deferoxamine has been researched along with Sepsis in 21 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathogenesis of sepsis is characterized by an overwhelming systemic inflammatory response that can lead to multiple organ failure." | 5.36 | Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis. ( Cassol, OJ; Dal-Pizzol, F; Ferreira, GK; Gonçalves, CL; Petronilho, FC; Rezin, GT; Roesler, R; Scaini, G; Schwartsmann, G; Streck, EL, 2010) |
| "N-Acetylcysteine plus deferoxamine increased survival in the cecal ligation and puncture model when administered 3 and 12 hours after sepsis induction." | 3.96 | Stratification to predict the response to antioxidant. ( Constantino, L; Dal-Pizzol, F; Damásio, D; Fraga, C; Gonçalves, RC; Michels, M; Ritter, C, 2020) |
| "The pathogenesis of sepsis is characterized by an overwhelming systemic inflammatory response that can lead to multiple organ failure." | 1.36 | Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis. ( Cassol, OJ; Dal-Pizzol, F; Ferreira, GK; Gonçalves, CL; Petronilho, FC; Rezin, GT; Roesler, R; Scaini, G; Schwartsmann, G; Streck, EL, 2010) |
| "Sepsis was induced in 40 rats using the cecal ligation and puncture method (CLP) and 20 rats randomly received twice subcutaneously DFX (total dose: 40 mg/kg)." | 1.32 | Deferoxamine administration in septic animals: improved survival and altered apoptotic gene expression. ( Antonakis, PT; Chatzigianni, E; Konstadoulakis, MM; Leandros, E; Memos, N; Messaris, E, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (52.38) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Ritter, C | 4 |
| Constantino, L | 2 |
| Michels, M | 1 |
| Gonçalves, RC | 1 |
| Fraga, C | 1 |
| Damásio, D | 1 |
| Dal-Pizzol, F | 5 |
| Andrades, M | 2 |
| de Oliveira, MR | 1 |
| Streck, EL | 2 |
| Fonseca Moreira, JC | 1 |
| Cassol, OJ | 1 |
| Rezin, GT | 1 |
| Petronilho, FC | 1 |
| Scaini, G | 1 |
| Gonçalves, CL | 1 |
| Ferreira, GK | 1 |
| Roesler, R | 1 |
| Schwartsmann, G | 1 |
| Crouser, ED | 1 |
| Messaris, E | 1 |
| Antonakis, PT | 1 |
| Memos, N | 1 |
| Chatzigianni, E | 1 |
| Leandros, E | 1 |
| Konstadoulakis, MM | 1 |
| Cross, CE | 1 |
| van Asbeck, BS | 1 |
| Halliwell, B | 1 |
| de Souza, LF | 1 |
| Pens Gelain, D | 1 |
| Bernard, EA | 1 |
| Moreira, JC | 1 |
| Barichello, T | 1 |
| Machado, RA | 1 |
| Valvassori, SS | 1 |
| Réus, GZ | 1 |
| Martins, MR | 1 |
| Petronilho, F | 1 |
| Quevedo, J | 1 |
| Gordts, B | 1 |
| Rummens, E | 1 |
| deMeirleir, L | 1 |
| Butzler, JP | 1 |
| Scharnetzky, M | 1 |
| König, R | 1 |
| Lakomek, M | 1 |
| Tillmann, W | 1 |
| Schröter, W | 1 |
| Moch, D | 1 |
| Schröppel, B | 1 |
| Schoenberg, MH | 1 |
| Schulz, HJ | 1 |
| Thorab, FC | 1 |
| Marzinzag, M | 1 |
| Hedlund, BE | 1 |
| Brückner, UB | 1 |
| Nouel, O | 1 |
| Voisin, PM | 1 |
| Vaucel, J | 1 |
| Dartois-Hoguin, M | 1 |
| Le Bris, M | 1 |
| Tielemans, C | 1 |
| Boelaert, J | 1 |
| Vergauwe, P | 1 |
| van Roost, G | 1 |
| Segaert, M | 1 |
| van Frachen, B | 1 |
| Lenclud, C | 1 |
| Masters, AP | 1 |
| Hopkinson, RB | 1 |
| Hoen, B | 1 |
| Renoult, E | 1 |
| Jonon, B | 1 |
| Kessler, M | 1 |
| Novotny, MJ | 1 |
| Laughlin, MH | 1 |
| Adams, HR | 1 |
| Hadjiminas, JM | 1 |
| Huang, CB | 1 |
| Löhr, H | 1 |
| Mofenson, HC | 1 |
| Caraccio, TR | 1 |
| Sharieff, N | 1 |
| Boelaert, JR | 1 |
| van Landuyt, HW | 1 |
| Valcke, YJ | 1 |
| Cantinieaux, B | 1 |
| Lornoy, WF | 1 |
| Vanherweghem, JL | 1 |
| Moreillon, P | 1 |
| Vandepitte, JM | 1 |
| Boyce, N | 1 |
| Wood, C | 1 |
| Holdsworth, S | 1 |
| Thomson, NM | 1 |
| Atkins, RC | 1 |
21 other studies available for deferoxamine and Sepsis
| Article | Year |
|---|---|
Stratification to predict the response to antioxidant.
