dehydroepiandrosterone has been researched along with Alzheimer Disease in 63 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This paper reviews the scientific literature published between 1990 and 2000 investigating the effects of oestrogen, testosterone and dehydroepiandrosterone (DHEA) on depression and dementia." | 4.81 | Sex hormones and their impact on dementia and depression: a clinical perspective. ( Almeida, OP; Barclay, L, 2001) |
| "The (auto)immune theory of Alzheimer dementia is briefly outlined, pointing to the possible involvement of steroids in brain ageing, immunosenescence and neuronal apoptosis." | 2.46 | Neuroimmunomodulatory steroids in Alzheimer dementia. ( Bicíková, M; Hampl, R, 2010) |
| " We don't know the possible negative consequences of long-term administration of DHEA\\DHEAS on cardiovascular disease and hormone-dependent cancers." | 2.42 | [DHEA and aging]. ( Pitti-Ferrandi, H, 2003) |
| "Younger caregivers were prone to cognitive impairments similar to older caregivers, although the degree and the neuropsychological correlates of the cognitive dysfunctions were somewhat different between the two groups." | 1.43 | Age Effects on Cognitive and Physiological Parameters in Familial Caregivers of Alzheimer's Disease Patients. ( Argimon, II; Bromberg, E; Corrêa, MS; Ferrari, P; Giacobbo, BL; Lima, DB; Vedovelli, K; Walz, JC, 2016) |
| "These results suggest that memory deficits in AD may be improved by sominone independently of reducing amyloid plaques and neuroinflammation." | 1.37 | Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD. ( Joyashiki, E; Matsuya, Y; Tohda, C, 2011) |
| "Alzheimer's disease was produced in young female ovariectomized rats by intraperitoneal administration of AlCl(3) (4." | 1.37 | Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease. ( Ahmed, HH; Aly, HF; Metwally, FM, 2011) |
| "A neurodegenerative disease such as Alzheimer's disease (AD) is associated with significantly higher dehydroepiandrosterone (DHEA) levels in cerebrospinal fluid (CSF)." | 1.32 | Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics. ( Hampl, R; Hill, M; Jo, DH; Kim, SB; Kwak, YT; Morfin, R, 2003) |
| "Twenty-three consecutive patients with Alzheimer's disease and 23 age- and sex-matched healthy controls were studied by measuring plasma cortisol and dehydroepiandrosterone sulfate (DHEAS) (by enzyme immunoassay), the number of type I and type II corticosteroid receptors in mononuclear leukocytes (by radio-receptor-assay), and the lymphocyte subpopulations (by cytofluorimetry)." | 1.32 | Alzheimer's disease: pathophysiological implications of measurement of plasma cortisol, plasma dehydroepiandrosterone sulfate, and lymphocytic corticosteroid receptors. ( Armanini, D; Basso, A; Fiore, C; Karbowiak, I; Mattarello, MJ; Milone, FF; Sartorato, P; Simoncini, M; Vecchio, F, 2003) |
