dehydroepiandrosterone has been researched along with Cancer of the Uterus in 40 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, cultured human choriocarcinoma JEG-3 cells were used as an experimental model in order to examine the effect of dehydroepiandrosterone sulfate on both de novo and low-density lipoprotein-stimulated progesterone secretion." | 7.67 | The effect of dehydroepiandrosterone sulfate on de novo and low-density lipoprotein-stimulated progesterone secretion by human choriocarcinoma JEG-3 cells. ( Benveniste, R; Ilekis, J; Moise, J; Scommegna, A, 1986) |
| "The purposes of this study were to investigate the effect of a superactive agonistic analog of gonadotropin-releasing hormone, nafarelin, on uterine leiomyomas and to assess the use of magnetic resonance imaging in monitoring uterine and myoma size." | 7.67 | Use of an agonistic analog of gonadotropin-releasing hormone (nafarelin) to treat leiomyomas: assessment by magnetic resonance imaging. ( Andreyko, JL; Blumenfeld, Z; Hricak, H; Jaffe, RB; Marshall, LA; Monroe, SE, 1988) |
| "The first-generation selective estrogen receptor modulator (SERM) tamoxifen has been the mainstream hormone therapy in breast cancer." | 4.84 | Drug insight: breast cancer prevention and tissue-targeted hormone replacement therapy. ( Labrie, F, 2007) |
| " In the present study, cultured human choriocarcinoma JEG-3 cells were used as an experimental model in order to examine the effect of dehydroepiandrosterone sulfate on both de novo and low-density lipoprotein-stimulated progesterone secretion." | 3.67 | The effect of dehydroepiandrosterone sulfate on de novo and low-density lipoprotein-stimulated progesterone secretion by human choriocarcinoma JEG-3 cells. ( Benveniste, R; Ilekis, J; Moise, J; Scommegna, A, 1986) |
| "The purposes of this study were to investigate the effect of a superactive agonistic analog of gonadotropin-releasing hormone, nafarelin, on uterine leiomyomas and to assess the use of magnetic resonance imaging in monitoring uterine and myoma size." | 3.67 | Use of an agonistic analog of gonadotropin-releasing hormone (nafarelin) to treat leiomyomas: assessment by magnetic resonance imaging. ( Andreyko, JL; Blumenfeld, Z; Hricak, H; Jaffe, RB; Marshall, LA; Monroe, SE, 1988) |
| "Clinical and metabolic effects of depot-injections of estradiol valerianate-dehydroepiandrosterone enanthate at a 1:50 ratio (Gynodian-depot) in the treatment of severe clinical manifestations of the vegetoneurotic syndrome were evaluated in menopuasal patients after hysterectomy for uterine myoma." | 3.66 | Clinical and metabolic effects of Gynodian-depot in vegetoneurotic disorders following removal of uterine myoma in menopausal patients. ( Talina, IS; Uvarova, EV; Vikhliaeva, EM, 1983) |
| "The presence of uterine leiomyomas correlates with an increase in urinary concentrations of estrogens and androgens, and it appears to be caused by a decrease in patients' metabolism of steroids." | 1.32 | Endogenous urinary steroids in premenopausal women with uterine leiomyomas. ( Bai, SW; Chung, BC; Jung, BH, 2004) |
| "Estrone sulfate was more efficient as a substrate than dehydroepiandrosterone sulfate, since the amount of product formed from estrone sulfate was approximately 3-fold greater than that formed from dehydroepiandrosterone sulfate." | 1.27 | In situ steroid sulfatase activity in human epithelial carcinoma cells of vaginal, ovarian, and endometrial origin. ( Milewich, L; Porter, JC, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (85.00) | 18.7374 |
| 1990's | 3 (7.50) | 18.2507 |
