2009 |
Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia.
Topics: Animals; Dehydroepiandrosterone; Diethylstilbestrol; Female; Growth Hormone; Hyperplasia; Insulin-Li | 2002 |
[ADRENOGENITAL SYNDROME CAUSED BY CONGENITAL HYPERPLASIA OF THE ADRENAL CORTEX: PATHOGENETIC IMPORTANCE OF TESTOSTERONE].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenal Gland Diseases; Adre | 1964 |
STUDY OF DELTA-5, 3-BETA-HYDROXYSTEROID DEHYDROGENASE IN NORMAL, HYPERPLASTIC AND NEOPLASTIC ADRENAL CORTICAL TISSUE.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 3-Hydroxysteroid Dehydrogenases; Adrenal Gland Diseases; | 1964 |
Steroidogenesis in human aldosterone-secreting adenomas and adrenal hyperplasias: effects of hypoxia in vitro.
Topics: Adrenal Glands; Adrenocortical Adenoma; Adrenocorticotropic Hormone; Aldosterone; Cell Hypoxia; Cell | 2006 |
Dehydroepiandrosterone causes hyperplasia and impairs regeneration in rat liver.
Topics: Adjuvants, Immunologic; Alanine Transaminase; Androstenedione; Animals; Aspartate Aminotransferases; | 2005 |
Testosterone/androstenedione ratio in the evaluation of women with ovarian androgen excess.
Topics: Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; | 1983 |
Effect of adrenocorticotropic hormone and human chorionic gonadotropin before and after bilateral oophorectomy in a patient with acquired adult-onset adrenal hyperplasia: a case report.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Castration; Chorionic Gonadotropin; Dehydroepian | 1983 |
Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Dehydroepiandrosterone; Disease Models, Animal; Hyperplasia; Indom | 1995 |
[Differential diagnosis of hirsutism in girls between 15-19 years old].
Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult; Dehydroepiandro | 1993 |
Inhibition by dehydroepiandrosterone of butylated hydroxyanisole (BHA) promotion of rat-bladder carcinogenesis and enhancement of BHA-induced forestomach hyperplasia.
Topics: Animals; Body Weight; Butylated Hydroxyanisole; Dehydroepiandrosterone; DNA; Drug Synergism; Hyperpl | 1993 |
Testosterone-producing solitary ovarian cyst with luteinized stromal-cell hyperplasia.
Topics: Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Hirsutism; Humans; Hyperplasi | 1996 |
Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin.
Topics: Administration, Cutaneous; Androgen Antagonists; Animals; Benzopyrans; Dehydroepiandrosterone; Estro | 2000 |
Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia and inflammation by the dehydroepiandrosterone analog 16alpha-fluoro-5-androsten-17-one and its reversal by NADPH liposomes.
Topics: Androstenes; Animals; Antineoplastic Agents; Binding, Competitive; Capillary Permeability; Carcinoge | 2001 |
Growth hormone and prolactin content of hyperplastic anterior pituitary of dehydroepiandrosterone treated rats.
Topics: Animals; Castration; Dehydroepiandrosterone; Female; Growth Hormone; Hyperplasia; Male; Organ Size; | 1975 |
"Acquired" adrenal hyperplasia with 21-hydroxylase deficiency is not the same genetic disorders as congenital adrenal hyperplasia.
Topics: Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenocor | 1979 |
Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone.
Topics: Aging; Animals; Antineoplastic Agents; Dehydroepiandrosterone; Diet; Hyperplasia; Leydig Cell Tumor; | 1992 |
Dissociated recovery of cortisol and dehydroepiandrosterone sulphate after treatment for Cushing's syndrome.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Aged; Cushing Syndrome; | 1991 |
Role of adrenal and gonadal androgens in insulin action and metabolism.
Topics: Adrenal Glands; Dehydroepiandrosterone; Erythrocytes; Female; Glucose Tolerance Test; Humans; Hyperp | 1991 |
Marked elevation of serum dehydroepiandrosterone sulphate in Cushing's disease with macronodular adrenocortical hyperplasia.
