dehydroepiandrosterone has been researched along with Blood Poisoning in 23 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently the benefit of subcutaneously applied dehydroepiandrosterone (DHEA) during sepsis was demonstrated." | 7.80 | Androstenediol modulates sepsis induced alterations of survival and immune functions in a murine model of sepsis. ( Lendemans, S; Oberbeck, R; Schmitz, D, 2014) |
| "Dehydroepiandrosterone (DHEA) was shown to improve the immune function and survival in experimental sepsis." | 7.80 | Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis. ( Al-Banna, N; Bac, VH; Balzer, C; Jaskulski, M; Lehmann, C; Nedeljkov, V; Pavlovic, D; Sharawi, N; Weber, S, 2014) |
| "Administration of dehydroepiandrosterone (DHEA) has been demonstrated to improve survival and cellular immune functions during systemic inflammation." | 7.76 | Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration. ( Hammes, F; Kobbe, P; Oberbeck, R; Schmitz, D; Wegner, A, 2010) |
| "The pathogenesis of sepsis is still undetermined to a large extent." | 5.32 | The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model. ( Hildebrand, F; Hoevel, P; Krettek, C; Pape, HC; van Griensven, M, 2003) |
| "Sepsis is associated with a marked depression of cellular immune function." | 5.31 | Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis. ( Dahlweid, M; Emmendörfer, A; Koch, R; Oberbeck, R; Pape, HC; Tscherne, H; van Griensven, M, 2001) |
| "At 24 hours after trauma-hemorrhage and resuscitation, the animals were killed and blood, spleens, and peritoneal macrophages were harvested." | 5.30 | Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage. ( Angele, MK; Ayala, A; Bland, KI; Catania, RA; Chaudry, IH; Cioffi, WG, 1998) |
| "Recently the benefit of subcutaneously applied dehydroepiandrosterone (DHEA) during sepsis was demonstrated." | 3.80 | Androstenediol modulates sepsis induced alterations of survival and immune functions in a murine model of sepsis. ( Lendemans, S; Oberbeck, R; Schmitz, D, 2014) |
| "Dehydroepiandrosterone (DHEA) was shown to improve the immune function and survival in experimental sepsis." | 3.80 | Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis. ( Al-Banna, N; Bac, VH; Balzer, C; Jaskulski, M; Lehmann, C; Nedeljkov, V; Pavlovic, D; Sharawi, N; Weber, S, 2014) |
| "Administration of dehydroepiandrosterone (DHEA) has been demonstrated to improve survival and cellular immune functions during systemic inflammation." | 3.76 | Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration. ( Hammes, F; Kobbe, P; Oberbeck, R; Schmitz, D; Wegner, A, 2010) |
| "Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet fully understood." | 3.75 | DHEA-dependent and organ-specific regulation of TNF-alpha mRNA expression in a murine polymicrobial sepsis and trauma model. ( Barkhausen, T; Hildebrand, F; Krettek, C; van Griensven, M, 2009) |
| "Dehydroepiandrosterone (DHEA) exerts a variety of positive effects on the immunologic alterations after trauma and sepsis." | 3.71 | Dehydroepiandrosterone (DHEA) modulates the activity and the expression of lymphocyte subpopulations induced by cecal ligation and puncture. ( Böttcher, F; Breddin, M; Dahlweid, FM; Giannoudis, PV; Pape, HC; van Griensven, M; Wittwer, T, 2002) |
| "Prednisone may be immunosuppressive and dehydroepiandrosterone may stimulate the immune response, but their effect on gut-origin sepsis caused by bacterial translocation has not been studied." | 3.69 | Steroid therapy can modulate gut barrier function, host defense, and survival in thermally injured mice. ( Alexander, JW; Fukushima, R; Gianotti, L; Pyles, T, 1996) |