| 2000's | 3 (7.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Samson, M | 1 |
| Labrie, F | 2 |
| Luu-The, V | 1 |
| JANATA, J | 1 |
| STARKA, L | 1 |
| PIPINO, G | 1 |
| WARREN, JC | 1 |
| FRENCH, AP | 1 |
| Jung, BH | 1 |
| Bai, SW | 1 |
| Chung, BC | 1 |
| Bremond, AG | 1 |
| Claustrat, B | 1 |
| Rudigoz, RC | 1 |
| Seffert, P | 1 |
| Corniau, J | 1 |
| Goh, HH | 2 |
| Ratnam, SS | 2 |
| Vikhliaeva, EM | 1 |
| Uvarova, EV | 1 |
| Talina, IS | 1 |
| Morikawa, S | 1 |
| Naito, M | 1 |
| Takamizawa, H | 1 |
| Brody, S | 2 |
| Carlström, K | 3 |
| Lagrelius, A | 2 |
| Lunell, NO | 3 |
| Rosenborg, L | 2 |
| Siiteri, PK | 1 |
| Fujita, Y | 1 |
| Mori, T | 1 |
| Suzuki, A | 1 |
| Nihnobu, K | 1 |
| Nishimura, T | 1 |
| Frigo, P | 1 |
| Eppel, W | 1 |
| Asseryanis, E | 1 |
| Sator, M | 1 |
| Golaszewski, T | 1 |
| Gruber, D | 1 |
| Lang, C | 1 |
| Huber, J | 1 |
| Murphy, AA | 1 |
| Kettel, LM | 1 |
| Morales, AJ | 1 |
| Roberts, VJ | 1 |
| Yen, SS | 1 |
| Chew, PC | 1 |
| Damber, MG | 1 |
| Furuhjelm, M | 1 |
| Joelsson, I | 1 |
| von Schoultz, B | 1 |
| Schut, HA | 1 |
| Townsley, JD | 1 |
| Schmitt-Robe, B | 1 |
| Eicher, W | 1 |
| Mück, AO | 1 |
| Klinga, K | 1 |
| Onsrud, M | 1 |
| Paus, E | 1 |
| Haug, E | 1 |
| Kjørstad, K | 1 |
| Holinka, CF | 1 |
| Hata, H | 1 |
| Kuramoto, H | 1 |
| Gurpide, E | 1 |
| Moise, J | 1 |
| Ilekis, J | 1 |
| Scommegna, A | 1 |
| Benveniste, R | 1 |
| Gimes, G | 1 |
| Szarvas, Z | 1 |
| Siklósi, G | 1 |
| Jones, DL | 2 |
| James, VH | 2 |
| Milewich, L | 1 |
| Porter, JC | 1 |
| Katsube, Y | 1 |
| Iwaoki, Y | 1 |
| Silverberg, SG | 1 |
| Fujiwara, A | 1 |
| Andreyko, JL | 1 |
| Blumenfeld, Z | 1 |
| Marshall, LA | 1 |
| Monroe, SE | 1 |
| Hricak, H | 1 |
| Jaffe, RB | 1 |
| Bonney, RC | 1 |
| Scanlon, MJ | 1 |
| Reed, MJ | 1 |
| Anderson, MC | 1 |
| Chihal, HJ | 1 |
| Baudier, MM | 1 |
| Plotz, EJ | 1 |
| Wiener, M | 1 |
| Stein, AA | 1 |
| Hahn, BD | 1 |
| Garnham, JR | 1 |
| Bulbrook, RD | 1 |
| Wang, DY | 1 |
| Mahesh, VG | 1 |
| McDonough, PG | 1 |
| Sciarra, F | 1 |
| Piro, C | 1 |
| Concolino, G | 1 |
| Conti, C | 1 |
| Kaiser, R | 1 |
| Lauritzen, C | 1 |
| Miasnikov, LA | 1 |
| Vinogradova, DA | 1 |
| Lemon, HM | 1 |
| Miller, DM | 1 |
| Marsiletti, GC | 1 |
| Lago, E | 1 |
| Grattarola, R | 1 |
| Bogdanova, AG | 1 |
| Mezinova, NN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DHEA + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women (Placebo Controlled, Double Blind and Randomized Phase III Study to Evaluate the Effects of 12-Week Treatment With DHEA (Prasterone) and Acolbifene on Vasomotor Symptoms (H[NCT01452373] | Phase 3 | 238 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| The Effect of Vaginal Mifepristone on Reduction of Uterine Fibroids Size and the Symptoms Associated With the Fibroids - Pilot Study (Phase IIa)[NCT00881140] | Phase 2 | 30 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825] | Phase 2 | 61 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy
| Intervention | ng/ML/day (Mean) | |
|---|---|---|
| AUC -1 | AUC - 2 | |
| Part 1 | 115 | 136 |
3 reviews available for dehydroepiandrosterone and Cancer of the Uterus
| Article | Year |
|---|---|
Drug insight: breast cancer prevention and tissue-targeted hormone replacement therapy.
Topics: Aromatase Inhibitors; Breast Neoplasms; Dehydroepiandrosterone; Estrogen Antagonists; Female; Hormon | 2007 |
Extraglandular oestrogen formation and serum binding of oestradiol: relationship to cancer.
Topics: Adipose Tissue; Androstenedione; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estrogens; Fem | 1981 |
Competition between steroids for hormonal receptor.
