dehydroepiandrosterone has been researched along with Adenocarcinoma in 37 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exposure to dehydroepiandrosterone caused a concentration-dependent accumulation of HT-29 human colonic adenocarcinoma cells in S-phase and sensitization toward the cytotoxic effects of fluorouracil deoxyriboside but not 5-fluorouracil." | 7.68 | Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells. ( Holbrook, CT; Klann, RC; Nyce, J, 1990) |
| " Prostate adenocarcinomas were induced in male Wistar-Unilever rats by a sequential regimen of cyproterone acetate and testosterone propionate, followed by a single i." | 3.70 | Chemoprevention of rat prostate carcinogenesis by early and delayed administration of dehydroepiandrosterone. ( Bosland, MC; Johnson, WD; Kelloff, GJ; Lubet, RA; McCormick, DL; Rao, KV; Steele, VE, 1999) |
| " Under sustained hyperprolactinemia induced by pimozide (PMZ) from day 21, DMBA was injected locally into the mammary glandular tissues on day 73." | 3.69 | Effects of dehydroepiandrosterone and other sex steroid hormones on mammary carcinogenesis by direct injection of 7,12-dimethylbenz(a) anthracene (DMBA) in hyperprolactinemic female rats. ( Inoue, M; Kohama, T; Suzuki, N; Terada, S, 1997) |
| "Exposure to dehydroepiandrosterone caused a concentration-dependent accumulation of HT-29 human colonic adenocarcinoma cells in S-phase and sensitization toward the cytotoxic effects of fluorouracil deoxyriboside but not 5-fluorouracil." | 3.68 | Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells. ( Holbrook, CT; Klann, RC; Nyce, J, 1990) |
| "Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate." | 3.67 | Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. ( Chilvers, CE; Dowsett, M; Easton, D; Jeffcoate, SL; Miller, J; Pocock, RD; Ponder, BA; Shearer, RJ, 1984) |
| "The conversion of dehydroepiandrosterone sulfate into testosterone, delta4-androstenedione, and dihydrotestosterone has been measured in minced prostatic adenocarcinoma tissue from three untreated patients, two patients treated with diethylstilbestrol, and one treated with cyproterone acetate." | 3.65 | Biosynthesis and metabolism of androgenic hormones in cancer of the prostate. ( Di Silverio, F; Gagliardi, V; Sciarra, F; Sorcini, G, 1976) |
| "The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/ml)." | 3.65 | Hyperprolactinemia and steroid metabolism by rat mammary adenocarcinomas. ( Miller, WR, 1976) |
| "Clinical virilization with or without hypercortisolism was found in all eight children, who were 5 years old or younger." | 2.37 | Virilizing adrenocortical tumors in childhood: eight cases and a review of the literature. ( Green, OC; Lee, PD; Winter, RJ, 1985) |
| "Ketoconazole can suppress androgen production and has a beneficial role in the hormonal therapy of patients with prostate cancer who have not undergone orchiectomy." | 1.27 | High-dose ketoconazole therapy in patients with metastatic prostate cancer. ( Al-Sarraf, M; Decker, DA; Kresge, C; Subramanian, MG; Tapazoglou, E, 1986) |
| "Estrone sulfate was more efficient as a substrate than dehydroepiandrosterone sulfate, since the amount of product formed from estrone sulfate was approximately 3-fold greater than that formed from dehydroepiandrosterone sulfate." | 1.27 | In situ steroid sulfatase activity in human epithelial carcinoma cells of vaginal, ovarian, and endometrial origin. ( Milewich, L; Porter, JC, 1987) |
