dehydroepiandrosterone has been researched along with Alloxan Diabetes in 33 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus." | 7.80 | Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats. ( Fujita, S; Iemitsu, M; Sato, K, 2014) |
| "Two metabolites of the adrenal steroid dehydroepiandrosterone (DHEA), 3 alpha-hydroxyetiocholanolone and 3 beta-hydroxyetiocholanolone, were found to have antiobesity properties with respect to both prevention of the development of obesity as well as weight reduction after obesity was established." | 7.67 | Antiobesity effects of etiocholanolones in diabetes (db), viable yellow (Avy), and normal mice. ( Coleman, DL, 1985) |
| "Acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus." | 3.80 | Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats. ( Fujita, S; Iemitsu, M; Sato, K, 2014) |
| "Two metabolites of the adrenal steroid dehydroepiandrosterone (DHEA), 3 alpha-hydroxyetiocholanolone and 3 beta-hydroxyetiocholanolone, were found to have antiobesity properties with respect to both prevention of the development of obesity as well as weight reduction after obesity was established." | 3.67 | Antiobesity effects of etiocholanolones in diabetes (db), viable yellow (Avy), and normal mice. ( Coleman, DL, 1985) |
| "Early diabetic retinopathy is characterized by a loss of pericytes and vascular endothelial cells, a breakdown of the blood-retinal barrier, vascular dysfunction and vascular-neuroinflammation." | 1.43 | MicroRNA-126 contributes to Niaspan treatment induced vascular restoration after diabetic retinopathy. ( Wang, Y; Yan, H, 2016) |
| "Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions in humans and rodents, but its effects on renal tissue have not yet been fully understood." | 1.37 | The effect of dehydroepiandrosterone (DHEA) on renal function and metabolism in diabetic rats. ( Araújo, AS; Belló-Klein, A; da Rocha Janner, D; Gomes, LF; Jacob, MH; Jahn, MP; Kucharski, LC; Ribeiro, MF, 2011) |
| "Neuropathy and encephalopathy represent important complications of diabetes." | 1.36 | Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats. ( Caruso, D; Garcia-Segura, LM; Giatti, S; Maschi, O; Melcangi, RC; Pesaresi, M, 2010) |
| "Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions." | 1.36 | The effect of long-term DHEA treatment on glucose metabolism, hydrogen peroxide and thioredoxin levels in the skeletal muscle of diabetic rats. ( Araújo, AS; Belló-Klein, A; Duarte, R; Gomes, LF; Jacob, MH; Jahn, MP; Kucharski, LC; Ribeiro, MF, 2010) |
| "Dehydroepiandrosterone has been reported to possess antioxidant properties." | 1.32 | Oxidative stress impairs skeletal muscle repair in diabetic rats. ( Aragno, M; Boccuzzi, G; Brignardello, E; Catalano, MG; Danni, O; Mastrocola, R, 2004) |
| "Dehydroepiandrosterone (DHEA) has been reported to possess antioxidant properties." | 1.31 | Oxidative derangement in rat synaptosomes induced by hyperglycaemia: restorative effect of dehydroepiandrosterone treatment. ( Aragno, M; Boccuzzi, G; Brignardello, E; Danni, O; Manti, R; Parola, S; Tamagno, E, 2000) |
| "Dehydroepiandrosterone-treatment (4 mg/day for 3 weeks) protected tissues against lipid peroxidation: liver, kidney and brain homogenates from dehydroepiandrosterone-treated animals showed a significant decrease of both thiobarbituric acid reactive substances and fluorescent chromolipids formation." | 1.30 | Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress. ( Aragno, M; Boccuzzi, G; Brignardello, E; Danni, O; Gatto, V; Parola, S; Tamagno, E, 1999) |
| "Dehydroepiandrosterone treatment also produced a 25-fold elevation in plasma testosterone levels and a significant increase in seminal vesicle weights, whereas treatment with 16 alpha-fluoro-5-androsten-17-one had no apparent effect on the weight of the seminal vesicle glands." | 1.29 | Antihyperglycemic effect of dehydroepiandrosterone analogue 16 alpha-fluoro-5-androsten-17-one in diabetic mice. ( Pashko, LL; Schwartz, AG, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (24.24) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 12 (36.36) | 29.6817 |
