deferoxamine has been researched along with Uremia in 40 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Considering that creatine kinase (CK) is important for brain energy homeostasis and is inhibited by free radicals, and that oxidative stress is probably involved in the pathogenesis of uremic encephalopathy, we measured CK activity (hippocampus, striatum, cerebellum, cerebral cortex and prefrontal cortex) in brain if rats submitted to renal ischemia and the effect of administration of antioxidants (N-acetylcysteine, NAC and deferoxamine, DFX) on this enzyme." | 7.74 | Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration. ( Burigo, M; Constantino, L; Dal-Pizzol, F; Di-Pietro, PB; Dias, ML; Machado, RA; Scaini, G; Streck, EL, 2008) |
| " Considering that creatine kinase (CK) is important for brain energy homeostasis and is inhibited by free radicals, and that oxidative stress is probably involved in the pathogenesis of uremic encephalopathy, we measured CK activity (hippocampus, striatum, cerebellum, cerebral cortex and prefrontal cortex) in brain if rats submitted to renal ischemia and the effect of administration of antioxidants (N-acetylcysteine, NAC and deferoxamine, DFX) on this enzyme." | 3.74 | Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration. ( Burigo, M; Constantino, L; Dal-Pizzol, F; Di-Pietro, PB; Dias, ML; Machado, RA; Scaini, G; Streck, EL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (47.50) | 18.7374 |
| 1990's | 15 (37.50) | 18.2507 |
| 2000's | 6 (15.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kinugasa, E | 1 |
| Sikole, A | 1 |
| Stojkovski, L | 1 |
| Cakalaroski, K | 1 |
| Stojcev, N | 1 |
| Amitov, V | 1 |
| Polenakovic, M | 1 |
| Di-Pietro, PB | 1 |
| Dias, ML | 1 |
| Scaini, G | 1 |
| Burigo, M | 1 |
| Constantino, L | 1 |
| Machado, RA | 1 |
| Dal-Pizzol, F | 1 |
| Streck, EL | 1 |
| Segoloni, GP | 1 |
| Canavese, C | 5 |
| D'Amicone, M | 3 |
| Lamon, S | 1 |
| Talarico, S | 1 |
| Vercellone, A | 1 |
| Kambova, L | 1 |
| Ionova, D | 1 |
| Kirijakov, Z | 1 |
| Gómez, M | 2 |
| Domingo, JL | 2 |
| del Castillo, D | 2 |
| Llobet, JM | 1 |
| Corbella, J | 1 |
| Romero, RA | 1 |
| Panico, F | 1 |
| Salvati, A | 1 |
| Scoppa, F | 1 |
| Testa, GF | 1 |
| Capobianco, A | 1 |
| Pacia, S | 1 |
| Lauriello, F | 1 |
| Aquino, A | 1 |
| Tedesco, V | 1 |
| Taccone, W | 1 |
| Andriani, M | 1 |
| Nordio, M | 1 |
| Saporiti, E | 1 |
| Jablonski, G | 1 |
| Klem, KH | 1 |
| Danielsen, CC | 1 |
| Mosekilde, L | 1 |
| Gordeladze, JO | 1 |
| Menéndez-Fraga, P | 1 |
| Fernández-Martín, JL | 2 |
| Blanco-González, E | 1 |
| Cannata-Andía, JB | 2 |
| Esparza, JL | 1 |
| Hernández, M | 1 |
| Huang, JY | 1 |
| Wu, MS | 1 |
| Wu, CH | 1 |
| Fernández-Soto, I | 1 |
| Acuña, G | 1 |
| Geffriaud, C | 1 |
| Allinne, E | 1 |
| Page, B | 1 |
| Zingraff, J | 2 |
| Jucquel, JP | 1 |
| Bardin, T | 1 |
| Drüeke, TB | 1 |
| Fournier, A | 2 |
| Morinière, P | 2 |
| Ben Hamida, F | 1 |
| el Esjer, N | 1 |
| Shenovda, M | 1 |
| Ghazali, A | 1 |
| Bouzernidj, M | 1 |
| Achard, JM | 1 |
| Westeel, PF | 1 |
| Gurioli, L | 2 |
| Cardelli, R | 1 |
| Caligaris, F | 1 |