| "Women with advanced ovarian cancer had lower DHEAS levels than those with local ovarian cancer." | 1.27 | Decreased serum level of dehydroepiandrosterone sulfate in postmenopausal women with ovarian cancer. ( Heinonen, PK; Koivula, T; Pystynen, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (54.05) | 18.7374 |
| 1990's | 15 (40.54) | 18.2507 |
| 2000's | 2 (5.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galvão, DA | 1 |
| Nosaka, K | 1 |
| Taaffe, DR | 1 |
| Peake, J | 1 |
| Spry, N | 1 |
| Suzuki, K | 1 |
| Yamaya, K | 1 |
| McGuigan, MR | 1 |
| Kristjanson, LJ | 1 |
| Newton, RU | 1 |
| Bonney, RC | 1 |
| Scanlon, MJ | 1 |
| Reed, MJ | 1 |
| Jones, DL | 1 |
| Beranek, PA | 1 |
| James, VH | 1 |
| Morikawa, S | 1 |
| Naito, M | 1 |
| Takamizawa, H | 1 |
| Ponder, BA | 1 |
| Shearer, RJ | 1 |
| Pocock, RD | 1 |
| Miller, J | 1 |
| Easton, D | 1 |
| Chilvers, CE | 1 |
| Dowsett, M | 1 |
| Jeffcoate, SL | 1 |
| Blaakaer, J | 2 |
| Høgdall, CK | 2 |
| Micic, S | 1 |
| Toftager-Larsen, K | 2 |
| Hørding, U | 2 |
| Bennett, P | 2 |
| Bock, J | 2 |
| Rainey, WE | 1 |
| Bird, IM | 1 |
| Mason, JI | 1 |
| Daugaard, S | 1 |
| Kohama, T | 1 |
| Terada, S | 1 |
| Suzuki, N | 1 |
| Inoue, M | 1 |
| Chetrite, G | 1 |
| Pasqualini, JR | 1 |
| Uno, M | 1 |
| Deguchi, T | 1 |
| Ehara, H | 1 |
| Ishihara, S | 1 |
| Kobayashi, S | 1 |
| Rao, KV | 1 |
| Johnson, WD | 1 |
| Bosland, MC | 1 |
| Lubet, RA | 1 |
| Steele, VE | 1 |
| Kelloff, GJ | 1 |
| McCormick, DL | 1 |
| Takezawa, Y | 1 |
| Nakata, S | 1 |
| Kobayashi, M | 1 |
| Kosaku, N | 1 |
| Fukabori, Y | 1 |
| Yamanaka, H | 1 |
| Di Silverio, F | 1 |
| Gagliardi, V | 1 |
| Sorcini, G | 1 |
| Sciarra, F | 1 |
| Miller, WR | 3 |
| Abul-Hajj, YJ | 1 |
| Iverson, R | 1 |
| Kiang, DT | 1 |
| Schulz, S | 2 |
| Klann, RC | 2 |
| Schönfeld, S | 1 |
| Nyce, JW | 2 |
| Ratajczak, HV | 1 |
| Lange, RW | 1 |
| Sothern, RB | 1 |
| Hagen, KL | 1 |
| Vescei, P | 1 |
| Wu, J | 1 |
| Halberg, F | 1 |
| Thomas, PT | 1 |
| La Rocca, RV | 1 |
| Danesi, R | 1 |
| Cooper, MR | 1 |
| Jamis-Dow, CA | 1 |
| Ewing, MW | 1 |
| Linehan, WM | 1 |
| Myers, CE | 1 |
| van Weerden, WM | 1 |
| van Kreuningen, A | 1 |
| Moerings, EP | 1 |
| de Jong, FH | 1 |
| van Steenbrugge, GJ | 1 |
| Schröder, FH | 1 |
| Schiller, CD | 1 |
| Schneider, MR | 1 |
| Hartmann, H | 1 |
| Graf, AH | 1 |
| Klocker, H | 1 |
| Bartsch, G | 1 |
| Ogiu, T | 1 |
| Hard, GC | 1 |
| Schwartz, AG | 1 |
| Magee, PN | 1 |
| Nyce, J | 1 |
| Holbrook, CT | 1 |
| Tapazoglou, E | 1 |
| Subramanian, MG | 1 |
| Al-Sarraf, M | 1 |
| Kresge, C | 1 |
| Decker, DA | 1 |
| Milewich, L | 1 |
| Porter, JC | 1 |
| Heinonen, PK | 1 |
| Koivula, T | 1 |
| Pystynen, P | 1 |
| Katsube, Y | 1 |
| Iwaoki, Y | 1 |
| Silverberg, SG | 1 |
| Fujiwara, A | 1 |
| Tomić, R | 1 |
| Ljungberg, B | 1 |
| Damber, JE | 1 |
| Bélanger, A | 1 |
| Labrie, F | 1 |
| Dupont, A | 1 |
| Brochu, M | 1 |
| Cusan, L | 1 |
| Lee, PD | 1 |
| Winter, RJ | 1 |
| Green, OC | 1 |
| Shivas, AA | 1 |
| Forrest, AP | 3 |
| Plotz, EJ | 1 |
| Wiener, M | 1 |
| Stein, AA | 1 |
| Hahn, BD | 1 |
| Morii, H | 1 |
| Tanae, A | 1 |
| Ibayashi, H | 1 |
| Nakao, K | 1 |
| Miller, W | 1 |
| Hamilton, T | 1 |
| Grattarola, R | 1 |
| Buchan, R | 1 |
| Lehmann, WD | 1 |
| Lauritzen, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oral Potassium Supplementation in Healthy Men - Interactions With the Renin-angiotensin-aldosterone System and the Sympathetic Nervous System[NCT02380157] | Phase 4 | 25 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for dehydroepiandrosterone and Adenocarcinoma
| Article | Year |
|---|---|
The NCI-H295 cell line: a pluripotent model for human adrenocortical studies.
