dehydroepiandrosterone has been researched along with Hormone-Dependent Neoplasms in 23 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "About one third of unselected postmenopausal women with advanced breast cancer respond to treatment with aminoglutethimide and hydrocortisone, but they all eventually relapse, and further progression of disease occurs." | 7.67 | Endocrine changes associated with relapse in advanced breast cancer patients on aminoglutethimide therapy. ( Dowsett, M; Harris, AL; Jeffcoate, SL; Smith, IE, 1984) |
| "Reports that MCF-7 human breast cancer cells can transform both estrone (E1)1 to estradiol (E2) and dehydroepiandrosterone (DHEA) to the estrogenic steroid 5-androstenediol (AED), have prompted us to investigate the 17-ketosteroid reductase activities (17-KSR's) which mediate these potentially important reactions." | 5.28 | Dehydroepiandrosterone and estrone 17-ketosteroid reductases in MCF-7 human breast cancer cells. ( Hinkhouse, M; MacIndoe, JH; Woods, G, 1990) |
| "About one third of unselected postmenopausal women with advanced breast cancer respond to treatment with aminoglutethimide and hydrocortisone, but they all eventually relapse, and further progression of disease occurs." | 3.67 | Endocrine changes associated with relapse in advanced breast cancer patients on aminoglutethimide therapy. ( Dowsett, M; Harris, AL; Jeffcoate, SL; Smith, IE, 1984) |
| "Treatment with dehydroepiandrosterone pellets, which produced clinical castration levels of serum testosterone, accelerated the MDA PCa 2b-hr but not MDA PCa 2b tumor growth in castrated mice and increased blood prostate-specific antigen levels in castrated mice bearing MDA PCa 2b-hr tumors but not in mice bearing MDA PCa 2b tumors." | 1.32 | Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline. ( Araki, H; Hara, T; Kusaka, M; Nakamura, K; Yamaoka, M, 2003) |
| " DHEA inhibits prostate cancer induction both when chronic administration is begun prior to carcinogen exposure, and when administration is delayed until preneoplastic prostate lesions are present." | 1.30 | Chemoprevention of hormone-dependent prostate cancer in the Wistar-Unilever rat. ( McCormick, DL; Rao, KV, 1999) |
| "The major focus in prostate cancer therapy currently is the role of the adrenal androgens." | 1.29 | Basis for hormonal management of advanced prostate cancer. ( Geller, J, 1993) |
| "Reports that MCF-7 human breast cancer cells can transform both estrone (E1)1 to estradiol (E2) and dehydroepiandrosterone (DHEA) to the estrogenic steroid 5-androstenediol (AED), have prompted us to investigate the 17-ketosteroid reductase activities (17-KSR's) which mediate these potentially important reactions." | 1.28 | Dehydroepiandrosterone and estrone 17-ketosteroid reductases in MCF-7 human breast cancer cells. ( Hinkhouse, M; MacIndoe, JH; Woods, G, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (17.39) | 18.7374 |
| 1990's | 13 (56.52) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamrath, C | 1 |
| Hartmann, MF | 1 |
| Wudy, S | 1 |
| Hara, T | 1 |
| Nakamura, K | 1 |
| Araki, H | 1 |
| Kusaka, M | 1 |
| Yamaoka, M | 1 |
| Labrie, F | 3 |
| Dowsett, M | 1 |
| Harris, AL | 1 |
| Smith, IE | 1 |
| Jeffcoate, SL | 1 |
| Geller, J | 1 |
| Decensi, A | 1 |
| Torrisi, R | 1 |
| Marroni, P | 1 |
| Pensa, F | 1 |
| Padovani, P | 1 |
| Boccardo, F | 1 |
| Maggino, T | 2 |
| Marcadella, CB | 2 |
| Romagnolo, C | 2 |
| O'Shaughnessy, JA | 1 |
| Dorgan, JF | 1 |
| Longcope, C | 1 |
| Stanczyk, FZ | 1 |
| Stephenson, HE | 1 |
| Hoover, RN | 1 |
| McCormick, DL | 1 |
| Rao, KV | 1 |
| Hida, N | 1 |
| Poulin, R | 1 |
| Veilleux, R | 1 |
| Luu-The, V | 1 |
| Lin, SX | 1 |
| Simard, J | 1 |
| Labrie, C | 1 |
| El-Alfy, M | 1 |
| Pelletier, G | 1 |
| Bélanger, A | 1 |
| Cramarossa, L | 1 |
| Caruso, AA | 1 |
| van Weerden, WM | 1 |
| van Kreuningen, A | 1 |
| Moerings, EP | 1 |
| de Jong, FH | 1 |
| van Steenbrugge, GJ | 1 |
| Schröder, FH | 1 |
| Schiller, CD | 1 |
| Schneider, MR | 1 |
| Hartmann, H | 1 |
| Graf, AH | 1 |
| Klocker, H | 1 |
| Bartsch, G | 1 |
| MacIndoe, JH | 1 |
| Hinkhouse, M | 1 |
| Woods, G | 1 |
| Basilio, E | 1 |
| Prats, M | 1 |
| Rivera, F | 1 |
| Najid, A | 1 |
| Klein, H | 1 |
| Bressel, M | 1 |
| Kastendieck, H | 1 |
| Voigt, KD | 1 |
| Pommier, RF | 1 |
| Woltering, EA | 1 |
| Keenan, EJ | 1 |
| Fletcher, WS | 1 |
| Shultz, TD | 1 |
| Wilcox, RB | 1 |
| Spuehler, JM | 1 |
| Howie, BJ | 1 |
4 reviews available for dehydroepiandrosterone and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
[The alternative androgen synthesis pathway in humans].
Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenal Hyperplasia, Con | 2013 |
[Keyrole of endocrinology in the victory against prostate cancer].
Topics: Adrenal Glands; Androgen Antagonists; Antineoplastic Agents, Hormonal; Dehydroepiandrosterone; Fluta | 2006 |
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adult; Androgens; Breast Neoplasms; Dehydroepiandr | 2000 |
[Replacement therapy in adrenopause. Dehydroepiandrosterone and aging].
Topics: Aging; Blood Glucose; Bone and Bones; Bone Density; Cardiovascular Physiological Phenomena; Central | 2001 |
1 trial available for dehydroepiandrosterone and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Effect of the nonsteroidal antiandrogen nilutamide on adrenal androgen secretion.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aged; Androgen Antagonists; Androgens; Androstenedione; | 1994 |
18 other studies available for dehydroepiandrosterone and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline.
Topics: Androgen Antagonists; Androgens; Anilides; Animals; Cell Division; Dehydroepiandrosterone; Humans; M | 2003 |
Endocrine changes associated with relapse in advanced breast cancer patients on aminoglutethimide therapy.
Topics: Aminoglutethimide; Androstenedione; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estrone; Fe | 1984 |
Basis for hormonal management of advanced prostate cancer.
Topics: Androstenedione; Animals; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Male; Neoplasm Recurr | 1993 |
The role of insulin and renin in the pathogenesis of hormone-dependent neoplasias. b). Renin.
Topics: Adipose Tissue; Androstenedione; Blood Pressure; Breast Neoplasms; Dehydroepiandrosterone; Endometri | 1993 |
The role of insulin and renin in the pathogenesis of hormone-dependent neoplasias. a). Insulin.
Topics: Androstenedione; Blood Glucose; Body Weight; Breast Neoplasms; Dehydroepiandrosterone; Endometrial N | 1993 |
Chemoprevention of breast cancer.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Carci | 1996 |
Re: Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women.
Topics: Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Female; Gonadal Steroid Hormones; Humans; Neopl | 1999 |
Chemoprevention of hormone-dependent prostate cancer in the Wistar-Unilever rat.
Topics: Alitretinoin; Animals; Antineoplastic Agents; Dehydroepiandrosterone; Disease Models, Animal; Immuno | 1999 |
Differential androgen sensitivity is associated with clonal heterogeneity in steroid metabolism, ornithine decarboxylase regulation and IL-1alpha action in mouse mammary tumor cells.
Topics: Androgens; Androstenediol; Androstenedione; Animals; Binding Sites; Cell Division; Clone Cells; Dehy | 1999 |
DHEA--cautions and concerns.
Topics: Contraindications; Dehydroepiandrosterone; Depression; HIV Infections; Humans; Neoplasms, Hormone-De | 2001 |
Pharmacia Award 1990. The biological significance of low testosterone levels and of adrenal androgens in transplantable prostate cancer lines.
Topics: Adenocarcinoma; Androstenedione; Animals; Awards and Prizes; Castration; Dehydroepiandrosterone; Eur | 1991 |
Growth-stimulating effect of adrenal androgens on the R3327 Dunning prostatic carcinoma.
Topics: Adenocarcinoma; Androstenedione; Animals; Castration; Dehydroepiandrosterone; Dehydroepiandrosterone | 1991 |
Dehydroepiandrosterone and estrone 17-ketosteroid reductases in MCF-7 human breast cancer cells.
Topics: 17-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Androstenediol; Breast Neoplasms; Carcino | 1990 |
[Prolactin receptors and breast cancer].
Topics: Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Female; Humans; Neoplasms, Hormone-Dependent; P | 1990 |
Aromatisation of dehydroepiandrosterone by hormone dependent human mammary cancer MCF-7 subcellular fractions.
Topics: Breast Neoplasms; Dehydroepiandrosterone; Female; Humans; Neoplasms, Hormone-Dependent; Subcellular | 1990 |
Androgens, adrenal androgen precursors, and their metabolism in untreated primary tumors and lymph node metastases of human prostatic cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenal Glands; Androgens; Androstenediols; Androstenedione; Aryls | 1988 |
The mechanism of hormone-sensitive breast cancer progression on antiestrogen therapy. Implications for treatment and protocol planning.
Topics: Adrenal Glands; Adrenalectomy; Adult; Aged; Breast Neoplasms; Castration; Dehydroepiandrosterone; Es | 1987 |
Dietary and hormonal interrelationships in premenopausal women: evidence for a relationship between dietary nutrients and plasma prolactin levels.
Topics: Adult; Breast Neoplasms; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diet, Vegetarian; D | 1987 |