| "The clinical course after multiple trauma depends on the balance or imbalance of the pro- and anti-inflammatory immune response." | 2.47 | Immunomodulation in polytrauma and polymicrobial sepsis - where do we stand? ( Andruszkow, H; Frink, M; Hildebrand, F; Krettek, C; Mommsen, P; Neunaber, C; Zeckey, C, 2011) |
| "The pathogenesis of sepsis is still undetermined to a large extent." | 1.32 | The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model. ( Hildebrand, F; Hoevel, P; Krettek, C; Pape, HC; van Griensven, M, 2003) |
| "Sepsis is associated with depression of T cell-dependent immune reactivity with proinflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, playing an important role." | 1.32 | Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents. ( Harwood, P; Hildebrand, F; Krettek, C; Pape, HC; van Griensven, M; Wittwer, T, 2004) |
| "Sepsis is associated with a marked depression of cellular immune function." | 1.31 | Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis. ( Dahlweid, M; Emmendörfer, A; Koch, R; Oberbeck, R; Pape, HC; Tscherne, H; van Griensven, M, 2001) |
| "At 24 hours after trauma-hemorrhage and resuscitation, the animals were killed and blood, spleens, and peritoneal macrophages were harvested." | 1.30 | Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage. ( Angele, MK; Ayala, A; Bland, KI; Catania, RA; Chaudry, IH; Cioffi, WG, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schmitz, D | 4 |
| Lendemans, S | 1 |
| Oberbeck, R | 6 |
| Al-Banna, N | 1 |
| Pavlovic, D | 1 |
| Sharawi, N | 1 |
| Bac, VH | 1 |
| Jaskulski, M | 1 |
| Balzer, C | 1 |
| Weber, S | 1 |
| Nedeljkov, V | 1 |
| Lehmann, C | 1 |
| Barkhausen, T | 2 |
| Hildebrand, F | 5 |
| Krettek, C | 5 |
| van Griensven, M | 6 |
| Kobbe, P | 4 |
| Zeckey, C | 2 |
| Hoevel, P | 2 |
| Müller, K | 1 |
| Wegner, A | 2 |
| Hammes, F | 2 |
| Neunaber, C | 1 |
| Andruszkow, H | 1 |
| Frink, M | 1 |
| Mommsen, P | 1 |
| Dahlweid, FM | 1 |
| Giannoudis, PV | 1 |
| Wittwer, T | 2 |
| Böttcher, F | 1 |
| Breddin, M | 1 |
| Pape, HC | 4 |
| Marx, C | 1 |
| Petros, S | 1 |
| Bornstein, SR | 1 |
| Weise, M | 1 |
| Wendt, M | 1 |
| Menschikowski, M | 1 |
| Engelmann, L | 1 |
| Höffken, G | 1 |
| Kirk-Bayley, J | 1 |
| Venn, R | 1 |
| KOELBLOVA, V | 1 |
| GREGOROVA, I | 1 |
| KOELBEL, F | 1 |
| SONKA, J | 1 |
| Harwood, P | 1 |
| Frantz, MC | 2 |
| Prix, NJ | 1 |
| Wichmann, MW | 1 |
| van den Engel, NK | 1 |
| Hernandez-Richter, T | 1 |
| Faist, E | 1 |
| Chaudry, IH | 4 |
| Jauch, KW | 1 |
| Angele, MK | 3 |
| Matsuda, A | 1 |
| Furukawa, K | 1 |
| Suzuki, H | 1 |
| Matsutani, T | 1 |
| Tajiri, T | 1 |
| Deckert, H | 1 |
| Bangen, J | 1 |
| Gianotti, L | 1 |
| Alexander, JW | 2 |
| Fukushima, R | 1 |
| Pyles, T | 1 |
| Gennari, R | 1 |
| Ottaway, CA | 1 |
| Fong, IW | 1 |
| da Silva, B | 1 |
| Singer, W | 1 |
| Karrass, L | 1 |
| Catania, RA | 1 |
| Ayala, A | 1 |
| Cioffi, WG | 1 |
| Bland, KI | 1 |
| Dahlweid, M | 1 |
| Koch, R | 1 |
| Emmendörfer, A | 1 |
| Tscherne, H | 1 |
4 reviews available for dehydroepiandrosterone and Blood Poisoning
| Article | Year |
|---|---|
Dehydroepiandrosterone (DHEA): a steroid with multiple effects. Is there any possible option in the treatment of critical illness?
Topics: Animals; Central Nervous System; Critical Illness; Dehydroepiandrosterone; Humans; Mice; Sepsis; Sho | 2010 |
Immunomodulation in polytrauma and polymicrobial sepsis - where do we stand?
Topics: Androstenediol; Animals; Dehydroepiandrosterone; Finasteride; Flutamide; Humans; Immunomodulation; L | 2011 |
Recently published papers: inflammation, elucidation, manipulation?
