Page last updated: 2024-11-07

dehydroepiandrosterone and Asthma

dehydroepiandrosterone has been researched along with Asthma in 18 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"Dehydroepiandrosterone sulphate (DHEA-SO4) values were measured as a guide to adrenal function in 72 asthmatic patients admitted to the Waikato Hospital with severe bronchospasm."7.67Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study. ( Dunn, PJ; Jury, DR; Mahood, CB; Speed, JF, 1984)
"In this study, we evaluated the anti-inflammatory response and the mechanism by which dehydroepiandrosterone modulates immunity in ovalbumin-sensitized asthmatic mice."3.77Dehydroepiandrosterone suppresses eosinophil infiltration and airway hyperresponsiveness via modulation of chemokines and Th2 cytokines in ovalbumin-sensitized mice. ( Huang, WC; Liou, CJ, 2011)
"Dehydroepiandrosterone sulphate (DHEA-SO4) values were measured as a guide to adrenal function in 72 asthmatic patients admitted to the Waikato Hospital with severe bronchospasm."3.67Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study. ( Dunn, PJ; Jury, DR; Mahood, CB; Speed, JF, 1984)
"Female patients with "intrinsic" bronchial asthma without corticosteroid therapy for at least 3 months revealed low blood concentration of total protein-unbound + protein-bound) and free (biologically active, protein-unbound) cortisol, dehydroepiandrosterone and dehydroepiandrosterone sulphate, as also a low urinary excretion of dehydroepiandrosterone metabolites."3.66Adrenocortical function in bronchial asthma. ( Fehér, KG; Fehér, T; Koó, E, 1983)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19905 (27.78)18.7374
1990's4 (22.22)18.2507
2000's4 (22.22)29.6817
2010's5 (27.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Espinoza, J1
Montaño, LM1
Perusquía, M1
Bossé, Y1
Choi, IS3
Cui, Y3
Koh, YA3
Lee, HC1
Cho, YB2
Won, YH2
Lin, XH2
Omura, Y1
Henoch, A1
Shimotsuura, Y1
Duvvi, H1
Kawashima, H1
Ohki, M1
Kasperska-Zajac, A1
Eusebio, M1
Grzelewski, T1
Pietruczuk, M1
Lewandowska, B1
Stelmach, I1
Liou, CJ1
Huang, WC1
Fehér, KG1
Koó, E2
Fehér, T2
Dunn, PJ2
Mahood, CB2
Speed, JF2
Jury, DR1
Smith, BJ1
Buxton, JR1
Dickeson, J1
Heller, RF1
Weinstein, RE1
Lobocki, CA1
Gravett, S1
Hum, H1
Negrich, R1
Herbst, J1
Greenberg, D1
Pieper, DR1
Nogueira, JM1
Pinto, PL1
Loureiro, V1
Prates, S1
Gaspar, A1
Almeida, MM1
Pinto, JE1
Mileva, Zh1
Maleeva, A1
Khristov, G1
Reid, IR1
Ibbertson, HK1
France, JT1
Pybus, J1
Karalus, NC1
Fehér, GK1
Füst, G1

Reviews

3 reviews available for dehydroepiandrosterone and Asthma

ArticleYear
Endocrine regulation of airway contractility is overlooked.
    The Journal of endocrinology, 2014, Volume: 222, Issue:2

    Topics: Adaptation, Physiological; Adiponectin; Androgens; Animals; Asthma; Bronchodilator Agents; Dehydroep

2014
Asthma and dehydroepiandrosterone (DHEA): facts and hypotheses.
    Inflammation, 2010, Volume: 33, Issue:5

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Dehydroepiandrosterone; Drug Therapy, Combination; Glucocort

2010
The patents on glucocorticosteroids and selected new therapies for the management of asthma in children.
    Recent patents on inflammation & allergy drug discovery, 2011, Volume: 5, Issue:1

    Topics: Asthma; Chemokine CCL11; Child; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Drug Therapy

2011

Trials

1 trial available for dehydroepiandrosterone and Asthma

ArticleYear
[Experience with dehydroepiandrosterone therapy in intrinsic steroid-dependent bronchial asthma].
    Orvosi hetilap, 1987, Sep-20, Volume: 128, Issue:38

    Topics: Adrenal Cortex Hormones; Asthma; Clinical Trials as Topic; Dehydroepiandrosterone; Dose-Response Rel

