Page last updated: 2024-11-07

dehydroepiandrosterone and Adrenocortical Carcinoma

dehydroepiandrosterone has been researched along with Adrenocortical Carcinoma in 9 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.

Research Excerpts

ExcerptRelevanceReference
"A 58-year-old man had adrenocortical carcinoma in the right adrenal gland."5.30Changes in neoplastic cell features and sensitivity to mitotane during mitotane-induced remission in a patient with recurrent, metastatic adrenocortical carcinoma. ( Demura, H; Hirohara, D; Kanazawa, M; Nomura, K; Sawada, T; Seki, M; Takasaki, K, 1999)
"To develop a monoclonal antibody against dehydroepiandrosterone (DHEA) and miniaturize it, generating a single-chain antibody variable fragment (scFv) against DHEA as an adrenocortical carcinoma (ACC) marker."3.91Biomolecular engineering of antidehydroepiandrosterone antibodies: a new perspective in cancer diagnosis and treatment using single-chain antibody variable fragment. ( Alvarenga, LM; Becker-Finco, A; Billiald, P; de Figueiredo, BC; de Moraes, RN; Fogaça, RL; Moura, J; Noiray, M; Noronha, L; Silva, SK; Teixeira, KN; Woiski, TD, 2019)
"Adrenocortical carcinoma is a heterogeneous and aggressive cancer that originates from steroidogenic cells within the adrenal cortex."1.72A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma. ( Abate, A; Berruti, A; Bornstein, SR; Bothou, C; Cosentini, D; Hantel, C; Peitzsch, M; Penton, D; Sigala, S; Tiberio, GAM, 2022)
"A 58-year-old man had adrenocortical carcinoma in the right adrenal gland."1.30Changes in neoplastic cell features and sensitivity to mitotane during mitotane-induced remission in a patient with recurrent, metastatic adrenocortical carcinoma. ( Demura, H; Hirohara, D; Kanazawa, M; Nomura, K; Sawada, T; Seki, M; Takasaki, K, 1999)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Sigala, S1
Bothou, C1
Penton, D1
Abate, A1
Peitzsch, M1
Cosentini, D1
Tiberio, GAM1
Bornstein, SR1
Berruti, A1
Hantel, C1
Fogaça, RL1
Alvarenga, LM1
Woiski, TD1
Becker-Finco, A1
Teixeira, KN1
Silva, SK1
de Moraes, RN1
Noronha, L1
Noiray, M1
de Figueiredo, BC1
Billiald, P1
Moura, J1
Ross, IL1
Louw, GJ1
Velikanova, LI1
Shafigullina, ZR1
Lisitsin, AA1
Vorokhobina, NV1
Grigoryan, K1
Kukhianidze, EA1
Strelnikova, EG1
Krivokhizhina, NS1
Krasnov, LM1
Fedorov, EA1
Sablin, IV1
Moskvin, AL1
Bessonova, EA1
Kouyama, R1
Hiraishi, K1
Sugiyama, T1
Izumiyama, H1
Yoshimoto, T2
Akashi, T1
Kihara, K1
Homma, K2
Shibata, H2
Hirata, Y2
KELLER, M1
Fukai, N1
Hirono, Y1
Doi, M1
Ohtsuka, Y1
Sasano, H1
Ideyama, Y1
Kudoh, M1
Tanimoto, K1
Susaki, Y1
Nanya, T1
Nakahara, T1
Ishikawa, H1
Fujikura, T1
Akaza, H1
Shikama, H1
Seki, M1
Nomura, K1
Hirohara, D1
Kanazawa, M1
Sawada, T1
Takasaki, K1
Demura, H1

Reviews

1 review available for dehydroepiandrosterone and Adrenocortical Carcinoma

ArticleYear
Embryological and molecular development of the adrenal glands.
    Clinical anatomy (New York, N.Y.), 2015, Volume: 28, Issue:2

    Topics: Addison Disease; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Carcinoma; Dehydroepiandros

2015

Other Studies

8 other studies available for dehydroepiandrosterone and Adrenocortical Carcinoma

ArticleYear
A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma.
    Cells, 2022, 04-24, Volume: 11, Issue:9

    Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Aldoste

2022
Biomolecular engineering of antidehydroepiandrosterone antibodies: a new perspective in cancer diagnosis and treatment using single-chain antibody variable fragment.
    Nanomedicine (London, England), 2019, Volume: 14, Issue:6

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Animals; Biomarkers, Tumor; Dehydroepiandrostero

2019
Different Types of Urinary Steroid Profiling Obtained by High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectrometry in Patients with Adrenocortical Carcinoma.
    Hormones & cancer, 2016, Volume: 7, Issue:5-6

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Adrenocortical Carcinoma; Adult; Chromatography, H

2016
Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical carcinoma.
    Endocrine journal, 2011, Volume: 58, Issue:7

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Cortex Neoplasms; Adrenocortical

2011
[HORMONE STUDIES IN A CASE OF FEMINIZING ADRENAL CORTEX CARCINOMA].
    Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie, 1963, Volume: 156

    Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Dehydroepiandros

1963
A case of estrogen-secreting adrenocortical carcinoma with subclinical Cushing's syndrome.
    Endocrine journal, 2006, Volume: 53, Issue:2

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Cushing Syndrome; Dehydroepiandrosterone;

2006
YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:2

    Topics: Adrenal Cortex Hormones; Adrenocortical Carcinoma; Androgens; Androstenedione; Carbazoles; Dehydroep

1999
Changes in neoplastic cell features and sensitivity to mitotane during mitotane-induced remission in a patient with recurrent, metastatic adrenocortical carcinoma.
    Endocrine-related cancer, 1999, Volume: 6, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; Dehydroepiandro

1999