| 2010's | 8 (24.24) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Ibán-Arias, R | 1 |
| Lisa, S | 1 |
| Poulaki, S | 1 |
| Mastrodimou, N | 1 |
| Charalampopoulos, I | 1 |
| Gravanis, A | 1 |
| Thermos, K | 1 |
| Kiersztan, A | 1 |
| Gaanga, K | 1 |
| Witecka, A | 1 |
| Jagielski, AK | 1 |
| Mukohara, S | 1 |
| Mifune, Y | 1 |
| Inui, A | 1 |
| Nishimoto, H | 1 |
| Kurosawa, T | 1 |
| Yamaura, K | 1 |
| Yoshikawa, T | 1 |
| Kuroda, R | 1 |
| Sato, K | 3 |
| Fujita, S | 2 |
| Iemitsu, M | 3 |
| Wang, Y | 1 |
| Yan, H | 1 |
| Pesaresi, M | 2 |
| Maschi, O | 1 |
| Giatti, S | 2 |
| Garcia-Segura, LM | 2 |
| Caruso, D | 2 |
| Melcangi, RC | 2 |
| Aragno, M | 10 |
| Meineri, G | 1 |
| Vercellinatto, I | 3 |
| Bardini, P | 2 |
| Raimondo, S | 1 |
| Peiretti, PG | 1 |
| Vercelli, A | 1 |
| Alloatti, G | 2 |
| Tomasinelli, CE | 2 |
| Danni, O | 9 |
| Boccuzzi, G | 10 |
| Aizawa, K | 1 |
| Ajisaka, R | 1 |
| Jahn, MP | 2 |
| Jacob, MH | 2 |
| Gomes, LF | 2 |
| Duarte, R | 1 |
| Araújo, AS | 2 |
| Belló-Klein, A | 2 |
| Ribeiro, MF | 2 |
| Kucharski, LC | 2 |
| da Rocha Janner, D | 1 |
| Cavaletti, G | 1 |
| Abbiati, F | 1 |
| Calabrese, D | 1 |
| Lombardi, R | 1 |
| Bianchi, R | 1 |
| Lauria, G | 1 |
| Mastrocola, R | 5 |
| Brignardello, E | 6 |
| Catalano, M | 1 |
| Robino, G | 1 |
| Manti, R | 4 |
| Parola, M | 1 |
| Yorek, MA | 1 |
| Coppey, LJ | 1 |
| Gellett, JS | 1 |
| Davidson, EP | 1 |
| Bing, X | 1 |
| Lund, DD | 1 |
| Dillon, JS | 1 |
| Yamada, Y | 1 |
| Nakajima, A | 1 |
| Sekihara, H | 1 |
| Catalano, MG | 3 |
| Medana, C | 1 |
| Geuna, S | 1 |
| Reffo, P | 1 |
| Penna, F | 1 |
| Baccino, FM | 1 |
| Costelli, P | 1 |
| Leaming, AB | 1 |
| Mathur, RS | 1 |
| Levine, JH | 1 |
| Coleman, DL | 4 |
| Leiter, EH | 3 |
| Schwizer, RW | 1 |
| Applezweig, N | 1 |
| Pashko, LL | 1 |
| Schwartz, AG | 1 |
| Ladriere, L | 1 |
| Laghmich, A | 1 |
| Malaisse-Lagae, F | 1 |
| Malaisse, WJ | 1 |
| Tamagno, E | 4 |
| Gatto, V | 1 |
| Parola, S | 4 |
| Mauro, A | 1 |
| Betteto, S | 1 |
| Higuchi, N | 1 |
| Sasaki, M | 1 |
| Arai, T | 1 |
| Oki, Y | 1 |
| Shimomura, Y | 1 |
| Bray, GA | 1 |
| Lee, M | 1 |
| Beamer, WG | 1 |
| Longcope, C | 1 |
| Gordon, GB | 1 |
| Shantz, LM | 1 |
| Talalay, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of DHEA on Skin Aging - Placebo-Controlled and Randomized Phase III Study in Postmenopausal Women.[NCT00248989] | Phase 3 | 150 participants (Actual) | Interventional | 2004-11-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for dehydroepiandrosterone and Alloxan Diabetes
| Article | Year |
|---|---|
Modulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone.
Topics: Adipose Tissue; Animals; Body Weight; Cell Differentiation; Cell Division; Dehydroepiandrosterone; D | 1987 |
32 other studies available for dehydroepiandrosterone and Alloxan Diabetes
| Article | Year |
|---|---|
Effect of topical administration of the microneurotrophin BNN27 in the diabetic rat retina.
Topics: Administration, Topical; Animals; Blotting, Western; Dehydroepiandrosterone; Diabetes Mellitus, Expe | 2019 |
DHEA-pretreatment attenuates oxidative stress in kidney-cortex and liver of diabetic rabbits and delays development of the disease.
Topics: Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Kidney Cortex; Liver; Male; Oxidat | 2021 |
In vitro and in vivo tenocyte-protective effectiveness of dehydroepiandrosterone against high glucose-induced oxidative stress.
Topics: Animals; Cells, Cultured; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Glucose; Oxidativ | 2021 |
Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats.
Topics: Animals; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2014 |
MicroRNA-126 contributes to Niaspan treatment induced vascular restoration after diabetic retinopathy.
Topics: Angiogenesis Inducing Agents; Angiogenic Proteins; Animals; Apoptosis; Ascorbic Acid; Blood Glucose; | 2016 |
Dioscorea esculenta-induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model.
