dehydroepiandrosterone has been researched along with Depression, Endogenous in 35 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders." | 3.85 | Attenuated DHEA and DHEA-S response to acute psychosocial stress in individuals with depressive disorders. ( An, H; Chen, Y; Fu, M; Jiang, X; Xiao, Z; Zhang, Z; Zhong, W, 2017) |
| " Levels of the GABA(A)--antagonistic neurosteroids plasma dehydroepiandrosterone (DHEA) and its sulphate derivate, dehydroepiandrosterone sulphate (DHEAS) may be relevant to depressive and anxiety disorders, including PTSD." | 3.70 | Elevated circulatory level of GABA(A)--antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder. ( Gil-Ad, I; Kotler, M; Maayan, R; Mester, R; Shtaif, B; Spivak, B; Weizman, A, 2000) |
| "Dehydroepiandrosterone was lowered at 8:00 AM and 8:00 PM compared with control subjects." | 2.69 | Altered salivary dehydroepiandrosterone levels in major depression in adults. ( Herbert, J; Jenaway, A; Michael, A; Paykel, ES, 2000) |
| "Patients with temporomandibular disorders (TMD) commonly experience myofascial and joint pain, pain-related disability, and other pain conditions including depression." | 1.43 | Association of pain intensity, pain-related disability, and depression with hypothalamus-pituitary-adrenal axis function in female patients with chronic temporomandibular disorders. ( Ahn, RS; Jo, KB; Lee, IG; Lee, SC; Lee, YJ; Park, JY, 2016) |
| "The symptoms of Gulf War syndrome are compatible with the hypothesis that the immune system of affected individuals is biased towards a Th2-cytokine pattern." | 1.30 | Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile? ( Rook, GA; Zumla, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.86) | 18.7374 |
| 1990's | 12 (34.29) | 18.2507 |
| 2000's | 16 (45.71) | 29.6817 |
| 2010's | 6 (17.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, X | 1 |
| Zhong, W | 1 |
| An, H | 1 |
| Fu, M | 1 |
| Chen, Y | 1 |
| Zhang, Z | 1 |
| Xiao, Z | 1 |
| Walther, A | 1 |
| Tsao, C | 1 |
| Pande, R | 1 |
| Kirschbaum, C | 1 |
| Field, E | 1 |
| Berkman, L | 1 |
| Molina-Carballo, A | 1 |
| Justicia-Martínez, F | 1 |
| Moreno-Madrid, F | 1 |
| Cubero-Millán, I | 1 |
| Machado-Casas, I | 1 |
| Moreno-García, L | 1 |
| León, J | 1 |
| Luna-Del-Castillo, JD | 1 |
| Uberos, J | 1 |
| Muñoz-Hoyos, A | 1 |
| Ben Dor, R | 1 |
| Marx, CE | 1 |
| Shampine, LJ | 1 |
| Rubinow, DR | 2 |
| Schmidt, PJ | 2 |
| Jo, KB | 1 |
| Lee, YJ | 1 |
| Lee, IG | 1 |
| Lee, SC | 1 |
| Park, JY | 1 |
| Ahn, RS | 1 |
| Jeckel, CM | 1 |
| Lopes, RP | 1 |
| Berleze, MC | 1 |
| Luz, C | 1 |
| Feix, L | 1 |
| Argimon, II | 1 |
| Stein, LM | 1 |
| Bauer, ME | 1 |
| Strous, RD | 1 |
| Maayan, R | 6 |
| Lapidus, R | 1 |
| Stryjer, R | 1 |
| Lustig, M | 1 |
| Kotler, M | 2 |
| Weizman, A | 6 |
| Daly, RC | 1 |
| Bloch, M | 1 |
| Smith, MJ | 1 |
| Danaceau, MA | 1 |
| St Clair, LS | 1 |
| Murphy, JH | 1 |
| Haq, N | 1 |
| Avital, A | 1 |
| Ram, E | 2 |
| Richter-Levin, G | 1 |
| Malkesman, O | 2 |
| Braw, Y | 1 |
| Kinor, N | 2 |
| Yadid, G | 3 |
| Weller, A | 2 |
| Shayit, M | 1 |
| Genud, R | 1 |
| Zangen, A | 1 |
| Rocco, A | 1 |
| Martocchia, A | 1 |
| Frugoni, P | 1 |
| Baldini, R | 1 |
| Sani, G | 1 |
| Di Simone Di Giuseppe, B | 1 |
| Vairano, A | 1 |
| Girardi, P | 1 |
| Monaco, E | 1 |
| Tatarelli, R | 1 |
| Falaschi, P | 1 |
| Touati-Werner, D | 1 |
| Shamir, D | 1 |
| Friedman, A | 1 |
| Eisner, D | 1 |
| Herman, I | 1 |
| Hansen, CR | 1 |
| Kroll, J | 1 |
| Mackenzie, TB | 1 |
| Matsunaga, H | 1 |
| Sarai, M | 1 |
| Murphy, BE | 2 |
| Filipini, D | 1 |
| Ghadirian, AM | 2 |
| Osran, H | 1 |
| Reist, C | 1 |
| Chen, CC | 1 |
| Lifrak, ET | 1 |
| Chicz-DeMet, A | 1 |