Topics: 3-Hydroxysteroid Dehydrogenases; Adenocarcinoma; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Co | 1994 |
Virilizing adrenocortical tumors in childhood: eight cases and a review of the literature.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adenoma; Adrenal Cortex Neoplasms; Child | 1985 |
35 other studies available for dehydroepiandrosterone and Adenocarcinoma
| Article | Year |
|---|---|
Endocrine and immune responses to resistance training in prostate cancer patients.
Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents, Hormonal; Biomarkers; Bone Remodeling; | 2008 |
Adrenal androgen concentrations in breast tumours and in normal breast tissue. The relationship to oestradiol metabolism.
Topics: 17-Hydroxysteroid Dehydrogenases; Adenocarcinoma; Adult; Aged; Androstenediol; Androstenediols; Brea | 1984 |
[Analysis of the high risk factors of endometrial adenocarcinoma--abnormal excretion in urinary steroids in androgen sterilized rats].
Topics: Adenocarcinoma; Androstanes; Androsterone; Animals; Dehydroepiandrosterone; Etiocholanolone; Female; | 1984 |
Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Proto | 1984 |
Ovarian carcinoma serum markers and ovarian steroid activity--is there a link in ovarian cancer? A correlation of inhibin, tetranectin and CA-125 to ovarian activity and the gonadotropin levels.
Topics: Adenocarcinoma; Aged; Biomarkers, Tumor; Blood Proteins; CA-125 Antigen; Dehydroepiandrosterone; Deh | 1995 |
Hormonal factors and prognosis in epithelial ovarian cancer: a multivariate analysis.
Topics: Adenocarcinoma; Adenocarcinoma, Clear Cell; Adenocarcinoma, Mucinous; Aging; Androstenedione; Carcin | 1993 |
Effects of dehydroepiandrosterone and other sex steroid hormones on mammary carcinogenesis by direct injection of 7,12-dimethylbenz(a) anthracene (DMBA) in hyperprolactinemic female rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Carcinogens; Cocarcinogenesis; Dehydroepi | 1997 |
Steroid sulphotransferase and 17beta-hydroxysteroid dehydrogenase activities in Ishikawa human endometrial adenocarcinoma cells.
Topics: 17-Hydroxysteroid Dehydrogenases; Adenocarcinoma; Dehydroepiandrosterone; Endometrial Neoplasms; Est | 1997 |
Prostatic cancer 30 years after bilateral orchidectomy.
Topics: Adenocarcinoma; Aged; Dehydroepiandrosterone; Fatal Outcome; Humans; Male; Orchiectomy; Penile Neopl | 1998 |
Chemoprevention of rat prostate carcinogenesis by early and delayed administration of dehydroepiandrosterone.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinoma; Cyproterone Aceta | 1999 |
Moderate dose diethylstilbestrol diphosphate therapy in hormone refractory prostate cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Dehydroepiandrosterone; De | 2001 |
Biosynthesis and metabolism of androgenic hormones in cancer of the prostate.
Topics: Adenocarcinoma; Androgens; Androstenedione; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Mal | 1976 |
Hyperprolactinemia and steroid metabolism by rat mammary adenocarcinomas.
Topics: Adenocarcinoma; Androstane-3,17-diol; Animals; Dehydroepiandrosterone; DNA, Neoplasm; Female; In Vit | 1976 |
Aromatization of androgens by human breast cancer.
Topics: Adenocarcinoma; Adipose Tissue; Adult; Aged; Breast Neoplasms; Dehydroepiandrosterone; Estrogens; Fe | 1979 |
Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis.
Topics: Adenocarcinoma; Cell Cycle; Cholesterol; Colonic Neoplasms; Dehydroepiandrosterone; Deoxyribonucleos | 1992 |
Surgical influence on murine immunity and tumor growth: relationship of body temperature and hormones with splenocytes.
Topics: Adenocarcinoma; Animals; Antigens, Surface; Body Temperature; Circadian Rhythm; Corticosterone; Dehy | 1992 |
Effect of suramin on human prostate cancer cells in vitro.
