dehydroepiandrosterone has been researched along with Experimental Mammary Neoplasms in 35 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| " treatment with dehydroepiandrosterone, an adrenal steroid found in subnormal plasma concentrations in women predisposed to develop breast cancer, inhibits the formation of spontaneous mammary cancer in female C3H(Avy/a) mice." | 7.66 | Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone. ( Schwartz, AG, 1979) |
| " Dehydroepiandrosterone (DHEA) is an over-the-counter dietary supplement used as an immunomodulating, anti-depressant, anti-aging, anti-cardiovascular disease, and anti-cancer agent and anti-obesity supplement." | 3.76 | Dehydroepiandrosterone intake protects against 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in the obese Zucker rat model. ( Hakkak, R; Jo, CH; Korourian, S; MacLeod, S; Shaaf, S, 2010) |
| "When pregnant rats received whole body irradiations with 260 cGy gamma-ray at day 20 of pregnancy, and were then implanted with a diethylstilbestrol (DES) pellet for an experimental period of 1 year under feeding of a control diet, a high incidence (96." | 3.69 | Chemoprevention by dietary dehydroepiandrosterone against promotion/progression phase of radiation-induced mammary tumorigenesis in rats. ( Inano, H; Ishii-Ohba, H; Onoda, M; Suzuki, K; Wakabayashi, K; Yamanouchi, H, 1995) |
| " Under sustained hyperprolactinemia induced by pimozide (PMZ) from day 21, DMBA was injected locally into the mammary glandular tissues on day 73." | 3.69 | Effects of dehydroepiandrosterone and other sex steroid hormones on mammary carcinogenesis by direct injection of 7,12-dimethylbenz(a) anthracene (DMBA) in hyperprolactinemic female rats. ( Inoue, M; Kohama, T; Suzuki, N; Terada, S, 1997) |
| " treatment with dehydroepiandrosterone, an adrenal steroid found in subnormal plasma concentrations in women predisposed to develop breast cancer, inhibits the formation of spontaneous mammary cancer in female C3H(Avy/a) mice." | 3.66 | Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone. ( Schwartz, AG, 1979) |
| "The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/ml)." | 3.65 | Hyperprolactinemia and steroid metabolism by rat mammary adenocarcinomas. ( Miller, WR, 1976) |
| "The low incidence of breast cancer in Japan disappears within 2 generations in migrant Japanese in the USA." | 2.38 | Human breast cancer: concerted role of diet, prolactin and adrenal C19-delta 5-steroids in tumorigenesis. ( Adams, JB, 1992) |
| " However, a dose-response reduction in invasive carcinoma growth was observed for both DFMO, an inhibitor of ornithine decarboxylase, and DHEA, the primary steroid precursor to both androgens and estrogens in primates." | 1.31 | 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice. ( Anver, MR; Green, JE; Kelloff, G; Lubet, R; Moon, RC; Shibata, E; Shibata, MA, 2001) |
| "In Japanese but not Caucasian breast cancer patients, the estradiol decreased." | 1.26 | Diet and endocrine-related cancer. ( Chan, P; Cohen, L; Hill, P; Kuno, K; Wynder, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (45.71) | 18.7374 |
| 1990's | 15 (42.86) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hakkak, R | 1 |
| Shaaf, S | 1 |
| Jo, CH | 1 |
| MacLeod, S | 1 |
| Korourian, S | 1 |
| Shilkaitis, A | 1 |
| Green, A | 1 |
| Punj, V | 1 |
| Steele, V | 1 |
| Lubet, R | 2 |
| Christov, K | 1 |
| Schwartz, AG | 2 |
| Hard, GC | 1 |
| Pashko, LL | 1 |
| Abou-Gharbia, M | 1 |
| Swern, D | 1 |
| Le Goff, JM | 1 |
| Belanger, A | 5 |
| Li, K | 1 |
| Chandra, DP | 1 |
| Pewnim, T | 1 |
| Foo, T | 1 |
| Adams, JB | 3 |
| Inano, H | 1 |
| Ishii-Ohba, H | 1 |
| Suzuki, K | 1 |
| Yamanouchi, H | 1 |
| Onoda, M | 1 |
| Wakabayashi, K | 1 |
| Li, S | 1 |
| Yan, X | 1 |
| Labrie, F | 7 |
| Santner, SJ | 1 |
| Santen, RJ | 1 |
| Prough, RA | 2 |
| Lei, XD | 2 |
| Xiao, GH | 1 |
| Wu, HQ | 1 |
| Geoghegan, TE | 1 |
| Webb, SJ | 1 |
| Lubet, RA | 2 |
| McCormick, DM | 1 |
| Gordon, GM | 1 |
| Grubbs, C | 1 |
| Steele, VE | 2 |
| Kelloff, GJ | 2 |
| Thomas, CF | 1 |
| Moon, RD | 1 |
| McCormick, DL | 1 |
| Rao, KV | 1 |
| Johnson, WD | 1 |
| Bowman-Gram, TA | 1 |
| Kellof, GJ | 1 |
| Boccuzzi, G | 1 |
| Brignardello, E | 1 |