1987

Other Studies

14 other studies available for dehydroepiandrosterone and Asthma

ArticleYear
Nongenomic bronchodilating action elicited by dehydroepiandrosterone (DHEA) in a guinea pig asthma model.
    The Journal of steroid biochemistry and molecular biology, 2013, Volume: 138

    Topics: Animals; Asthma; Bronchial Spasm; Dehydroepiandrosterone; Guinea Pigs; In Vitro Techniques; Male; Mu

2013
Effects of dehydroepiandrosterone on Th2 cytokine production in peripheral blood mononuclear cells from asthmatics.
    The Korean journal of internal medicine, 2008, Volume: 23, Issue:4

    Topics: Adjuvants, Immunologic; Adolescent; Adult; Asthma; Cell Culture Techniques; Cytokines; Dehydroepiand

2008
Effects of combined bacille Calmette-Guérin and dehydroepiandrosterone treatment on established asthma in mice.
    Experimental lung research, 2009, Volume: 35, Issue:3

    Topics: Animals; Asthma; Biological Therapy; Bronchoalveolar Lavage Fluid; Combined Modality Therapy; Dehydr

2009
Severe asthma with markedly increased asbestos of 2 types & TXB2, and markedly reduced acetylcholine, DHEA & drug uptake in parts of upper lungs, & similar abnormalities at respiratory & cardiac center of medulla oblongata: complete elimination of this as
    Acupuncture & electro-therapeutics research, 2009, Volume: 34, Issue:1-2

    Topics: Acetylcholine; Acupuncture Therapy; Aged; Asbestos; Asthma; Astragalus Plant; Dehydroepiandrosterone

2009
Dehydroepiandrosterone suppresses eosinophil infiltration and airway hyperresponsiveness via modulation of chemokines and Th2 cytokines in ovalbumin-sensitized mice.
    Journal of clinical immunology, 2011, Volume: 31, Issue:4

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Cells, Cultured; Chemokines; Cytokines

2011
Effects of combined BCG and DHEA treatment in preventing the development of asthma.
    Immunological investigations, 2008, Volume: 37, Issue:3

    Topics: Animals; Asthma; Bronchial Provocation Tests; Dehydroepiandrosterone; Female; Humans; Immunoglobulin

2008
Adrenocortical function in bronchial asthma.
    Acta medica Hungarica, 1983, Volume: 40, Issue:2-3

    Topics: Adolescent; Adrenal Cortex; Adult; Aged; Asthma; Carrier Proteins; Dehydroepiandrosterone; Female; H

1983
Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study.
    The New Zealand medical journal, 1984, Nov-28, Volume: 97, Issue:768

    Topics: Acute Disease; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aged; Asthma; Child; Dehydr

1984
Does beclomethasone dipropionate suppress dehydroepiandrosterone sulphate in postmenopausal women?
    Australian and New Zealand journal of medicine, 1994, Volume: 24, Issue:4

    Topics: Age Distribution; Aged; Asthma; Beclomethasone; Confounding Factors, Epidemiologic; Dehydroepiandros

1994
Decreased adrenal sex steroid levels in the absence of glucocorticoid suppression in postmenopausal asthmatic women.
    The Journal of allergy and clinical immunology, 1996, Volume: 97, Issue:1 Pt 1

    Topics: Adrenergic beta-Agonists; Aged; Asthma; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estr

1996
Soluble CD30, dehydroepiandrosterone sulfate and dehydroepiandrosterone in atopic and non atopic children.
    Allergie et immunologie, 1998, Volume: 30, Issue:1

    Topics: Adolescent; Animals; Asthma; Child; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female;

1998
[Androstenedione, DHEA sulfate, cortisol, aldosterone and testosterone in bronchial asthma patients].
    Vutreshni bolesti, 1990, Volume: 29, Issue:4

    Topics: Adrenal Cortex Hormones; Adult; Aldosterone; Androstenedione; Asthma; Chronic Disease; Circadian Rhy

1990
Plasma testosterone concentrations in asthmatic men treated with glucocorticoids.
    British medical journal (Clinical research ed.), 1985, Aug-31, Volume: 291, Issue:6495

    Topics: Adult; Aged; Asthma; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Follicle Stimulating Ho

1985
Adrenal function in acute severe asthma.
    The New Zealand medical journal, 1985, Oct-09, Volume: 98, Issue:788

    Topics: Acute Disease; Adolescent; Adrenal Cortex; Adrenal Cortex Function Tests; Adrenal Cortex Hormones; A

1985