Page last updated: 2024-11-07

dehydroepiandrosterone and Critical Illness

dehydroepiandrosterone has been researched along with Critical Illness in 9 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Critical Illness: A disease or state in which death is possible or imminent.

Research Excerpts

ExcerptRelevanceReference
"As part of a study on the effect of dopamine therapy on pituitary dependent hormone secretion in critical illness, we documented the impact of this inotropic and vasoactive catecholamine on the serum concentrations of dehydroepiandrosterone sulphate (DHEAS)."9.08Dehydroepiandrosterone sulphate in critical illness: effect of dopamine. ( de Zegher, F; Ferdinande, P; Lauwers, P; Schetz, M; Van den Berghe, G; Verwaest, C; Wouters, P, 1995)
"As part of a study on the effect of dopamine therapy on pituitary dependent hormone secretion in critical illness, we documented the impact of this inotropic and vasoactive catecholamine on the serum concentrations of dehydroepiandrosterone sulphate (DHEAS)."5.08Dehydroepiandrosterone sulphate in critical illness: effect of dopamine. ( de Zegher, F; Ferdinande, P; Lauwers, P; Schetz, M; Van den Berghe, G; Verwaest, C; Wouters, P, 1995)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's4 (44.44)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Oberbeck, R2
Kobbe, P2
Schmitz, D1
Wegner, A1
Hammes, F1
Sharshar, T1
Bastuji-Garin, S1
Polito, A1
De Jonghe, B1
Stevens, RD1
Maxime, V1
Rodriguez, P1
Cerf, C1
Outin, H1
Touraine, P1
Laborde, K1
Dhatariya, KK1
Chen, CC1
Parker, CR1
Arafah, BM1
Conrad, C1
Niess, H1
Jauch, KW1
Bruns, CJ1
Hartl, W1
Welker, L1
Van den Berghe, G1
de Zegher, F1
Wouters, P1
Schetz, M1
Verwaest, C1
Ferdinande, P1
Lauwers, P1
Marcos Sánchez, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Music as a Potential Intervention to Improve Hemodynamic Tolerability of Repetitive Sub-Anesthetic IV Ketamine Infusions in Bipolar and Unipolar Depression: A Pilot Study[NCT04701866]32 participants (Actual)Interventional2021-01-11Completed
A Randomized Controlled Trial of Music vs. No Music During Cesarean Delivery on Patient Satisfaction[NCT03412019]22 participants (Actual)Interventional2018-02-21Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Hemodynamic Parameter (Mean Arterial Pressure, MAP)

This is the post-procedure mean arterial pressure of the patients. (NCT03412019)
Timeframe: post procedure

InterventionmmHg (Mean)
Control Group82.2
Intervention Group80.4

Patient Anxiety

Change in anxiety before and after surgery using a numeric rating scale from 0 (no anxiety at all) to 10 (greatest anxiety) (NCT03412019)
Timeframe: Perioperatively

InterventionNRS scale (0-10) (Mean)
Control Group2.5
Intervention Group2.7

Patient Satisfaction

"This outcome will be measured using Morgan's Maternal Satisfaction Scale for Cesarean Section (MSSCS).~It is a 22-item questionnaire, each item have a Likert scale from 1-7 (1 =strongly disagree, 7=strongly agree), yielding a composite (total) score ranging 22-154, representing lowest to highest satisfaction. The questionnaire will be given to participants on post-operative day one during the hours of 8am-1pm." (NCT03412019)
Timeframe: 1 Day

Interventionunits on a scale (Mean)
Control Group120
Intervention Group116

Reviews

4 reviews available for dehydroepiandrosterone and Critical Illness

ArticleYear
Dehydroepiandrosterone (DHEA): a steroid with multiple effects. Is there any possible option in the treatment of critical illness?
    Current medicinal chemistry, 2010, Volume: 17, Issue:11

    Topics: Animals; Central Nervous System; Critical Illness; Dehydroepiandrosterone; Humans; Mice; Sepsis; Sho

2010
Is there a role for dehydroepiandrosterone replacement in the intensive care population?
    Intensive care medicine, 2003, Volume: 29, Issue:11

    Topics: Adjuvants, Immunologic; Adrenal Insufficiency; Age Factors; Critical Care; Critical Illness; Dehydro

2003
Adrenal androgens and the immune system.
    Seminars in reproductive medicine, 2004, Volume: 22, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adrenal Glands; Androgens; Animals; Arthritis, Rheumatoid; Criti

2004
Hypothalamic pituitary adrenal function during critical illness: limitations of current assessment methods.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:10

    Topics: Adrenal Glands; Adrenal Insufficiency; Critical Illness; Dehydroepiandrosterone; Dehydroepiandroster

2006

Trials

2 trials available for dehydroepiandrosterone and Critical Illness

ArticleYear
Overture for growth hormone: requiem for interleukin-6?
    Critical care medicine, 2007, Volume: 35, Issue:12

    Topics: Aged; Blood Pressure; Critical Illness; Dehydroepiandrosterone; Epinephrine; Female; Human Growth Ho

2007
Overture for growth hormone: requiem for interleukin-6?
    Critical care medicine, 2007, Volume: 35, Issue:12

    Topics: Aged; Blood Pressure; Critical Illness; Dehydroepiandrosterone; Epinephrine; Female; Human Growth Ho

2007
Overture for growth hormone: requiem for interleukin-6?
    Critical care medicine, 2007, Volume: 35, Issue:12

    Topics: Aged; Blood Pressure; Critical Illness; Dehydroepiandrosterone; Epinephrine; Female; Human Growth Ho

2007
Overture for growth hormone: requiem for interleukin-6?
    Critical care medicine, 2007, Volume: 35, Issue:12

    Topics: Aged; Blood Pressure; Critical Illness; Dehydroepiandrosterone; Epinephrine; Female; Human Growth Ho

2007
Dehydroepiandrosterone sulphate in critical illness: effect of dopamine.
    Clinical endocrinology, 1995, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Critical Illness; Dehydroepiandrosterone; Dehydroepiandr

1995

Other Studies

3 other studies available for dehydroepiandrosterone and Critical Illness

ArticleYear
Dehydroepiandrosterone during sepsis: does the timing of administration influence the effectiveness.
    The Journal of surgical research, 2010, Volume: 163, Issue:2

    Topics: Animals; Critical Illness; Dehydroepiandrosterone; Interleukin-1beta; Interleukin-6; Lymphocyte Acti

2010
Hormonal status in protracted critical illness and in-hospital mortality.
    Critical care (London, England), 2011, Volume: 15, Issue:1

    Topics: Aged; Biomarkers; Critical Illness; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female;

2011
[Dehydroepiandrosterone sulfate and testosterone in acute myocardial infarction].
    Revista clinica espanola, 1993, Volume: 192, Issue:1

    Topics: Critical Illness; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Myocardial Infarct

1993