| Kohama, T | 1 |
| Terada, S | 1 |
| Suzuki, N | 1 |
| Inoue, M | 1 |
| Luo, S | 2 |
| Labrie, C | 3 |
| Sourla, A | 1 |
| Couillard, S | 1 |
| Candas, B | 1 |
| Pouliot, F | 1 |
| Hida, N | 1 |
| Poulin, R | 1 |
| Veilleux, R | 1 |
| Green, JE | 1 |
| Shibata, MA | 1 |
| Shibata, E | 1 |
| Moon, RC | 2 |
| Anver, MR | 1 |
| Kelloff, G | 1 |
| Yang, S | 1 |
| Fu, Z | 1 |
| Wang, F | 1 |
| Cao, Y | 1 |
| Han, R | 1 |
| Lemon, HM | 2 |
| Miller, WR | 3 |
| Hill, P | 1 |
| Chan, P | 1 |
| Cohen, L | 1 |
| Wynder, E | 1 |
| Kuno, K | 1 |
| Archibald, L | 1 |
| Clarke, C | 1 |
| Stewart, R | 1 |
| Hawkins, RA | 1 |
| Godefroi, VC | 1 |
| Locke, ER | 1 |
| Singh, DV | 1 |
| Brooks, SC | 1 |
| Ratajczak, HV | 1 |
| Lange, RW | 1 |
| Sothern, RB | 1 |
| Hagen, KL | 1 |
| Vescei, P | 1 |
| Wu, J | 1 |
| Halberg, F | 1 |
| Thomas, PT | 1 |
| Ratko, TA | 1 |
| Detrisac, CJ | 1 |
| Mehta, RG | 1 |
| Spinola, PG | 1 |
| Marchetti, B | 1 |
| Bégin, D | 1 |
| Luthy, IA | 1 |
| King, JB | 1 |
| Panattoni, M | 1 |
| Gordon, J | 1 |
| Baker, R | 1 |
| Miller, DM | 1 |
| Miller, W | 1 |
| Hamilton, T | 2 |
| Forrest, AP | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of DHEA on Skin Aging - Placebo-Controlled and Randomized Phase III Study in Postmenopausal Women.[NCT00248989] | Phase 3 | 150 participants (Actual) | Interventional | 2004-11-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dehydroepiandrosterone and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Adrenal androgen action in breast cancer.
Topics: Adrenal Glands; Androgens; Animals; Breast Neoplasms; Cell Division; Dehydroepiandrosterone; Estradi | 1996 |
Human breast cancer: concerted role of diet, prolactin and adrenal C19-delta 5-steroids in tumorigenesis.
Topics: Adrenal Glands; Animals; Breast Neoplasms; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; D | 1992 |
Competition between steroids for hormonal receptor.
Topics: Animals; Antineoplastic Agents; Body Fluids; Breast Neoplasms; Castration; Dehydroepiandrosterone; E | 1971 |
1 trial available for dehydroepiandrosterone and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Effect of dehydroepiandrosterone on bone mass, serum lipids, and dimethylbenz(a)anthracene-induced mammary carcinoma in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaline Phosphatase; Animals; Body Weight; Bone Density; Calcium; | 1997 |
31 other studies available for dehydroepiandrosterone and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Dehydroepiandrosterone intake protects against 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in the obese Zucker rat model.
Topics: Aging; Animals; Benz(a)Anthracenes; Body Weight; Carcinogens; Carcinoma, Ductal, Breast; Cytoprotect | 2010 |
Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism.
Topics: Adjuvants, Immunologic; Alkylating Agents; Animals; Breast Neoplasms; Carcinoma in Situ; Cell Transf | 2005 |
Dehydroepiandrosterone: an anti-obesity and anti-carcinogenic agent.
Topics: Animals; Body Weight; Crosses, Genetic; Dehydroepiandrosterone; Female; Male; Mammary Neoplasms, Exp | 1981 |
Metabolism of tritiated C19 steroids by Shionogi mouse mammary tumors.
Topics: Androgens; Androstenediols; Androstenedione; Androsterone; Animals; Castration; Dehydroepiandrostero | 1984 |
Effect of hormone manipulation on oxidation, reduction and sulphurylation of dehydroepiandrosterone and oestrone in DMBA-induced rat mammary tumours.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenine Nucleotides; Animals; Castration; Dehydroepiandrosterone; | 1980 |
Chemoprevention by dietary dehydroepiandrosterone against promotion/progression phase of radiation-induced mammary tumorigenesis in rats.
Topics: Animals; Dehydroepiandrosterone; Diet; Diethylstilbestrol; Female; Mammary Neoplasms, Experimental; | 1995 |
Prevention by dehydroepiandrosterone of the development of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Dehydroepiandrosterone; Dehydroe | 1994 |
Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogens.
Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Binding, Competitive; Dehydroepiandrosterone; Dehydroepia | 1993 |
Regulation of cytochromes P450 by DHEA and its anticarcinogenic action.
