deguelin has been researched along with Lung Neoplasms in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 13 (50.00) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, D; Lu, G; Yao, Y; Zhang, X; Zhou, J | 1 |
| Gao, F; Li, M; Li, W; Liu, H; Liu, W; Yu, X; Zhou, L | 1 |
| Dong, Y; Ma, X; Xu, J; Xu, S; Zhou, H | 1 |
| Dong, X; Gao, F; Li, W; Ma, X; Wang, R; Wang, W | 1 |
| Chen, Y; Cui, D; Han, W; Liu, X; Zhao, D | 1 |
| Bi, Y; Chen, Y; Ma, F; Wang, A; Wang, W; Wei, X | 1 |
| Chen, JC; Chung, JG; Fan, MJ; Hsia, TC; Hsiao, YT; Huang, AC; Lien, JC; Lin, JJ; Wu, RS | 1 |
| Li, W; Liu, H; Liu, L; Ma, X; Wang, J; Xia, Z; Xie, L; Yang, Y; Yu, X; Zhou, H; Zhou, X | 1 |
| Alimirah, F; Gupta, A; Kalra, A; Katta, H; Mehta, RG; Mehta, RR; Murillo, G; Muzzio, M; Patel, R; Peng, X; Unni, A | 1 |
| Choi, H; Hong, HS; Kim, H; Kim, HS; Kim, KC; Kim, KW; Lee, HY; Lee, J; Lee, MY; Lee, SC; Min, HY; Park, HJ; Park, SJ; Seo, JH; Seong, MA; Suh, YG | 1 |
| Lee, D; Lee, HE; Lee, HY; Lee, SH; Lee, YM; Nguyen, MP | 1 |
| Chiang, JH; Chung, JG; Hsia, TC; Hsu, YC; Lai, KC; Lien, JC; Wu, RS; Yu, CS; Yu, FS | 1 |
| Jiao, Y; Zhang, Z; Zhao, H | 1 |
| Bao, Z; Lu, G; Yan, B; Yao, Y; Zhao, D; Zhou, J | 1 |
| Chang, DJ; Geo, SY; Han, SH; Hennessy, B; Hong, WK; Kang, HJ; Kim, KW; Kim, WY; Kim, YS; Lee, HY; Mills, G; Park, HJ; Seo, SY; Suh, YG; Yoo, J | 1 |
| Choi, DS; Gilbert, BE; Hong, WK; Lee, HY; Tran, HT; Woo, JK | 1 |
| Dennis, PA; Memmott, RM | 1 |
| Chung, JG; Hsia, TC; Ji, BC; Ko, YC; Lai, KC; Lai, TY; Lin, JJ; Yang, JS; Yang, ST; Yu, CC | 1 |
| Crowell, JA; Steele, VE | 1 |
| Chun, KH; Hong, WK; Kosmeder, JW; Lee, HY; Lotan, R; Pezzuto, JM; Sun, S | 1 |
| Hong, WK; Kosmeder, JW; Kurie, JM; Lee, HY; Pezzuto, JM; Suh, YA | 1 |
| Lee, HY | 1 |
| Hecht, SS | 1 |
| Cody, D; Hong, WK; Kim, WY; Lee, HY; Moriarty, RM; Oh, SH; Pezzuto, JM; Price, RE; Tran, H; Van Pelt, CS; Woo, JK | 1 |
| Lubet, RA; Tan, Q; Wang, Y; Yan, Y; You, M | 1 |
| Behrens, C; Bekele, BN; Feng, L; Hong, WK; Jin, Q; Lee, HY; Wistuba, II | 1 |
26 other study(ies) available for deguelin and Lung Neoplasms
| Article | Year |
|---|---|
Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway.
Topics: A549 Cells; Animals; Carcinoma, Non-Small-Cell Lung; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Lung Neoplasms; Mice; Neoplasm Metastasis; PTEN Phosphohydrolase; Rotenone; Signal Transduction | 2022 |
Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; F-Box-WD Repeat-Containing Protein 7; Female; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Mice, Nude; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Protein Kinase Inhibitors; Protein Stability; Rotenone; Signal Transduction; Tumor Burden; Ubiquitination; Xenograft Model Antitumor Assays | 2020 |
Development of a novel truncated deguelin derivative possessing nitric oxide donor as a potential anti-lung cancer agent.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Molecular Structure; Nitric Oxide Donors; Rotenone | 2020 |
Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Down-Regulation; Glycolysis; Hexokinase; Humans; Lung Neoplasms; Mice; Rotenone | 2017 |
Deguelin inhibits epithelial-to-mesenchymal transition and metastasis of human non-small cell lung cancer cells by regulating NIMA-related kinase 2.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasm Metastasis; NIMA-Related Kinases; Rotenone | 2017 |
Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox).