Topics: Animals; Antineoplastic Agents; Body Fluids; Breast Neoplasms; Castration; Dehydroepiandrosterone; E | 1971 |
1 trial available for dehydroepiandrosterone and Cancer of the Uterus
| Article | Year |
|---|---|
The effects of hormone substitution in depot form on the uterus in a group of 50 perimenopausal women--a vaginosonographic study.
Topics: Dehydroepiandrosterone; Delayed-Action Preparations; Drug Combinations; Endometrium; Estradiol; Estr | 1995 |
36 other studies available for dehydroepiandrosterone and Cancer of the Uterus
| Article | Year |
|---|---|
Specific estradiol biosynthetic pathway in choriocarcinoma (JEG-3) cell line.
Topics: 3-Hydroxysteroid Dehydrogenases; Aromatase; Carbon Radioisotopes; Cell Line, Tumor; Choriocarcinoma; | 2009 |
EFFECT OF CORTISOL ON THE PRODUCTION OF OVARIAN ANDROGENS.
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Amenorrhea; Androgens; Biomedical Research; Dehydroepi | 1964 |
[CLINICAL EVALUATION OF THE PROTEO-ANABOLIC ACTIVITY OF L-METHYL-DELTA ANDROSTENOLONE IN PATIENTS WITH MALIGNANT NEOPLASMS DURING ACTINOTHERAPY].
Topics: Anabolic Agents; Blood Protein Electrophoresis; Breast Neoplasms; Carcinoma, Bronchogenic; Cobalt Is | 1964 |
DISTRIBUTION OF STEROID SULFATASE IN HUMAN TISSUES.
Topics: Abnormalities, Severe Teratoid; Adipose Tissue; Anencephaly; Animals; Carbon Isotopes; Cattle; Corpu | 1965 |
Endogenous urinary steroids in premenopausal women with uterine leiomyomas.
Topics: Adult; Androgens; Androstenols; Androsterone; Case-Control Studies; Corticosterone; Cortodoxone; Deh | 2004 |
Estradiol, androstenedione, testosterone, and dehydroepiandrosterone sulfate in the ovarian and peripheral blood of postmenopausal patients with and without endometrial cancer.
Topics: Aged; Androstenedione; Dehydroepiandrosterone; Estradiol; Female; Gonadal Steroid Hormones; Humans; | 1982 |
Steroidogenesis in hydatidiform mole--sources of androgens.
Topics: Dehydroepiandrosterone; Female; Humans; Hydatidiform Mole; In Vitro Techniques; Pregnancy; Testoster | 1982 |
Clinical and metabolic effects of Gynodian-depot in vegetoneurotic disorders following removal of uterine myoma in menopausal patients.
Topics: Climacteric; Dehydroepiandrosterone; Drug Combinations; Estradiol; Female; Gonadotropins, Pituitary; | 1983 |
[Analysis of the high risk factors of endometrial adenocarcinoma--abnormal excretion in urinary steroids in androgen sterilized rats].
Topics: Adenocarcinoma; Androstanes; Androsterone; Animals; Dehydroepiandrosterone; Etiocholanolone; Female; | 1984 |
Adrenal steroids, bone mineral content and endometrial pathology in postmenopausal women.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Bone and Bones; Dehydroepiandrosterone; Dehydr | 1981 |
Adrenocortical steroids, bone mineral content and endometrial condition in post-menopausal women.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Bone and Bones; Dehydroepiandrosterone; Estron | 1982 |
Functional and structural relationships in steroidogenesis in vitro by human corpora lutea during development and regression.
Topics: Acetates; Adult; Androgens; Corpus Luteum; Dehydroepiandrosterone; Estrogens; Female; Hormones; Huma | 1981 |
Regression of uterine leiomyomata in response to the antiprogesterone RU 486.
Topics: Adolescent; Adult; Androstenedione; Bone Density; Dehydroepiandrosterone; Dehydroepiandrosterone Sul | 1993 |
Testosterone production with hydatidiform moles--in vitro and in vivo studies.
Topics: Androstenedione; Dehydroepiandrosterone; Estradiol; Female; Humans; Hydatidiform Mole; In Vitro Tech | 1979 |
Serum levels of total dehydroepiandrosterone and total estrone in postmenopausal women with special regard to carcinoma of the uterine corpus.
Topics: Aged; Dehydroepiandrosterone; Estrone; Female; Humans; Menopause; Middle Aged; Uterine Neoplasms | 1979 |
Oestrogen formation from C19 precursors in human choriocarcinoma in culture.
Topics: Algestone; Androgens; Androstenedione; Bucladesine; Cell Line; Cholesterol; Choriocarcinoma; Clone C | 1977 |
[Subjective complaints and hormonal reactions in the first 6 weeks after hysterectomy].