Topics: Animals; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Enzyme Indu | 1995 |
Effects of dehydroepiandrosterone on MNU-induced breast cancer in Sprague-Dawley rats.
Topics: Animals; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Mammary | 1995 |
Exceptional chemopreventive activity of low-dose dehydroepiandrosterone in the rat mammary gland.
Topics: Animals; Anticarcinogenic Agents; Carbenoxolone; Carcinogens; Dehydroepiandrosterone; Diet; Drug Adm | 1996 |
Effects of dehydroepiandrosterone and other sex steroid hormones on mammary carcinogenesis by direct injection of 7,12-dimethylbenz(a) anthracene (DMBA) in hyperprolactinemic female rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Carcinogens; Cocarcinogenesis; Dehydroepi | 1997 |
Combined effects of dehydroepiandrosterone and EM-800 on bone mass, serum lipids, and the development of dimethylbenz(A)anthracene-induced mammary carcinoma in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaline Phosphatase; Animals; Benzopyrans; Bone Density; Calcium; | 1997 |
Effect of dehydroepiandrosterone and the antiestrogen EM-800 on growth of human ZR-75-1 breast cancer xenografts.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Benzopyrans; Breast Neoplasms; Dehydroepia | 1998 |
Differential androgen sensitivity is associated with clonal heterogeneity in steroid metabolism, ornithine decarboxylase regulation and IL-1alpha action in mouse mammary tumor cells.
Topics: Androgens; Androstenediol; Androstenedione; Animals; Binding Sites; Cell Division; Clone Cells; Dehy | 1999 |
2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice.
Topics: Animals; Anticarcinogenic Agents; Antigens, Polyomavirus Transforming; Apoptosis; Cell Division; Deh | 2001 |
[Anti-mutagenicity activity of dehydroepiandrosterone].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Animals; Antimutagenic Agents; Dehydroepia | 2002 |
Estriol prevention of mammary carcinoma induced by 7,12-dimethylbenzanthracene and procarbazine.
Topics: Animals; Benz(a)Anthracenes; Carcinogens; Castration; Corticosterone; Dehydroepiandrosterone; Estrad | 1975 |
Hyperprolactinemia and steroid metabolism by rat mammary adenocarcinomas.
Topics: Adenocarcinoma; Androstane-3,17-diol; Animals; Dehydroepiandrosterone; DNA, Neoplasm; Female; In Vit | 1976 |
Diet and endocrine-related cancer.
Topics: Adult; Animals; Asian People; Breast Neoplasms; Bromocriptine; Dehydroepiandrosterone; Dietary Fats; | 1977 |
Adrenal dehydroepiandrosterone and human mammary cancer.
Topics: Adrenal Glands; Androstenediol; Animals; Binding, Competitive; Breast Neoplasms; Cell Nucleus; Cytos | 1978 |
Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone.
Topics: Animals; Body Weight; Breast Neoplasms; Dehydroepiandrosterone; Female; Glucosephosphate Dehydrogena | 1979 |
Hormonal status and steroid metabolism in two transplantable rat mammary tumours.
Topics: Animals; Carcinoma; Castration; Dehydroepiandrosterone; Estradiol; Mammary Neoplasms, Experimental; | 1979 |
The steroid alcohol and estrogen sulfotransferases in rodent and human mammary tumors.
Topics: Alcohols; Animals; Breast Neoplasms; Castration; Chick Embryo; Dehydroepiandrosterone; Estrogens; Es | 1975 |
Surgical influence on murine immunity and tumor growth: relationship of body temperature and hormones with splenocytes.
Topics: Adenocarcinoma; Animals; Antigens, Surface; Body Temperature; Circadian Rhythm; Corticosterone; Dehy | 1992 |
Inhibition of rat mammary gland chemical carcinogenesis by dietary dehydroepiandrosterone or a fluorinated analogue of dehydroepiandrosterone.
Topics: Androstenes; Animals; Antineoplastic Agents; Dehydroepiandrosterone; Diet; Drug Therapy, Combination | 1991 |
Adrenal steroids stimulate growth and progesterone receptor levels in rat uterus and DMBA-induced mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenal Cortex Hormones; Androstenediol; Androstenedione; Animals; | 1986 |
Adrenal precursor C19 steroids are potent stimulators of growth of androgen-sensitive mouse mammary carcinoma Shionogi cells in vitro.
Topics: Androgens; Androstenediol; Androstenediols; Androstenedione; Animals; Cell Line; Dehydroepiandroster | 1988 |
The metabolism of steroids by tissue from normal and neoplastic rat breast.
Topics: Animals; Benz(a)Anthracenes; Carcinogens; Dehydroepiandrosterone; Estradiol; Estrone; Female; Hydrox | 1965 |
Steroidogenesis in human and rat mammary adenocarcinoma.
Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Breast Neoplasms; Carbon Isotopes; Chromatography, Thin | 1972 |
Steroid metabolism by human breast and rat mammary carcinomata.
Topics: Adult; Androstanes; Animals; Benz(a)Anthracenes; Breast Neoplasms; Carbon Radioisotopes; Carcinoma; | 1974 |