dehydroepiandrosterone has been researched along with Cancer of Colon in 14 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exposure to dehydroepiandrosterone caused a concentration-dependent accumulation of HT-29 human colonic adenocarcinoma cells in S-phase and sensitization toward the cytotoxic effects of fluorouracil deoxyriboside but not 5-fluorouracil." | 7.68 | Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells. ( Holbrook, CT; Klann, RC; Nyce, J, 1990) |
| "Exposure to dehydroepiandrosterone caused a concentration-dependent accumulation of HT-29 human colonic adenocarcinoma cells in S-phase and sensitization toward the cytotoxic effects of fluorouracil deoxyriboside but not 5-fluorouracil." | 3.68 | Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells. ( Holbrook, CT; Klann, RC; Nyce, J, 1990) |
| "This is the first study of colon cancer carcinogenesis demonstrating that DHEA treatment can decrease the number of ACF without apparently modifying their malignant potential." | 1.31 | Chemoprevention of precursors to colon cancer by dehydroepiandrosterone (DHEA). ( Matsuhashi, N; Nagase, H; Nakagama, H; Nakajima, A; Ochiai, M; Omura, M; Osawa, E; Sekihara, H; Ueno, N; Wada, K; Yoshida, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anagnostopoulou, V | 1 |
| Pediaditakis, I | 1 |
| Alkahtani, S | 1 |
| Alarifi, SA | 1 |
| Schmidt, EM | 1 |
| Lang, F | 1 |
| Gravanis, A | 1 |
| Charalampopoulos, I | 1 |
| Stournaras, C | 1 |
| Osawa, E | 2 |
| Nakajima, A | 2 |
| Yoshida, S | 1 |
| Omura, M | 1 |
| Nagase, H | 1 |
| Ueno, N | 1 |
| Wada, K | 1 |
| Matsuhashi, N | 1 |
| Ochiai, M | 1 |
| Nakagama, H | 1 |
| Sekihara, H | 2 |
| Aoki, K | 1 |
| Mukasa, K | 1 |
| Mori, Y | 1 |
| Kent, S | 1 |
| Nyce, JW | 3 |
| Magee, PN | 1 |
| Hard, GC | 1 |
| Schwartz, AG | 1 |
| Alberg, AJ | 1 |
| Gordon, GB | 2 |
| Hoffman, SC | 1 |
| Comstock, GW | 1 |
| Helzlsouer, KJ | 1 |
| Nakayama, Y | 1 |
| Sakamoto, H | 1 |
| Satoh, K | 1 |
| Yamamoto, T | 1 |
| Schulz, S | 2 |
| Klann, RC | 2 |
| Schönfeld, S | 1 |
| Hamilton, SR | 1 |
| Floyd, J | 1 |
| Golightly, S | 1 |
| Rao, CV | 1 |
| Tokumo, K | 1 |
| Rigotty, J | 1 |
| Zang, E | 1 |
| Kelloff, G | 1 |
| Reddy, BS | 1 |
| Pereira, MA | 1 |
| Khoury, MD | 1 |
| Nyce, J | 1 |
| Holbrook, CT | 1 |
| Miura, K | 1 |
| Demura, H | 1 |
| Sato, E | 1 |
| Sasano, N | 1 |
| Shimizu, N | 1 |
1 review available for dehydroepiandrosterone and Cancer of Colon
| Article | Year |
|---|---|
Prevention of diabetes, hepatic injury, and colon cancer with dehydroepiandrosterone.
Topics: Aging; Animals; Colonic Neoplasms; Dehydroepiandrosterone; Diabetes Mellitus; Gluconeogenesis; Human | 2003 |
13 other studies available for dehydroepiandrosterone and Cancer of Colon
| Article | Year |
|---|---|
Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors.
Topics: Animals; Apoptosis; Cell Proliferation; Colonic Neoplasms; Dehydroepiandrosterone; Humans; Male; Ner | 2013 |
Chemoprevention of precursors to colon cancer by dehydroepiandrosterone (DHEA).
Topics: Adjuvants, Immunologic; Animals; Azoxymethane; beta Catenin; Carcinogens; Chemoprevention; Colonic N | 2002 |
DHEA: "miracle" drug?
Topics: Adrenal Glands; Adult; Aged; Aging; Animals; Breast Neoplasms; Colonic Neoplasms; Dehydroepiandroste | 1982 |
Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone.
Topics: Animals; Body Weight; Cell Cycle; Colonic Neoplasms; Dehydroepiandrosterone; Dimethylhydrazines; DNA | 1984 |
Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and the subsequent risk of developing colon cancer.
Topics: Adult; Age Factors; Aged; Case-Control Studies; Colonic Neoplasms; Dehydroepiandrosterone; Dehydroep | 2000 |
Tamoxifen and gonadal steroids inhibit colon cancer growth in association with inhibition of thymidylate synthase, survivin and telomerase expression through estrogen receptor beta mediated system.
Topics: Antineoplastic Agents, Hormonal; Cell Division; Colonic Neoplasms; Dehydroepiandrosterone; Dose-Resp | 2000 |
Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis.
Topics: Adenocarcinoma; Cell Cycle; Cholesterol; Colonic Neoplasms; Dehydroepiandrosterone; Deoxyribonucleos | 1992 |
Evaluation of dietary dehydroepiandrosterone for chemoprotection against tumorigenesis in premalignant colonic epithelium of male F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neo | 1991 |
Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination.
Topics: Animals; Body Weight; Colonic Neoplasms; Dehydroepiandrosterone; Drug Combinations; Drug Evaluation, | 1991 |
Inhibition of protein isoprenylation and p21ras membrane association by dehydroepiandrosterone in human colonic adenocarcinoma cells in vitro.
Topics: Adenocarcinoma; Blotting, Western; Cell Compartmentation; Cell Division; Cell Membrane; Colonic Neop | 1991 |
Prevention by chemopreventive agents of azoxymethane-induced foci of aberrant crypts in rat colon.
Topics: Acetylcysteine; Allyl Compounds; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neop | 1991 |
Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells.
Topics: Adenocarcinoma; Carbon Radioisotopes; Colonic Neoplasms; Dehydroepiandrosterone; Fluorouracil; Human | 1990 |
A case of ACTH-secreting cancer of the colon.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Androsterone; Biological As | 1970 |