dehydroepiandrosterone has been researched along with Allergic Encephalomyelitis in 6 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental allergic encephalomyelitis (EAE) is a Th1-mediated inflammatory demyelinating disease in the CNS, an animal model of multiple sclerosis." | 5.31 | Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice. ( Du, C; Khalil, MW; Sriram, S, 2001) |
| "Experimental autoimmune encephalomyelitis was induced in C57/BL6 mice." | 1.40 | HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental optic neuritis. ( Ahlem, C; Dine, K; Khan, RS; Luna, E; Shindler, KS, 2014) |
| " HE3286 is orally bioavailable and treats established disease in models of ulcerative colitis, collagen-induced arthritis, and collagen antibody-induced arthritis, reducing clinical signs of disease and proinflammatory signals, including IL-6 and matrix metallopeptidase 3." | 1.35 | HE3286: a novel synthetic steroid as an oral treatment for autoimmune disease. ( Ahlem, C; Auci, D; Frincke, J; Mangano, K; Nicoletti, F; Reading, C; Stickney, D, 2009) |
| "Experimental allergic encephalomyelitis (EAE), a Th1 polarized demyelinating disease of the central nervous system (CNS), shares many pathological and clinical similarities with multiple sclerosis (MS), and thus represents an attractive animal model for this disease." | 1.31 | A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing-remitting EAE. ( Auci, DL; Drought, H; Matejuk, A; Morgan, EE; Offner, H; Reading, CL; Vandenbark, AA; Zamora, A, 2002) |
| "Experimental allergic encephalomyelitis (EAE) is a Th1-mediated inflammatory demyelinating disease in the CNS, an animal model of multiple sclerosis." | 1.31 | Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice. ( Du, C; Khalil, MW; Sriram, S, 2001) |
| "Dehydroepiandrosterone (DHEA) is a native neurosteroid with immunomodulating activity." | 1.30 | Dehydroepiandrosterone selectively inhibits production of tumor necrosis factor alpha and interleukin-6 [correction of interlukin-6] in astrocytes. ( Brenner, T; Danenberg, HD; Galilly, R; Kipper-Galperin, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boghozian, R | 1 |
| McKenzie, BA | 1 |
| Saito, LB | 1 |
| Mehta, N | 1 |
| Branton, WG | 1 |
| Lu, J | 1 |
| Baker, GB | 1 |
| Noorbakhsh, F | 1 |
| Power, C | 1 |
| Khan, RS | 1 |
| Dine, K | 1 |
| Luna, E | 1 |
| Ahlem, C | 2 |
| Shindler, KS | 1 |
| Auci, D | 1 |
| Mangano, K | 1 |
| Reading, C | 1 |
| Frincke, J | 1 |
| Stickney, D | 1 |
| Nicoletti, F | 1 |
| Offner, H | 1 |
| Zamora, A | 1 |
| Drought, H | 1 |
| Matejuk, A | 1 |
| Auci, DL | 1 |
| Morgan, EE | 1 |
| Vandenbark, AA | 1 |
| Reading, CL | 1 |
| Kipper-Galperin, M | 1 |
| Galilly, R | 1 |
| Danenberg, HD | 1 |
| Brenner, T | 1 |
| Du, C | 1 |
| Khalil, MW | 1 |
| Sriram, S | 1 |
6 other studies available for dehydroepiandrosterone and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Suppressed oligodendrocyte steroidogenesis in multiple sclerosis: Implications for regulation of neuroinflammation.
Topics: Animals; Astrocytes; Case-Control Studies; Cells, Cultured; Central Nervous System; Cytokines; Dehyd | 2017 |
HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental optic neuritis.
Topics: Animals; Anti-Inflammatory Agents; Axons; Dehydroepiandrosterone; Disease Models, Animal; Encephalom | 2014 |
HE3286: a novel synthetic steroid as an oral treatment for autoimmune disease.
Topics: Administration, Oral; Androstenols; Animals; Autoimmune Diseases; Clinical Trials as Topic; Colitis, | 2009 |
A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing-remitting EAE.
Topics: Androstenes; Androstenols; Animals; CD4-Positive T-Lymphocytes; Cell Division; Dehydroepiandrosteron | 2002 |
Dehydroepiandrosterone selectively inhibits production of tumor necrosis factor alpha and interleukin-6 [correction of interlukin-6] in astrocytes.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Astrocytes; Cells, Cultured; Corticostero | 1999 |
Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Cell Nucleus; Cells, Cultured; De | 2001 |