Page last updated: 2024-11-07

dehydroepiandrosterone and Aggression

dehydroepiandrosterone has been researched along with Aggression in 50 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"Dehydroepiandrosterone (DHEA) is a testosterone/oestrogen precursor and known modulator of vertebrate aggression."7.83Dehydroepiandrosterone Heightens Aggression and Increases Androgen Receptor and Aromatase mRNA Expression in the Brain of a Male Songbird. ( Champion, TL; Davis, JE; Jones, LJ; Khalaj, S; Meddle, SL; Wacker, DW; Wingfield, JC, 2016)
"Dehydroepiandrosterone (DHEA) is a major circulating neurosteroid in humans and its administration has demonstrated efficacy in the improvement of mood, with increased energy, interest, confidence and activity levels."5.32Increased circulatory dehydroepiandrosterone and dehydroepiandrosterone-sulphate in first-episode schizophrenia: relationship to gender, aggression and symptomatology. ( Goredetsky, L; Kotler, M; Lapidus, R; Maayan, R; Strous, RD; Weizman, A; Zeldich, E, 2004)
" To determine the influence of endogenous androgens on annual timing of hibernation we first measured circulating levels of T and dehydroepiandrosterone (DHEA), an adrenal androgen implicated in non-mating season aggression in other species, in free-living male arctic ground squirrels (Urocitellus parryii, AGS)."3.85The influence of androgens on hibernation phenology of free-living male arctic ground squirrels. ( Barnes, BM; Buck, CL; Fenn, AM; O'Reilly, KM; Richter, MM, 2017)
" The pro-hormone dehydroepiandrosterone (DHEA) is elevated in song sparrow plasma and brain during the non-breeding season and may be locally converted to sex steroids in the brain to regulate aggression."3.76Aggressive interactions rapidly increase androgen synthesis in the brain during the non-breeding season. ( Newman, AE; Pradhan, DS; Schlinger, BA; Soma, KK; Wacker, DW; Wingfield, JC, 2010)
"This study explores the potential relationship between social behavior (aggression, dominance, and affiliation) and testosterone, androstenedione, and DHEA measurements in 5-year-old children while also analyzing the moderating effect of IQ on the hormone-behavior relationship."3.73Aggression, dominance, and affiliation: Their relationships with androgen levels and intelligence in 5-year-old children. ( Azurmendi, A; Braza, F; Braza, P; García, A; Muñoz, JM; Sánchez-Martín, JR, 2006)
"Dehydroepiandrosterone (DHEA) is a major circulating neurosteroid in humans and its administration has demonstrated efficacy in the improvement of mood, with increased energy, interest, confidence and activity levels."1.32Increased circulatory dehydroepiandrosterone and dehydroepiandrosterone-sulphate in first-episode schizophrenia: relationship to gender, aggression and symptomatology. ( Goredetsky, L; Kotler, M; Lapidus, R; Maayan, R; Strous, RD; Weizman, A; Zeldich, E, 2004)
" In Experiment II the effects of D-CH3 dosed at 20, 40 or 80 micrograms/day were measured in the same testing situation."1.28Suppressive effects of dehydroepiandrosterone and 3-beta-methylandrost-5-en-17-one on attack towards lactating female intruders by castrated male mice. ( Baulieu, EE; Brain, PF; Haug, M; Ouss-Schlegel, ML; Robel, P; Simon, V; Spetz, JF, 1989)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19907 (14.00)18.7374
1990's6 (12.00)18.2507
2000's17 (34.00)29.6817
2010's18 (36.00)24.3611
2020's2 (4.00)2.80