Topics: Biomarkers; Dehydroepiandrosterone; Humans; Hydrocortisone; Inflammation; Respiration, Artificial; S | 2003 |
Gender and sex hormones influence the response to trauma and sepsis: potential therapeutic approaches.
Topics: Adjuvants, Immunologic; Androgen Receptor Antagonists; Androgens; Blood Circulation; Dehydroepiandro | 2006 |
19 other studies available for dehydroepiandrosterone and Blood Poisoning
| Article | Year |
|---|---|
Androstenediol modulates sepsis induced alterations of survival and immune functions in a murine model of sepsis.
Topics: Administration, Intravenous; Androstenediol; Animals; Apoptosis; Body Temperature; Cytokines; Dehydr | 2014 |
Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis.
Topics: Animals; Capillaries; Cell Adhesion; Chemotaxis, Leukocyte; Cytokines; Dehydroepiandrosterone; Disea | 2014 |
DHEA-dependent and organ-specific regulation of TNF-alpha mRNA expression in a murine polymicrobial sepsis and trauma model.
Topics: Animals; Base Sequence; Dehydroepiandrosterone; Disease Models, Animal; DNA Primers; Femoral Fractur | 2009 |
Activity of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment in IL-6 knockout mice.
Topics: Adjuvants, Immunologic; Animals; CD8-Positive T-Lymphocytes; Dehydroepiandrosterone; Disease Models, | 2010 |
Dehydroepiandrosterone during sepsis: does the timing of administration influence the effectiveness.
Topics: Animals; Critical Illness; Dehydroepiandrosterone; Interleukin-1beta; Interleukin-6; Lymphocyte Acti | 2010 |
Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration.
Topics: Animals; Apoptosis; Cell Proliferation; Cytokines; Dehydroepiandrosterone; Disease Models, Animal; D | 2010 |
Dehydroepiandrosterone (DHEA) modulates the activity and the expression of lymphocyte subpopulations induced by cecal ligation and puncture.
Topics: Adjuvants, Immunologic; Animals; CD8-Positive T-Lymphocytes; Dehydroepiandrosterone; Disease Models, | 2002 |
Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol.
Topics: Adrenocorticotropic Hormone; Age Factors; Aged; APACHE; C-Reactive Protein; Calcitonin; Dehydroepian | 2003 |
[CHANGES IN THE EXCRETION OF DEHYDROEPIANDROSTERONE IN PREGNANCY].
Topics: 17-Ketosteroids; Dehydroepiandrosterone; Female; Humans; Pregnancy; Sepsis; Toxemia; Urine | 1964 |
The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model.
Topics: Adjuvants, Immunologic; Animals; Antigens, CD; Cytokines; Dehydroepiandrosterone; Interleukin-1; Int | 2003 |
Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents.
Topics: Animals; Body Temperature; Body Weight; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dehy | 2004 |
Dehydroepiandrosterone restores depressed peripheral blood mononuclear cell function following major abdominal surgery via the estrogen receptors.
Topics: Abdomen; Adjuvants, Immunologic; Adult; Aged; Cells, Cultured; Cytokines; Dehydroepiandrosterone; Es | 2005 |
Dehydroepiandrosterone modulates toll-like receptor expression on splenic macrophages of mice after severe polymicrobial sepsis.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Cell Membrane; Dehydroepiandrosterone; DN | 2005 |
Dehydroepiandrosterone: a modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis.
Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; HSP70 Heat-Shock Proteins; Immunity, Cellul | 2007 |
Steroid therapy can modulate gut barrier function, host defense, and survival in thermally injured mice.
Topics: Animals; Bacterial Translocation; Burns; Dehydroepiandrosterone; Digestive System; Escherichia coli; | 1996 |
Arginine, glutamine, and dehydroepiandrosterone reverse the immunosuppressive effect of prednisone during gut-derived sepsis.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Bacterial Translocation; Dehydroepiandrosterone; Evalua | 1997 |
Integrative aspects of a human model of endotoxemia.
Topics: Adrenocorticotropic Hormone; Cytokines; Dehydroepiandrosterone; Hormones; Humans; Hydrocortisone; In | 1998 |
Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage.
Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; Hemorrhage; Macrophages; Male; Mice; Mice, | 1998 |
Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Dehydroepiandrosterone; Disease Models, Anima | 2001 |