dehydroepiandrosterone has been researched along with Anorexia Nervosa in 29 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Anorexia Nervosa: An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to determine the status of dehydroepiandrosterone (DHEA) in women with anorexia nervosa (AN) and to assess the efficacy of DHEA supplementation as a treatment for bone health in women with AN." | 9.22 | Dehydroepiandrosterone status and efficacy of dehydroepiandrosterone supplementation for bone health in anorexia nervosa: A systematic review and meta-analysis. ( Cheng, YC; Fan, KC; Huang, YC; Kao, TW; Lin, J; Liu, CW, 2022) |
| "We investigated the effects of the administration of dehydroepiandrosterone (DHEA) on weight, bone metabolism, bone density and clinical mood symptoms in outpatient Anorexia Nervosa (AN) patients." | 9.16 | Dehydroepiandrosterone treatment effects on weight, bone density, bone metabolism and mood in women suffering from anorexia nervosa-a pilot study. ( Bloch, M; Greenman, Y; Ish-Shalom, S; Klein, E; Latzer, Y, 2012) |
| "Allopregnanolone and dehydroepiendrosterone (DHEA) have been supposed to be involved in some psychiatric disorders including anorexia nervosa (AN)." | 9.12 | Impaired reduction of enhanced levels of dehydroepiandrosterone by oral dexamethasone in anorexia nervosa. ( Casarosa, E; Genazzani, AR; Longobardi, N; Luisi, M; Maj, M; Martiadis, V; Monteleone, P; Serritella, C, 2006) |
| "Young women with anorexia nervosa (AN) have subnormal levels of dehydroepiandrosterone (DHEA) and estrogen that may be mechanistically linked to the bone loss seen in this disease." | 9.10 | Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial. ( Becker, KA; Emans, SJ; Feldman, HA; Goodman, E; Gordon, CM; Grace, E; Gundberg, CM; LeBoff, MS; Rosen, CJ, 2002) |
| "Only scarce data exist concerning the relationship between dehydroepiandrosterone (DHEA) and/or its sulfate form DHEAS and bone status in adolescents with anorexia nervosa (AN)." | 7.78 | Dehydroepiandrosterone sulfate, osteoprotegerin and its soluble ligand sRANKL and bone metabolism in girls with anorexia nervosa. ( Ostrowska, Z; Oświęcimska, J; Swiętochowska, E; Wołkowska-Pokrywa, K; Ziora, K, 2012) |
| "The effects of epimestrol (5 mg every 6 hours for 5 days) on basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (Prl), estradiol, progesterone, and dehydroepiandrosterone sulfate, and on the response to LH-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) stimulation, were studied in 18 cases of secondary amenorrhea and oligomenorrhea of hypothalamic-pituitary origin, in three cases of anorexia nervosa, in two cases of long-lasting progestin-induced amenorrhea, and in one case of precocious menopause." | 7.66 | Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea. ( de Leo, V; Facchinetti, F; Franchi, F; Genazzani, AR; Kicovic, PM; Parrini, D; Picciolini, E, 1978) |
| "Adolescents with anorexia nervosa (AN) have decreased dehydroepiandrosterone (DHEA) and estrogen concentrations that may contribute to skeletal deficits." | 5.30 | Impact of Adrenal Hormone Supplementation on Bone Geometry in Growing Teens With Anorexia Nervosa. ( DiVasta, AD; Feldman, HA; Gordon, CM; Leonard, MB; Long, J; O'Donnell, JM, 2019) |
| "Young women with anorexia nervosa (AN) have reduced secretion of dehydroepiandrosterone (DHEA) and estrogen contributing to skeletal deficits." | 5.19 | Does hormone replacement normalize bone geometry in adolescents with anorexia nervosa? ( Beck, TJ; DiVasta, AD; Feldman, HA; Gordon, CM; LeBoff, MS, 2014) |
| "Anorexia nervosa (AN) is characterized by subnormal estrogen and dehydroepiandrosterone (DHEA) levels." | 5.16 | The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa. ( Divasta, AD; Feldman, HA; Giancaterino, C; Gordon, CM; Leboff, MS; Rosen, CJ, 2012) |