Topics: Adrenal Cortex Diseases; Adult; Cushing Syndrome; Dehydroepiandrosterone; Dehydroepiandrosterone Sul | 1989 |
Chronic administration of dehydroepiandrosterone reduces pancreatic beta-cell hyperplasia and hyperinsulinemia in genetically obese Zucker rats.
Topics: Animals; Blood Glucose; Dehydroepiandrosterone; Female; Hyperinsulinism; Hyperplasia; Insulin; Islet | 1985 |
Biosynthesis of sexual steroids by hyperplastic adrenal glands of castrated female C3H/Ep mice.
Topics: Adrenal Gland Neoplasms; Androgens; Animals; Castration; Chromatography, Paper; Cricetinae; Dehydroe | 1966 |
Urinary testosterone fractions. Studies on the origin in certain diseases associated with elevated testosterone excretion.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Cushing Syndrome; Dehydroepiandr | 1967 |
[Adrenal hirsutism (3-beta-hydroxysteroid dehydrogenase deficiency). Studies using chromatographic separation of the urinary 17-ketosteroid fraction. 3. On the differential diagnosis of adrenal hirsutism (M. Cushing, congenital adrenogenital syndrome)].
Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre | 1968 |
Virilizing male pseudohermaphroditism. Association with abnormal testicular function.
Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Chorion | 1969 |
Urinary steroid excretion in a hirsute patient with ovarian cortical stromal hyperplasia and endometrial carcinoma.
Topics: Adrenal Cortex Hormones; Adult; Androgens; Androsterone; Dehydroepiandrosterone; Dexamethasone; Estr | 1969 |
In vivo and in vitro studies of androgen metabolism in a patient with pure gonadal dysgenesis and Leydig cell hyperplasia.
Topics: 17-Hydroxycorticosteroids; Acetates; Adult; Androgens; Dehydroepiandrosterone; Female; Humans; Hydro | 1969 |
High resolution gas chromatography of urinary steroids on glass capillary columns.
Topics: Adrenal Gland Diseases; Adult; Androsterone; Catalysis; Chemistry, Clinical; Child; Chromatography, | 1971 |
Partial 3 -hydroxysteroid dehydrogenase (3 -HSD) deficiency in a family with congenital adrenal hyperplasia: evidence for increasing 3 -HSD activity with age.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Aging; Aldosterone; Androstanes; | 1971 |
The determination of urinary pregnanetriol and the neutral 17-ketosteroids by gas-liquid chromatography.
Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre | 1971 |
Urinary excretion of dehydroepiandrosterone in normal children and in patients with adrenocortical disorders.
Topics: Adenoma; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Carcinoma; Child; Child, Presc | 1972 |
Toxicity in beagle dogs of three alkylating esters with antitumor activity: phenesterin (NSC-104469), estradiol mustard (NSC-112259), and dehydroepiandrosterone mustard (NSC-12121).
Topics: Animals; Appetite; Blood Urea Nitrogen; Body Weight; Central Nervous System; Dehydroepiandrosterone; | 1973 |
Excretion patterns of urinary 17-KS and 17-OHCS in patients with Cushing's syndrome.
Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal | 1974 |
[Prolonged prednisone treatment of hirsutism caused by virilizing adrenal hyperplasia without abnormalities on cortisol production].
Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adult; Androsterone; Dehydroepiandrosterone; Female; Hirsut | 1967 |
Problems related to the determination of the secretion and interconversion of androgens by "urinary" methods.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Carbon Isotopes; Chorionic Gonadotropin; Chr | 1967 |
+On a procedure for determination of the adrenal cortex secreion rate of cortisol and dehydroepiandrosterone.
Topics: Adrenal Glands; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; | 1965 |
[Adrenal hirsutism (3-beta-hydroxysteroid dehydrogenase deficiency). Studies using a chromatographic separation of the urinary 17-ketosteroid fraction. 2. Dehydroepiandrosterone-forming adrenal hyperplasia and constitutional hirsutism].
Topics: 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; An | 1967 |
Arrhenoblastoma associated with adrenal androgenic hyperfunction.
Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adult; Amenorrhea; Androgens; Androstenedione; Contra | 1974 |