dehydroepiandrosterone has been researched along with Diabetes Mellitus, Type 1 in 17 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus." | 7.80 | Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats. ( Fujita, S; Iemitsu, M; Sato, K, 2014) |
| "Acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus." | 3.80 | Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats. ( Fujita, S; Iemitsu, M; Sato, K, 2014) |
| "Dehydroepiandrosterone (DHEA) is believed to exert, besides others, positive effects on the insulin resistance or its secretion and glucose metabolism." | 3.78 | Dehydroepiandrosterone in the type 1 diabetes mellitus. ( Duskova, M; Hill, M; Hruskovicova, H; Starka, L, 2012) |
| "Our analyses suggest that chronic PTSD, particularly comorbid PTSD or complex PTSD, is associated with all of these conditions." | 1.32 | Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. ( Boscarino, JA, 2004) |
| " Thus, in patients with insulin-dependent diabetes, an approximately 30% increase in insulin dosage should be anticipated with the onset of puberty." | 1.27 | Puberty decreases insulin sensitivity. ( Bloch, CA; Clemons, P; Sperling, MA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, K | 1 |
| Fujita, S | 1 |
| Iemitsu, M | 1 |
| Kvasnickova, H | 1 |
| Hampl, R | 1 |
| Vondra, K | 1 |
| Kosiewicz, MM | 1 |
| Auci, DL | 1 |
| Fagone, P | 1 |
| Mangano, K | 1 |
| Caponnetto, S | 1 |
| Tucker, CF | 1 |
| Azeem, N | 1 |
| White, SK | 1 |
| Frincke, JM | 1 |
| Reading, CL | 1 |
| Nicoletti, F | 1 |
| Duskova, M | 1 |
| Hruskovicova, H | 1 |
| Hill, M | 1 |
| Starka, L | 1 |
| BRETAN, M | 1 |
| SZABO, Z | 1 |
| JAKAB, L | 1 |
| BALAZSI, I | 1 |
| Boscarino, JA | 1 |
| Cohen, HN | 1 |
| Paterson, KR | 1 |
| Wallace, AM | 1 |
| Beastall, GH | 2 |
| Manderson, WG | 1 |
| MacCuish, AC | 2 |
| Loviselli, A | 1 |
| Pisanu, P | 1 |
| Cossu, E | 1 |
| Caradonna, A | 1 |
| Massa, GM | 1 |
| Cirillo, R | 1 |
| Balestrieri, A | 1 |
| Radetti, G | 1 |
| Paganini, C | 1 |
| Gentili, L | 1 |
| Barbin, F | 1 |
| Pasquino, B | 1 |
| Zachmann, M | 1 |
| Ebeling, P | 1 |
| Stenman, UH | 1 |
| Seppälä, M | 1 |
| Koivisto, VA | 1 |
| Durant, S | 1 |
| Christeff, N | 1 |
| Coulaud, J | 1 |
| Nunez, EA | 1 |
| Dardenne, M | 1 |
| Homo-Delarche, F | 1 |
| Bech, P | 1 |
| Raabaek Olsen, L | 1 |
| Jarløv, N | 1 |
| Hammer, M | 1 |
| Schütze, T | 1 |
| Breum, L | 1 |
| Couch, RM | 1 |
| Vexiau, P | 1 |
| Fiet, J | 1 |
| Boudou, P | 1 |
| Villette, JM | 1 |
| Feutren, G | 1 |
| Hardy, N | 1 |
| Julien, R | 1 |
| Dreux, C | 1 |
| Bach, JF | 1 |
| Cathelineau, G | 1 |
| Haffner, SM | 1 |
| Klein, R | 1 |
| Dunn, JF | 1 |
| Moss, SE | 1 |
| Klein, BE | 1 |
| Small, M | 1 |
| Gray, CE | 1 |
| Bloch, CA | 1 |
| Clemons, P | 1 |
| Sperling, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diabetes and Cardiovascular Risk In Mexico City (San Antonio Heart Study)[NCT00005146] | 0 participants | Observational | 1979-05-31 | Completed | |||
| Exercise Snacks and Glutamine to Improve Glucose Control in Adolescents With Type 1 Diabetes[NCT03199638] | 14 participants (Actual) | Interventional | 2016-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Percent of BG between 70 and 180 mg/dL, as measured using Continuous Glucose Monitor (CGM) (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | Percentage of Blood Glucose (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 57.6 | 69.2 |
| an Exercise Group | 63.7 | 46.4 |
MAGE describes the average amplitude of glycemic variations measured using continuous glucose monitoring (CGM) (NCT03199638)
Timeframe: before vs. at 3 months
| Intervention | mg/dL (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 108 | 123 |
| an Exercise Group | 129 | 139 |
change in glycated hemoglobin (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | percentage of total hemoglobin (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 8.3 | 8.4 |
| an Exercise Group | 7.9 | 8.0 |
Change in insulin dose (Units/kg/day) used at home (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | Units/kg/day (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 0.98 | 1.0 |
| an Exercise Group | 1.0 | 0.8 |
Change in insulin sensitivity score, determined using SEARCH ISS model published equation: logeIS = 4.64725 - 0.02032 × (waist, cm) - 0.09779 × (HbA1c, %) - 0.00235 × (Triglycerides, mg/dL). The range of ISS scores is between 1-15. Higher scores imply a better insulin sensistivity. (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | score on a scale (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 2.10 | 2.16 |
| an Exercise Group | 2.17 | 2.20 |
Change in Percent of BG above 180 mg, as determined using Continuous Glucose Monitor (CGM) (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | Percentage of Blood Glucose (Mean) | |
|---|---|---|
| basline | at 3 months | |
| an Exercise + Glutamine Group | 39.4 | 26.6 |
| an Exercise Group | 29.1 | 46.4 |
Change in Percent of BG below 70 mg/dL, as determined by Continuous Glucose Monitor (CGM) (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | Percentage of Blood Glucose (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 3.1 | 4.4 |
| an Exercise Group | 7.2 | 7.2 |
3 trials available for dehydroepiandrosterone and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
[Low levels of dehydroepiandrosterone sulfate in adult males with insulin-dependent diabetes mellitus].