| "We investigated the effects of the administration of dehydroepiandrosterone (DHEA) on weight, bone metabolism, bone density and clinical mood symptoms in outpatient Anorexia Nervosa (AN) patients." | 5.16 | Dehydroepiandrosterone treatment effects on weight, bone density, bone metabolism and mood in women suffering from anorexia nervosa-a pilot study. ( Bloch, M; Greenman, Y; Ish-Shalom, S; Klein, E; Latzer, Y, 2012) |
| "Allopregnanolone and dehydroepiendrosterone (DHEA) have been supposed to be involved in some psychiatric disorders including anorexia nervosa (AN)." | 5.12 | Impaired reduction of enhanced levels of dehydroepiandrosterone by oral dexamethasone in anorexia nervosa. ( Casarosa, E; Genazzani, AR; Longobardi, N; Luisi, M; Maj, M; Martiadis, V; Monteleone, P; Serritella, C, 2006) |
| "Young women with anorexia nervosa (AN) have subnormal levels of dehydroepiandrosterone (DHEA) and estrogen that may be mechanistically linked to the bone loss seen in this disease." | 5.10 | Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial. ( Becker, KA; Emans, SJ; Feldman, HA; Goodman, E; Gordon, CM; Grace, E; Gundberg, CM; LeBoff, MS; Rosen, CJ, 2002) |
| "Although there is well-documented evidence for hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis function in anorexia nervosa (AN), there has been little research into secretory patterns of salivary cortisol and dehydroepiandrosterone (DHEA) in this condition." | 3.78 | Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa. ( Clow, A; Hucklebridge, F; Loveday, C; Oskis, A; Thorn, L, 2012) |
| "Nineteen female adolescent inpatients diagnosed with anorexia nervosa, restricting type (AN-R) and 16 non-eating disordered (ED) controls were assessed for plasma dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulphate (DHEA-S), and cortisol levels, and for eating-related and non-eating-related psychopathology." | 3.73 | Circulatory neurosteroid levels in underweight female adolescent anorexia nervosa inpatients and following weight restoration. ( Achiron, A; Feigin, M; Loewenthal, R; Maayan, R; Modan-Moses, D; Ram, A; Stein, D; Valevski, A; Weizman, A, 2005) |
| "Cortisol (F) and dehydroepiandrosterone (DHA) were measured following each 5 kg gain in weight in a group of 16 patients with anorexia nervosa admitted to hospital for refeeding." | 3.67 | Anorexia nervosa and the adrenal: the effect of weight gain. ( Russell, GF; Safieh, B; Treasure, J; Wheeler, MJ, 1985) |
| "The effects of epimestrol (5 mg every 6 hours for 5 days) on basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (Prl), estradiol, progesterone, and dehydroepiandrosterone sulfate, and on the response to LH-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) stimulation, were studied in 18 cases of secondary amenorrhea and oligomenorrhea of hypothalamic-pituitary origin, in three cases of anorexia nervosa, in two cases of long-lasting progestin-induced amenorrhea, and in one case of precocious menopause." | 3.66 | Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea. ( de Leo, V; Facchinetti, F; Franchi, F; Genazzani, AR; Kicovic, PM; Parrini, D; Picciolini, E, 1978) |
| "Seventeen of 19 patients presented delayed puberty, and in some, hypogonadism persisted after recovery from anorexia nervosa." | 1.27 | [Growth of anorexic adolescents]. ( Chaussain, JL; Job, JC; Kholy, ME, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (44.83) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, J | 1 |
| Kao, TW | 1 |
| Cheng, YC | 1 |
| Fan, KC | 1 |
| Huang, YC | 1 |
| Liu, CW | 1 |
| DiVasta, AD | 3 |
| Feldman, HA | 4 |
| O'Donnell, JM | 1 |
| Long, J | 1 |
| Leonard, MB | 1 |
| Gordon, CM | 5 |
| Beck, TJ | 1 |
| LeBoff, MS | 4 |
| Peixoto, C | 1 |
| Devicari Cheda, JN | 1 |
| Nardi, AE | 1 |
| Veras, AB | 1 |
| Cardoso, A | 1 |
| Lawson, EA | 1 |
| Misra, M | 1 |
| Meenaghan, E | 1 |
| Rosenblum, L | 1 |
| Donoho, DA | 1 |
| Herzog, D | 1 |
| Klibanski, A | 1 |
| Miller, KK | 1 |
| Giancaterino, C | 1 |
| Rosen, CJ | 2 |
| Oskis, A | 1 |
| Loveday, C | 1 |
| Hucklebridge, F | 1 |
| Thorn, L | 1 |
| Clow, A | 1 |