| Bongiorno, P | 1 |
| Arnaud, A | 1 |
| Mattiello, G | 1 |
| Marchiori, M | 1 |
| De Marchi, S | 1 |
| Cecchin, E | 1 |
| Salomone, M | 2 |
| Pacitti, A | 3 |
| Mangiarotti, G | 2 |
| Thea, A | 3 |
| Dogliani, M | 1 |
| Serra, A | 1 |
| Casati, S | 1 |
| Campise, M | 1 |
| Ponticelli, C | 1 |
| Winterberg, B | 1 |
| Bertram, HP | 1 |
| Salusky, IB | 1 |
| Coburn, JW | 2 |
| Nelson, P | 1 |
| Goodman, WG | 1 |
| Segoloni, G | 2 |
| Stratta, P | 2 |
| Rossi, P | 1 |
| Sabbioni, E | 1 |
| Pietra, R | 1 |
| Constantini, S | 2 |
| Ureña, P | 1 |
| Basile, C | 1 |
| Grateau, G | 1 |
| Lacour, B | 1 |
| Vassault, A | 1 |
| Bourdeau, A | 1 |
| Bourdon, R | 1 |
| Dubost, C | 1 |
| Drüeke, T | 1 |
| Giordini, R | 1 |
| Hamed, LM | 1 |
| Winward, KE | 1 |
| Glaser, JS | 1 |
| Schatz, NJ | 1 |
| Verbeelen, D | 1 |
| Smeyers-Verbeke, J | 1 |
| van Hooff, I | 1 |
| de Roy, G | 1 |
| Weiss, LG | 1 |
| Danielson, BG | 1 |
| Fellström, B | 1 |
| Wikström, B | 1 |
| Ackrill, P | 1 |
| Day, JP | 1 |
| Ahmed, R | 1 |
| Leung, FY | 1 |
| Niblock, AE | 1 |
| Bradley, C | 1 |
| Henderson, AR | 1 |
| Fagioli, F | 1 |
| Locatelli, C | 1 |
| Gilli, P | 1 |
| D'Haese, PC | 1 |
| Van de Vyver, FL | 1 |
| Lamberts, LV | 1 |
| De Broe, ME | 1 |
| Marumo, F | 1 |
| Umetani, N | 1 |
| Sato, N | 1 |
| Takahashi, Y | 1 |
| Veis, JH | 1 |
| Contiguglia, R | 1 |
| Klein, M | 1 |
| Mishell, J | 1 |
| Alfrey, AC | 1 |
| Shapiro, JI | 1 |
| Freundlich, M | 1 |
| Zilleruelo, G | 1 |
| Faugere, MC | 1 |
| Abitbol, C | 1 |
| Strauss, J | 1 |
| Malluche, HH | 1 |
| Hino, M | 1 |
| Yamamoto, I | 1 |
| Shigeno, C | 1 |
| Aoki, J | 1 |
| Torizuka, K | 1 |
| Iwamoto, N | 1 |
| Yamazaki, S | 1 |
| Fukuda, T | 1 |
| Kondo, M | 1 |
| Yamamoto, N | 1 |
| Andress, DL | 1 |
| Kopp, JB | 1 |
| Maloney, NA | 1 |
| Sherrard, DJ | 1 |
| Fohrer, P | 1 |
| Leflon, P | 1 |
| Tolani, M | 1 |
| Lambrey, G | 1 |
| Demontis, R | 1 |
| Sebert, JL | 1 |
| Van Devyver, F | 1 |
| Debroe, M | 1 |
| Baldamus, CA | 1 |
| Schmidt, H | 1 |
| Scheuermann, EH | 1 |
| Werner, E | 1 |
| Kaltwasser, JP | 1 |
| Schoeppe, W | 1 |
| Neuwirtová, R | 1 |
| Setková, O | 1 |
| Dufek, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Incidence and Causes of Disc Edema in Patients With Chronic Kidney Disease[NCT00769834] | 0 participants (Actual) | Observational | 2010-01-31 | Withdrawn (stopped due to All investigators have moved to different oranizations) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for deferoxamine and Uremia
| Article | Year |
|---|---|
[Uremic encephalopathy, dialysis encephalopathy].
Topics: Aluminum; Brain Diseases, Metabolic; Deferoxamine; Diagnosis, Differential; Hemofiltration; Humans; | 2004 |
Aluminum, vanadium, and lead intoxication of uremic patients undergoing hemodialysis in Venezuela.
Topics: Aluminum; Deferoxamine; Humans; Lead Poisoning; Renal Dialysis; Uremia; Vanadium; Venezuela; Water P | 1994 |
Use of alkaline calcium salts as phosphate binder in uremic patients.
Topics: Aluminum; Calcinosis; Calcitriol; Calcium; Deferoxamine; Humans; Hyperparathyroidism, Secondary; Pho | 1992 |
Aluminum and iron overload in chronic dialysis.
