dehydroepiandrosterone has been researched along with Hepatocellular Carcinoma in 25 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cortisol production by hepatocellular carcinoma (HCC) has not been previously reported and dehydroepiandrosterone (DHEA) secretion by HCC is rare." | 3.81 | Possible ACTH-independent, cortisol-secreting and DHEA-secreting metastatic hepatocellular carcinoma causing Cushing's syndrome. ( Bahtiyar, G; Inoue, T; Sacerdote, A; Thomas, N, 2015) |
| "Dehydroepiandrosterone sulfate was first detected in the hepatoma G2 cell culture media at 12 hours of incubation." | 1.35 | Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells. ( Azziz, R; Magoffin, D; Nguyen, M; Pall, M, 2009) |
| "Dehydroepiandrosterone (DHEA) is an endogenous steroid that is synthesized mainly in the adrenal cortex; it is found in plasma as the sulfate-conjugated form (DHEA-S)." | 1.33 | Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone. ( Hirayama, T; Honda, A; Jiang, Y; Matsuzaki, Y; Miyazaki, T; Tanaka, N; Yoshida, S, 2005) |
| "A transformed human hepatoma cell line was examined to determine if it was an appropriate model system for studying the mechanism of action of two peroxisome proliferators that lower blood lipids." | 1.29 | Inverse relationship between peroxisomal and mitochondrial beta-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid. ( Chance, DS; McIntosh, MK; Wu, SM, 1995) |
| "Dehydroepiandrosterone was administered in the diet at a concentration of 0." | 1.28 | Hepatocarcinogenicity of dehydroepiandrosterone in the rat. ( Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 11 (44.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mclean, MA | 1 |
| Scoten, OC | 1 |
| Yu, W | 1 |
| Ye, XY | 1 |
| Petrie, J | 1 |
| Church, PT | 1 |
| Soraisham, AS | 1 |
| Mirea, LS | 1 |
| Weinberg, J | 1 |
| Synnes, AR | 1 |
| O'Brien, K | 1 |
| Grunau, RE | 1 |
| Teng, Y | 1 |
| Radde, BN | 1 |
| Litchfield, LM | 1 |
| Ivanova, MM | 1 |
| Prough, RA | 1 |
| Clark, BJ | 1 |
| Doll, MA | 1 |
| Hein, DW | 1 |
| Klinge, CM | 1 |
| Sacerdote, A | 1 |
| Inoue, T | 1 |
| Thomas, N | 1 |
| Bahtiyar, G | 1 |
| Cheng, ML | 3 |
| Chi, LM | 1 |
| Wu, PR | 1 |
| Ho, HY | 3 |
| Pall, M | 1 |
| Nguyen, M | 1 |
| Magoffin, D | 1 |
| Azziz, R | 1 |
| Chiu, HY | 1 |
| Weng, SF | 2 |
| Chiu, DT | 2 |
| Shiao, MS | 1 |
| Tang, HY | 1 |
| Jiang, Y | 1 |
| Miyazaki, T | 1 |
| Honda, A | 1 |
| Hirayama, T | 1 |
| Yoshida, S | 1 |
| Tanaka, N | 1 |
| Matsuzaki, Y | 2 |
| Mine, T | 1 |
| Yamashita, R | 1 |
| Saito, T | 1 |
| Satoh, S | 1 |
| Aoki, K | 1 |
| Kaburagi, Y | 1 |
| Sekihara, H | 1 |
| Rypka, M | 2 |
| Cervenková, K | 2 |
| Uherková, L | 2 |
| Poczatková, H | 2 |
| Bogdanová, K | 2 |
| Veselý, J | 2 |
| Jiang, YF | 1 |
| Zhao, PW | 1 |
| Tan, Y | 1 |
| Liu, LH | 1 |
| Li, MH | 1 |
| Niu, JQ | 1 |
| Panin, LE | 1 |
| Khoshchenko, OM | 1 |
| Poliakov, LM | 1 |
| Riegrová, D | 1 |
| Fehér, KG | 2 |
| Rákász, E | 1 |
| Bíró, J | 1 |
| Falus, A | 2 |
| Chance, DS | 1 |
| Wu, SM | 1 |
| McIntosh, MK | 1 |
| Farinati, F | 1 |
| De Maria, N | 1 |
| Marafin, C | 1 |
| Fagiuoli, S | 1 |
| Della Libera, G | 1 |
| Naccarato, R | 1 |
| Metzger, C | 1 |
| Bannasch, P | 2 |
| Mayer, D | 2 |
| Nehrbass, D | 1 |
| Klimek, F | 1 |
| Simile, M | 1 |
| De Miglio, M | 1 |
| Calvisi, D | 1 |
| Muroni, M | 1 |
| Frau, M | 1 |
| Asara, G | 1 |
| Daino, L | 1 |
| Deiana, L | 1 |
| Pascale, R | 1 |
| Feo, F | 1 |
| Narasaka, T | 1 |
| Moriya, T | 1 |
| Endoh, M | 1 |
| Suzuki, T | 1 |
| Shizawa, S | 1 |
| Mizokami, Y | 1 |
| Matsuoka, T | 1 |
| Sasano, H | 1 |
| Rao, MS | 2 |
| Subbarao, V | 2 |
| Yeldandi, AV | 2 |
| Reddy, JK | 2 |
| Kumar, S | 1 |
| Walcz, E | 1 |
| Brozik, M | 1 |
| Füst, G | 1 |
| Hidvégi, T | 1 |
| Fehér, T | 1 |
| Merétey, K | 1 |
| Plymate, SR | 1 |
| Hoop, RC | 1 |
| Jones, RE | 1 |
| Matej, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Family Integrated Care Model For The Neonatal Intensive Care Unit: A Cluster Randomised Controlled Trial[NCT01852695] | 720 participants (Actual) | Interventional | 2013-03-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for dehydroepiandrosterone and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Lower Maternal Chronic Physiological Stress and Better Child Behavior at 18 Months: Follow-Up of a Cluster Randomized Trial of Neonatal Intensive Care Unit Family Integrated Care.