Topics: Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dioscor | 2017 |
Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats.
Topics: Animals; Brain; Brain Diseases; Case-Control Studies; Dehydroepiandrosterone; Diabetes Mellitus, Exp | 2010 |
Cardiac impairment in rabbits fed a high-fat diet is counteracted by dehydroepiandrosterone supplementation.
Topics: Animals; Blotting, Western; Body Weight; Cell Nucleus; Chromatography, High Pressure Liquid; Cytosol | 2009 |
DHEA improves impaired activation of Akt and PKC zeta/lambda-GLUT4 pathway in skeletal muscle and improves hyperglycaemia in streptozotocin-induced diabetes rats.
Topics: Adjuvants, Immunologic; Animals; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Experimen | 2009 |
The effect of long-term DHEA treatment on glucose metabolism, hydrogen peroxide and thioredoxin levels in the skeletal muscle of diabetic rats.
Topics: Animals; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Glucose; Hydrogen P | 2010 |
The effect of dehydroepiandrosterone (DHEA) on renal function and metabolism in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Creatinine; Dehydroepiandrosterone; Diabetes Mellitus, Experime | 2011 |
Sex-dimorphic effects of dehydroepiandrosterone in diabetic neuropathy.
Topics: Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Female; Mal | 2011 |
Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats.
Topics: Aldehydes; Animals; Antioxidants; Binding Sites; Biomarkers; Blotting, Western; Cell Nucleus; Dehydr | 2002 |
Effect of treatment of diabetic rats with dehydroepiandrosterone on vascular and neural function.
Topics: Adjuvants, Immunologic; Animals; Arterioles; Blood Glucose; Body Weight; Dehydroepiandrosterone; Dia | 2002 |
Supplement. Anti-apoptotic effect of dehydroepiandrosterone and its role in an aging society.
Topics: Animals; Apoptosis; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Dietary Supplements; Fr | 2004 |
Oxidative stress impairs skeletal muscle repair in diabetic rats.
Topics: Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Male; Muscle, Skeletal; Oxidative | 2004 |
Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes.
Topics: Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; | 2006 |
Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats.
Topics: Animals; Connective Tissue Growth Factor; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; D | 2008 |
Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress.
Topics: Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; DNA; Male; Muscular Atrophy; MyoD | 2008 |
Increased plasma testosterone in streptozotocin-diabetic female rats.
Topics: 3-O-Methylglucose; Adrenalectomy; Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; | 1982 |
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.
Topics: Animals; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Female; Male; Mice; | 1982 |
Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db).
Topics: Androsterone; Animals; Blood Glucose; Body Weight; Dehydroepiandrosterone; Dehydroepiandrosterone Su | 1984 |
Antihyperglycemic effect of dehydroepiandrosterone analogue 16 alpha-fluoro-5-androsten-17-one in diabetic mice.
Topics: Androstenes; Animals; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Hypoglycemic Agents; | 1993 |
Effect of dehydroepiandrosterone in hereditarily diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Diet; | 1997 |
Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress.
Topics: Animals; Antioxidants; Brain; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; Drug Evaluati | 1999 |
Oxidative derangement in rat synaptosomes induced by hyperglycaemia: restorative effect of dehydroepiandrosterone treatment.
Topics: Animals; Antioxidants; Axons; Cell Membrane; Dehydroepiandrosterone; Diabetes Mellitus, Experimental | 2000 |
Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.
Topics: Animals; Antioxidants; Brain Ischemia; Cell Membrane; Dehydroepiandrosterone; Diabetes Mellitus, Exp | 2000 |
Oxidative stress and eicosanoids in the kidneys of hyperglycemic rats treated with dehydroepiandrosterone.
Topics: Animals; Antioxidants; Arachidonic Acids; Dehydroepiandrosterone; Diabetes Mellitus, Experimental; D | 2001 |
[Effect of androgen on the onset of diabetes in the KK mice treated with monosodium aspartate].
Topics: Age Factors; Androgens; Animals; Aspartic Acid; Blood Glucose; Castration; Dehydroepiandrosterone; D | 1989 |
Antiobesity effects of etiocholanolones in diabetes (db), viable yellow (Avy), and normal mice.
Topics: Animals; Blood Glucose; Body Weight; Dehydroepiandrosterone; Diabetes Mellitus; Diabetes Mellitus, E | 1985 |
Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice.
Topics: Adrenal Glands; Adrenalectomy; Animals; Body Weight; Cortisone; Dehydroepiandrosterone; Desoxycortic | 1987 |
Androgenic and estrogenic metabolites in serum of mice fed dehydroepiandrosterone: relationship to antihyperglycemic effects.
Topics: Androgens; Animals; Biotransformation; Blood Glucose; Body Weight; Castration; Dehydroepiandrosteron | 1987 |