Authors

AuthorsStudies
Munley, KM2
Trinidad, JC1
Demas, GE9
Ren, CC1
Sylvia, KE1
Deyoe, JE1
Henderson, SG1
Vu, MP1
Johnson, M1
Vitacco, MJ1
Shirtcliff, EA2
Kimonis, ER3
Fleming, GE1
Wilbur, RR2
Groer, MW2
Granger, DA3
Goulter, N2
Denson, TF1
Begg, DP1
Fokidis, HB1
Prior, NH2
Soma, KK12
Rendon, NM3
Boonstra, R1
Albers, HE2
Rudolph, LM1
Sengelaub, DR1
Hawes, DJ1
Wacker, DW3
Khalaj, S1
Jones, LJ1
Champion, TL1
Davis, JE1
Meddle, SL1
Wingfield, JC5
Richter, MM1
Barnes, BM1
O'Reilly, KM1
Fenn, AM1
Buck, CL1
Poisbleau, M1
Lacroix, A1
Chastel, O1
Scotti, MA3
Belén, J1
Jackson, JE1
Golubchik, P1
Mozes, T1
Maayan, R2
Weizman, A2
Sánchez-Martín, JR2
Azurmendi Imaz, A1
Fano Ardanaz, E1
Braza Lloret, F1
Muñoz Sánchez, JM1
Carreras de Alba, MR1
Schmidt, KL1
Newman, AE4
Bonu, T1
Gutzler, SJ1
Karom, M1
Erwin, WD1
Pradhan, DS1
Schlinger, BA2
Rosado, B1
García-Belenguer, S1
León, M1
Chacón, G1
Villegas, A1
Palacio, J1
Hau, M2
Beebe, K1
Bedrosian, TA1
Fonken, LK1
Nelson, RJ1
Maddison, CJ1
Anderson, RC1
Taves, MD1
Landys, MM1
Goymann, W1
Slagsvold, T1
Gavrilova, VA1
Ivanova, SA1
Gusev, SI1
Trofimova, MV1
Bokhan, NA1
Stoddard, ST1
Strous, RD1
Lapidus, R1
Goredetsky, L1
Zeldich, E1
Kotler, M1
Goodson, JL1
Evans, AK1
Calfee, R1
Fadale, P1
Azurmendi, A1
Braza, F1
García, A1
Braza, P1
Muñoz, JM1
Charlier, TD1
Brown, GL1
McGarvey, EL1
Keller, A1
Flavin, K1
Haug, M7
Spetz, JF4
Schlegel, ML3
Robel, P7
Young, J2
Corpéchot, C3
Mayo, W1
Perché, F1
Simon, H1
Baulieu, EE4
Bergman, B1
Brismar, B1
Constantino, JN1
Grosz, D1
Saenger, P1
Chandler, DW1
Nandi, R1
Earls, FJ1
Majewska, MD1
Susman, EJ1
Murowchick, E1
Ponirakis, A1
Worrall, BK1
Engel, SR1
Grant, KA1
Wissman, AM1
Brenowitz, EA1
Gandelman, R1
Simon, NG1
McDermott, NJ1
Gobaille, S1
Ouss-Schlegel, ML2
Brain, PF1
Simon, V1
Bourreau, E1
Dang, DC1
Halberg, F1
Clarke, C1
Synguelakis, M1
Vourch, C1
Paroli, E1
Pantaleoni, GC1
Valeri, P1
Nencini, P1
Jame, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Can Psychopathy be Prevented? Clinical, Neuroimaging and Genetic Data[NCT06028620]25 participants (Actual)Interventional2020-02-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for dehydroepiandrosterone and Aggression

ArticleYear
DHEA effects on brain and behavior: insights from comparative studies of aggression.
    The Journal of steroid biochemistry and molecular biology, 2015, Volume: 145

    Topics: Aggression; Androgens; Animals; Aromatase; Behavior, Animal; Brain; Cricetinae; Dehydroepiandrostero

2015
Novel mechanisms for neuroendocrine regulation of aggression.
    Frontiers in neuroendocrinology, 2008, Volume: 29, Issue:4

    Topics: Adrenal Glands; Aggression; Animals; Behavior, Animal; Brain; Dehydroepiandrosterone; Humans; Melato

2008
Biosynthesis and assay of neurosteroids in rats and mice: functional correlates.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 53, Issue:1-6

    Topics: Adrenalectomy; Aggression; Aging; Animals; Behavior, Animal; Dehydroepiandrosterone; Dihydrotestoste

1995
Neuronal actions of dehydroepiandrosterone. Possible roles in brain development, aging, memory, and affect.
    Annals of the New York Academy of Sciences, 1995, Dec-29, Volume: 774

    Topics: Aggression; Aging; Animals; Brain; Circadian Rhythm; Cognition; Dehydroepiandrosterone; Dehydroepian

1995
Neurosteroids and behavior.
    International review of neurobiology, 2001, Volume: 46

    Topics: Aggression; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Dehydroepiandrosterone; Humans; Pre

2001

Other Studies

45 other studies available for dehydroepiandrosterone and Aggression

ArticleYear
Sex-specific endocrine regulation of seasonal aggression in Siberian hamsters.
    Proceedings. Biological sciences, 2022, 09-14, Volume: 289, Issue:1982

    Topics: Aggression; Animals; Cricetinae; Dehydroepiandrosterone; Female; Male; Melatonin; Phodopus; Seasons