Topics: Adrenocorticotropic Hormone; Adult; Androstenedione; Cross-Sectional Studies; Dehydroepiandrosterone | 1994 |
Altered adrenal and thyroid function in children with insulin-dependent diabetes mellitus.
Topics: Adolescent; Adrenal Glands; Age Factors; Blood Glucose; Child; Child, Preschool; Cholesterol; Dehydr | 1994 |
Increase in plasma 5 alpha-androstane-3 alpha,17 beta-diol glucuronide as a marker of peripheral androgen action in hirsutism: a side-effect induced by cyclosporine A.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androstane-3,17-diol; Androstanols; Cyclosporins; Dehydroepia | 1990 |
14 other studies available for dehydroepiandrosterone and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats.
Topics: Animals; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2014 |
DHEA, DHEAS and prolactin correlate with glucose control parameters in women of fertile age with type-1 diabetes mellitus.
Topics: Adult; Biomarkers; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabetes Mellitus, Type 1 | 2015 |
HE3286, an orally bioavailable synthetic analogue of an active DHEA metabolite suppresses spontaneous autoimmune diabetes in the non-obese diabetic (NOD) mouse.
Topics: Administration, Oral; Animals; Biological Availability; CD4 Antigens; Dehydroepiandrosterone; Diabet | 2011 |
Dehydroepiandrosterone in the type 1 diabetes mellitus.
Topics: Adolescent; Adult; Age Factors; Aging; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone | 2012 |
[EFFECT OF TREATMENT WITH NOR-ANDROSTENOLONE AND DECANOATE ON DIABETIC RETINOPATHY].
Topics: Adolescent; Carbohydrate Metabolism; Decanoates; Dehydroepiandrosterone; Diabetes Mellitus, Type 1; | 1964 |
Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Dehydroepiandrosterone; Diabetes Mellitus, Type 1; Femal | 2004 |
Dissociation of adrenarche and gonadarche in diabetes mellitus.
Topics: Adolescent; Adrenal Glands; Age Determination by Skeleton; Dehydroepiandrosterone; Dehydroepiandrost | 1984 |
Androgens and insulin resistance in type 1 diabetic men.
Topics: Adult; Calorimetry, Indirect; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabetes Melli | 1995 |
Basal concentrations of various steroids in the nonobese diabetic (NOD) mouse and effect of immobilization stress.
Topics: Adrenalectomy; Androstenedione; Animals; Corticosterone; Dehydroepiandrosterone; Diabetes Mellitus, | 1998 |
A case of sequential anti-stress medication in a patient with major depression resistant to amine-reuptake inhibitors.
Topics: Amines; Antidepressive Agents; Anxiety Disorders; Dehydroepiandrosterone; Depressive Disorder, Major | 1999 |
Dissociation of cortisol and adrenal androgen secretion in poorly controlled insulin-dependent diabetes mellitus.
Topics: Adolescent; Adrenal Glands; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabe | 1992 |
Increased testosterone in type I diabetic subjects with severe retinopathy.
Topics: Adolescent; Adult; Body Constitution; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabet | 1990 |
Adrenal androgens in insulin-dependent diabetes mellitus.
Topics: Adrenal Cortex Hormones; Adult; Androstenedione; C-Peptide; Dehydroepiandrosterone; Dehydroepiandros | 1989 |
Puberty decreases insulin sensitivity.
Topics: Adolescent; Blood Glucose; Body Height; Body Weight; Child; Dehydroepiandrosterone; Diabetes Mellitu | 1987 |