Topics: A549 Cells; Apoptosis; Apoptosis Regulatory Proteins; Doxorubicin; Humans; Lung Neoplasms; Proto-Oncogene Proteins; Rotenone | 2018 |
Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-[Formula: see text]B Signaling Pathways.
Topics: Antineoplastic Agents, Phytogenic; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Gene Expression; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Rotenone; Signal Transduction | 2018 |
Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway.
Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cathepsin Z; Cell Line, Tumor; Cell Movement; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasm Metastasis; Rotenone; Signal Transduction | 2018 |
Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells.
Topics: Animals; Cell Division; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Rotenone | 2013 |
Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90.
Topics: Animals; Antineoplastic Agents; Benzopyrans; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms; Mice; Mice, SCID; Quinolines; Rotenone; Signal Transduction; Xenograft Model Antitumor Assays | 2015 |
Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion.
Topics: Actins; Angiogenesis Inhibitors; Animals; Apoptosis; Carcinogenesis; Carcinoma, Lewis Lung; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemoprevention; Endothelial Progenitor Cells; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; G1 Phase Cell Cycle Checkpoints; Green Fluorescent Proteins; Humans; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Protein Serine-Threonine Kinases; Rotenone; Xenograft Model Antitumor Assays | 2015 |
Antitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts model.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Calcium; Caspase 3; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Rotenone; Xenograft Model Antitumor Assays | 2017 |
Deguelin inhibits the migration and invasion of lung cancer A549 and H460 cells via regulating actin cytoskeleton rearrangement.
Topics: Actin Cytoskeleton; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pseudopodia; rac1 GTP-Binding Protein; rho-Associated Kinases; Rotenone; Signal Transduction | 2015 |
Deguelin Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells through Regulating the Expression of Galectin-1.
Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Female; Galectin 1; Humans; Immunoblotting; Immunoprecipitation; Lung Neoplasms; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; Rotenone; Signal Transduction | 2016 |
A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chemoprevention; Gene Expression; Humans; Lung Neoplasms; Rotenone; Signal Transduction | 2008 |
Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
Topics: Administration, Intranasal; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromatography, High Pressure Liquid; Genes, ras; Humans; Immunohistochemistry; Liposomes; Lung Neoplasms; Mice; Mice, Mutant Strains; Precancerous Conditions; Rotenone; Tissue Distribution | 2009 |
The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.
Topics: Animals; Carcinogens; Humans; Indoles; Inositol; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Mice; Nicotiana; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Sirolimus; Smoking; TOR Serine-Threonine Kinases | 2010 |
Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; Comet Assay; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; DNA Topoisomerases, Type I; DNA-Activated Protein Kinase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Electrophoresis, Agar Gel; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nuclear Proteins; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; RNA, Messenger; Rotenone; Time Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2012 |
AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment.
Topics: Antineoplastic Agents; Cell Cycle; Humans; Lung Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Tumor Cells, Cultured | 2003 |
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.
Topics: Antineoplastic Agents; Apoptosis; Bronchial Neoplasms; Cell Cycle; Cells, Cultured; Drug Screening Assays, Antitumor; Genetic Vectors; Humans; Immunoblotting; Lung Neoplasms; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Signal Transduction; Tumor Cells, Cultured | 2003 |
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells.
Topics: Apoptosis; Blotting, Western; Bronchi; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cyclooxygenase 2; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Immunoblotting; Isoenzymes; Lung Neoplasms; Male; Membrane Proteins; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rotenone; Time Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2004 |
Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells.
Topics: Apoptosis; Cell Survival; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Lung Neoplasms; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rotenone; Tumor Cells, Cultured | 2004 |
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution | 2005 |
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Bronchial Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution | 2005 |
Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Topics: Adenoma; Administration, Oral; Animals; Benzo(a)pyrene; Disease Models, Animal; Lung Neoplasms; Mice; Mice, Inbred A; Rotenone; Silybin; Silybum marianum; Silymarin | 2005 |
Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin.
Topics: AMP-Activated Protein Kinases; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Microtubule-Associated Proteins; Multienzyme Complexes; Neoplasm Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Rotenone; Survivin; Transfection; Uncoupling Agents | 2007 |