Topics: Aluminum; Bone Diseases; Deferoxamine; Humans; Iron; Renal Dialysis; Uremia | 1988 |
2 trials available for deferoxamine and Uremia
| Article | Year |
|---|---|
Hepatic computed tomography for monitoring the iron status of haemodialysis patients with haemosiderosis treated with recombinant human erythropoietin.
Topics: Adult; Aged; Chelation Therapy; Deferoxamine; Erythropoietin; Female; Ferritins; Hemosiderosis; Huma | 1991 |
Concomitant iron and aluminum mass transfer following deferoxamine infusion during hemofiltration.
Topics: Adult; Aluminum; Deferoxamine; Female; Ferritins; Hemofiltration; Humans; Iron; Male; Middle Aged; U | 1991 |
34 other studies available for deferoxamine and Uremia
| Article | Year |
|---|---|
Successful treatment of soft tissue calcifications in uremia.
Topics: Buttocks; Calcinosis; Deferoxamine; Diphosphonates; Drug Therapy, Combination; Female; Humans; Kidne | 2006 |
Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration.
Topics: Acetylcysteine; Animals; Antioxidants; Brain; Brain Diseases, Metabolic; Creatine Kinase; Deferoxami | 2008 |
Zinc, copper and magnesium kinetics during desferrioxamine treatment in uremic patients.
Topics: Copper; Deferoxamine; Humans; Magnesium; Uremia; Zinc | 1984 |
Aluminium overload influences cognitive function in patients on dialysis.
Topics: Adult; Aluminum; Brain Diseases; Chelating Agents; Cognition; Deferoxamine; Female; Humans; Male; Mi | 1994 |
Comparative aluminium mobilizing actions of several chelators in aluminium-loaded uraemic rats.
Topics: Aluminum; Animals; Chelating Agents; Citrates; Citric Acid; Deferiprone; Deferoxamine; Female; Injec | 1994 |
[Interaction between active metabolites of vitamin D3 and blood aluminum in chronic uremic patients on dialysis].
Topics: Adolescent; Adult; Aged; Aluminum; Aluminum Hydroxide; Calcitriol; Chronic Disease; Deferoxamine; Dr | 1993 |
Estimation of statistical moments for desferrioxamine and its iron and aluminum chelates: contribution to optimisation of therapy in uremic patients.
Topics: Aluminum; Antidotes; Chelating Agents; Data Interpretation, Statistical; Deferoxamine; Drug Administ | 1996 |
Aluminium-induced bone disease in uremic rats: effect of deferoxamine.
Topics: Adenylyl Cyclases; Aluminum; Animals; Biomechanical Phenomena; Bone and Bones; Bone Diseases; Bone R | 1996 |
Low percentage of aluminoxamine and ferrioxamine in uremic serum after desferrioxamine administration.
Topics: Aluminum; Chelating Agents; Chromatography, High Pressure Liquid; Deferoxamine; Ferric Compounds; Hu | 1998 |
Age-Related differences on aluminium mobilization by chelating agents in aluminium-loaded uraemic rats.
Topics: Administration, Oral; Aging; Aluminum; Aluminum Compounds; Animals; Anthelmintics; Chelating Agents; | 2000 |
The effect of an iron supplement on serum aluminum level and desferrioxamine mobilization test in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Aluminum; Anemia, Iron-Deficiency; Deferoxamine; Female; Ferritins; | 2001 |
Bone aluminum uptake in uremic rats receiving intraperitoneal iron.
Topics: Aluminum; Animals; Bone and Bones; Deferoxamine; Erythropoietin; Iron; Male; Rats; Rats, Wistar; Ren | 2001 |
Decrease of tumor-like calcification in uremia despite aggravation of secondary hyperparathyroidism: a case report.
Topics: Aluminum; Calcinosis; Chelation Therapy; Connective Tissue Diseases; Deferoxamine; Female; Humans; H | 1992 |
Kinetics of aluminoxamine and feroxamine chelates in dialysis patients.
Topics: Adult; Aged; Aluminum; Chelating Agents; Deferoxamine; Humans; Iron; Kinetics; Middle Aged; Organome | 1992 |
Aluminium interference in the treatment with recombinant human erythropoietin.
Topics: Aluminum; Anemia; Deferoxamine; Drug Resistance; Erythropoietin; Humans; Recombinant Proteins; Uremi | 1990 |
Aluminum removal in uremic patients after desferrioxamine infusion: is hemofiltration more effective than hemodialysis?
