dehydroepiandrosterone has been researched along with Addison Disease in 42 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Addison Disease: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A daily replacement dose of 50 mg of DHEA results in near physiological levels of DHEA, DHEA(S) androstenedione and testosterone in women with Addison's disease, without severe side-effects." | 9.09 | Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease. ( Berne, C; Gebre-Medhin, G; Helström, L; Husebye, ES; Kämpe, O; Karlsson, FA; Mallmin, H, 2000) |
| "Oral replacement of the near-total deficiency of dehydroepiandrosterone (DHEA) in patients with Addison's disease (adrenal insufficiency) enhances mood and well-being and reduces fatigue." | 7.73 | Dehydroepiandrosterone replacement in patients with Addison's disease has a bimodal effect on regulatory (CD4+CD25hi and CD4+FoxP3+) T cells. ( Chatterjee, VK; Coles, AJ; Cox, AL; Curran, S; Gurnell, EM; Thompson, S, 2005) |
| "Addison's disease is a rare endocrine disorder which can be life-threatening." | 5.31 | Dehydroepiandrosterone replacement in addison's disease. ( Brody, KH; Kim, SS, 2001) |
| "A daily replacement dose of 50 mg of DHEA results in near physiological levels of DHEA, DHEA(S) androstenedione and testosterone in women with Addison's disease, without severe side-effects." | 5.09 | Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease. ( Berne, C; Gebre-Medhin, G; Helström, L; Husebye, ES; Kämpe, O; Karlsson, FA; Mallmin, H, 2000) |
| " Hydrocortisone and fludrocortisone are the preferred therapy for Addison's disease." | 4.88 | [Addison's disease]. ( Quinkler, M, 2012) |
| "Oral replacement of the near-total deficiency of dehydroepiandrosterone (DHEA) in patients with Addison's disease (adrenal insufficiency) enhances mood and well-being and reduces fatigue." | 3.73 | Dehydroepiandrosterone replacement in patients with Addison's disease has a bimodal effect on regulatory (CD4+CD25hi and CD4+FoxP3+) T cells. ( Chatterjee, VK; Coles, AJ; Cox, AL; Curran, S; Gurnell, EM; Thompson, S, 2005) |
| " This loss, combined with the low plasma concentrations of androstenedione, dehydroepiandrosterone, and testosterone (and low concentrations of oestrone of adrenal origin), indicates that adrenal androgens may be essential for the maintenance of bone mass in postmenopausal women with Addison's disease." | 3.67 | Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass. ( Crabbé, J; Devogelaer, JP; Nagant de Deuxchaisnes, C, 1987) |
| "Although further long-term studies of DHEA therapy, with dosage adjustment, are desirable, our results support some beneficial effects of prolonged DHEA treatment in Addison's disease." | 2.73 | Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial. ( Chatterjee, VK; Compston, JE; Conway, CL; Curran, SE; Gurnell, EM; Herbert, J; Hunt, PJ; Huppert, FA; Pullenayegum, EM, 2008) |
| "Primary adrenal insufficiency affects 11 of 100,000 individuals." | 2.53 | [Addison's disease : Primary adrenal insufficiency]. ( Burger-Stritt, S; Hahner, S; Pulzer, A, 2016) |
| " New preparations are being developed to better mimic normal physiological cortisol levels with convenient, once-daily dosing which may improve treatment outcomes." | 2.49 | Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe. ( Grossman, A; Johannsson, G; Quinkler, M; Zelissen, P, 2013) |
| "Over 80% of Addison's disease is of the autoimmune type, though almost any systemic destructive process can cause similar steroid insufficiency." | 2.37 | Adrenocortical insufficiency. ( Burke, CW, 1985) |
| "Fasting ketoacidosis was postulated to have precipitated the Addisonian crisis." | 1.40 | Ketoacidosis and adrenocortical insufficiency. ( de Froidmont, S; Lobrinus, JA; Mangin, P; Palmiere, C; Werner, D, 2014) |