| Bloch, M | 1 |
| Ish-Shalom, S | 1 |
| Greenman, Y | 1 |
| Klein, E | 1 |
| Latzer, Y | 1 |
| Yamamotova, A | 1 |
| Kmoch, V | 1 |
| Papezova, H | 1 |
| Ostrowska, Z | 1 |
| Ziora, K | 1 |
| Oświęcimska, J | 1 |
| Swiętochowska, E | 1 |
| Wołkowska-Pokrywa, K | 1 |
| Grace, E | 2 |
| Emans, SJ | 2 |
| Goodman, E | 2 |
| Becker, KA | 1 |
| Gundberg, CM | 1 |
| Lanfranco, F | 1 |
| Gianotti, L | 1 |
| Picu, A | 1 |
| Fassino, S | 1 |
| Abbate Daga, G | 1 |
| Mondelli, V | 1 |
| Giordano, R | 1 |
| Grottoli, S | 1 |
| Ghigo, E | 1 |
| Arvat, E | 1 |
| Stein, D | 1 |
| Maayan, R | 1 |
| Ram, A | 1 |
| Loewenthal, R | 1 |
| Achiron, A | 1 |
| Modan-Moses, D | 1 |
| Feigin, M | 1 |
| Weizman, A | 1 |
| Valevski, A | 1 |
| Monteleone, P | 1 |
| Luisi, M | 1 |
| Martiadis, V | 1 |
| Serritella, C | 1 |
| Longobardi, N | 1 |
| Casarosa, E | 1 |
| Genazzani, AR | 2 |
| Maj, M | 1 |
| Jayasinghe, Y | 1 |
| Grover, SR | 1 |
| Zacharin, M | 1 |
| Zumoff, B | 1 |
| Walsh, BT | 1 |
| Katz, JL | 1 |
| Levin, J | 1 |
| Rosenfeld, RS | 1 |
| Kream, J | 1 |
| Weiner, H | 1 |
| Sirinathsinghji, DJ | 2 |
| Mills, IH | 2 |
| Kim, MH | 1 |
| Chang, FE | 1 |
| Crawford, MH | 1 |
| Facchinetti, F | 1 |
| de Leo, V | 1 |
| Picciolini, E | 1 |
| Franchi, F | 1 |
| Parrini, D | 1 |
| Kicovic, PM | 1 |
| Boyar, RM | 1 |
| Devesa, J | 1 |
| Pérez-Fernández, R | 1 |
| Bokser, L | 1 |
| Gaudiero, GJ | 1 |
| Lima, L | 1 |
| Casanueva, FF | 1 |
| Treasure, J | 1 |
| Wheeler, MJ | 1 |
| Safieh, B | 1 |
| Russell, GF | 2 |
| Kholy, ME | 1 |
| Job, JC | 1 |
| Chaussain, JL | 1 |
| Adams, JB | 1 |
| Winterer, J | 1 |
| Gwirtsman, HE | 1 |
| George, DT | 1 |
| Kaye, WH | 1 |
| Loriaux, DL | 1 |
| Cutler, GB | 1 |
| Bell, ET | 1 |
| Harkness, RA | 1 |
| Loraine, JA | 1 |
| Skutsch, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Adrenal and Gonadal Hormone Replacement in Young Women With Anorexia Nervosa[NCT00310791] | Phase 2/Phase 3 | 80 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00310791)
Timeframe: 18-Months
| Intervention | g/cm2 (Mean) |
|---|---|
| Placebo | 0.88 |
| Active | 0.89 |
5 reviews available for dehydroepiandrosterone and Anorexia Nervosa
| Article | Year |
|---|---|
Dehydroepiandrosterone status and efficacy of dehydroepiandrosterone supplementation for bone health in anorexia nervosa: A systematic review and meta-analysis.
Topics: Adolescent; Adult; Anorexia Nervosa; Bone Density; Dehydroepiandrosterone; Dietary Supplements; Fema | 2022 |
The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: a systematic review.
Topics: Adrenal Insufficiency; Anorexia Nervosa; Antidepressive Agents; Databases, Bibliographic; Dehydroepi | 2014 |
Current concepts in bone and reproductive health in adolescents with anorexia nervosa.
Topics: Adolescent; Anorexia Nervosa; Bone Density; Bone Density Conservation Agents; Bone Diseases; Bone Re | 2008 |
Control of the onset of puberty.
Topics: Adolescent; Adrenocorticotropic Hormone; Androstenedione; Anorexia Nervosa; Dehydroepiandrosterone; | 1978 |
Control of secretion and the function of C19-delta 5-steroids of the human adrenal gland.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; | 1985 |
7 trials available for dehydroepiandrosterone and Anorexia Nervosa
| Article | Year |
|---|---|
Impact of Adrenal Hormone Supplementation on Bone Geometry in Growing Teens With Anorexia Nervosa.
Topics: Absorptiometry, Photon; Adolescent; Anorexia Nervosa; Bone Density; Child; Dehydroepiandrosterone; D | 2019 |
Does hormone replacement normalize bone geometry in adolescents with anorexia nervosa?
Topics: Absorptiometry, Photon; Adolescent; Adult; Anorexia Nervosa; Bone Density; Contraceptives, Oral, Com | 2014 |
The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Composition; Bone and Bones; Bone Density; Contraceptives, | 2012 |
Dehydroepiandrosterone treatment effects on weight, bone density, bone metabolism and mood in women suffering from anorexia nervosa-a pilot study.