| "The early differential diagnosis of Alzheimer's disease (AD) remains still problematic." | 1.32 | Plasma levels of 7-hydroxylated dehydroepiandrosterone (DHEA) metabolites and selected amino-thiols as discriminatory tools of Alzheimer's disease and vascular dementia. ( Bicíková, M; Hampl, R; Havlíková, H; Hill, M; Jirák, R; Rípová, D; Tallová, J, 2004) |
| "Dehydroepiandrosterone (DHEA) is a steroid that circulates in abundance in the form of a sulfated reserve (DHEA-S)." | 1.31 | Dehydroepiandrosterone inhibits microglial nitric oxide production in a stimulus-specific manner. ( Barger, SW; Chavis, JA; Drew, PD, 2000) |
| "Patients were administered the Alzheimer's Disease Assessment Scale (ADAS) and Folstein Mini-Mental State Examination (MMSE) at approximately 6-month intervals." | 1.30 | Cognitive and noncognitive symptoms in dementia patients: relationship to cortisol and dehydroepiandrosterone. ( Kennedy, Q; Mauricio, M; Miller, TP; Rogerson, S; Schatzberg, A; Taylor, J; Tinklenberg, J; Yesavage, J, 1998) |
| "Dehydroepiandrosterone was significantly lowered in subjects of all ages." | 1.28 | Different regulation of adrenocorticotropin and cortisol secretion in young, mentally healthy elderly and patients with senile dementia of Alzheimer's type. ( Born, J; Dittmann, J; Dodt, C; Fehm, HL; Hruby, J; Schüttler, R; Späth-Schwalbe, E, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.76) | 18.7374 |
| 1990's | 22 (34.92) | 18.2507 |
| 2000's | 25 (39.68) | 29.6817 |
| 2010's | 12 (19.05) | 24.3611 |
| 2020's | 1 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Strac, DS | 1 |
| Konjevod, M | 1 |
| Perkovic, MN | 1 |
| Tudor, L | 1 |
| Erjavec, GN | 1 |
| Pivac, N | 1 |
| Jiménez-Rubio, G | 1 |
| Herrera-Pérez, JJ | 1 |
| Hernández-Hernández, OT | 1 |
| Martínez-Mota, L | 1 |
| Corrêa, MS | 2 |
| Vedovelli, K | 2 |
| Giacobbo, BL | 2 |
| de Souza, CE | 1 |
| Ferrari, P | 2 |
| de Lima Argimon, II | 1 |
| Walz, JC | 2 |
| Kapczinski, F | 1 |
| Bromberg, E | 2 |
| Sugimoto, K | 1 |
| Yajima, H | 1 |
| Hayashi, Y | 1 |
| Minato, D | 1 |
| Terasaki, S | 1 |
| Tohda, C | 3 |
| Matsuya, Y | 3 |
| Lima, DB | 1 |
| Argimon, II | 2 |
| Yamakawa, Y | 1 |
| Teshigawara, K | 1 |
| Yamada, M | 1 |
| Nemoto, H | 1 |
| Jeckel, CM | 1 |
| Lopes, RP | 1 |
| Berleze, MC | 1 |
| Luz, C | 1 |
| Feix, L | 1 |
| Stein, LM | 1 |
| Bauer, ME | 1 |
| Hampl, R | 3 |
| Bicíková, M | 2 |
| Pizza, V | 1 |
| Agresta, A | 1 |
| D'Acunto, CW | 1 |
| Festa, M | 1 |