Topics: Carcinoma, Hepatocellular; Child; Child Behavior; Dehydroepiandrosterone; Delivery of Health Care, I | 2022 |
24 other studies available for dehydroepiandrosterone and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.
Topics: Adjuvants, Immunologic; Carcinoma, Hepatocellular; CSK Tyrosine-Protein Kinase; Dehydroepiandrostero | 2015 |
Possible ACTH-independent, cortisol-secreting and DHEA-secreting metastatic hepatocellular carcinoma causing Cushing's syndrome.
Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Biopsy | 2015 |
Dehydroepiandrosterone-induced changes in mitochondrial proteins contribute to phenotypic alterations in hepatoma cells.
Topics: Antineoplastic Agents, Hormonal; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Ce | 2016 |
Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; | 2009 |
Dehydroepiandrosterone induces growth arrest of hepatoma cells via alteration of mitochondrial gene expression and function.
Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Proliferation; Dehydroepiandrosterone; DNA, | 2008 |
Biochemical disorders associated with antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Chrom | 2011 |
Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dehydroepiandrosterone; | 2005 |
The role of dehydroepiandrosterone in apoptosis and proliferation and its relation to the phosphatidyl inositol-3-kinase/Akt signaling pathway.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dehydroepiandrosterone; | 2005 |
Effects of dehydroepiandrosterone on gluconeogenic enzymes and glucose uptake in human hepatoma cell line, HepG2.
Topics: Blotting, Northern; Carcinoma, Hepatocellular; Cell Line, Tumor; Dehydroepiandrosterone; Deoxyglucos | 2005 |
Changes in mRNA levels of intracellular fatty acid metabolism regulators in human hepatoma HepG2 cells following their treatment with non-esterified fatty acids and dehydroepiandrosterone.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Dehydroepiandrosterone; Fatty Acid-Binding Proteins; Fa | 2005 |
[Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines].
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Dehydroepiandrosterone; Dehydr | 2007 |
[Effect of apolipoprotein A-1 containing steroid hormones on DNA and protein biosynthesis in cells of ascitic hepatoma HA-1].
Topics: Apolipoprotein A-I; Ascites; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Dehydroepiandrostero | 2007 |
Dehydroepiandrosterone effects on the mRNA levels of peroxisome proliferator-activated receptors and their coactivators in human hepatoma HepG2 cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cycloheximide; Dactinomycin; Dehydroepiandrosterone; Ge | 2007 |
Dehydroepiandrosterone modulates the spontaneous and IL-6 stimulated fibrinogen production of human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Dehydroepiandrosterone; Dexamethasone; Fibrinogen; Humans; Immunologic Fa | 1995 |
Inverse relationship between peroxisomal and mitochondrial beta-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid.
Topics: Analysis of Variance; Biomarkers; Carcinoma, Hepatocellular; Carnitine O-Palmitoyltransferase; Catal | 1995 |
Hepatocellular carcinoma in alcoholic cirrhosis: is sex hormone imbalance a pathogenetic factor?
Topics: Adult; Aged; Aged, 80 and over; Androgens; Androstenedione; Carcinoma, Hepatocellular; Dehydroepiand | 1995 |
Enhancement and phenotypic modulation of N-nitrosomorpholine-induced hepatocarcinogenesis by dehydroepiandrosterone.
Topics: Adenoma, Liver Cell; Animals; Carcinogens; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Drug S | 1997 |
Insulin receptor substrate-1 is over-expressed in glycogenotic but not in amphophilic preneoplastic hepatic foci induced in rats by N-nitrosomorpholine and dehydroepiandrosterone.
Topics: Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Female; Glycogen; I | 1999 |
Long-term dehydroepiandrosterone and 16alpha-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats.
Topics: Animals; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Diet; Diethylnitrosamine; DNA; DNA Repli | 2001 |
17Beta-hydroxysteroid dehydrogenase type 2 and dehydroepiandrosterone sulfotransferase in the human liver.
Topics: 17-Hydroxysteroid Dehydrogenases; Aged; Carcinoma, Hepatocellular; Cholangiocarcinoma; Dehydroepiand | 2000 |
Hepatocarcinogenicity of dehydroepiandrosterone in the rat.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Dehydroepiand | 1992 |
Phenotypic properties of liver tumors induced by dehydroepiandrosterone in F-344 rats.
Topics: Animals; Blotting, Northern; Carcinogens; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Histocy | 1992 |
Hormonal regulation of complement biosynthesis in human cell lines--I. Androgens and gamma-interferon stimulate the biosynthesis and gene expression of C1 inhibitor in human cell lines U937 and HepG2.
Topics: Carcinoma, Hepatocellular; Complement C1 Inactivator Proteins; Dehydroepiandrosterone; Gene Expressi | 1990 |
Regulation of sex hormone-binding globulin production by growth factors.
Topics: Carcinoma, Hepatocellular; Cell Line; Dehydroepiandrosterone; Epidermal Growth Factor; Growth Substa | 1990 |