dehydroepiandrosterone has been researched along with Experimental Hepatoma in 23 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "25% dehydroepiandrosterone (DHEA) during and subsequent to 7 weeks treatment with N-nitrosomorpholine (NNM) resulted in significantly reduced development of adrenal cortical lesions and hemangiosarcomas in the liver." | 7.67 | Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone. ( Bannasch, P; Moore, MA; Weber, E, 1988) |
| "25% dehydroepiandrosterone (DHEA) during and subsequent to 7 weeks treatment with N-nitrosomorpholine (NNM) resulted in significantly reduced development of adrenal cortical lesions and hemangiosarcomas in the liver." | 3.67 | Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone. ( Bannasch, P; Moore, MA; Weber, E, 1988) |
| " Trout have critical and unique advantages allowing for cancer studies with 40,000 animals to determine dose-response at levels orders of magnitude lower than possible in rodents." | 2.48 | The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention. ( Williams, DE, 2012) |
| ", which corresponds to a daily dosage one-half that previously administered to humans in clinical trials." | 1.29 | Dehydroepiandrosterone is a complete hepatocarcinogen and potent tumor promoter in the absence of peroxisome proliferation in rainbow trout. ( Bailey, GS; Carpenter, HM; Hendricks, JD; Mathews, C; Orner, GA; Williams, DE, 1995) |
| "Dehydroepiandrosterone (DHEA) is an adrenal steroid with chemoprotective effects against a wide variety of conditions including cancer, obesity, diabetes, and cardiovascular disease." | 1.29 | Comparison of the enhancing effects of dehydroepiandrosterone with the structural analog 16 alpha-fluoro-5-androsten-17-one on aflatoxin B1 hepatocarcinogenesis in rainbow trout. ( Curtis, LR; Donohoe, RM; Hendricks, JD; Orner, GA; Williams, DE, 1996) |
| "Dehydroepiandrosterone was administered in the diet at a concentration of 0." | 1.28 | Hepatocarcinogenicity of dehydroepiandrosterone in the rat. ( Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 14 (60.87) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, YF | 1 |
| Zhao, PW | 1 |
| Qin, JJ | 1 |
| Li, MH | 1 |
| Yasushi, M | 1 |
| Niu, JQ | 1 |
| Williams, DE | 5 |
| Mayer, D | 4 |
| Forstner, K | 1 |
| Pascale, RM | 1 |
| Simile, MM | 2 |
| De Miglio, MR | 1 |
| Nufris, A | 1 |
| Seddaiu, MA | 2 |
| Muroni, MR | 1 |
| Danni, O | 1 |
| Rao, KN | 2 |
| Feo, F | 4 |
| Hayashi, F | 1 |
| Tamura, H | 1 |
| Yamada, J | 1 |
| Kasai, H | 1 |
| Suga, T | 1 |
| Rao, MS | 4 |
| Ide, H | 1 |
| Yeldandi, AV | 3 |
| Kumar, S | 2 |
| Reddy, JK | 3 |
| Orner, GA | 4 |
| Mathews, C | 1 |
| Hendricks, JD | 4 |
| Carpenter, HM | 1 |
| Bailey, GS | 1 |
| Donohoe, RM | 1 |
| Curtis, LR | 1 |
| Arbogast, D | 2 |
| Subbarao, V | 3 |
| Metzger, C | 2 |
| Bannasch, P | 6 |
| Leonetti, P | 1 |
| Beier, K | 1 |
| Benner, A | 1 |
| Nehrbass, D | 1 |
| Klimek, F | 1 |
| Simile, M | 1 |
| De Miglio, M | 1 |
| Calvisi, D | 1 |
| Muroni, M | 1 |
| Frau, M | 1 |
| Asara, G | 1 |
| Daino, L | 3 |
| Deiana, L | 1 |
| Pascale, R | 3 |
| McKeating, JA | 1 |
| Davliakos, GP | 1 |
| Sudol, KS | 1 |
| Melhem, MF | 1 |
| Moore, MA | 4 |
| Thamavit, W | 1 |
| Tsuda, H | 1 |
| Sato, K | 1 |
| Ichihara, A | 1 |
| Ito, N | 1 |
| Weber, E | 3 |
| Garcea, R | 1 |
| Frassetto, S | 1 |
| Cozzolino, P | 1 |
| Ruggiu, ME | 1 |
| Thornton, M | 1 |
2 reviews available for dehydroepiandrosterone and Experimental Hepatoma
| Article | Year |
|---|---|
The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention.
Topics: Aflatoxin B1; Animals; Benzopyrenes; Caprylates; Chemoprevention; Chlorophyllides; Dehydroepiandrost | 2012 |
Impact of dehydroepiandrosterone on hepatocarcinogenesis in the rat (Review).