| Capasso, A | 1 |
| Joyashiki, E | 1 |
| Rammouz, G | 1 |
| Lecanu, L | 1 |
| Aisen, P | 1 |
| Papadopoulos, V | 1 |
| Rasmuson, S | 1 |
| Näsman, B | 3 |
| Olsson, T | 3 |
| Aly, HF | 1 |
| Metwally, FM | 1 |
| Ahmed, HH | 1 |
| Xu, B | 1 |
| Yang, R | 1 |
| Chang, F | 1 |
| Chen, L | 2 |
| Xie, G | 1 |
| Sokabe, M | 1 |
| Weill-Engerer, S | 1 |
| David, JP | 1 |
| Sazdovitch, V | 1 |
| Liere, P | 1 |
| Schumacher, M | 1 |
| Delacourte, A | 1 |
| Baulieu, EE | 1 |
| Akwa, Y | 1 |
| Knopman, D | 1 |
| Henderson, VW | 1 |
| Wolkowitz, OM | 1 |
| Kramer, JH | 1 |
| Reus, VI | 1 |
| Costa, MM | 1 |
| Yaffe, K | 1 |
| Walton, P | 1 |
| Raskind, M | 1 |
| Peskind, E | 1 |
| Newhouse, P | 1 |
| Sack, D | 1 |
| De Souza, E | 1 |
| Sadowsky, C | 1 |
| Roberts, E | 1 |
| Kim, SB | 1 |
| Hill, M | 2 |
| Kwak, YT | 1 |
| Jo, DH | 1 |
| Morfin, R | 2 |
| Armanini, D | 1 |
| Vecchio, F | 1 |
| Basso, A | 1 |
| Milone, FF | 1 |
| Simoncini, M | 1 |
| Fiore, C | 1 |
| Mattarello, MJ | 1 |
| Sartorato, P | 1 |
| Karbowiak, I | 1 |
| Hoskin, EK | 1 |
| Tang, MX | 1 |
| Manly, JJ | 1 |
| Mayeux, R | 1 |
| Urani, A | 1 |
| Romieu, P | 1 |
| Roman, FJ | 1 |
| Yamada, K | 1 |
| Noda, Y | 1 |
| Kamei, H | 1 |
| Manh Tran, H | 1 |
| Nagai, T | 1 |
| Nabeshima, T | 1 |
| Maurice, T | 1 |
| Dudas, B | 1 |
| Hanin, I | 1 |
| Rose, M | 1 |
| Wülfert, E | 1 |
| Leblhuber, F | 3 |
| Haller, H | 1 |
| Steiner, K | 1 |
| Fuchs, D | 1 |
| Rípová, D | 1 |
| Jirák, R | 1 |
| Havlíková, H | 1 |
| Tallová, J | 1 |
| Solerte, SB | 1 |
| Ferrari, E | 2 |
| Cuzzoni, G | 1 |
| Locatelli, E | 1 |
| Giustina, A | 1 |
| Zamboni, M | 1 |
| Schifino, N | 1 |
| Rondanelli, M | 1 |
| Gazzaruso, C | 1 |
| Fioravanti, M | 1 |
| Pitti-Ferrandi, H | 1 |
| Cameron, DR | 1 |
| Braunstein, GD | 1 |
| Magri, F | 1 |
| Cravello, L | 1 |
| Barili, L | 1 |
| Sarra, S | 1 |
| Cinchetti, W | 1 |
| Salmoiraghi, F | 1 |
| Micale, G | 1 |
| Marx, CE | 2 |
| Trost, WT | 1 |
| Shampine, LJ | 2 |
| Stevens, RD | 1 |
| Hulette, CM | 2 |
| Steffens, DC | 2 |
| Ervin, JF | 2 |
| Butterfield, MI | 1 |
| Blazer, DG | 2 |
| Massing, MW | 2 |
| Lieberman, JA | 2 |
| Fuller, SJ | 1 |
| Tan, RS | 1 |
| Martins, RN | 1 |
| Naylor, JC | 1 |
| Payne, VM | 1 |
| Kilts, JD | 1 |
| Strauss, JL | 1 |
| Calhoun, PS | 1 |
| Calnaido, RP | 1 |
| Madison, RD | 1 |
| Neubauer, C | 2 |
| Peichl, M | 1 |
| Reisecker, F | 2 |
| Steinparz, FX | 1 |
| Windhager, E | 2 |
| Dienstl, E | 2 |
| Birkenhäger-Gillesse, EG | 1 |
| Derksen, J | 1 |
| Lagaay, AM | 1 |
| Adinoff, B | 1 |
| Martin, PR | 1 |
| Eckardt, MJ | 1 |
| Linnoila, M | 1 |
| Fagerlund, M | 1 |
| Eriksson, S | 2 |
| Viitanen, M | 2 |
| Carlström, K | 1 |
| Danenberg, HD | 2 |
