dehydroepiandrosterone has been researched along with Autoimmune Diabetes in 17 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus." | 7.80 | Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats. ( Fujita, S; Iemitsu, M; Sato, K, 2014) |
| "Acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus." | 3.80 | Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats. ( Fujita, S; Iemitsu, M; Sato, K, 2014) |
| "Dehydroepiandrosterone (DHEA) is believed to exert, besides others, positive effects on the insulin resistance or its secretion and glucose metabolism." | 3.78 | Dehydroepiandrosterone in the type 1 diabetes mellitus. ( Duskova, M; Hill, M; Hruskovicova, H; Starka, L, 2012) |
| "Our analyses suggest that chronic PTSD, particularly comorbid PTSD or complex PTSD, is associated with all of these conditions." | 1.32 | Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. ( Boscarino, JA, 2004) |
| " Thus, in patients with insulin-dependent diabetes, an approximately 30% increase in insulin dosage should be anticipated with the onset of puberty." | 1.27 | Puberty decreases insulin sensitivity. ( Bloch, CA; Clemons, P; Sperling, MA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, K | 1 |
| Fujita, S | 1 |
| Iemitsu, M | 1 |
| Kvasnickova, H | 1 |
| Hampl, R | 1 |
| Vondra, K | 1 |
| Kosiewicz, MM | 1 |
| Auci, DL | 1 |
| Fagone, P | 1 |
| Mangano, K | 1 |
| Caponnetto, S | 1 |
| Tucker, CF | 1 |
| Azeem, N | 1 |
| White, SK | 1 |
| Frincke, JM | 1 |
| Reading, CL | 1 |
| Nicoletti, F | 1 |
| Duskova, M | 1 |
| Hruskovicova, H | 1 |
| Hill, M | 1 |
| Starka, L | 1 |
| BRETAN, M | 1 |
| SZABO, Z | 1 |
| JAKAB, L | 1 |
| BALAZSI, I | 1 |
| Boscarino, JA | 1 |
| Cohen, HN | 1 |
| Paterson, KR | 1 |
| Wallace, AM | 1 |
| Beastall, GH | 2 |
| Manderson, WG | 1 |
| MacCuish, AC | 2 |
| Loviselli, A | 1 |
| Pisanu, P | 1 |
| Cossu, E | 1 |
| Caradonna, A | 1 |
| Massa, GM | 1 |
| Cirillo, R | 1 |
| Balestrieri, A | 1 |
| Radetti, G | 1 |
| Paganini, C | 1 |
| Gentili, L | 1 |
| Barbin, F | 1 |
| Pasquino, B | 1 |
| Zachmann, M | 1 |
| Ebeling, P | 1 |
| Stenman, UH | 1 |
| Seppälä, M | 1 |
| Koivisto, VA | 1 |
| Durant, S | 1 |
| Christeff, N | 1 |
| Coulaud, J | 1 |
| Nunez, EA | 1 |
| Dardenne, M | 1 |
| Homo-Delarche, F | 1 |
| Bech, P | 1 |
| Raabaek Olsen, L | 1 |
| Jarløv, N | 1 |
| Hammer, M | 1 |
| Schütze, T | 1 |
| Breum, L | 1 |
| Couch, RM | 1 |
| Vexiau, P | 1 |
| Fiet, J | 1 |
| Boudou, P | 1 |
| Villette, JM | 1 |
| Feutren, G | 1 |
| Hardy, N | 1 |
| Julien, R | 1 |
| Dreux, C | 1 |
| Bach, JF | 1 |
| Cathelineau, G | 1 |
| Haffner, SM | 1 |
| Klein, R | 1 |
| Dunn, JF | 1 |
| Moss, SE | 1 |
| Klein, BE | 1 |
| Small, M | 1 |
| Gray, CE | 1 |
| Bloch, CA | 1 |
| Clemons, P | 1 |
| Sperling, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diabetes and Cardiovascular Risk In Mexico City (San Antonio Heart Study)[NCT00005146] | 0 participants | Observational | 1979-05-31 | Completed | |||
| Exercise Snacks and Glutamine to Improve Glucose Control in Adolescents With Type 1 Diabetes[NCT03199638] | 14 participants (Actual) | Interventional | 2016-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Percent of BG between 70 and 180 mg/dL, as measured using Continuous Glucose Monitor (CGM) (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | Percentage of Blood Glucose (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 57.6 | 69.2 |
| an Exercise Group | 63.7 | 46.4 |
MAGE describes the average amplitude of glycemic variations measured using continuous glucose monitoring (CGM) (NCT03199638)
Timeframe: before vs. at 3 months
| Intervention | mg/dL (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 108 | 123 |
| an Exercise Group | 129 | 139 |
change in glycated hemoglobin (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | percentage of total hemoglobin (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 8.3 | 8.4 |
| an Exercise Group | 7.9 | 8.0 |
Change in insulin dose (Units/kg/day) used at home (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | Units/kg/day (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 0.98 | 1.0 |
| an Exercise Group | 1.0 | 0.8 |
Change in insulin sensitivity score, determined using SEARCH ISS model published equation: logeIS = 4.64725 - 0.02032 × (waist, cm) - 0.09779 × (HbA1c, %) - 0.00235 × (Triglycerides, mg/dL). The range of ISS scores is between 1-15. Higher scores imply a better insulin sensistivity. (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | score on a scale (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 2.10 | 2.16 |
| an Exercise Group | 2.17 | 2.20 |
Change in Percent of BG above 180 mg, as determined using Continuous Glucose Monitor (CGM) (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | Percentage of Blood Glucose (Mean) | |
|---|---|---|
| basline | at 3 months | |
| an Exercise + Glutamine Group | 39.4 | 26.6 |
| an Exercise Group | 29.1 | 46.4 |
Change in Percent of BG below 70 mg/dL, as determined by Continuous Glucose Monitor (CGM) (NCT03199638)
Timeframe: baseline vs. at 3 months
| Intervention | Percentage of Blood Glucose (Mean) | |
|---|---|---|
| baseline | at 3 months | |
| an Exercise + Glutamine Group | 3.1 | 4.4 |
| an Exercise Group | 7.2 | 7.2 |
3 trials available for dehydroepiandrosterone and Autoimmune Diabetes
| Article | Year |
|---|---|
[Low levels of dehydroepiandrosterone sulfate in adult males with insulin-dependent diabetes mellitus].
