defibrotide and Respiration-Disorders

For patients with untreated hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) with multi-organ dysfunction (MOD), mortality is >80%. We conducted a pooled analysis of three studies that assessed Day 100 survival in relationship to MOD severity, with dialysis and/or ventilator dependence representing the most severe organ dysfunction. All patients in the analysis were diagnosed using Baltimore criteria/biopsy. This analysis of patients with VOD/SOS and MOD after haematopoietic cell transplantation (HCT; n = 651) demonstrated higher Day 100 survival rates amongst defibrotide-treated patients with VOD/SOS with less versus more severe forms of MOD. Even patients with severe forms of MOD post-HCT benefitted from defibrotide.

Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Confidence Intervals; Female; Fibrinolytic Agents; Hematopoietic Stem Cell Transplantation; Hemorrhage; Hepatic Veno-Occlusive Disease; Humans; Infant; Infant, Newborn; Male; Middle Aged; Multicenter Studies as Topic; Multiple Organ Failure; Odds Ratio; Polydeoxyribonucleotides; Renal Dialysis; Respiration Disorders; Respiration, Artificial; Retrospective Studies; Transplantation Conditioning; Young Adult