| Ben-Yehuda, A | 1 |
| Yanase, T | 1 |
| Fukahori, M | 1 |
| Taniguchi, S | 1 |
| Nishi, Y | 1 |
| Sakai, Y | 1 |
| Takayanagi, R | 1 |
| Haji, M | 1 |
| Nawata, H | 1 |
| Haring, R | 1 |
| Fisher, A | 1 |
| Pittel, Z | 1 |
| Gurwitz, D | 1 |
| Heldman, E | 1 |
| Hashimoto, S | 1 |
| Katou, M | 1 |
| Dong, Y | 1 |
| Murakami, K | 1 |
| Terada, S | 1 |
| Inoue, M | 1 |
| Morrison, MF | 1 |
| Attal-Khémis, S | 1 |
| Dalmeyda, V | 1 |
| Michot, JL | 1 |
| Roudier, M | 1 |
| Herrington, DM | 1 |
| Miller, TP | 1 |
| Taylor, J | 1 |
| Rogerson, S | 1 |
| Mauricio, M | 1 |
| Kennedy, Q | 1 |
| Schatzberg, A | 1 |
| Tinklenberg, J | 1 |
| Yesavage, J | 1 |
| Bastianetto, S | 3 |
| Ramassamy, C | 2 |
| Poirier, J | 2 |
| Quirion, R | 3 |
| Nippoldt, TB | 1 |
| Nair, KS | 1 |
| Averill, D | 1 |
| Beffert, U | 1 |
| Theroux, L | 1 |
| Lussier-Cacan, S | 1 |
| Cohn, JS | 1 |
| Christen, Y | 1 |
| Davignon, J | 1 |
| Doré, S | 1 |
| Kar, S | 1 |
| Bernardi, F | 2 |
| Lanzone, A | 1 |
| Cento, RM | 1 |
| Spada, RS | 1 |
| Pezzani, I | 1 |
| Genazzani, AD | 1 |
| Luisi, S | 2 |
| Luisi, M | 2 |
| Petraglia, F | 2 |
| Genazzani, AR | 2 |
| Cyr, M | 1 |
| Calon, F | 1 |
| Morissette, M | 1 |
| Grandbois, M | 1 |
| Di Paolo, T | 1 |
| Callier, S | 1 |
| Barger, SW | 1 |
| Chavis, JA | 1 |
| Drew, PD | 1 |
| Almeida, OP | 1 |
| Barclay, L | 1 |
| Monteleone, P | 1 |
| Stomati, M | 1 |
| Cobellis, L | 1 |
| Casarosa, E | 1 |
| Masera, RG | 1 |
| Prolo, P | 1 |
| Sartori, ML | 1 |
| Staurenghi, A | 1 |
| Griot, G | 1 |
| Ravizza, L | 1 |
| Dovio, A | 1 |
| Chiappelli, F | 1 |
| Angeli, A | 1 |
| Weber, J | 1 |
| Schneider, LS | 1 |
| Hinsey, M | 1 |
| Lyness, S | 1 |
| Bäckström, T | 1 |
| Grankvist, K | 1 |
| Bucht, G | 1 |
| Dodt, C | 2 |
| Dittmann, J | 2 |
| Hruby, J | 1 |
| Späth-Schwalbe, E | 2 |
| Born, J | 1 |
| Schüttler, R | 2 |
| Fehm, HL | 2 |
| Sunderland, T | 1 |
| Merril, CR | 1 |
| Harrington, MG | 1 |
| Lawlor, BA | 1 |
| Molchan, SE | 1 |
| Martinez, R | 1 |
| Murphy, DL | 1 |
| Mohan, PF | 1 |
| Svec, F | 1 |
| Lopez, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biological Effects of DHEA in the Elderly[NCT00111930] | 144 participants | Interventional | 2000-08-31 | Completed | |||
| Early Mental Response to Hormonal Treatment in Transgender Men - The EMRE Study[NCT05649605] | 70 participants (Anticipated) | Interventional | 2023-03-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for dehydroepiandrosterone and Alzheimer Disease
| Article | Year |
|---|---|
Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans | 2020 |
Relationship between androgen deficiency and memory impairment in aging and Alzheimer’s disease.
