deferoxamine has been researched along with Spinal Cord Injuries in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lesion-induced scarring is a major impediment for regeneration of injured axons in the central nervous system (CNS)." | 1.42 | Pharmacological Suppression of CNS Scarring by Deferoxamine Reduces Lesion Volume and Increases Regeneration in an In Vitro Model for Astroglial-Fibrotic Scarring and in Rat Spinal Cord Injury In Vivo. ( Brazda, N; Estrada, V; Faissner, A; König, B; Krafft, S; Müller, HW; Vogelaar, CF; Ziegler, B, 2015) |
| "Deferoxamine treatment 30 min before and 1 and 6 h after the SCI significantly reduced: (1) GFAP immunoreactivity, (2) neutrophil infiltration, (3) NF-kappaB activation, (4) iNOS expression, (5) nitrotyrosine and MDA formation, (6) DNA damage (methyl green pyronin staining and PAR formation and (7) apoptosis (TUNEL staining, FasL, Bax and Bcl-2 expression, S-100 expression)." | 1.36 | Modulation of inflammatory response after spinal cord trauma with deferoxamine, an iron chelator. ( Bramanti, P; Cuzzocrea, S; Emanuela, E; Galuppo, M; Mazzon, E; Paola, RD; Paterniti, I, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, G | 1 |
| Chen, Y | 1 |
| Chen, J | 1 |
| Chen, Z | 1 |
| Jiang, W | 1 |
| Dinc, C | 1 |
| Iplikcioglu, AC | 1 |
| Atabey, C | 1 |
| Eroglu, A | 1 |
| Topuz, K | 1 |
| Ipcioglu, O | 1 |
| Demirel, D | 1 |
| Vogelaar, CF | 1 |
| König, B | 1 |
| Krafft, S | 1 |
| Estrada, V | 1 |
| Brazda, N | 1 |
| Ziegler, B | 1 |
| Faissner, A | 1 |
| Müller, HW | 1 |
| Paterniti, I | 1 |
| Mazzon, E | 1 |
| Emanuela, E | 1 |
| Paola, RD | 1 |
| Galuppo, M | 1 |
| Bramanti, P | 1 |
| Cuzzocrea, S | 1 |
| Liu, J | 1 |
| Tang, T | 1 |
| Yang, H | 1 |
| de Castro, R | 1 |
| Alcock, NW | 1 |
| McAdoo, DJ | 1 |
6 other studies available for deferoxamine and Spinal Cord Injuries
| Article | Year |
|---|---|
Deferoxamine Ameliorates Compressed Spinal Cord Injury by Promoting Neovascularization in Rats.
Topics: Animals; Deferoxamine; Hypoxia-Inducible Factor 1, alpha Subunit; Injections, Intraperitoneal; Male; | 2020 |
Comparison of deferoxamine and methylprednisolone: protective effect of pharmacological agents on lipid peroxidation in spinal cord injury in rats.
Topics: Animals; Catalase; Combined Modality Therapy; Deferoxamine; Glutathione Peroxidase; Laminectomy; Lip | 2013 |
Pharmacological Suppression of CNS Scarring by Deferoxamine Reduces Lesion Volume and Increases Regeneration in an In Vitro Model for Astroglial-Fibrotic Scarring and in Rat Spinal Cord Injury In Vivo.
Topics: Animals; Astrocytes; Axons; Central Nervous System; Cicatrix; Collagen Type IV; Cyclic AMP; Deferoxa | 2015 |
Modulation of inflammatory response after spinal cord trauma with deferoxamine, an iron chelator.
Topics: Animals; Apoptosis; Blotting, Western; Deferoxamine; Immunohistochemistry; In Situ Nick-End Labeling | 2010 |
Protective effect of deferoxamine on experimental spinal cord injury in rat.
Topics: Animals; Deferoxamine; Disease Models, Animal; Hindlimb; Injections, Intraperitoneal; Laminectomy; O | 2011 |
Sampling of low molecular weight iron by microdialysis following spinal cord injury.
Topics: Animals; Deferoxamine; Iron; Lipid Peroxidation; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Sp | 1999 |