Topics: Adenocarcinoma; Androstenedione; Antineoplastic Agents; Cell Line; Dehydroepiandrosterone; Dehydroep | 1991 |
Pharmacia Award 1990. The biological significance of low testosterone levels and of adrenal androgens in transplantable prostate cancer lines.
Topics: Adenocarcinoma; Androstenedione; Animals; Awards and Prizes; Castration; Dehydroepiandrosterone; Eur | 1991 |
Growth-stimulating effect of adrenal androgens on the R3327 Dunning prostatic carcinoma.
Topics: Adenocarcinoma; Androstenedione; Animals; Castration; Dehydroepiandrosterone; Dehydroepiandrosterone | 1991 |
Inhibition of protein isoprenylation and p21ras membrane association by dehydroepiandrosterone in human colonic adenocarcinoma cells in vitro.
Topics: Adenocarcinoma; Blotting, Western; Cell Compartmentation; Cell Division; Cell Membrane; Colonic Neop | 1991 |
Investigation into the effect of DHEA on renal carcinogenesis induced in the rat by a single dose of DMN.
Topics: Adenocarcinoma; Adenoma; Animals; Body Weight; Cocarcinogenesis; Dehydroepiandrosterone; Diet; Dimet | 1990 |
Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells.
Topics: Adenocarcinoma; Carbon Radioisotopes; Colonic Neoplasms; Dehydroepiandrosterone; Fluorouracil; Human | 1990 |
High-dose ketoconazole therapy in patients with metastatic prostate cancer.
Topics: Adenocarcinoma; Aged; Androstenedione; Combined Modality Therapy; Dehydroepiandrosterone; Dexamethas | 1986 |
In situ steroid sulfatase activity in human epithelial carcinoma cells of vaginal, ovarian, and endometrial origin.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Line; Cystadenocarcinoma; Dehydroepiandrosterone; Deh | 1987 |
Decreased serum level of dehydroepiandrosterone sulfate in postmenopausal women with ovarian cancer.
Topics: Adenocarcinoma; Age Factors; Aged; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; H | 1987 |
Sclerosing stromal tumor of the ovary associated with endometrial adenocarcinoma: a case report.
Topics: Adenocarcinoma; Adult; Dehydroepiandrosterone; Estradiol; Female; Gonadotropins, Pituitary; Humans; | 1988 |
Hormonal effects of high dose medroxyprogesterone acetate treatment in males with renal or prostatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carcinoma, Renal Cell; Dehydroepiandrosterone; Estradiol; F | 1988 |
Endocrine effects of combined treatment with an LHRH agonist in association with flutamide in metastatic prostatic carcinoma.
Topics: Adenocarcinoma; Adrenal Cortex Hormones; Androgens; Androstane-3,17-diol; Androstenediol; Androstene | 1988 |
Steriod metabolism by human normal thyroid, nodular goitre and thyroid cancer.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Child; Dehydroepiandrosterone; Female; Goiter, Nodular; Hum | 1974 |
Enzymatic activities related to steroidogenesis in postmenopausal ovaries of patients with and without endometrial carcinoma.
Topics: Adenocarcinoma; Aged; Androgens; Carbon Isotopes; Cholesterol; Dehydroepiandrosterone; Endometrium; | 1967 |
Effects of calcitonin in metastatic bone carcinoma, osteoporosis, polyostotic fibrous dysplasia and hypercalcemia.
Topics: Adenocarcinoma; Adult; Aged; Alkaline Phosphatase; Bone Neoplasms; Calcitonin; Calcium; Child, Presc | 1971 |
Steroidogenesis in human and rat mammary adenocarcinoma.
Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Breast Neoplasms; Carbon Isotopes; Chromatography, Thin | 1972 |
Misdiagnosis of endometrial adenoacanthoma in a 27-year old woman with adrenocortical tumor.
Topics: 17-Ketosteroids; Adenocarcinoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Androsterone; Dehydr | 1973 |
Proceedings: The effects of fentazin on androgen metabolism in DMBA induced rat adenocarcinomata.
Topics: Adenocarcinoma; Androgens; Animals; Benz(a)Anthracenes; Dehydroepiandrosterone; Female; Neoplasms, E | 1974 |
[Combined dexamethasone suppression and chorionic gonadotrophin stimulation test in the diagnosis of androgenic functional ovarian tumors].
Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Androgens; Chorionic Gonadotropin; Dehydroepiandrosterone; D | 1972 |