| " In conclusion, the steroid substitution in Addison's disease requires individually tailored dosage and adequate monitoring." | 1.37 | [Metabolic assessment of hydrocortisone replacement therapy in patients with primary adrenocortical insufficiency]. ( Fichna, M; Gryczyńska, M; Sowińska, A; Sowiński, J, 2011) |
| "Primary adrenal insufficiency is most frequently caused by autoimmune adrenalitis, and hypothalamic-pituitary tumors represent the most frequent cause of secondary adrenal insufficiency." | 1.35 | The approach to the adult with newly diagnosed adrenal insufficiency. ( Arlt, W, 2009) |
| "Addison's disease is a rare endocrine disorder which can be life-threatening." | 1.31 | Dehydroepiandrosterone replacement in addison's disease. ( Brody, KH; Kim, SS, 2001) |
| "Paracoccidioidomycosis is an important cause of Addison's disease in South America." | 1.28 | Adrenocortical dysfunction in paracoccidioidomycosis: comparison between plasma beta-lipotrophin/adrenocorticotrophin levels and adrenocortical tests. ( Castro, M; Elias, LL; Martinez, R; Moreira, AC, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (45.24) | 18.7374 |
| 1990's | 1 (2.38) | 18.2507 |
| 2000's | 14 (33.33) | 29.6817 |
| 2010's | 8 (19.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grossman, A | 1 |
| Johannsson, G | 1 |
| Quinkler, M | 2 |
| Zelissen, P | 1 |
| Palmiere, C | 1 |
| de Froidmont, S | 1 |
| Mangin, P | 1 |
| Werner, D | 1 |
| Lobrinus, JA | 1 |
| Fichna, M | 2 |
| Fichna, P | 1 |
| Gryczyńska, M | 2 |
| Czarnywojtek, A | 1 |
| Żurawek, M | 1 |
| Ruchała, M | 1 |
| Ross, IL | 1 |
| Louw, GJ | 1 |
| Pulzer, A | 1 |
| Burger-Stritt, S | 1 |
| Hahner, S | 1 |
| Arlt, W | 2 |
| Tiede, N | 1 |
| Hofbauer, LC | 1 |
| Bornstein, SR | 1 |
| Kirch, W | 1 |
| Sowińska, A | 1 |
| Sowiński, J | 1 |
| Laureti, S | 1 |
| Candeloro, P | 1 |
| Aglietti, MC | 1 |
| Giordano, R | 1 |
| Arvat, E | 1 |
| Ghigo, E | 1 |
| Santeusanio, F | 1 |
| Falorni, A | 1 |
| Perry, CG | 1 |
| Connell, JM | 1 |
| NATOLI, A | 1 |
| MAGLIOCCA, R | 1 |
| HENI, F | 1 |
| GOBEL, P | 1 |
| MAST, H | 1 |
| KOMOR, K | 1 |
| POCHI, PE | 1 |
| STRAUSS, JS | 1 |
| MESCON, H | 1 |
| IACONO, G | 1 |
| BRANCACCIO, A | 1 |
| D ALESSANDRO, B | 1 |
| DELUCA, R | 1 |
| REPOLE, R | 1 |
| DENEVE, L | 1 |
| VERMEULEN, A | 1 |
| Libè, R | 1 |
| Barbetta, L | 1 |
| Dall'Asta, C | 1 |
| Salvaggio, F | 1 |
| Gala, C | 1 |
| Beck-Peccoz, P | 1 |
| Ambrosi, B | 1 |
| Coles, AJ | 1 |
| Thompson, S | 1 |
| Cox, AL | 1 |
| Curran, S | 1 |
| Gurnell, EM | 3 |
| Chatterjee, VK | 3 |
| Bassotti, G | 1 |
| Di Sarra, D | 1 |
| Pietrobono, D | 1 |
| Schiaffini, R | 1 |
| Battocletti, T | 1 |
| D'Amico, T | 1 |
| Gargiulo, P | 1 |
| Hunt, PJ | 2 |
| Curran, SE | 1 |
| Conway, CL | 1 |
| Pullenayegum, EM | 1 |
| Huppert, FA | 2 |
| Compston, JE | 1 |
| Herbert, J | 2 |
| Brückel, J | 1 |
| Urban, MD | 1 |
| Lee, PA | 1 |
| Gutai, JP | 1 |
| Migeon, CJ | 1 |
| Gebre-Medhin, G | 1 |
| Husebye, ES | 1 |
| Mallmin, H | 1 |
| Helström, L | 1 |
| Berne, C | 1 |
| Karlsson, FA | 1 |
| Kämpe, O | 1 |
| Richards, C | 1 |
| Prevost, AT | 1 |
| Wass, JA | 1 |
| Achermann, JC | 1 |
| Silverman, BL | 1 |
| Kim, SS | 1 |
| Brody, KH | 1 |
| Martin-Du Pan, RC | 1 |
| Nieschlag, E | 1 |
| Kley, HK | 1 |
| Sizonenko, PC | 3 |
| Paunier, L | 2 |
| Carmignac, D | 1 |
| Moreira, AC | 1 |
| Martinez, R | 1 |
| Castro, M | 1 |
| Elias, LL | 1 |
| Devogelaer, JP | 1 |
| Crabbé, J | 1 |
| Nagant de Deuxchaisnes, C | 1 |
| Burke, CW | 1 |
| Vaitukaitis, JL | 1 |
| Melby, JC | 2 |
| Cathro, DM | 1 |
| Lever, M | 1 |
| Crook, D | 1 |
| Blunck, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dehydroepiandrosterone(DHEA) Substitution in Adolescent and Young Women With Central Adrenal Insufficiency. A Multicenter, Randomised Double Blind Trial[NCT00575341] | Phase 3 | 23 participants (Actual) | Interventional | 2003-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for dehydroepiandrosterone and Addison Disease
| Article | Year |
|---|---|
Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe.