Topics: Adrenocorticotropic Hormone; Adult; Androstenedione; Cross-Sectional Studies; Dehydroepiandrosterone | 1994 |
Altered adrenal and thyroid function in children with insulin-dependent diabetes mellitus.
Topics: Adolescent; Adrenal Glands; Age Factors; Blood Glucose; Child; Child, Preschool; Cholesterol; Dehydr | 1994 |
Increase in plasma 5 alpha-androstane-3 alpha,17 beta-diol glucuronide as a marker of peripheral androgen action in hirsutism: a side-effect induced by cyclosporine A.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androstane-3,17-diol; Androstanols; Cyclosporins; Dehydroepia | 1990 |
14 other studies available for dehydroepiandrosterone and Autoimmune Diabetes
| Article | Year |
|---|---|
Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats.
Topics: Animals; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2014 |
DHEA, DHEAS and prolactin correlate with glucose control parameters in women of fertile age with type-1 diabetes mellitus.
Topics: Adult; Biomarkers; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabetes Mellitus, Type 1 | 2015 |
HE3286, an orally bioavailable synthetic analogue of an active DHEA metabolite suppresses spontaneous autoimmune diabetes in the non-obese diabetic (NOD) mouse.
Topics: Administration, Oral; Animals; Biological Availability; CD4 Antigens; Dehydroepiandrosterone; Diabet | 2011 |
Dehydroepiandrosterone in the type 1 diabetes mellitus.
Topics: Adolescent; Adult; Age Factors; Aging; Blood Glucose; Dehydroepiandrosterone; Dehydroepiandrosterone | 2012 |
[EFFECT OF TREATMENT WITH NOR-ANDROSTENOLONE AND DECANOATE ON DIABETIC RETINOPATHY].
Topics: Adolescent; Carbohydrate Metabolism; Decanoates; Dehydroepiandrosterone; Diabetes Mellitus, Type 1; | 1964 |
Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Dehydroepiandrosterone; Diabetes Mellitus, Type 1; Femal | 2004 |
Dissociation of adrenarche and gonadarche in diabetes mellitus.
Topics: Adolescent; Adrenal Glands; Age Determination by Skeleton; Dehydroepiandrosterone; Dehydroepiandrost | 1984 |
Androgens and insulin resistance in type 1 diabetic men.
Topics: Adult; Calorimetry, Indirect; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabetes Melli | 1995 |
Basal concentrations of various steroids in the nonobese diabetic (NOD) mouse and effect of immobilization stress.
Topics: Adrenalectomy; Androstenedione; Animals; Corticosterone; Dehydroepiandrosterone; Diabetes Mellitus, | 1998 |
A case of sequential anti-stress medication in a patient with major depression resistant to amine-reuptake inhibitors.
Topics: Amines; Antidepressive Agents; Anxiety Disorders; Dehydroepiandrosterone; Depressive Disorder, Major | 1999 |
Dissociation of cortisol and adrenal androgen secretion in poorly controlled insulin-dependent diabetes mellitus.
Topics: Adolescent; Adrenal Glands; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabe | 1992 |
Increased testosterone in type I diabetic subjects with severe retinopathy.
Topics: Adolescent; Adult; Body Constitution; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diabet | 1990 |
Adrenal androgens in insulin-dependent diabetes mellitus.
Topics: Adrenal Cortex Hormones; Adult; Androstenedione; C-Peptide; Dehydroepiandrosterone; Dehydroepiandros | 1989 |
Puberty decreases insulin sensitivity.
Topics: Adolescent; Blood Glucose; Body Height; Body Weight; Child; Dehydroepiandrosterone; Diabetes Mellitu | 1987 |