2022
Photoperiod modulates the gut microbiome and aggressive behavior in Siberian hamsters.
    The Journal of experimental biology, 2020, 01-31, Volume: 223, Issue:Pt 3

    Topics: Aggression; Animals; Dehydroepiandrosterone; Female; Gastrointestinal Microbiome; Male; Phodopus; Ph

2020
Callous-unemotional traits and early life stress predict treatment effects on stress and sex hormone functioning in incarcerated male adolescents.
    Stress (Amsterdam, Netherlands), 2018, Volume: 21, Issue:2

    Topics: Adolescent; Aggression; Antisocial Personality Disorder; Dehydroepiandrosterone; Emotions; Empathy;

2018
Dehydroepiandrosterone (DHEA) and its ratio to cortisol moderate associations between maltreatment and psychopathology in male juvenile offenders.
    Psychoneuroendocrinology, 2019, Volume: 101

    Topics: Adolescent; Aggression; Child Abuse; Criminals; Dehydroepiandrosterone; Emotions; Humans; Hydrocorti

2019
Female primary and secondary psychopathic variants show distinct endocrine and psychophysiological profiles.
    Psychoneuroendocrinology, 2019, Volume: 104

    Topics: Adult; Aggression; Anger; Antisocial Personality Disorder; Anxiety; Conduct Disorder; Dehydroepiandr

2019
Fasting increases aggression and differentially modulates local and systemic steroid levels in male zebra finches.
    Endocrinology, 2013, Volume: 154, Issue:11

    Topics: Aggression; Animals; Brain; Dehydroepiandrosterone; Estradiol; Finches; Food Deprivation; Male; Musc

2013
The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens.
    Proceedings. Biological sciences, 2015, Nov-22, Volume: 282, Issue:1819

    Topics: Adrenal Glands; Aggression; Animals; Dehydroepiandrosterone; Female; Melatonin; Phodopus; Photoperio

2015
Bi-directional actions of dehydroepiandrosterone and aggression in female Siberian hamsters.
    Journal of experimental zoology. Part A, Ecological genetics and physiology, 2016, Volume: 325, Issue:2

    Topics: Adrenocorticotropic Hormone; Aggression; Animals; Cricetinae; Dehydroepiandrosterone; Female; Phodop

2016
Neuroendocrine factors distinguish juvenile psychopathy variants.
    Developmental psychobiology, 2017, Volume: 59, Issue:2

    Topics: Adolescent; Aggression; Antisocial Personality Disorder; Anxiety; Dehydroepiandrosterone; Humans; Hy

2017
Dehydroepiandrosterone Heightens Aggression and Increases Androgen Receptor and Aromatase mRNA Expression in the Brain of a Male Songbird.
    Journal of neuroendocrinology, 2016, Volume: 28, Issue:12

    Topics: Aggression; Animals; Aromatase; Avian Proteins; Brain; Dehydroepiandrosterone; Male; Receptors, Andr

2016
The influence of androgens on hibernation phenology of free-living male arctic ground squirrels.
    Hormones and behavior, 2017, Volume: 89

    Topics: Aggression; Androgens; Animals; Body Temperature; Castration; Dehydroepiandrosterone; Hibernation; M

2017
DHEA levels and social dominance relationships in wintering brent geese (Branta bernicla bernicla).
    Behavioural processes, 2009, Volume: 80, Issue:1

    Topics: Aggression; Animals; Dehydroepiandrosterone; Female; Geese; Male; Radioimmunoassay; Seasons; Social

2009
The role of androgens in the mediation of seasonal territorial aggression in male Siberian hamsters (Phodopus sungorus).
    Physiology & behavior, 2008, Dec-15, Volume: 95, Issue:5

    Topics: Aggression; Animals; Cricetinae; Dehydroepiandrosterone; Male; Phodopus; Photoperiod; Seasons; Terri

2008
Neurosteroid blood levels in delinquent adolescent boys with conduct disorder.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:1

    Topics: Adolescent; Aggression; Conduct Disorder; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hu

2009
[Androgen levels, parenting styles and aggressive behavior in 5-6-year-old boys and girls].
    Psicothema, 2009, Volume: 21, Issue:1

    Topics: Adult; Aggression; Androstenedione; Authoritarianism; Child; Child, Preschool; Dehydroepiandrosteron

2009
Aggressive encounters differentially affect serum dehydroepiandrosterone and testosterone concentrations in male Siberian hamsters (Phodopus sungorus).
    Hormones and behavior, 2009, Volume: 56, Issue:4

