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dehydroepiandrosterone and Brain Neoplasms

dehydroepiandrosterone has been researched along with Brain Neoplasms in 8 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Research Excerpts

ExcerptRelevanceReference
"The efficacy of oral dehydroepiandrosterone (DHEA) in the treatment of atrichia pubis and psychological distress in young females with central adrenal insufficiency is unknown."9.14Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. ( Bettendorf, M; Binder, G; Doerr, HG; Ehrismann, M; Hartmann, MF; Heinrich, U; Keller, E; Maier, L; Meisner, C; Pfaeffle, RW; Ranke, MB; Weber, S; Wudy, SA; Zaiser, N, 2009)
"The efficacy of oral dehydroepiandrosterone (DHEA) in the treatment of atrichia pubis and psychological distress in young females with central adrenal insufficiency is unknown."5.14Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. ( Bettendorf, M; Binder, G; Doerr, HG; Ehrismann, M; Hartmann, MF; Heinrich, U; Keller, E; Maier, L; Meisner, C; Pfaeffle, RW; Ranke, MB; Weber, S; Wudy, SA; Zaiser, N, 2009)
"Cortisol production by hepatocellular carcinoma (HCC) has not been previously reported and dehydroepiandrosterone (DHEA) secretion by HCC is rare."3.81Possible ACTH-independent, cortisol-secreting and DHEA-secreting metastatic hepatocellular carcinoma causing Cushing's syndrome. ( Bahtiyar, G; Inoue, T; Sacerdote, A; Thomas, N, 2015)
" C6 rat glioma tumor cells in culture biosynthesize both pregnenolone (P) and D."3.70Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells. ( Cascio, C; Lieberman, S; Lin, YY; Papadopoulos, V; Prasad, VV, 1998)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's3 (37.50)18.2507
2000's1 (12.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yang, WB1
Chuang, JY1
Ko, CY1
Chang, WC1
Hsu, TI1
Sacerdote, A1
Inoue, T1
Thomas, N1
Bahtiyar, G1
Binder, G1
Weber, S1
Ehrismann, M1
Zaiser, N1
Meisner, C1
Ranke, MB1
Maier, L1
Wudy, SA1
Hartmann, MF1
Heinrich, U1
Bettendorf, M1
Doerr, HG1
Pfaeffle, RW1
Keller, E1
Ciaccio, M1
Belgorosky, A1
Rivarola, MA1
Azuma, T1
Matsubara, T1
Shima, Y1
Haeno, S1
Fujimoto, T1
Tone, K1
Shibata, N1
Sakoda, S1
Cascio, C1
Prasad, VV1
Lin, YY1
Lieberman, S1
Papadopoulos, V1
Maeyama, M1
Ifuku, M1
Nakahara, K1
Ernould, HJ1
Thibaut, A1
Decamps, G1

Trials

1 trial available for dehydroepiandrosterone and Brain Neoplasms

ArticleYear
Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:4

    Topics: Adolescent; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Blood Pressure; Brain Neoplas

2009

Other Studies

7 other studies available for dehydroepiandrosterone and Brain Neoplasms

ArticleYear
Dehydroepiandrosterone Induces Temozolomide Resistance Through Modulating Phosphorylation and Acetylation of Sp1 in Glioblastoma.
    Molecular neurobiology, 2019, Volume: 56, Issue:4

    Topics: Acetylation; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Dehydroepiandrosterone; DNA Damage; Dr

2019
Possible ACTH-independent, cortisol-secreting and DHEA-secreting metastatic hepatocellular carcinoma causing Cushing's syndrome.
    BMJ case reports, 2015, Dec-23, Volume: 2015

    Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Biopsy

2015
Differences in serum insulin-like growth factor I and sex-hormone-binding globulin levels between late and early prepuberty in patients with idiopathic and organic growth hormone deficiency.
    Acta endocrinologica, 1993, Volume: 129, Issue:5

    Topics: Age Determination by Skeleton; Analysis of Variance; Body Height; Brain Neoplasms; Child; Child, Pre

1993
Neurosteroids in cerebrospinal fluid in neurologic disorders.
    Journal of the neurological sciences, 1993, Dec-01, Volume: 120, Issue:1

    Topics: Adult; Age Factors; Aged; Brain Neoplasms; Cerebellar Diseases; Cerebral Infarction; Dehydroepiandro

1993
Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Mar-17, Volume: 95, Issue:6

    Topics: Aminoglutethimide; Animals; Brain Neoplasms; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-45

1998
Steroidogenesis in cerebral metastatic chorionepithelioma tissue in vitro.
    The Journal of endocrinology, 1975, Volume: 65, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; Androstenedione; Brain Neoplasms; Choriocarcinoma; Dehydroepiandroster

1975
[Case of precocious puberty with neoplasm in the region of the mamillary bodies: treatment by interstitial radiotherapy (author's transl)].
    Journal of neuro-visceral relations, 1971, Volume: 0, Issue:0

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Bone Development; Brain Neoplasms; Child; Child, Prescho

1971