Topics: Addison Disease; Adrenal Insufficiency; Cardiovascular Diseases; Circadian Rhythm; Dehydroepiandrost | 2013 |
Embryological and molecular development of the adrenal glands.
Topics: Addison Disease; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Carcinoma; Dehydroepiandros | 2015 |
[Addison's disease : Primary adrenal insufficiency].
Topics: Addison Disease; Dehydroepiandrosterone; Drug Monitoring; Emergency Medical Services; Evidence-Based | 2016 |
[Addison's disease].
Topics: Addison Disease; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Critical Care; Dehydroepiand | 2012 |
Key developments in endocrinology.
Topics: Addison Disease; Adjuvants, Immunologic; Dehydroepiandrosterone; Endocrine System Diseases; Female; | 2003 |
[Replacement and supplementation of DHEA--is it a wellness hormone?].
Topics: Addison Disease; Adjuvants, Immunologic; Administration, Oral; Adult; Age Factors; Aged; Aged, 80 an | 2005 |
Dehydroepiandrosterone replacement for patients with adrenal insufficiency.
Topics: Addison Disease; Adjuvants, Immunologic; Adult; Aged; Aging; Dehydroepiandrosterone; Female; Humans; | 2001 |
[Is there an indication for dehydroepiandrosterone (DHEA) treatment in elderly women with Addison disease? Beneficial and adverse effects of DHEA].
Topics: Addison Disease; Adjuvants, Immunologic; Dehydroepiandrosterone; Female; Humans; Male; Middle Aged | 2001 |
Adrenocortical insufficiency.
Topics: Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aldosterone; Androstenedione; A | 1985 |
Assessment of adrenocortical function.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aldoster | 1971 |
[Some diagnostic and therapeutic aspects of adrenal disorders in childhood (author's transl)].
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; A | 1973 |
4 trials available for dehydroepiandrosterone and Addison Disease
| Article | Year |
|---|---|
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism.
Topics: Addison Disease; Adrenal Insufficiency; Adult; Affect; Aged; Androstenedione; Behavior; Blood Glucos | 2004 |
Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial.
Topics: Absorptiometry, Photon; Addison Disease; Adult; Aged; Body Composition; Bone Density; Cognition; Deh | 2008 |
Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease.
Topics: Addison Disease; Administration, Oral; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiand | 2000 |
Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial.
Topics: Addison Disease; Adult; Affect; Aged; Body Composition; Bone Density; Cognition; Cross-Over Studies; | 2000 |
27 other studies available for dehydroepiandrosterone and Addison Disease
| Article | Year |
|---|---|
Ketoacidosis and adrenocortical insufficiency.
Topics: 17-Hydroxycorticosteroids; 3-Hydroxybutyric Acid; Addison Disease; Adult; Aldosterone; C-Reactive Pr | 2014 |
Steroid replacement in primary adrenal failure does not appear to affect circulating adipokines.
Topics: Addison Disease; Adiponectin; Adrenal Cortex Hormones; Adult; Body Composition; Body Mass Index; Deh | 2015 |
The approach to the adult with newly diagnosed adrenal insufficiency.
Topics: Addison Disease; Androgens; Dehydroepiandrosterone; Diagnosis, Differential; Glucocorticoids; Health | 2009 |
[Therapy of Addison's disease].
Topics: Addison Disease; Administration, Oral; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Blood | 2010 |
[Metabolic assessment of hydrocortisone replacement therapy in patients with primary adrenocortical insufficiency].
Topics: Addison Disease; Adolescent; Adult; Aged; Dehydroepiandrosterone; Drug Therapy, Combination; Female; | 2011 |
Dehydroepiandrosterone, 17alpha-hydroxyprogesterone and aldosterone responses to the low-dose (1 micro g) ACTH test in subjects with preclinical adrenal autoimmunity.
Topics: 17-alpha-Hydroxyprogesterone; Addison Disease; Adolescent; Adrenal Cortex Function Tests; Adrenocort | 2002 |
[Urinary elimination of 17-ketosteroids and dehydroisoandrosterone in patients with various endocrine diseases (Addison's disease, Cushing's disease, Cushing's syndrome, precocious puberty caused by congenital adrenal hyperplasia, acromegaly)].