Topics: Adolescent; Adult; Affect; Anorexia Nervosa; Body Mass Index; Body Weight; Bone and Bones; Bone Dens | 2012 |
Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial.
Topics: Adipose Tissue; Adolescent; Adult; Alkaline Phosphatase; Anorexia Nervosa; Body Composition; Body Im | 2002 |
Impaired reduction of enhanced levels of dehydroepiandrosterone by oral dexamethasone in anorexia nervosa.
Topics: Adult; Analysis of Variance; Anorexia Nervosa; Body Weight; Dehydroepiandrosterone; Dexamethasone; F | 2006 |
Changes in bone turnover markers and menstrual function after short-term oral DHEA in young women with anorexia nervosa.
Topics: Administration, Oral; Adolescent; Adult; Alkaline Phosphatase; Androgens; Anorexia Nervosa; Biomarke | 1999 |
17 other studies available for dehydroepiandrosterone and Anorexia Nervosa
| Article | Year |
|---|---|
Adrenal glucocorticoid and androgen precursor dissociation in anorexia nervosa.
Topics: Adult; Anorexia Nervosa; Area Under Curve; Contraceptives, Oral; Cross-Sectional Studies; Dehydroepi | 2009 |
Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa.
Topics: Adolescent; Anorexia Nervosa; Circadian Rhythm; Dehydroepiandrosterone; Female; Humans; Hydrocortiso | 2012 |
Role of dehydroepiandrosterone and cortisol in nociceptive sensitivity to thermal pain in anorexia nervosa and healthy women.
Topics: Adult; Anorexia Nervosa; Case-Control Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfat | 2012 |
Dehydroepiandrosterone sulfate, osteoprotegerin and its soluble ligand sRANKL and bone metabolism in girls with anorexia nervosa.
Topics: Adolescent; Anorexia Nervosa; Biomarkers; Bone and Bones; Collagen Type I; Dehydroepiandrosterone; D | 2012 |
The adrenal sensitivity to ACTH stimulation is preserved in anorexia nervosa.
Topics: Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Anorexia Nervosa; Dehyd | 2004 |
Circulatory neurosteroid levels in underweight female adolescent anorexia nervosa inpatients and following weight restoration.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Mass Index; Dehydroepiandrosterone; Dehydroepiandrosterone | 2005 |
Subnormal plasma dehydroisoandrosterone to cortisol ratio in anorexia nervosa: a second hormonal parameter of ontogenic regression.
Topics: Adult; Anorexia Nervosa; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hyd | 1983 |
Effect of human pituitary luteinizing hormone administration on plasma levels of dehydroepiandrosterone, androstenediol and their sulphates and testosterone in women with secondary amenorrhoea.
Topics: Amenorrhea; Androgens; Androstenediol; Anorexia Nervosa; Chromatography, Gas; Dehydroepiandrosterone | 1983 |
Chronic anovulation.
Topics: Adrenocortical Hyperfunction; Amenorrhea; Anorexia Nervosa; Anovulation; Breast Neoplasms; Chronic D | 1984 |
Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea.
Topics: Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Dehydroepiandrosterone; Epimestrol; Estradiol; Estr | 1978 |
Adrenal androgen secretion and dopaminergic activity in anorexia nervosa.
Topics: Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgens; Androstenedione; Anorexia | 1988 |
Anorexia nervosa and the adrenal: the effect of weight gain.
Topics: Adolescent; Adrenal Cortex; Adult; Anorexia Nervosa; Body Weight; Dehydroepiandrosterone; Female; Hu | 1985 |
[Growth of anorexic adolescents].
Topics: Adolescent; Anorexia Nervosa; Child; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating | 1986 |
Adrenocorticotropin-stimulated adrenal androgen secretion in anorexia nervosa: impaired secretion at low weight with normalization after long-term weight recovery.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgens; Androstenedione; Anorexia Nervosa; Bo | 1985 |
Concentration patterns of plasma dehydroepiandrosterone, delta 5-androstenediol and their sulphates, testosterone and cortisol in normal healthy women and in women with anorexia nervosa.
Topics: Adult; Androstenediol; Androstenediols; Anorexia Nervosa; Circadian Rhythm; Dehydroepiandrosterone; | 1985 |
Hormone assay studies in patients with anorexia nervosa.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Animals; Anorexia Nervosa; Biological | 1966 |
Anorexia nervosa.
Topics: Adolescent; Adrenal Glands; Amenorrhea; Animals; Anorexia Nervosa; Dehydroepiandrosterone; Estriol; | 1971 |