Topics: Aged; Aging; Alzheimer Disease; Dehydroepiandrosterone; Humans; Memory Disorders; Testosterone | 2017 |
Neuroimmunomodulatory steroids in Alzheimer dementia.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Autoimmunity; Brain; Dehydroepiandrost | 2010 |
Neuroinflammation and ageing: current theories and an overview of the data.
Topics: Aging; Alzheimer Disease; Apoptosis; Atherosclerosis; Biological Evolution; Brain; Cellular Senescen | 2011 |
[DHEA and aging].
Topics: Adjuvants, Immunologic; Aged; Aging; Alzheimer Disease; Cognition Disorders; Dehydroepiandrosterone; | 2003 |
The use of dehydroepiandrosterone therapy in clinical practice.
Topics: Adrenal Insufficiency; Aging; Alzheimer Disease; Bone Density; Cardiovascular Diseases; Dehydroepian | 2005 |
Stress and dementia: the role of the hypothalamicpituitary-adrenal axis.
Topics: Adult; Aged; Aging; Alzheimer Disease; Case-Control Studies; Circadian Rhythm; Cognition Disorders; | 2006 |
Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions.
Topics: Aged; Aging; Alzheimer Disease; Androgens; Cognition Disorders; Dehydroepiandrosterone; Follicle Sti | 2007 |
[Physiologic importance of dehydroepiandrosterone].
Topics: Adult; Alzheimer Disease; Dehydroepiandrosterone; Female; HIV Infections; Humans; Lipoproteins; Male | 1996 |
Is there a case for DHEA replacement?
Topics: Adult; Aged; Aging; Alzheimer Disease; Animals; Arteriosclerosis; Bone Remodeling; Carbohydrate Meta | 1998 |
Drugs with estrogen-like potency and brain activity: potential therapeutic application for the CNS.
Topics: Alzheimer Disease; Animals; Brain; Dehydroepiandrosterone; Depression; Estrogens; Female; Humans; Ma | 2000 |
Sex hormones and their impact on dementia and depression: a clinical perspective.
Topics: Alzheimer Disease; Dehydroepiandrosterone; Depression; Estrogens; Gonadal Steroid Hormones; Humans; | 2001 |
Clinical implications of circulating neurosteroids.
Topics: Aging; Alzheimer Disease; Dehydroepiandrosterone; Female; Humans; Male; Menopause; Menstrual Cycle; | 2001 |
Plasma dehydroepiandrosterone sulfate in Alzheimer's disease.
Topics: Age Factors; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Dehydroepiandrosterone; Dehydroepia | 1992 |
3 trials available for dehydroepiandrosterone and Alzheimer Disease
| Article | Year |
|---|---|
DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study.
Topics: Aged; Akathisia, Drug-Induced; Alzheimer Disease; Cognition; Confusion; Dehydroepiandrosterone; Dehy | 2003 |
Age and sex differences of dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels in normal controls and Alzheimer's disease (AD).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Atrophy; Cerebral Cortex; Dehy | 1993 |
Plasma dehydroepiandrosterone sulfate in Alzheimer's disease.
Topics: Age Factors; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Dehydroepiandrosterone; Dehydroepia | 1992 |
47 other studies available for dehydroepiandrosterone and Alzheimer Disease
| Article | Year |
|---|---|
Psychophysiological correlates of cognitive deficits in family caregivers of patients with Alzheimer Disease.
Topics: Aged; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Caregivers; Cognition Disorders; Dehydro | 2015 |
Synthesis of Denosomin-Vitamin D3 Hybrids and Evaluation of Their Anti-Alzheimer's Disease Activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Cholecalciferol; Dehydroepiandrosterone; Mo | 2015 |
Age Effects on Cognitive and Physiological Parameters in Familial Caregivers of Alzheimer's Disease Patients.