Topics: Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Follicle Stimulati | 1992 |
Intramuscular administration of hydroxyprogesterone caproate in patients with endometrial carcinoma. Pharmacokinetics and effects on adrenal function.
Topics: 17 alpha-Hydroxyprogesterone Caproate; Adrenal Glands; Androstenedione; Dehydroepiandrosterone; Estr | 1985 |
Effects of steroid hormones and antisteroids on alkaline phosphatase activity in human endometrial cancer cells (Ishikawa line).
Topics: Alkaline Phosphatase; Androgen Antagonists; Cell Line; Dehydroepiandrosterone; Dibutyryl Cyclic GMP; | 1986 |
The effect of dehydroepiandrosterone sulfate on de novo and low-density lipoprotein-stimulated progesterone secretion by human choriocarcinoma JEG-3 cells.
Topics: Cell Line; Cells, Cultured; Choriocarcinoma; Culture Media; Dehydroepiandrosterone; Dehydroepiandros | 1986 |
Endocrine factors in the etiology of endometrial carcinoma.
Topics: Aged; Androstenedione; Dehydroepiandrosterone; Estradiol; Estrone; Female; Follicle Stimulating Horm | 1986 |
Determination of dehydroepiandrosterone and dehydroepiandrosterone sulphate in blood and tissue. Studies of normal women and women with breast or endometrial cancer.
Topics: Adult; Age Factors; Aged; Body Weight; Breast Neoplasms; Circadian Rhythm; Cross Reactions; Dehydroe | 1987 |
In situ steroid sulfatase activity in human epithelial carcinoma cells of vaginal, ovarian, and endometrial origin.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Line; Cystadenocarcinoma; Dehydroepiandrosterone; Deh | 1987 |
Sclerosing stromal tumor of the ovary associated with endometrial adenocarcinoma: a case report.
Topics: Adenocarcinoma; Adult; Dehydroepiandrosterone; Estradiol; Female; Gonadotropins, Pituitary; Humans; | 1988 |
Use of an agonistic analog of gonadotropin-releasing hormone (nafarelin) to treat leiomyomas: assessment by magnetic resonance imaging.
Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Drug Evaluation; Est | 1988 |
The relationship between oestradiol metabolism and adrenal steroids in the endometrium of postmenopausal women with and without endometrial cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenal Cortex; Androstenediol; Dehydroepiandrosterone; Endometriu | 1986 |
Polycystic ovary syndrome.
Topics: Androgens; Clomiphene; Contraceptives, Oral; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; | 1985 |
Enzymatic activities related to steroidogenesis in postmenopausal ovaries of patients with and without endometrial carcinoma.
Topics: Adenocarcinoma; Aged; Androgens; Carbon Isotopes; Cholesterol; Dehydroepiandrosterone; Endometrium; | 1967 |
Conjugated and unconjugated dehydroepiandrosterone, aetiocholanolone and androsterone in the peripheral plasma of patients with cancer of the breast, ovary, uterus or prostate.
Topics: Adult; Androsterone; Breast Neoplasms; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Male | 1969 |
Urinary steroid excretion in a hirsute patient with ovarian cortical stromal hyperplasia and endometrial carcinoma.
Topics: Adrenal Cortex Hormones; Adult; Androgens; Androsterone; Dehydroepiandrosterone; Dexamethasone; Estr | 1969 |
[Metabolism of dehydroepiandrosterone at the cutaneous level: in vitro experiments].
Topics: Adult; Carbon Isotopes; Culture Techniques; Dehydroepiandrosterone; Female; Fibroma; Humans; Menopau | 1968 |
Hormone assay in a pregnant woman with carcinoma colli under x-ray treatment.
Topics: Adult; Carcinoma; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Femal | 1970 |
[Estrogens and androgens in dyshormonal cardiopathy and coronary atherosclerosis in women].
Topics: 17-Ketosteroids; Adult; Androgens; Androsterone; Arteriosclerosis; Chromatography, Thin Layer; Coron | 1971 |
[Problems of therapy of uterine myofibroma with special reference to the hormonal and opotherapeutic opotherapeutic treatment].
Topics: Age Factors; Breast; Dehydroepiandrosterone; Female; Humans; Leiomyoma; Tissue Extracts; Uterine Neo | 1971 |
Misdiagnosis of endometrial adenoacanthoma in a 27-year old woman with adrenocortical tumor.
Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Androsterone; Dehydr | 1973 |
[Excretion of adrenal cortex hormones in precancerous processes and uterine cancer].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Androsterone; Chromatography, Thin Layer; C | 1973 |