| Parker, LN | 1 |
| Goodyer, IM | 5 |
| Herbert, J | 6 |
| Altham, PM | 4 |
| Pearson, J | 2 |
| Secher, SM | 2 |
| Shiers, HM | 2 |
| Wolkowitz, OM | 2 |
| Reus, VI | 2 |
| Roberts, E | 2 |
| Manfredi, F | 1 |
| Chan, T | 1 |
| Raum, WJ | 1 |
| Ormiston, S | 1 |
| Johnson, R | 1 |
| Canick, J | 1 |
| Brizendine, L | 2 |
| Weingartner, H | 1 |
| Rook, GA | 1 |
| Zumla, A | 1 |
| Romeo, E | 1 |
| Ströhle, A | 1 |
| Spalletta, G | 1 |
| di Michele, F | 1 |
| Hermann, B | 1 |
| Holsboer, F | 1 |
| Pasini, A | 1 |
| Rupprecht, R | 1 |
| Keebler, A | 1 |
| Nelson, N | 1 |
| Friedland, M | 1 |
| Coryell, W | 1 |
| Michael, A | 1 |
| Jenaway, A | 1 |
| Paykel, ES | 1 |
| Tamplin, A | 1 |
| Pies, R | 1 |
| Park, RJ | 1 |
| Netherton, CM | 1 |
| Fava, M | 1 |
| Cogan, E | 1 |
| Spivak, B | 1 |
| Mester, R | 1 |
| Gil-Ad, I | 1 |
| Shtaif, B | 1 |
| Young, AH | 1 |
| Gallagher, P | 1 |
| Porter, RJ | 1 |
| Dhar, V | 1 |
| Chouinard, G | 1 |
| Keller, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Relationship Between Central Sensitization and Alteration of Circulating Neurosteroid Following Bilateral Total Knee Arthroplasty[NCT03298711] | 69 participants (Actual) | Observational | 2017-11-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for dehydroepiandrosterone and Depression, Endogenous
| Article | Year |
|---|---|
Adverse neuropsychiatric reactions to herbal and over-the-counter "antidepressants".
Topics: Adverse Drug Reaction Reporting Systems; Antidepressive Agents; Dehydroepiandrosterone; Depressive D | 2000 |
Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology.
Topics: Brain; Child; Child Development; Dehydroepiandrosterone; Depressive Disorder; Humans; Hydrocortisone | 2001 |
Augmentation and combination strategies in treatment-resistant depression.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Central Nervous Syste | 2001 |
[DHEA: orthodox or alternative medicine?].
Topics: Adjuvants, Immunologic; Adrenal Insufficiency; Aged; Aging; Complementary Therapies; Dehydroepiandro | 2001 |
10 trials available for dehydroepiandrosterone and Depression, Endogenous
| Article | Year |
|---|---|
DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.
Topics: Androsterone; Antidepressive Agents; Cross-Over Studies; Dehydroepiandrosterone; Depressive Disorder | 2015 |
Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia.
Topics: Adult; Antipsychotic Agents; Anxiety Disorders; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfa | 2003 |
Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression.
Topics: Aged; Ambulatory Care; Cross-Over Studies; Dehydroepiandrosterone; Depressive Disorder; Depressive D | 2005 |
The effect of DHEA complementary treatment on heroin addicts participating in a rehabilitation program: a preliminary study.
Topics: Adjuvants, Immunologic; Analysis of Variance; Dehydroepiandrosterone; Depressive Disorder; Double-Bl | 2008 |
Possible use of glucocorticoid receptor antagonists in the treatment of major depression: preliminary results using RU 486.
Topics: Adrenocorticotropic Hormone; Adult; Dehydroepiandrosterone; Depressive Disorder; Female; Humans; Hyd | 1993 |
Dehydroepiandrosterone (DHEA) treatment of depression.
Topics: Aged; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Female; Humans; Hydrocorti | 1997 |
Effects of antidepressant treatment on neuroactive steroids in major depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Female; | 1998 |
Double-blind treatment of major depression with dehydroepiandrosterone.
Topics: Adult; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Double-Blind Method; Drug | 1999 |
Altered salivary dehydroepiandrosterone levels in major depression in adults.