Topics: Adult; Age Factors; Aged; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Caregivers; Case-Con | 2016 |
Synthesis of sominone and its derivatives based on an RCM strategy: discovery of a novel anti-Alzheimer's disease medicine candidate "denosomin".
Topics: Alzheimer Disease; Dehydroepiandrosterone; Drug Design; Molecular Structure | 2009 |
Neuroendocrine and immunological correlates of chronic stress in 'strictly healthy' populations.
Topics: Aged; Alzheimer Disease; Anxiety Disorders; Caregivers; Cell Count; Cell Proliferation; Cohort Studi | 2010 |
Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD.
Topics: Alzheimer Disease; Animals; Axons; Cell Count; Cells, Cultured; Cerebral Cortex; Dehydroepiandroster | 2011 |
A lead study on oxidative stress-mediated dehydroepiandrosterone formation in serum: the biochemical basis for a diagnosis of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Case-Control Studies; Cognition Di | 2011 |
Increased serum levels of dehydroepiandrosterone (DHEA) and interleukin-6 (IL-6) in women with mild to moderate Alzheimer's disease.
Topics: Adrenocorticotropic Hormone; Aged; Alzheimer Disease; Case-Control Studies; Circadian Rhythm; Dehydr | 2011 |
Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease.
Topics: Acetylcholine; Acetylcholinesterase; Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Anima | 2011 |
Neurosteroid PREGS protects neurite growth and survival of newborn neurons in the hippocampal dentate gyrus of APPswe/PS1dE9 mice.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Dehydroepiandrosterone; Dentate Gyrus; Disease Models, | 2012 |
In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients.
Topics: 17-Hydroxysteroid Dehydrogenases; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Androstenediol; | 2003 |
DHEA for Alzheimer's disease: a modest showing by a superhormone.
Topics: Alzheimer Disease; Dehydroepiandrosterone; Double-Blind Method; Humans; Patient Dropouts; Patient Se | 2003 |
Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Dehydroepiandroste | 2003 |
Alzheimer's disease: pathophysiological implications of measurement of plasma cortisol, plasma dehydroepiandrosterone sulfate, and lymphocytic corticosteroid receptors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Dehydroepiandrosterone; Female; Fl | 2003 |
Elevated sex-hormone binding globulin in elderly women with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Analysis of Variance; Apolipoprotein E4; Apolipop | 2004 |
Enhanced antidepressant efficacy of sigma1 receptor agonists in rats after chronic intracerebroventricular infusion of beta-amyloid-(1-40) protein.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Brain; Cinnamates; Conditi | 2004 |
Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aziridines; Cell Death; Choline; Choline O-Acetyl | 2004 |
DHEA treatment of Alzheimer's disease: A randomized, double-blind, placebo-controlled trial.
Topics: Age Factors; Aged; Aging; Alzheimer Disease; Dehydroepiandrosterone; Double-Blind Method; Female; Hi | 2004 |
Plasma levels of 7-hydroxylated dehydroepiandrosterone (DHEA) metabolites and selected amino-thiols as discriminatory tools of Alzheimer's disease and vascular dementia.
Topics: 17-alpha-Hydroxypregnenolone; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Chromatography | 2004 |
Decreased release of the angiogenic peptide vascular endothelial growth factor in Alzheimer's disease: recovering effect with insulin and DHEA sulfate.
Topics: Adult; Age Factors; Aged; Alzheimer Disease; Amyloid beta-Peptides; Angiogenic Proteins; Brain; Cell | 2005 |
Dehydroepiandrosterone (DHEA).
Topics: Adjuvants, Immunologic; Adolescent; Adrenal Insufficiency; Adult; Aging; Alzheimer Disease; Dehydroe | 2005 |
The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; D | 2006 |
Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dehydroepiandrosterone; Humans; Pregnenolone; Temporal L | 2008 |
Dehydroepiandrosterone sulphate (DHEAS) in the oldest old, aged 85 and over.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dehydroepiandrosterone; Dehydroepiandrosterone Su | 1994 |
Role of DHEA and DHEA-S in Alzheimer's disease.