Topics: Acetylcysteine; Adult; Aged; Animals; Antioxidants; Deferoxamine; Humans; Male; Middle Aged; Prognos | 2020 |
Antioxidant treatment reverses organ failure in rat model of sepsis: role of antioxidant enzymes imbalance, neutrophil infiltration, and oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Deferoxamine; Disease Models, Animal; Kidney; Lung; | 2011 |
Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis.
Topics: Acetylcysteine; Animals; Bombesin; Brain; Creatine Kinase; Deferoxamine; Electron Transport; Male; P | 2010 |
Therapeutic benefits of antioxidants during sepsis: is protection against oxidant-mediated tissue damage only half the story?
Topics: Acetylcysteine; Animals; Antioxidants; Deferoxamine; Free Radical Scavengers; Humans; Iron Chelating | 2004 |
Deferoxamine administration in septic animals: improved survival and altered apoptotic gene expression.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 8; Caspases; Cytochromes c; Deferoxamine; Fr | 2004 |
More antioxidants in sepsis: still paved with uncertainties.
Topics: Acetylcysteine; Animals; Bronchoalveolar Lavage Fluid; Deferoxamine; Disease Models, Animal; Humans; | 2006 |
Mitochondrial superoxide production is related to the control of cytokine release from peritoneal macrophage after antioxidant treatment in septic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Cytokines; Deferoxamine; Macrophages, Peritoneal; Male; Mitoc | 2007 |
Antioxidant treatment prevented late memory impairment in an animal model of sepsis.
Topics: Acetylcysteine; Animals; Antioxidants; Avoidance Learning; Cecum; Deferoxamine; Disease Models, Anim | 2007 |
Yersinia pseudotuberculosis septicaemia in thalassaemia major.
Topics: Adolescent; Deferoxamine; Female; Humans; Sepsis; Thalassemia; Yersinia Infections; Yersinia pseudot | 1984 |
Prophylaxis of systemic yersinosis in thalassaemia major.
Topics: Child; Deferoxamine; Female; Humans; Risk; Sepsis; Thalassemia; Yersinia Infections | 1984 |
Protective effects of hydroxyethyl starch-deferoxamine in early sepsis.
Topics: Animals; Deferoxamine; Glutathione; Hydroxyethyl Starch Derivatives; Intestine, Small; Kidney; Lipid | 1995 |
[Yersinia enterocolitica septicemia associated with idiopathic hemochromatosis and deferoxamine therapy. A case].
Topics: Deferoxamine; Hemochromatosis; Humans; Infusions, Intravenous; Male; Middle Aged; Risk Factors; Seps | 1991 |
Deferoxamine does not increase the risk for bacteremia in hemodialysis patients.
Topics: Adolescent; Adult; Aged; Child; Deferoxamine; Female; Humans; Kidney Failure, Chronic; Male; Middle | 1989 |
Yersinia enterocolitica septicaemia.
Topics: Adult; Deferoxamine; Hemosiderosis; Humans; Sepsis; Thalassemia; Yersinia enterocolitica; Yersinia I | 1988 |
Septicemia due to Yersinia enterocolitica in a long-term hemodialysis patient after a single desferrioxamine administration.
Topics: Deferoxamine; Humans; Male; Middle Aged; Renal Dialysis; Sepsis; Yersinia enterocolitica; Yersinia I | 1988 |
Evidence for lack of importance of oxygen free radicals in Escherichia coli endotoxemia in dogs.
Topics: Animals; Cardiovascular System; Catalase; Deferoxamine; Dogs; Endotoxins; Escherichia coli Infection | 1988 |
Yersiniosis in acutely iron-loaded children treated with desferrioxamine.
Topics: Child; Deferoxamine; Humans; Infant; Iron; Sepsis; Yersinia Infections | 1988 |
[Yersinia septicemia in children with thalassaemia major].
Topics: Child; Child, Preschool; Deferoxamine; Female; Hemosiderosis; Humans; Male; Risk Factors; Sepsis; Th | 1987 |
Iron sepsis: Yersinia enterocolitica septicemia possibly caused by an overdose of iron.
Topics: Acute Disease; Deferoxamine; Diseases in Twins; Female; Humans; Infant; Iron; Male; Sepsis; Yersinia | 1987 |
The role of iron overload in Yersinia enterocolitica and Yersinia pseudotuberculosis bacteremia in hemodialysis patients.
Topics: Adult; Aged; Deferoxamine; Female; Ferritins; Humans; Iron; Male; Middle Aged; Renal Dialysis; Sepsi | 1987 |
Life-threatening sepsis complicating heavy metal chelation therapy with desferrioxamine.
Topics: Adult; Deferoxamine; Humans; Iron; Male; Renal Dialysis; Sepsis; Yersinia Infections | 1985 |