Topics: 17-Ketosteroids; Acromegaly; Addison Disease; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperf | 1955 |
[Hormonal tests in the diagnosis of Addison's disease; hormonal excretion (Porter-Silber chromogenes, 17-ketosteroids, dehydroepiandrosterone) and intravenous ACTH test in diagnosis of Addison's disease].
Topics: 17-Ketosteroids; Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Dehydroepiandr | 1958 |
[ON THE TREATMENT OF ADRENAL CORTEX DISEASES].
Topics: Addison Disease; Adrenal Cortex Diseases; Adrenal Insufficiency; Adrenocortical Hyperfunction; Adren | 1963 |
THE ROLE OF ADRENOCORTICAL STEROIDS IN THE CONTROL OF HUMAN SEBACEOUS GLAND ACTIVITY.
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Androsterone; Cushin | 1963 |
[STUDY OF ADRENAL CORTEX FUNCTION AFTER ADMINISTRATION OF HYDROCHLOROTHIAZIDE IN NORMAL SUBJECTS AND PATIENTS WITH ADRENAL GLAND DISEASES].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adrenal Cortex; Adrenal Gland Diseases; | 1964 |
THE DETERMINATION OF 17-OXOSTEROID SULPHATES IN HUMAN PLASMA.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenalectomy; Androsterone; Blood Chemical Analysis; | 1965 |
Dehydroepiandrosterone replacement in patients with Addison's disease has a bimodal effect on regulatory (CD4+CD25hi and CD4+FoxP3+) T cells.
Topics: Addison Disease; Adjuvants, Immunologic; Administration, Oral; Adult; CD4 Lymphocyte Count; Cell Pro | 2005 |
Polyglandular autoimmune endocrine insufficiency complicated by severe osteoporosis.
Topics: Addison Disease; Adult; Asthenia; Bone Density; Dehydroepiandrosterone; Female; Gonadal Steroid Horm | 2006 |
Androgens in pubertal males with Addison's disease.
Topics: Addison Disease; Adolescent; Adult; Androgens; Androstenedione; Child; Dehydroepiandrosterone; Gonad | 1980 |
Dehydroepiandrosterone replacement in addison's disease.
Topics: Addison Disease; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Axilla; Blood Glucose; Cortison | 2001 |
Quality of life in Addison's disease--the case for DHEA replacement.
Topics: Addison Disease; Adjuvants, Immunologic; Dehydroepiandrosterone; Growth Hormone; Health Status; Horm | 2002 |
Possibility of adrenal-testicular interaction as indicated by plasma androgens in response to HCG in men with normal, suppressed and impaired adrenal function.
Topics: Addison Disease; Adrenal Cortex Hormones; Adult; Androgens; Androstenedione; Chorionic Gonadotropin; | 1975 |
Hormonal changes in puberty III: Correlation of plasma dehydroepiandrosterone, testosterone, FSH, and LH with stages of puberty and bone age in normal boys and girls and in patients with Addison's disease or hypogonadism or with premature or late adrenarc
Topics: Addison Disease; Adolescent; Bone Development; Child; Dehydroepiandrosterone; Female; Follicle Stimu | 1975 |
Hormonal changes during puberty. IV. Longitudinal study of acrenal androgen secretions.
Topics: Addison Disease; Child; Dehydroepiandrosterone; Female; Humans; Male; Puberty; Puberty, Precocious; | 1976 |
Proceedings: Maturation of the adrenal androgen secretion during puberty.
Topics: Addison Disease; Adolescent; Age Determination by Skeleton; Child; Dehydroepiandrosterone; Female; H | 1975 |
Adrenocortical dysfunction in paracoccidioidomycosis: comparison between plasma beta-lipotrophin/adrenocorticotrophin levels and adrenocortical tests.
Topics: Addison Disease; Adolescent; Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aldosterone; Andros | 1992 |
Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass.
Topics: Addison Disease; Adult; Aged; Androgens; Androstenedione; Bone and Bones; Dehydroepiandrosterone; Es | 1987 |
Menstrual disorders associated with adrenal dysfunction.
Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; | 1969 |
The effect of clomiphene on the androgen production of pubertal and prepubertal boys.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Gland Diseases; Androgens; Child; Child, Presc | 1969 |
Some improvements on the fluorometric determination of serum corticosteroids.
Topics: 17-Hydroxycorticosteroids; Acetates; Addison Disease; Adrenal Cortex Hormones; Alcohols; Algestone A | 1971 |
The routine measurement of urinary 17-oxosteroids and 17-oxogenic steroids using gas-liquid chromatography.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Androgens; Androsterone; Chromat | 1972 |