    Topics: Aggression; Animals; Cricetinae; Dehydroepiandrosterone; Male; Phodopus; Photoperiod; Territoriality

2009
Photoperiodic regulation of adrenal hormone secretion and aggression in female Syrian hamsters.
    Hormones and behavior, 2009, Volume: 56, Issue:4

    Topics: Aggression; Analysis of Variance; Animals; Cricetinae; Dehydroepiandrosterone; Estradiol; Estrous Cy

2009
Aggressive interactions rapidly increase androgen synthesis in the brain during the non-breeding season.
    Hormones and behavior, 2010, Volume: 57, Issue:4-5

    Topics: 3-Hydroxysteroid Dehydrogenases; Aggression; Androgens; Animals; Brain Chemistry; Chromatography, Hi

2010
Effect of fluoxetine on blood concentrations of serotonin, cortisol and dehydroepiandrosterone in canine aggression.
    Journal of veterinary pharmacology and therapeutics, 2011, Volume: 34, Issue:5

    Topics: Aggression; Animals; Behavior, Animal; Dehydroepiandrosterone; Dogs; Female; Fluoxetine; Hydrocortis

2011
Plastic endocrine regulation of year-round territorial aggression in tropical male spotted antbirds.
    General and comparative endocrinology, 2011, Jun-01, Volume: 172, Issue:2

    Topics: Aggression; Animals; Behavior, Animal; Dehydroepiandrosterone; Endocrine System; Female; Male; Passe

2011
Aggressive interactions differentially modulate local and systemic levels of corticosterone and DHEA in a wild songbird.
    Hormones and behavior, 2011, Volume: 60, Issue:4

    Topics: Aggression; Animals; Animals, Wild; Behavior, Animal; Body Constitution; Corticosterone; Dehydroepia

2011
Photoperiod-dependent effects of neuronal nitric oxide synthase inhibition on aggression in Siberian hamsters.
    Hormones and behavior, 2012, Volume: 61, Issue:2

    Topics: Aggression; Animals; Behavior, Animal; Cricetinae; Dehydroepiandrosterone; Estradiol; Indazoles; Mal

2012
Soft song during aggressive interactions: seasonal changes and endocrine correlates in song sparrows.
    Hormones and behavior, 2012, Volume: 62, Issue:4

    Topics: Aggression; Animals; Dehydroepiandrosterone; Hormones; Male; Reproduction; Seasons; Singing; Songbir

2012
Year-round territorial aggression is independent of plasma DHEA in the European nuthatch Sitta europaea.
    Hormones and behavior, 2013, Volume: 63, Issue:1

    Topics: Aggression; Animals; Behavior, Animal; Dehydroepiandrosterone; Female; Male; Passeriformes; Seasons;

2013
Neurosteroids dehydroepiandrosterone and its sulfate in individuals with personality disorders convicted of serious violent crimes.
    Bulletin of experimental biology and medicine, 2012, Volume: 154, Issue:1

    Topics: Adult; Aggression; Crime; Criminals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans;

2012
Territorial aggression and hormones during the non-breeding season in a tropical bird.
    Hormones and behavior, 2004, Volume: 45, Issue:1

    Topics: Aggression; Animals; Behavior, Animal; Dehydroepiandrosterone; Estradiol; Female; Gonadal Steroid Ho

2004
Increased circulatory dehydroepiandrosterone and dehydroepiandrosterone-sulphate in first-episode schizophrenia: relationship to gender, aggression and symptomatology.
    Schizophrenia research, 2004, Dec-01, Volume: 71, Issue:2-3

    Topics: Adult; Aggression; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocort

2004
Neural responses to aggressive challenge correlate with behavior in nonbreeding sparrows.
    Neuroreport, 2005, Oct-17, Volume: 16, Issue:15

    Topics: Aggression; Animals; Behavior, Animal; Brain Chemistry; Dehydroepiandrosterone; Genes, fos; Immunohi

2005
Popular ergogenic drugs and supplements in young athletes.
    Pediatrics, 2006, Volume: 117, Issue:3

    Topics: Adolescent; Affect; Aggression; Anabolic Agents; Creatine; Dehydroepiandrosterone; Dietary Supplemen

2006
Aggression, dominance, and affiliation: Their relationships with androgen levels and intelligence in 5-year-old children.
    Hormones and behavior, 2006, Volume: 50, Issue:1

    Topics: Aggression; Analysis of Variance; Androgens; Androstenedione; Child; Child, Preschool; Dehydroepiand

