dehydrocurvularin has been researched along with Adenocarcinoma* in 1 studies
1 other study(ies) available for dehydrocurvularin and Adenocarcinoma
| Article | Year |
|---|---|
Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells.
Cell adhesion plays a crucial role in candidiasis through invasion of the human body and obtaining resistance to drugs by forming biofilms. Cell adhesion thus is a critical target for combating candidiasis by preventing the entry of fungal hyphae into the epithelium. We report here that dehydrocurvularin (1), isolated from the marine-derived fungus Curvularia aeria, exhibited anti-fungal activities for Candida albicans and Candida auris. This compound also prevented the adherence of C. albicans to human adenocarcinoma cells. Real-time RT-PCR analysis showed that exposure to 1 results in decreased expression of HWP1, EFG1, and ECE1, genes involved in Candida adhesion to epithelial cells and hyphal morphogenesis. Topics: Adenocarcinoma; Antifungal Agents; Biofilms; Candida; Candida albicans; Candidiasis; Fungal Proteins; Gene Expression Regulation, Fungal; Humans; Zearalenone | 2022 |