Topics: Aluminum; Deferoxamine; Hemofiltration; Humans; Infusions, Parenteral; Renal Dialysis; Uremia | 1990 |
Prospective evaluation of aluminum loading from formula in infants with uremia.
Topics: Aluminum; Bone and Bones; Deferoxamine; Dialysis Solutions; Follow-Up Studies; Histocytochemistry; H | 1990 |
Clinical and histological results of long-term management of aluminium overloading in uraemic patients with desferrioxamine.
Topics: Adult; Aluminum; Bone and Bones; Chelation Therapy; Deferoxamine; Electroencephalography; Female; Fo | 1989 |
Short-term effects of parathyroidectomy on plasma biochemistry in chronic uremia.
Topics: Alkaline Phosphatase; Aluminum; Bone and Bones; Calcifediol; Calcium; Chronic Disease; Cohort Studie | 1989 |
Prevention and treatment of aluminum overload in uremic patients: long-term results.
Topics: Adult; Aluminum; Deferoxamine; Dialysis Solutions; Female; Humans; Male; Middle Aged; Uremia | 1989 |
Optic neuropathy in uremia.
Topics: Adult; Deferoxamine; Female; Humans; Kidney Diseases; Male; Methylprednisolone; Middle Aged; Optic N | 1989 |
Vitamin D, desferrioxamine and aluminum-induced bone disease in uremic rats.
Topics: Aluminum; Animals; Bone and Bones; Brain Chemistry; Chronic Kidney Disease-Mineral and Bone Disorder | 1989 |
Aluminum removal with hemodialysis, hemofiltration and charcoal hemoperfusion in uremic patients after desferrioxamine infusion. A comparison of efficiency.
Topics: Aluminum; Charcoal; Deferoxamine; Hemodialysis Solutions; Hemofiltration; Hemoperfusion; Humans; Inf | 1989 |
Speciation studies of serum aluminum/citrate complex by liquid chromatography-furnace AAS.
Topics: Aluminum; Chromatography, Gel; Chromatography, Liquid; Citrates; Citric Acid; Deferoxamine; Humans; | 1988 |
Determination of aluminium in serum by atomic absorption spectrometry with the L'vov platform at different resonance lines.
Topics: Aluminum; Deferoxamine; Humans; Renal Dialysis; Spectrophotometry, Atomic; Uremia | 1987 |
Aluminum an uremic toxin.
Topics: Aluminum; Deferoxamine; Humans; Renal Dialysis; Tissue Distribution; Toxins, Biological; Uremia | 1987 |
Deferoxamine (DFO): the effectiveness for noninvasive diagnosis of aluminum-related bone disease, and for treatment of the disease.
Topics: Aluminum; Bone and Bones; Bone Diseases; Calcitriol; Calcium; Deafness; Deferoxamine; Eye; Humans; R | 1987 |
Mucormycosis in deferoxamine-treated patients on dialysis.
Topics: Deferoxamine; Humans; Mucormycosis; Renal Dialysis; Uremia | 1987 |
Treatment of aluminum toxicity in infantile uremia with deferoxamine.
Topics: Aluminum; Bone and Bones; Deferoxamine; Humans; Infant; Male; Peritoneal Dialysis; Uremia | 1986 |
[Aluminum associated bone disease in patients undergoing long-term hemodialysis].
Topics: Adult; Aluminum; Bone and Bones; Calcinosis; Chronic Kidney Disease-Mineral and Bone Disorder; Defer | 1986 |
Early deposition of aluminum in bone in diabetic patients on hemodialysis.
Topics: Aluminum; Bone and Bones; Bone Development; Deferoxamine; Diabetes Mellitus, Type 1; Diabetic Nephro | 1987 |
The desferrioxamine test predicts bone aluminium burden induced by A1(OH)3 in uraemic patients but not mild histological osteomalacia.
Topics: Aged; Aluminum; Aluminum Hydroxide; Bone and Bones; Deferoxamine; Female; Humans; Male; Middle Aged; | 1985 |
Desferrioxamine treatment for aluminium and iron overload in uraemic patients by haemodialysis or haemofiltration.
Topics: Adult; Aluminum; Blood; Deferoxamine; Female; Humans; Iron; Male; Middle Aged; Renal Dialysis; Ultra | 1985 |
[The deferoxamine test].
Topics: Deferoxamine; Hematologic Diseases; Hemosiderosis; Humans; Injections, Intramuscular; Iron; Uremia | 1970 |