dehydroepiandrosterone has been researched along with Cancer of Liver in 30 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A group of 122 postmenopausal patients with histologically proven node-positive primary breast cancer have been randomized to receive aminoglutethimide-hydrocortisone or placebo aminoglutethimide-placebo hydrocortisone for 2 years." | 9.05 | Adjuvant aminoglutethimide therapy for postmenopausal patients with primary breast cancer: progress report. ( Bettelheim, R; Chilvers, C; Coombes, RC; Dowsett, M; Ford, HT; Gazet, JC; Gordon, C; Powles, TJ; Smith, IE; Zava, D, 1982) |
| "25% dehydroepiandrosterone (DHEA) during and subsequent to 7 weeks treatment with N-nitrosomorpholine (NNM) resulted in significantly reduced development of adrenal cortical lesions and hemangiosarcomas in the liver." | 7.67 | Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone. ( Bannasch, P; Moore, MA; Weber, E, 1988) |
| "A group of 122 postmenopausal patients with histologically proven node-positive primary breast cancer have been randomized to receive aminoglutethimide-hydrocortisone or placebo aminoglutethimide-placebo hydrocortisone for 2 years." | 5.05 | Adjuvant aminoglutethimide therapy for postmenopausal patients with primary breast cancer: progress report. ( Bettelheim, R; Chilvers, C; Coombes, RC; Dowsett, M; Ford, HT; Gazet, JC; Gordon, C; Powles, TJ; Smith, IE; Zava, D, 1982) |
| "Cortisol production by hepatocellular carcinoma (HCC) has not been previously reported and dehydroepiandrosterone (DHEA) secretion by HCC is rare." | 3.81 | Possible ACTH-independent, cortisol-secreting and DHEA-secreting metastatic hepatocellular carcinoma causing Cushing's syndrome. ( Bahtiyar, G; Inoue, T; Sacerdote, A; Thomas, N, 2015) |
| "25% dehydroepiandrosterone (DHEA) during and subsequent to 7 weeks treatment with N-nitrosomorpholine (NNM) resulted in significantly reduced development of adrenal cortical lesions and hemangiosarcomas in the liver." | 3.67 | Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone. ( Bannasch, P; Moore, MA; Weber, E, 1988) |
| "Perfluorooctanoic acid (PFOA) is a potent hepatocarcinogen and peroxisome proliferator (PP) in rodents." | 1.35 | Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout. ( Benninghoff, AD; Carpenter, HM; Hendricks, JD; Orner, GA; Pereira, CB; Tilton, SC; Williams, DE, 2008) |
| "A transformed human hepatoma cell line was examined to determine if it was an appropriate model system for studying the mechanism of action of two peroxisome proliferators that lower blood lipids." | 1.29 | Inverse relationship between peroxisomal and mitochondrial beta-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid. ( Chance, DS; McIntosh, MK; Wu, SM, 1995) |
| "Primary liver cancer occasionally presents with feminization." | 1.26 | Mechanism of feminization in primary liver cancer. ( Abrahams, GE; Katz, M; Kew, MC; Kirschner, MA, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (33.33) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Mclean, MA | 1 |
| Scoten, OC | 1 |
| Yu, W | 1 |
| Ye, XY | 1 |
| Petrie, J | 1 |
| Church, PT | 1 |
| Soraisham, AS | 1 |
| Mirea, LS | 1 |
| Weinberg, J | 1 |
| Synnes, AR | 1 |
| O'Brien, K | 1 |
| Grunau, RE | 1 |
| Teng, Y | 1 |
| Radde, BN | 1 |
| Litchfield, LM | 1 |
| Ivanova, MM | 1 |
| Prough, RA | 2 |
| Clark, BJ | 1 |
| Doll, MA | 1 |
| Hein, DW | 1 |
| Klinge, CM | 1 |
| Sacerdote, A | 1 |
| Inoue, T | 1 |
| Thomas, N | 1 |
| Bahtiyar, G | 1 |
| Cheng, ML | 3 |
| Chi, LM | 1 |
| Wu, PR | 1 |
| Ho, HY | 3 |
| Tilton, SC | 1 |
| Orner, GA | 1 |
| Benninghoff, AD | 1 |
| Carpenter, HM | 1 |
| Hendricks, JD | 1 |
| Pereira, CB | 1 |
| Williams, DE | 1 |
| Chiu, HY | 1 |
| Weng, SF | 2 |
| Chiu, DT | 2 |
| Shiao, MS | 1 |
| Tang, HY | 1 |
| Yamashita, R | 1 |
| Saito, T | 1 |
| Satoh, S | 1 |
| Aoki, K | 1 |