Topics: Age Factors; Alcohol Amnestic Disorder; Alzheimer Disease; Dehydroepiandrosterone; Dehydroepiandrost | 1993 |
Blunted adrenocorticotropin and increased adrenal steroid response to human corticotropin-releasing hormone in Alzheimer's disease.
Topics: Adrenocorticotropic Hormone; Aged; Aged, 80 and over; Alzheimer Disease; Androstenedione; Corticotro | 1996 |
Serum dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) in Alzheimer's disease and in cerebrovascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Disorders; Dehydroepiandrosterone; Dehyd | 1996 |
Dehydroepiandrosterone (DHEA) increases production and release of Alzheimer's amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Count; Dehydroepiandrosterone; Dose | 1996 |
Effects of hormone replacement therapy on serum amyloid P component in postmenopausal women.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Arteriosclerosis; Biomarkers; | 1997 |
Androgens in the elderly: will androgen replacement therapy improve mood, cognition, and quality of life in aging men and women.
Topics: Affect; Aged; Alzheimer Disease; Androgens; Cognition; Dehydroepiandrosterone; Depression; Female; G | 1997 |
Increased total 7 alpha-hydroxy-dehydroepiandrosterone in serum of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dehydroepiandrosterone; Female; Gas Chromatography-Mass | 1998 |
DHEA: a biologic conundrum.
Topics: Aging; Alzheimer Disease; Cardiovascular Diseases; Dehydroepiandrosterone; Erectile Dysfunction; Fem | 1998 |
Cognitive and noncognitive symptoms in dementia patients: relationship to cortisol and dehydroepiandrosterone.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Behavioral Symptoms; Biomarkers; Dehydroepiandrosterone; | 1998 |
Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage.
Topics: Adjuvants, Immunologic; Aged; Aging; Alzheimer Disease; Animals; Cells, Cultured; Dehydroepiandroste | 1999 |
Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype.
Topics: Aged; Alzheimer Disease; Antioxidants; Apolipoproteins E; Brain; Dehydroepiandrosterone; Female; Fla | 1999 |
Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons.
Topics: Adjuvants, Immunologic; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cul | 1999 |
Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer's disease and vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Area Under Curve; Case-Control Studies; Corticotropin-Re | 2000 |
Dehydroepiandrosterone inhibits microglial nitric oxide production in a stimulus-specific manner.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Cells, Cultured; Dehydroepiandrosterone; Dehydroepiand | 2000 |
Mental deterioration correlates with response of natural killer (NK) cell activity to physiological modifiers in patients with short history of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cytokines; Cytotoxicity, Immunologic; Dehydroepiandrosterone; Disease Progr | 2002 |
Antiglucocorticoid effects of DHEA-S in Alzheimer's disease.
Topics: Adolescent; Adult; Age Factors; Aged; Alzheimer Disease; Dehydroepiandrosterone; Dehydroepiandroster | 1992 |
Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood-Brain Barrier; Dehydroepiandrosterone; Dehydroepia | 1991 |
Different regulation of adrenocorticotropin and cortisol secretion in young, mentally healthy elderly and patients with senile dementia of Alzheimer's type.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Corticotropin-Releas | 1991 |
Dehydroepiandrosterone sulphate in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hyd | 1990 |
Dehydroepiandrosterone sulphate in Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Dehydroepiandrosterone; Dehydr | 1990 |
Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease.
Topics: Age Factors; Aged; Alzheimer Disease; Dehydroepiandrosterone; Evaluation Studies as Topic; Female; H | 1989 |
Dehydroepiandrosterone and Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Dehydroepiandrosterone; Humans; Liver | 1989 |
Antiglucocorticoid actions of dehydroepiandrosterone and low concentrations in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dehydroepiandrosterone; Female; Humans; Hydrocort | 1989 |