Topics: Animals; Cell Lineage; Dehydroepiandrosterone; Energy Metabolism; Humans; Liver; Liver Neoplasms, Ex | 2004 |
21 other studies available for dehydroepiandrosterone and Experimental Hepatoma
| Article | Year |
|---|---|
[The effect of DHEA on AKT signal pathway on transplanted Morris hepatomas in rats].
Topics: Animals; Antineoplastic Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dehydroepian | 2009 |
Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase activity and gene expression by dehydroepiandrosterone in preneoplastic liver nodules.
Topics: 17-Ketosteroids; Animals; Body Weight; Cholesterol; Dehydroepiandrosterone; Gene Expression; Hydroxy | 1995 |
Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Dehydroepiandrosterone; Deoxyguanosine; Diethylhe | 1994 |
Expression of peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase enzyme and its mRNA in peroxisome proliferator-induced liver tumors.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Cell Division; Clofibric Acid; Dehydroepiandrosterone; En | 1994 |
Dehydroepiandrosterone is a complete hepatocarcinogen and potent tumor promoter in the absence of peroxisome proliferation in rainbow trout.
Topics: Aflatoxin B1; Animals; Carcinogens; Cocarcinogenesis; Dehydroepiandrosterone; Genes, ras; Liver Neop | 1995 |
Comparison of the enhancing effects of dehydroepiandrosterone with the structural analog 16 alpha-fluoro-5-androsten-17-one on aflatoxin B1 hepatocarcinogenesis in rainbow trout.
Topics: Aflatoxin B1; Androstenes; Animals; Anticarcinogenic Agents; Carcinogens; Dehydroepiandrosterone; Dr | 1996 |
Modulation of N-methyl-N'-nitro-nitrosoguanidine multiorgan carcinogenesis by dehydroepiandrosterone in rainbow trout.
Topics: Animals; Carcinogens; Dehydroepiandrosterone; Kidney Neoplasms; Liver Neoplasms, Experimental; Methy | 1996 |
Modulation of aflatoxin-B1 hepatocarcinogenesis in trout by dehydroepiandrosterone: initiation/post-initiation and latency effects.
Topics: Aflatoxin B1; Animals; Carcinogens; CDC2 Protein Kinase; Cell Cycle; Dehydroepiandrosterone; Diet; D | 1998 |
Sex differences in dehydroepiandrosterone-induced hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Female; Liver Neoplasms, Experimental; Male; Rats; Rat | 1998 |
Enhancement and phenotypic modulation of N-nitrosomorpholine-induced hepatocarcinogenesis by dehydroepiandrosterone.
Topics: Adenoma, Liver Cell; Animals; Carcinogens; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Drug S | 1997 |
Differential expression of key enzymes of energy metabolism in preneoplastic and neoplastic rat liver lesions induced by N-nitrosomorpholine and dehydroepiandrosterone.
Topics: Animals; Carcinogens; Dehydroepiandrosterone; Energy Metabolism; Female; Glucosephosphate Dehydrogen | 1998 |
Insulin receptor substrate-1 is over-expressed in glycogenotic but not in amphophilic preneoplastic hepatic foci induced in rats by N-nitrosomorpholine and dehydroepiandrosterone.
Topics: Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Female; Glycogen; I | 1999 |
Long-term dehydroepiandrosterone and 16alpha-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats.
Topics: Animals; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Diet; Diethylnitrosamine; DNA; DNA Repli | 2001 |
Hepatocarcinogenicity of dehydroepiandrosterone in the rat.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Dehydroepiand | 1992 |
Phenotypic properties of liver tumors induced by dehydroepiandrosterone in F-344 rats.
Topics: Animals; Blotting, Northern; Carcinogens; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Histocy | 1992 |
Differential effects of dehydroepiandrosterone and deoxyribonucleosides on DNA synthesis and de novo cholesterogenesis in hepatocarcinogenesis in rats.
Topics: Animals; Cholesterol; Cocarcinogenesis; Dehydroepiandrosterone; Deoxyribonucleosides; DNA, Neoplasm; | 1991 |
Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats.
Topics: Animals; Body Weight; Carcinogens; Dehydroepiandrosterone; gamma-Glutamyltransferase; Glucosephospha | 1986 |
Modulating influence of dehydroepiandrosterone administration on the morphology and enzyme phenotype of dimethylaminoazobenzene-induced hepatocellular foci and nodules.
Topics: Animals; Dehydroepiandrosterone; Histocytochemistry; Immunohistochemistry; Liver Neoplasms, Experime | 1988 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neo | 1987 |
Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone.
Topics: Adenoma; Adrenal Cortex Diseases; Animals; Dehydroepiandrosterone; Hemangiosarcoma; Liver Neoplasms; | 1988 |
Sex-dependent, tissue-specific opposing effects of dehydroepiandrosterone on initiation and modulation stages of liver and lung carcinogenesis induced by dihydroxy-di-n-propylnitrosamine in F344 rats.
Topics: Animals; Dehydroepiandrosterone; Female; Glucosephosphate Dehydrogenase; Glutathione Transferase; Li | 1988 |