dehydroepiandrosterone has been researched along with Cell Transformation, Neoplastic in 8 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The possibility of an increased risk of prostate cancer for healthy men has also been suggested on theoretical basis but recent experimental data showed that androgens may act in prevention of prostate cancer." | 2.42 | Prevention of prostate cancer by androgens: experimental paradox or clinical reality. ( Algarté-Génin, M; Costa, P; Cussenot, O, 2004) |
| "Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats." | 1.34 | Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone. ( Bosland, MC; Johnson, WD; Kozub, NM; Lubet, RA; McCormick, DL; Rao, KV; Steele, VE, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, KN | 1 |
| Halfyard, SJ | 1 |
| Yaskowiak, ES | 1 |
| Shultz, KL | 1 |
| Beamer, WG | 1 |
| Dorward, AM | 1 |
| Algarté-Génin, M | 1 |
| Cussenot, O | 1 |
| Costa, P | 1 |
| Shilkaitis, A | 1 |
| Green, A | 1 |
| Punj, V | 1 |
| Steele, V | 1 |
| Lubet, R | 1 |
| Christov, K | 1 |
| McCormick, DL | 1 |
| Johnson, WD | 1 |
| Kozub, NM | 1 |
| Rao, KV | 1 |
| Lubet, RA | 1 |
| Steele, VE | 1 |
| Bosland, MC | 1 |
| Luo, S | 1 |
| Sourla, A | 1 |
| Labrie, C | 1 |
| Bélanger, A | 1 |
| Labrie, F | 1 |
| Schwartz, AG | 1 |
| Perantoni, A | 1 |
| van Weerden, WM | 1 |
| van Steenbrugge, GJ | 1 |
| van Kreuningen, A | 1 |
| Moerings, EP | 1 |
| De Jong, FH | 1 |
| Schröder, FH | 1 |
| Regelson, W | 1 |
| Loria, R | 1 |
| Kalimi, M | 1 |
2 reviews available for dehydroepiandrosterone and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Prevention of prostate cancer by androgens: experimental paradox or clinical reality.
Topics: Adult; Aged; Aged, 80 and over; Androgens; Animals; Apoptosis; Cell Differentiation; Cell Proliferat | 2004 |
Hormonal intervention: "buffer hormones" or "state dependency". The role of dehydroepiandrosterone (DHEA), thyroid hormone, estrogen and hypophysectomy in aging.
Topics: Aging; Animals; Cell Transformation, Neoplastic; Dehydroepiandrosterone; Diabetes Mellitus; Estrogen | 1988 |
6 other studies available for dehydroepiandrosterone and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Fine map of the Gct1 spontaneous ovarian granulosa cell tumor locus.
Topics: Alleles; Androgens; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Transform | 2013 |
Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism.
Topics: Adjuvants, Immunologic; Alkylating Agents; Animals; Breast Neoplasms; Carcinoma in Situ; Cell Transf | 2005 |
Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone.
Topics: Animals; Cell Transformation, Neoplastic; Chemoprevention; Dehydroepiandrosterone; Male; Prostatic N | 2007 |
Combined effects of dehydroepiandrosterone and EM-800 on bone mass, serum lipids, and the development of dimethylbenz(A)anthracene-induced mammary carcinoma in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaline Phosphatase; Animals; Benzopyrans; Bone Density; Calcium; | 1997 |
Protective effect of dehydroepiandrosterone against aflatoxin B1-and 7,12-dimethylbenz(a)anthracene-induced cytotoxicity and transformation in cultured cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Benz(a)Anthracenes; Cell Division; Cell Trans | 1975 |
Effects of low testosterone levels and of adrenal androgens on growth of prostate tumor models in nude mice.
Topics: Animals; Cell Transformation, Neoplastic; Dehydroepiandrosterone; Dihydrotestosterone; Female; Male; | 1990 |