Topics: Adult; Aging; Antidepressive Agents; Circadian Rhythm; Dehydroepiandrosterone; Depressive Disorder; | 2000 |
Response to steroid suppression in major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Dexame | 1991 |
21 other studies available for dehydroepiandrosterone and Depression, Endogenous
| Article | Year |
|---|---|
Attenuated DHEA and DHEA-S response to acute psychosocial stress in individuals with depressive disorders.
Topics: Adolescent; Adult; Case-Control Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dep | 2017 |
Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women.
Topics: Adult; Aged; Aged, 80 and over; Androgens; Anxiety; Anxiety Disorders; Cohort Studies; Dehydroepiand | 2019 |
Differential responses of two related neurosteroids to methylphenidate based on ADHD subtype and the presence of depressive symptomatology.
Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Biomarkers; Central Nervous Sy | 2014 |
Association of pain intensity, pain-related disability, and depression with hypothalamus-pituitary-adrenal axis function in female patients with chronic temporomandibular disorders.
Topics: Adult; Chronic Pain; Circadian Rhythm; Comorbidity; Dehydroepiandrosterone; Depression; Depressive D | 2016 |
Neuroendocrine and immunological correlates of chronic stress in 'strictly healthy' populations.
Topics: Aged; Alzheimer Disease; Anxiety Disorders; Caregivers; Cell Count; Cell Proliferation; Cohort Studi | 2010 |
Effects of early-life stress on behavior and neurosteroid levels in the rat hypothalamus and entorhinal cortex.
Topics: Affective Symptoms; Age Factors; Animals; Cognition Disorders; Dehydroepiandrosterone; Dehydroepiand | 2006 |
Dehydroepiandrosterone and monoamines in the limbic system of a genetic animal model of childhood depression.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Child; Data Interpretation, Statistical; Dehydroepian | 2008 |
Dehydroepiandrosterone in the nucleus accumbens is associated with early onset of depressive-behavior: a study in an animal model of childhood depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age of Onset; Animals; Biogenic Monoamines; Child; Dehydroepiandrost | 2007 |
Inverse correlation between morning plasma cortisol levels and MMPI psychasthenia and depression scale scores in victims of mobbing with adjustment disorders.
Topics: Adjustment Disorders; Adrenocorticotropic Hormone; Adult; Anxiety Disorders; Circadian Rhythm; Crime | 2007 |
Dehydroepiandrosterone and affective disorders.
Topics: Adolescent; Adult; Dehydroepiandrosterone; Depressive Disorder; Female; Humans | 1982 |
Elevated serum LH and androgens in affective disorder related to the menstrual cycle: with reference to polycystic ovary syndrome.
Topics: Adolescent; Adult; Androgens; Androstenedione; Bipolar Disorder; Dehydroepiandrosterone; Dehydroepia | 1993 |
Adrenal androgens and cortisol in major depression.
Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Dehydroepiandrosterone; Depressive Disorder; D | 1993 |
Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation.
Topics: Adolescent; Adrenal Glands; Child; Circadian Rhythm; Dehydroepiandrosterone; Depressive Disorder; Fe | 1996 |
Adrenal secretion and major depression in 8- to 16-year-olds, II. Influence of co-morbidity at presentation.
Topics: Adolescent; Adrenal Glands; Child; Child Behavior Disorders; Circadian Rhythm; Comorbidity; Dehydroe | 1996 |
Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile?
Topics: Affect; Animals; Cytokines; Dehydroepiandrosterone; Depressive Disorder; Fatigue Syndrome, Chronic; | 1997 |
Adrenal steroid secretion and major depression in 8- to 16-year-olds, III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression.
Topics: Adolescent; Analysis of Variance; Chi-Square Distribution; Child; Circadian Rhythm; Confidence Inter | 1998 |
DHEA for depression.
Topics: Dehydroepiandrosterone; Depressive Disorder; Humans | 1999 |
Augmentation strategies for inadequate antidepressant response: a review of placebo-controlled studies.
Topics: Adjuvants, Immunologic; Dehydroepiandrosterone; Depressive Disorder; Drug Therapy, Combination; Huma | 2000 |
Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents.
Topics: Adolescent; Child; Dehydroepiandrosterone; Depressive Disorder; Female; Humans; Hydrocortisone; Life | 2000 |
Elevated circulatory level of GABA(A)--antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder.
Topics: Adult; Anxiety Disorders; Circadian Rhythm; Combat Disorders; Dehydroepiandrosterone; Dehydroepiandr | 2000 |
Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients.
Topics: Adolescent; Adult; Biomarkers; Circadian Rhythm; Cognition Disorders; Dehydroepiandrosterone; Depres | 2002 |