| Kaburagi, Y | 1 |
| Sekihara, H | 1 |
| Rypka, M | 1 |
| Cervenková, K | 1 |
| Uherková, L | 1 |
| Poczatková, H | 1 |
| Bogdanová, K | 1 |
| Veselý, J | 1 |
| Jiang, YF | 1 |
| Zhao, PW | 1 |
| Tan, Y | 1 |
| Liu, LH | 1 |
| Li, MH | 1 |
| Matsuzaki, Y | 1 |
| Niu, JQ | 1 |
| Panin, LE | 1 |
| Khoshchenko, OM | 1 |
| Poliakov, LM | 1 |
| Coombes, RC | 1 |
| Chilvers, C | 1 |
| Dowsett, M | 1 |
| Gazet, JC | 1 |
| Ford, HT | 1 |
| Bettelheim, R | 1 |
| Gordon, C | 1 |
| Smith, IE | 1 |
| Zava, D | 1 |
| Powles, TJ | 1 |
| Fehér, KG | 2 |
| Rákász, E | 1 |
| Bíró, J | 1 |
| Falus, A | 2 |
| Simile, M | 1 |
| Pascale, RM | 1 |
| De Miglio, MR | 1 |
| Nufris, A | 1 |
| Daino, L | 1 |
| Seddaiu, MA | 1 |
| Muroni, MR | 1 |
| Rao, KN | 1 |
| Feo, F | 1 |
| Chance, DS | 1 |
| Wu, SM | 1 |
| McIntosh, MK | 1 |
| Lubet, RA | 1 |
| McCormick, DM | 1 |
| Gordon, GM | 1 |
| Grubbs, C | 1 |
| Lei, XD | 1 |
| Steele, VE | 1 |
| Kelloff, GJ | 1 |
| Thomas, CF | 1 |
| Moon, RD | 1 |
| Coe, JE | 1 |
| Narasaka, T | 1 |
| Moriya, T | 1 |
| Endoh, M | 1 |
| Suzuki, T | 1 |
| Shizawa, S | 1 |
| Mizokami, Y | 1 |
| Matsuoka, T | 1 |
| Sasano, H | 1 |
| Ciolino, HP | 1 |
| MacDonald, CJ | 1 |
| Yeh, GC | 1 |
| Kew, MC | 1 |
| Kirschner, MA | 1 |
| Abrahams, GE | 1 |
| Katz, M | 1 |
| Walcz, E | 1 |
| Brozik, M | 1 |
| Füst, G | 1 |
| Hidvégi, T | 1 |
| Fehér, T | 1 |
| Merétey, K | 1 |
| Plymate, SR | 1 |
| Hoop, RC | 1 |
| Jones, RE | 1 |
| Matej, LA | 1 |
| Thornton, M | 1 |
| Moore, MA | 4 |
| Ito, N | 2 |
| Weber, E | 2 |
| Bannasch, P | 2 |
| Thamavit, W | 1 |
| Hiasa, Y | 1 |
| Dao, TL | 2 |
| Libby, PR | 2 |
| Leung, BS | 2 |
| Jack, W | 1 |
| Wood, DC | 2 |
| Fletcher, WS | 1 |
| Lindell, TD | 1 |
| Krippaechne, WW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Family Integrated Care Model For The Neonatal Intensive Care Unit: A Cluster Randomised Controlled Trial[NCT01852695] | 720 participants (Actual) | Interventional | 2013-03-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for dehydroepiandrosterone and Cancer of Liver
| Article | Year |
|---|---|
Hormonal influence on hepatocarcinogenesis.
Topics: Animals; Cricetinae; Dehydroepiandrosterone; Gonadal Steroid Hormones; Hormones; Humans; Liver Neopl | 1996 |
2 trials available for dehydroepiandrosterone and Cancer of Liver
| Article | Year |
|---|---|
Lower Maternal Chronic Physiological Stress and Better Child Behavior at 18 Months: Follow-Up of a Cluster Randomized Trial of Neonatal Intensive Care Unit Family Integrated Care.
Topics: Carcinoma, Hepatocellular; Child; Child Behavior; Dehydroepiandrosterone; Delivery of Health Care, I | 2022 |
Adjuvant aminoglutethimide therapy for postmenopausal patients with primary breast cancer: progress report.
Topics: Adult; Aged; Aminoglutethimide; Breast Neoplasms; Clinical Trials as Topic; Dehydroepiandrosterone; | 1982 |
27 other studies available for dehydroepiandrosterone and Cancer of Liver
| Article | Year |
|---|---|
Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.
Topics: Adjuvants, Immunologic; Carcinoma, Hepatocellular; CSK Tyrosine-Protein Kinase; Dehydroepiandrostero | 2015 |
Possible ACTH-independent, cortisol-secreting and DHEA-secreting metastatic hepatocellular carcinoma causing Cushing's syndrome.
Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Biopsy | 2015 |
Dehydroepiandrosterone-induced changes in mitochondrial proteins contribute to phenotypic alterations in hepatoma cells.
Topics: Antineoplastic Agents, Hormonal; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Ce | 2016 |
Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout.
Topics: Aflatoxin B1; Animals; Caprylates; Carcinogenicity Tests; Clofibrate; Cluster Analysis; Dehydroepian | 2008 |
Dehydroepiandrosterone induces growth arrest of hepatoma cells via alteration of mitochondrial gene expression and function.
Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Proliferation; Dehydroepiandrosterone; DNA, | 2008 |
Biochemical disorders associated with antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Chrom | 2011 |
Effects of dehydroepiandrosterone on gluconeogenic enzymes and glucose uptake in human hepatoma cell line, HepG2.
Topics: Blotting, Northern; Carcinoma, Hepatocellular; Cell Line, Tumor; Dehydroepiandrosterone; Deoxyglucos | 2005 |
Changes in mRNA levels of intracellular fatty acid metabolism regulators in human hepatoma HepG2 cells following their treatment with non-esterified fatty acids and dehydroepiandrosterone.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Dehydroepiandrosterone; Fatty Acid-Binding Proteins; Fa | 2005 |
[Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines].
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Dehydroepiandrosterone; Dehydr | 2007 |
[Effect of apolipoprotein A-1 containing steroid hormones on DNA and protein biosynthesis in cells of ascitic hepatoma HA-1].
Topics: Apolipoprotein A-I; Ascites; Carcinoma, Hepatocellular; Dehydroepiandrosterone; Dehydroepiandrostero | 2007 |
Dehydroepiandrosterone modulates the spontaneous and IL-6 stimulated fibrinogen production of human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Dehydroepiandrosterone; Dexamethasone; Fibrinogen; Humans; Immunologic Fa | 1995 |
Inhibition by dehydroepiandrosterone of growth and progression of persistent liver nodules in experimental rat liver carcinogenesis.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Glucosephosphate Dehydrogenase; Liver; Liver Diseases; | 1995 |
Inverse relationship between peroxisomal and mitochondrial beta-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid.
Topics: Analysis of Variance; Biomarkers; Carcinoma, Hepatocellular; Carnitine O-Palmitoyltransferase; Catal | 1995 |
Effects of dehydroepiandrosterone on MNU-induced breast cancer in Sprague-Dawley rats.
Topics: Animals; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Mammary | 1995 |
17Beta-hydroxysteroid dehydrogenase type 2 and dehydroepiandrosterone sulfotransferase in the human liver.
Topics: 17-Hydroxysteroid Dehydrogenases; Aged; Carcinoma, Hepatocellular; Cholangiocarcinoma; Dehydroepiand | 2000 |
Inhibition of carcinogen-activating enzymes by 16alpha-fluoro-5-androsten-17-one.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Biotransform | 2002 |
Mechanism of feminization in primary liver cancer.
Topics: Adult; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Estriol; Estrogens; Estrone; Femin | 1977 |
Hormonal regulation of complement biosynthesis in human cell lines--I. Androgens and gamma-interferon stimulate the biosynthesis and gene expression of C1 inhibitor in human cell lines U937 and HepG2.
Topics: Carcinoma, Hepatocellular; Complement C1 Inactivator Proteins; Dehydroepiandrosterone; Gene Expressi | 1990 |
Regulation of sex hormone-binding globulin production by growth factors.
Topics: Carcinoma, Hepatocellular; Cell Line; Dehydroepiandrosterone; Epidermal Growth Factor; Growth Substa | 1990 |
Modifying influence of dehydroepiandrosterone or butylated hydroxytoluene treatment on initiation and development stages of azaserine-induced acinar pancreatic preneoplastic lesions in the rat.
Topics: Animals; Azaserine; Butylated Hydroxytoluene; Dehydroepiandrosterone; Liver Neoplasms; Male; Pancrea | 1989 |
Enzyme histochemical and morphological phenotype of amphophilic foci and amphophilic/tigroid cell adenomas in rat liver after combined treatment with dehydroepiandrosterone and N-nitrosomorpholine.
Topics: Animals; Carcinogens; Dehydroepiandrosterone; Drug Interactions; Liver; Liver Neoplasms; Male; Nitro | 1988 |
Early lesions induced by DHPN in Syrian golden hamsters: influence of concomitant Opisthorchis infestation, dehydroepiandrosterone or butylated hydroxyanisole administration.
Topics: Animals; Butylated Hydroxyanisole; Chemical and Drug Induced Liver Injury; Cricetinae; Dehydroepiand | 1988 |
Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone.
Topics: Adenoma; Adrenal Cortex Diseases; Animals; Dehydroepiandrosterone; Hemangiosarcoma; Liver Neoplasms; | 1988 |
Conjugation of steroid hormones by normal and neoplastic tissues.
Topics: Adult; Aged; Breast; Breast Neoplasms; Chromatography, Paper; Dehydroepiandrosterone; Desoxycorticos | 1968 |
Conjugation of steroid hormones by breast cancer tissue and selection of patients for adrenalectomy.
Topics: Adrenalectomy; Aged; Breast Neoplasms; Dehydroepiandrosterone; Estradiol; Estrone; Humans; Liver; Li | 1969 |
Steroid sulfurylation in normal tissues and mammary tumors: a micro method.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Adult; Aged; Animals; Binding Sites; Breast Neoplas | 1972 |
Predictability of response to endocrine ablation in advanced breast carcinoma. A correlation to estrogen receptor and steroid sulfurylation.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Breast Neoplasms; Dehydroepiandrosterone; Estra | 1973 |