2006
Combined effects of DHEA and fadrozole on aggression and neural VIP immunoreactivity in the non-breeding male song sparrow.
    Hormones and behavior, 2008, Volume: 53, Issue:1

    Topics: Aggression; Analysis of Variance; Androgens; Animals; Aromatase Inhibitors; Dehydroepiandrosterone;

2008
Salivary cortisol, dehydroepiandrosterone, and testosterone interrelationships in healthy young males: a pilot study with implications for studies of aggressive behavior.
    Psychiatry research, 2008, May-30, Volume: 159, Issue:1-2

    Topics: Aggression; Dehydroepiandrosterone; Humans; Hydrocortisone; Male; Pilot Projects; Saliva; Testostero

2008
[Dehydroepiandrosterone inhibits aggressive behavior in castrated male mice].
    Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 1983, Volume: 296, Issue:20

    Topics: Aggression; Animals; Castration; Dehydroepiandrosterone; Humans; Male; Mice

1983
Hormone levels and personality traits in abusive and suicidal male alcoholics.
    Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:2

    Topics: Adult; Aggression; Alcoholism; Antisocial Personality Disorder; Dehydroepiandrosterone; Dehydroepian

1994
Testosterone and aggression in children.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1993, Volume: 32, Issue:6

    Topics: Aggression; Androgens; Biomarkers; Child; Child Behavior Disorders; Child, Preschool; Dehydroepiandr

1993
Gonadal and adrenal hormones. Developmental transitions and aggressive behavior.
    Annals of the New York Academy of Sciences, 1996, Sep-20, Volume: 794

    Topics: Adolescent; Adult; Aggression; Androstenedione; Anxiety; Child; Dehydroepiandrosterone; Estradiol; F

1996
Dehydroepiandrosterone in songbird plasma: seasonal regulation and relationship to territorial aggression.
    General and comparative endocrinology, 2001, Volume: 123, Issue:2

    Topics: Adrenal Glands; Aggression; Aging; Animals; Breeding; Dehydroepiandrosterone; Dehydroepiandrosterone

2001
Dehydroepiandrosterone (DHEA) increases territorial song and the size of an associated brain region in a male songbird.
    Hormones and behavior, 2002, Volume: 41, Issue:2

    Topics: Aggression; Animals; Brain; Dehydroepiandrosterone; Male; Organ Size; Songbirds; Testosterone; Vocal

2002
Prenatal exposure to testosterone and its precursors influences morphology and later behavioral responsiveness to testosterone of female mice.
    Physiology & behavior, 1979, Volume: 23, Issue:1

    Topics: Aggression; Animals; Behavior, Animal; Castration; Dehydroepiandrosterone; Female; Humans; Maternal-

1979
Suppressive effects of dehydroepiandrosterone and 3 beta-methyl-androst-5-en-17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids.
    Biochemical and biophysical research communications, 1991, Jan-31, Volume: 174, Issue:2

    Topics: Aggression; Androstenes; Animals; Brain; Dehydroepiandrosterone; Female; Lactation; Male; Mice; Orch

1991
Suppressive effects of dehydroepiandrosterone and 3-beta-methylandrost-5-en-17-one on attack towards lactating female intruders by castrated male mice.
    Physiology & behavior, 1989, Volume: 46, Issue:6

    Topics: Aggression; Androstenes; Animals; Dehydroepiandrosterone; Female; Lactation; Male; Mice; Orchiectomy

1989
Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders.
    Physiology & behavior, 1985, Volume: 34, Issue:6

    Topics: Aggression; Androstenediol; Androstenediols; Animals; Brain Chemistry; Dehydroepiandrosterone; Dehyd

1985
Neuro-steroids: 3 beta-hydroxy-delta 5-derivatives in rat and monkey brain.
    Journal of steroid biochemistry, 1987, Volume: 27, Issue:4-6

    Topics: Adrenal Glands; Adrenalectomy; Aggression; Animals; Brain; Castration; Circadian Rhythm; Dehydroepia

1987
[The role of dehydroepiandrosterone and pregnenolone in the expression of stress behavior towards lactating females in mice].
    Pathologie-biologie, 1988, Volume: 36, Issue:8

    Topics: Aggression; Animals; Brain Chemistry; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Fema

1988
Inhibitory effect of dehydroepiandrosterone on aggressive behaviour.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 196

    Topics: 17-Ketosteroids; Aggression; Animals; Behavior, Animal; Brain Chemistry; Castration; Corticosterone;

1972